Complete Detoxification Kit

Complete Detoxification Kit

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  • Includes Curcumin Extreme (30 Servings); Timeless Prescription Oxygen Extreme (30 Servings) and NutriClean Hepatocleanse (30 Servings)

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Includes Curcumin Extreme (30 Servings); Timeless Prescription Oxygen Extreme (30 Servings) and NutriClean Hepatocleanse (30 Servings)
 

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Product Information

  • Save $25 compared to purchasing these products separately - a 26% savings!
  • Supports a healthy liver
  • Supports the body’s natural ability to produce detoxification enzymes, which scavenge harmful toxins in the body
  • Helps to cleanse and detoxify the liver and blood
  • Helps excrete toxins that accumulate over time
  • Provides strong antioxidant protection and protects the body from the negative effects of free radicals
  • Supports healthy immune function
  • Promotes apoptosis in unhealthy cells
  • Helps maintain healthy glutathione levels
  • Supports normal glutathione synthesis

Product Information

Complete Detoxification Kit

Toxins build up in our bodies over time through the air we breathe, the foods we eat and the stress we put our bodies under on a daily basis. While commercial detox products or a one-time detox supplement might offer temporary relief, taking care of toxic buildup inside the body doesn't happen overnight.

The master filter in our body - the liver - works to cleanse the body of these toxins to keep them from disrupting the normal functions and operations of the body; essentially, keeping you healthy. Unfortunately, the overabundance of toxins our bodies build up, causes undue stress on our liver; and often the liver can't keep up with the demand. It needs help to remove these toxins and keep you healthy.

To promote regular detoxification, we've created the Complete Detoxification Kit, a combination of three liver detox supplements - Timeless Prescription Oxygen Extreme, Curcumin Extreme, and NutriClean HepatoCleanse - that work synergistically to support overall liver health, promote normal cleansing and detoxification of the liver, and provide antioxidant support to keep your body - including the liver - healthy over time.

No other detox kit on the market contains the unique formulas and ingredients included in the detox supplements in the Complete Detoxification Kit. Plus, by purchasing the Complete Detoxification Kit instead of buying these detox supplements individually, you save 26% - a $25.00 value!

*These statements have not been evaluated by the Food and Drug Administration. This product(s) is not intended to diagnose, treat, cure or prevent any disease.

REVIEW SNAPSHOT®

by PowerReviews
Isotonix®Complete Detoxification Kit
 
5.0

(based on 1 review)

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(8 of 10 customers found this review helpful)

 
5.0

Amazing, just amazing!!

By EdwardB

from USA

Comments about Isotonix® Complete Detoxification Kit:

Finding this kit was an amazing life changer. I think everybody out there should look into this kit as a daily life and body enhancer. So many benefits from this kit and the savings are amazing!!

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Ingredients

Timeless Prescription® Oxygen Extreme™:

Vitamin A (Beta-Carotene) 5000 IU
Vitamin A is an anti-aging micronutrient of the highest order, standing firmly alongside vitamins C, E and the mineral selenium in its ability to help maintain health. Studies conducted over several years indicate that beta-carotene may play a significant role in helping to maintain overall health. Beta-carotene acts as a precursor of vitamin A and is, therefore, called a pro-vitamin A compound. Foods or supplements containing beta-carotene are converted to vitamin A for the maintenance of healthy skin, good vision and a robust immune system.

Vitamin C 200 mg 
Also called ascorbic acid, vitamin C helps to maintain healthy collagen in the skin, promotes normal healing, promotes healthy teeth and bones, and boosts the immune system. Vitamin C is one of the more powerful and well-known antioxidants. Just as exposing a cut from an apple to air causes it to quickly turn brown, cells of the body can also suffer when exposed to oxygen, a process known as oxidation. Oxidation causes aging of the skin, as well as all other organs and tissues of the body. Vitamin C, as a free-radical fighter, helps the body maintain its youthful qualities for longer periods of time.  

Vitamin E  30 IU 
Vitamin E supports the respiratory system. It also promotes a healthy immune system. Vitamin E protects the body from oxidation, a normal aging process by which oxygen breaks down the body’s tissues. It works to neutralize free radicals, which are naturally occurring unstable molecules that can damage the body’s healthy molecules by taking electrons to balance themselves. When enough vitamin E is present in the body, unstable free radicals get their electrons from the vitamin E molecules and leave the healthy molecules alone, thus promoting the health of tissues.

Selenium 200 mcg
 

Selenium is one of the most important micronutrients to include in a longevity-minded health regimen and is frequently cited by anti-aging specialists as an antioxidant that should be included on an anti-aging checklist. Selenium and vitamin E, another powerful antioxidant, are synergists, meaning they each improve the efficiency of the other. Moreover, selenium promotes the body’s production of glutathione peroxidase, the body's master antioxidant. Selenium is an essential trace mineral that works closely with vitamin E to provide the body with powerful antioxidant protection from free radicals. Selenium protects the body from free radicals in two ways: It is incorporated into proteins to make selenoproteins, which are important antioxidant enzymes, and it supports the body’s manufacture of its own natural antioxidant, glutathione.

Bilberry 25 mg 
Bilberry’s chief action as an antioxidant is its powerful synergy with vitamin E. On the most basic level, it supports the normal resistance of blood capillaries and promotes their impermeable nature. Bilberry anthocyanosides also supports the operation of crucial enzymes in the enzymes in the retinal cellular metabolism and function. It also supports a healthy heart. Bilberry promotes normal platelet activity.  

Green Tea Extract 300 mg 
Green tea extract is a health-promoting antioxidant. It is rich in polyphenols that have been shown to promote health.

Ginkgo Biloba 50 mg 
Ginkgo biloba helps to support memory, brain function, mood, cerebral and peripheral circulation, and oxygenation and blood flow.

Milk Thistle 50 mg 
Milk thistle is used to promote liver health. Contains some of the most potent liver-supporting substances known. Protects against free radicals by acting as an antioxidant, protecting the liver. Supports the normal production of new liver cells.  

Curcumin Extreme™:

Curcumin (BCM-95®) 400 mg
Scientists have long been aware of the wide array of health benefits from the Indian spice turmeric, which is a source of the active phytochemical curcumin. Until now, curcumin has been known to have poor bioavailability, requiring high doses to promote health. BCM-95® delivers significantly more pharmacologically bioactive curcumin into the blood than other curcumin sources. This new delivery system allows for a variety of health benefits.

How is this possible? Traditional 95 percent extract focuses strictly on one part of the Turmeric rhizome. This bioactive substance of turmeric (curcuma longa) contains “curcuminoids” and curcumin is the most important molecule. Research has shown its tremendous health benefit. Even though curcumin is the most important molecule, the bioavailability of the regular turmeric 95 percent extracts sold on the market is not very good in terms of uptake or sustainability in the blood stream. There are other essential components present in turmeric rhizome which have been neglected during the traditional method of manufacturing of turmeric 95 percent extract. BCM-95® represents the natural spectrum of turmeric rhizome. It is 100 percent natural and has been proven to provide optimal bioavailability for synergistic effect. This new method of manufacture offers tremendous value in terms of bioavailability.

Antioxidants have received increased attention, and it’s important to know what nutrients are antioxidants and information about them. One such nutrient is curcumin. Curcumin is a natural extract from the spice turmeric. Turmeric is derived from the plant curcuma longa, a member of the ginger family.

Curcumin is employed mostly as an antioxidant; though it was traditionally used to promote stomach and joint comfort. The immune-balancing activity of curcumin has been demonstrated through multiple mechanisms to support normal COX-2 and NF-KappaB levels in the body.

The neuroprotective properties of curcumin are among the most studied. Curcumin has been designated as a strong candidate for the promotion of neurological health and cognitive function. Curcumin can cross the blood-brain barrier and support the normal uptake of amyloid-beta in the brain. This supports the brain's memory and learning abilities as we age. Another neuroprotective property of curcumin is its ability to promote normal levels of glutathione, superoxide dismutase and catalase in the brain. This can help to maintain the health of neurological tissues.

Curcumin supports the normal production of Phase II liver detoxification enzymes, including glutathione synthase, heme-oxygenase and catalase. The liver plays several roles in detoxification: it filters the blood to remove large toxins, synthesizes and secretes bile full of cholesterol and other fat-soluble toxins, and enzymatically disassembles unwanted chemicals. This enzymatic process usually occurs in two steps referred to as phase I and phase II. They promote the body’s natural enzyme antioxidant defense systems and function as a powerful indirect antioxidant. These enzymes promote the body’s normal metabolism of harmful chemicals such as heavy metals, toxins and pollutants into less reactive molecules. Curcumin has also been shown to promote normal hepatic tissue repair.

Broccoli Seed Extract (6% Sulphoraphane Glucosinolates) 167 mg
The health benefits and protective properties of broccoli and other cruciferous vegetables have been well documented over the past 25 years. Broccoli seed extract is a powerful source of sulphoraphane glucosinolates. Sulforaphanes support the normal production of Phase II liver detoxification enzymes, including glutathione synthase, heme-oxygenase and catalase. Sulforaphanes promote the body’s natural enzyme antioxidant defense systems and function as a powerful indirect antioxidant. Sulphoraphanes work to support gene transcription, which is the process by which genetic information is copied from DNA to RNA, resulting in a specific protein formation. Conclusively, sulphoraphanes work to support the body’s natural defense systems and to maintain elevated levels of glutathione.

Glutathione is the master antioxidant of the body. It is an important chemical that acts as a powerful antioxidant to preserve and protect the brain and other body tissues by protecting them from the damage of free radicals. It also acts to recycle vitamin C and E, which also reduce free radicals. Since glutathione cannot be absorbed intact orally due to gastrointestinal degradation, sulphoraphane supplementation may be the most effective way to increase endogenous glutathione concentration.

Selenium (Selenomethionine) 100 mcg
Selenium is a required cofactor for selenoproteins, such as glutathione peroxidase. Selenomethionine is incorporated directly into proteins because selenomethionine cannot be distinguished from methionine during the translation of mRNA into protein. This serves as a storage form of selenium and is liberated upon protein catabolism. Selenium accumulates in the prostate, promoting the health of the prostate. Selenium supports immune function by promoting normal growth and development of T helper cells.

NutriClean® HepatoCleanse:

Milk Thistle Seed (extract standardized to 80% silymarin)
Milk thistle promotes liver and gallbladder health by providing free-radical scavenging activity, stimulation of liver cell regeneration and prevention of toxin uptake by the liver cells. It has been seen to demonstrate strong protective activity when liver cells are challenged by a variety of toxins. Milk thistle supports the regeneration of damaged liver tissue, supports healthy liver and bile cholesterol, and helps limit liver damage as a result of disrupted oxygen supply. Milk thistle contains a compound called silymarin, a potent antioxidant that scavenges harmful free radicals. It has been found to also have a renewing effect on the kidneys and may be beneficial for the prostate gland. The name silymarin is a general term for the active chemicals, known as flavonolignans, which are found only in the seeds of milk thistle plant. Silymarin, as well as an isolated form of flavonolignan called silybin, has a particular effect in the liver where it can support a healthy liver by reducing or preventing damage by toxins, such as alcohol, environmental and bacterial toxins, and poisons. There is preliminary evidence that silymarin may support healthy serum transaminase levels and liver health. There have been many studies that indicate silymarin's effectiveness in cleansing the liver. 

N-Acetyl-L-cysteine
N-Acetyl Cysteine (NAC) is derived from the sulfur-containing amino acid, cysteine. It is produced naturally in the body and is found in foods. NAC mediates (along with glutamic acid and glycine) the conversion of cysteine into glutathione. Glutiathione is one of the body's primary cellular antioxidants. NAC has been indicated to enhance the immune system, detoxify heavy metals, support a healthy heart, relieve hangover symptoms and reduce exercise fatigue. It is thought that NAC's suggested benefits come from either of its two primary actions in the body. First, NAC is quickly metabolized to intracellular glutathione. Glutathione (GTH), and the enzyme complexes that it forms, acts as reducing agents and antioxidants in the body. GTH also detoxifies chemicals into less harmful compounds, as well as detoxifying heavy metals, such as mercury and lead. GTH is also known to aid in the transport of nutrients to lymphocytes and phagocytes, two major types of immune cells, and to protect cell membranes. NAC is thought to be the best source method of boosting cellular GTH levels. NAC cleaves disulfide bonds by converting them to two sulfhydryl groups. This results in the breakup of mucoproteins in lung mucus, reducing their chain lengths and thinning the mucus. Further, NAC has also been shown to support healthy platelet aggregation and supports healthy lipoprotein levels. 

Several studies have confirmed that NAC is converted to glutathione in the body. Reviews of these studies show that oral NAC supplementation was successful in enhancing the levels of glutathione in the liver, in plasma and in the bronchioles of the lungs. NAC has also been shown to help reduce levels of fatigue and improve ability for muscle contraction during exhaustive exercise (possibly due to reduced levels of oxidative stress).

Dandelion Root  
The dandelion, the common stubborn plant of many front lawns, is an unusually nutritious food. Its leaves contain substantial amounts of vitamin A, as well as moderate amounts of vitamin D, vitamin C, various B vitamins, iron, silicon, magnesium, zinc and manganese. Dandelion takes its name from the French dent de lion, or lion's tooth - a reference to the toothed edges of its leaves. Dandelion root has been shown to support healthy liver, kidney, gallbladder and joints. 

Dandelion root is regarded as a "liver tonic," a substance believed to support the liver in an unspecified way. The bitter properties of dandelion help to support healthy bile production in the gallbladder and bile flow from the liver. These compounds are unique to the dandelion plant and were previously referred to as taraxacin. These constituents are sesquiterpene lactones of the eudesmanolide and germacranolide classification. The bitters from dandelion are recommended to speed up slow liver function. The increase in bile flow may also help support healthy fat (including cholesterol) metabolism in the body. Dandelion root is also used like other bitter herbs to help support a healthy appetite and support a healthy digestive system.

Garlic Bulb
Garlic was used in China as early as A.D. 510. Louis Pasteur studied the antibacterial action of garlic in 1858. These days it is largely used because it exerts a positive effect on the cardiovascular system. Garlic experts agree that the herb does support healthy cholesterol levels which, in turn, fights hardening of the arteries. It may also support healthy triglyceride levels. Garlic also has some antioxidant properties. 

Hawthorn Berry Extract
Hawthorn, or Crataegus oxyacantha, grows as a thorny shrub with white or pink flowers and berries that resemble miniature apples. This shrub is native to northern temperate climates in Asia, Europe and eastern North America. Hawthorn has been used in China for centuries for digestion and other ailments. As early as the Renaissance, Europeans have used this supplement for digestive ailments; beginning in the late 1800s, doctors in Europe began to use hawthorn to promote a healthy heart. More recently, hawthorn has been used as a cardiotonic (to strengthen the heart muscle and promote more forceful contractions). The main benefit of hawthorn seems to be in heart health. Hawthorn contains a group of chemicals known as flavonoids, the main group of components in this plant, thought to work together to support the heart in several ways. First, hawthorn extract can support health vessels of the heart, improving blood flow. Hawthorn supports healthy blood pressure. As an antioxidant, hawthorn helps to maintain healthy collagen matrices of arterial walls so that the vessels maintain elasticity.

Schizandra Chinensis Fruit and Seed Extract
Schizandra has an extensive history in ancient Chinese medicine as an herb promoting general well-being and vitality. Schizandra originates from the red berries that grow on a vine-like plant belonging to the magnolia family. Approximately 25 species of schizandra exist, and all are indigenous to Asia except for a rare form of the vine that grows in wooded areas in North Carolina and surrounding states. In addition to its traditional uses for increasing energy and helping decrease stress-induced fatigue, schizandra has traditionally been taken to strengthen the sex organs, to promote mental function, to beautify the skin and to treat night sweats. It promotes liver and kidney health, enhances aerobic capacity and energy levels, helps with vision, and supports mental functioning. 

Schizandra is part of the adaptogen family made up of compounds believed to promote balance in the body. Schizandra contain lignans, which are a concentrated component of the seeds of the schisandra berry that may stimulate the immune system, protect the liver and increase the body's ability to cope with stress.

Yellow Dock Root
Yellow dock is related to the buckwheat family that is native to northern Europe and Asia, but its ability to adjust to various climates has allowed it to spread to many parts of the world. It is also known as curly dock because of the shape of its leaves, or sour dock, due to its bitter taste. In ancient times, the Chinese and Romans used yellow dock as a digestive aid and for skin conditions. Today, it can be found in many forms, and is still used for skin conditions, as well as a mild laxative and for liver conditions. Yellow dock helps support a healthy digestive system. It stimulates the appetite, increasing bile flow and enhancing digestion. Like other popular herbal laxatives, aloe and senna, yellow dock also contains anthraquinone glycosides, contributing to the herb's frequent usage as a laxative to support healthy bowel movements. The tannins in yellow dock also give it a digestive bitter quality that could stimulate appetite and bile flow, supporting the removal of toxic metabolites that could contribute to poor digestion.

Burdock Root
Burdock is a well-respected medicinal herb. It was used to support healthy joints and a healthy digestive system. Burdock root also contains high amounts of inulin and mucilage. This may explain its soothing effects on the gastrointestinal tract. Plus, burdock has been shown to support a healthy liver. Burdock is widely used in the treatment of scaly, dry skin conditions. 

Licorice Root
Licorice root has long been used in both foods and medicine. In Chinese medicine, licorice is an ingredient in nearly all herbal formulas. Among its most prominent uses are as a demulcent (soothing, coating agent) in the digestive and urinary tracts.

Barberry Bark and Root
Barberry has been used extensively throughout the world for its healing properties.  Berberine is isolated from the roots and bark of Berberis vulgaris. Berberine is a plant alkaloid with a long history of medicinal use in both Ayurvedic and Chinese medicine. Berberine inhibits the growth of many microorganisms. Berberine is also a key constituent of the immune enhancing herb, goldenseal (Hydrastis canadensis). Berberine hinders bacteria from attaching to human cells, thus helping to support a healthy immune system. This compound also supports healthy bowel movements.  Berbamine is another alkaloid found in barberry. It is an antioxidant. The bitter compounds present in barberry, including the alkaloids mentioned above, bring about enhanced digestion. Additionally, barberry has shown to support healthy liver and gallbladder functions.

Rosemary Leaf
Herbalists have long used rosemary as an energy booster for the elderly and to help with indigestion. In China its used for head discomfort. Rosemary has been used to support a healthy appetite, healthy blood pressure, liver and gallbladder. Germany's Commission E has even approved rosemary leaf for support of dyspepsia (non-specific digestive distress). Some less-than-conclusive evidence hints that rosemary, or its constituents, may have antioxidant effects. 

Ginger Root
Ginger is a shoot-like plant with a single, purple-green flower that contains a thick root from which uses for this plant originate. It is native to coastal India, but it now grows and is harvested in Jamaica, China, Africa and the West Indies. The root is the source of ginger's aroma and is also the source of the spice. Ginger has been used for years to support healthy gastrointestinal health and to support healthy bowel movements. Its health benefits include the alleviation of motion sickness and nausea. Ginger also supports a healthy cardiovascular system.

Green Tea Leaf Extract 
Green tea has been used medicinally for centuries in India and China. A number of beneficial health effects are related to regular consumption of green tea, and dried/powdered extracts are available as a part of dietary supplements. Green tea is prepared by picking, lightly steaming and allowing the leaves to dry. The active components in green tea are a family of polyphenols (catechins) and flavonols which possess potent antioxidant activity. Tannins, large polyphenol molecules, form the bulk of the active compounds in green tea, with catechins comprising nearly 90 percent. Several catechins are present in major quantities: epicatechin (EC), epigallocatechin (EGC), epicatechin gallate (ECG) and epigallocatechin gallate (EGCG). EGCG makes up around 10-50 percent of the total catechin content and appears to be the most powerful of all the catechins - with antioxidant activity about 25-100 times more powerful than vitamins C and E. Green tea extract is reported to have positive effects, including cardiovascular system support via supporting healthy cholesterol levels and triglycerides levels. It is a potent immune enhancer and has been found to be a potent energy promoter. Recent studies have suggested that catechins may be important in promoting weight loss. In some studies, green tea is associated with a mild increase in thermogenesis (increased caloric expenditure), which is generally attributed to its caffeine content. At least one study has shown that green tea extract stimulates thermogenesis to an extent that is much greater than can be attributed to its caffeine content per se, meaning that the thermogenic properties of green tea may be due to an interaction between its high content of catechin-polyphenols along with caffeine. A probable theory for the thermogenic effect of green tea is an increase in levels of norepinephrine because catechin-polyphenols are known to inhibit catechol-O-methyl-transferase (the enzyme that degrades norepinephrine).

Hyssop (aerial parts)
The herb hyssop, also known as Hyssop officinalis, has been used for ages in both the religious and medical arenas. A two-foot high evergreen shrub with dark blue flowers, hyssop grows naturally throughout the Mediterranean region but is also cultivated elsewhere. Hyssop has been used to treat a wide spectrum of digestive problems. The volatile oils are believed to contribute to hyssop's carminative actions and use for mild cramping and discomfort in the digestive tract, including stomach aches and intestinal gas.

Red Clover Flower
Red clover is a member of the legume (bean) family - the same class of plants as chickpeas and soybeans. Red clover was, and is, considered one of the premier purifying herbs for the blood. Red clover extracts are used as dietary supplements for their high content of isoflavone compounds. These compounds have proven to be of some benefit for women going through menopause due to their ability to mimic the activities of estrogen within the body. A double-blind trial found that red clover supported a healthy cardiovascular system in menopausal women. It is claimed that red clover can balance moods, support healthy sleeping patterns, reduce hot flashes, improve libido, support heart health and promote the maintenance of bone mass.     

Turmeric Root Extract
Turmeric is part of the ginger family. Its stalk is used in both food and medicine, creating the common yellow ingredient that colors and adds flavor to curry. In traditional Indian Ayurveda, turmeric is thought to support general body strength, vision and stimulate milk secretion. Within dietary supplements, turmeric is found alone and in combination with products created to exert antioxidant activity, and provide gastrointestinal protection and support. The primary active compounds in turmeric are the flavonoid, curcumin and related "curcuminoid" compounds, which deliver potent antioxidant properties. As a part of the Nutriclean system, turmeric exerts positive effects with regards to indigestion

Science

Timeless Prescription® Oxygen Extreme™: 

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  • Lasse, M., et al.  Anthocyanins Induce Cell Cycle Perturbations and Apoptosis in Different Human Cell Lines.  Carcinogenesis.  25(8): 1427-1433, 2004.
  • Li, L., et al. Silibinin Prevents UV-Induced HaCaT Cell Apoptosis Partly through Inhibition of Caspase-8 Pathway.  Biological & Pharmaceutical Bulletin.  29(6): 1096-1101, 2006.
  • Logan, A. and Wong, C. Chronic Fatigue Syndrome: Oxidative Stress and Dietary Modifications.  Alternative Medicine Review.  6(5): 450-459, 2001.
  • Manna, S.  Silymarin Suppresses TNF-induced Activation of NF-kappa B, c-Jun N-terminal Kinase, and Apoptosis.  Journal of Immunology.  163(12): 6800-6809, 1999.
  • Mantena, S., et al.  Orally Administered Green Tea Polyphenols Prevent Ultraviolet Radiation-Induced Skin Cancer in Mice through Activation of Cytotoxic T Cells and Inhibition of Angiogenesis in Tumors.  Journal of Nutrition.  135: 2871-2877, 2005.
  • Mayne, S.  Antioxidant Nutrients and Chronic Disease: Use of Biomarkers of Exposure and Oxidative Stress Status in Epidemiologic Research.  Journal of Nutrition.  133: 933S-940S, 2003.
  • Mayne, S.  Antioxidant Nutrients and Chronic Disease: Use of Biomarkers of Exposure and Oxidative Stress Status in Epidemiologic Research.  Journal of Nutrition.  133: 933S-940S, 2003.
  • McArdle, F., et al. Effects of Oral Vitamin E and ß-carotene Supplementation on Ultraviolet Radiation–induced Oxidative Stress in Human Skin.  American Journal of Clinical Nutrition.  80(5): 1270-1275, 2004.
  • Nakajima, J., et al. LC/PDA/ESI-MS Profiling and Radical Scavenging Activity of Anthocyanins in Various Berries.  Journal of Biomedicine and Biotechnology.  2004(5): 241-247, 2004.
  • Ogasawara, M., et al.   Differential Effects of Antioxidants on the In Vitro Invasion, Growth and Lung Metastasis of Murine Colon Cancer Cells.  Biological & Pharmaceutical Bulletin.  30(1):200-204, 2007.
  • Ohta, Y., et al.  Effect of Oral Vitamin E Administration on Acute Gastric Mucosal Lesion Progression in Rats Treated with Compound 48/80, a Mast Cell Degranulator.  Biological & Pharmaceutical Bulletin. 29 (4):675-683, 2006.
  • Paleologos, M., et al. Cohort Study of Vitamin C Intake and Cognitive Impairment. American Journal of Epidemiology. 148(1):45-50, 1998.
  • Park, Y., et al.  Preventive Effect of Ginkgo biloba Extract (GBB) on the Lipopolysaccharide-induced Expressions of Inducible Nitric Oxide Synthase and Cyclooxygenase-2 via Suppression of Nuclear Factor-kappaB in RAW 264.7 Cells.  Biological & Pharmaceutical Bulletin.  29(5): 985-990, 2006.
  • Pence, B., et al.  Effects of Dietary Selenium on UVB-Induced Skin Carcinogenesis and Epidermal Antioxidant Status.  Journal of Investigative Dermatology.  102: 759-761, 1994.
  • Placzek, M., et al.  Ultraviolet B-Induced DNA Damage in Human Epidermis Is Modified by the Antioxidants Ascorbic Acid and D-alpha-Tocopherol.  Journal of Investigative Dermatology.  124: 304-307, 2005.
  • Ravindranath, M., et al.  Epicatechins Purified from Green Tea (Camellia Sinensis) Differentially Suppress Growth of Gender-Dependent Human Cancer Cell Lines.  Evidence Based Complementary and Alternative Medicine.  3(2): 237-247, 2006.
  • Ruggiero, P., et al.  Red Wine and Green Tea Reduce H pylori- or VacA-induced Gastritis in a Mouse Model.  World Journal of Gastroenterology.  13(3): 349-354, 2007.
  • Salonen, R., et al. Six-Year Effect of Combined Vitamin C and E Supplementation on Atherosclerotic Progression: The Antioxidant Supplementation in Atherosclerosis Prevention (ASAP) Study. Circulation. 107: 947 – 953, 2003.
  • Sato, Y., et al.  The Feeding of ?-Carotene Down-Regulates Serum IgE Levels and Inhibits the Type I Allergic Response in Mice.  Biological & Pharmaceutical Bulletin.  27(7): 978-984, 2004.
  • Shen, X., et al.  Effects of Dietary Supplementation with Vitamin E and Selenium on Rat Hepatic Stellate Cell Apoptosis. World Journal of Gastroenterology.  11(32): 4957-4961, 2005.
  • Simon, J., et al.  Relation of Serum Ascorbic Acid to Mortality among US Adults. Journal of the American College of Nutrition. 20: 255-263, 2001.
  • Singh, R., et al. Dietary feeding of Silibinin Inhibits Advance Human Prostate Carcinoma Growth in Athymic Nude Mice and Increases Plasma Insulin-like Growth Factor-binding Protein-3 Levels. Cancer Research. 62(11): 3063-3069, 2002.
  • Sparrow, J., et al. A2E-epoxides Damage DNA in Retinal Pigment Epithelial Cells. Vitamin E and Other Antioxidants Inhibit A2E-epoxide Formation.  Journal of Biological Chemistry. 278(20): 18207-18213, 2003.
  • Trevithick-Sutton, C., et al.  The Retinal Carotenoids Zeaxanthin and Lutein Scavenge Superoxide and Hydroxyl Radicals: A ChemilumInescence and ESR Study. Molecular Vision.  12: 1127-1135, 2006.
  • Tyagi, A., et al. Silibinin Strongly Synergizes Human Prostate Carcinoma DU145 Cells to Doxorubicin-induced Growth Inhibition, G2-M Arrest, and Apoptosis. Clinical Cancer Research. 8(11): 3512-3119, 2002.
  • Vahlquist, A., et al.  Vitamin A in Human Skin: II Concentrations of Carotene, Retinol and Dehydroretinol in Various Components of Normal Skin.  Journal of Investigative Dermatology.  79: 94-97, 1982.
  • van der Brandt, P., et al.  Toenail Selenium Levels and the Subsequent Risk of Prostate Cancer:  a Prospective Cohort Study.  Cancer Epidemiology Biomarkers & Prevention.  12: 866-871, 2003.
  • van Rooij, J., et al.  Oral Vitamins C and E as Additional Treatment in Patients with Acute Anterior Uveitis: a Randomised Double Masked Study in 145 Patients.  British Journal of Ophthalmology.  83: 1277-1282, 1999.
  • Varghese, L., et al. Silibinin Efficacy against Human Hepatocellular Carcinoma.  Clinical Cancer Research.  11: 8441-8448, 2005.
  • Wang, Z., et al.  Inhibitory Effects of Black Tea, Green Tea, Decaffeinated Black Tea, and Decaffeinated Green Tea on Ultraviolet B Light-induced Skin Carcinogenesis in 7,12-Dimethylbenz[a]anthracene-initiated SKH-1 Mice.  Cancer Research. 54(13): 3428-3435, 1994.
  • Wei, W., et al.  Prospective Study of Serum Selenium Concentrations and Esophageal and Gastric Cardia Cancer, Heart Disease, Stroke, and Total Death. American Journal of Clinical Nutrition. 79(1): 80-85, 2004.
  • Wertz, K., et al. -Carotene Interferes with Ultraviolet Light A-Induced Gene Expression by Multiple Pathways. Journal of Investigative Dermatology.  124: 428-434, 2005.
  • Xu, A., et al.  Therapeutic Mechanism of Ginkgo biloba Exocarp Polysaccharides on Gastric Cancer.  World Journal of Gastroenterology.  9(11): 2424-2427, 2003.
  • Yoshida, M., et al.  Combined Effect of Vitamin E and Insulin on Cataracts of Diabetic Rats Fed a High Cholesterol Diet.  Biological & Pharmaceutical Bulletin.  27(3): 338-344, 2004.
  • You, W. Gastric Dysplasia and Gastric Cancer: Helicobacter pylori, Serum Vitamin C, and Other Risk Factors. Journal of the National Cancer Institute.  92(19): 1607-1612, 2000.
  • Zhang, X., et al. Effect of Tea Polyphenol on Cytokine Gene Expression in Rats with Alcoholic Liver Disease.  Hepatobiliary & Pancreatic Disease International.  5(2): 268-272, 2006.
  • Zhou, B., et al. Silibinin Protects Rat Cardiac Myocyte from Isoproterenol-Induced DNA Damage Independent on Regulation of Cell Cycle.  Biological & Pharmaceutical Bulletin.  29(9): 1900-1905, 2006.
  • Zigman, S.  Effects of Green Tea Polyphenols on Lens Photooxidative Stress.  Biological Bulletin.  197: 285-286, 1999.

 Curcumin Extreme™:

  • Araujo, C. and Leon, L. Biological activities of Curcuma longa L. Memorias do Instituto Oswaldo Cruz. 96(5): 723-728, 2001.
  • Bhattacharyya, S., et al. Curcumin prevents tumor-induced T cell apoptosis through Stat-5a-mediated Bcl-2 induction. Journal of Biological Chemistry. 282(22): 15954-15964.
  • Biswas, S., et al. Curcumin induces glutathione biosynthesis and inhibits NF-kappaB activation and interleukin-8 release in alveolar epithelial cells: mechanism of free radical scavenging activity. Antioxidants and Redox Signaling. 7(1-2): 32-41, 2005.
  • Cheng, Y., et al. Effects of curcumin on peroxisome proliferator-activated receptor gamma expression and nuclear translocation/redistribution in culture-activated rat hepatic stellate cells. Chinese Medical Journal. 120(9): 794-801, 2007.
  • Churchill, M., et al. Inhibition of intestinal tumors by curcumin is associated with changes in the intestinal immune cell profile. Journal of Surgical Research. 89(2): 169-175, 2000.
  • Cornblatt, B., et al. Preclinical and clinical evaluation of sulforaphane for chemoprevention in the breast. 28(7): 1485-1490, 2007.
  • Dairam, A., et al. Curcuminoids, curcumin, and demethoxycurcumin reduce lead-induced memory deficits in male Wistar rats. Journal of Agricultural and Food Chemistry. 55(3): 1039-1044, 2007.
  • Dickinson, D., et al. Curcumin alters EpRE and AP-1 binding complexes and elevates glutamate-cysteine ligase gene expression. FASEB. 17(3): 473-475, 2003.
  • Fahey, J., et al. Sulforaphane inhibits extracellular, intracellular, and antibiotic-resistant strains of Helicobacter pylori and prevents benzo[a]pyrene-induced stomach tumors. Proceedings of the National Academy of Sciences of the United States of America. 99(11): 7610-7615, 2002.
  • Farombi, E., et al. Curcumin attenuates dimethylnitrosamine-induced liver injury in rats through Nrf2-mediated induction of heme oxygenase-1. Food and Chemical Toxicology. 46(4): 1279-1287, 2008.
  • Funk, J., et al. Turmeric extracts containing curcuminoids prevent experimental rheumatoid arthritis. Journal of Natural Products. 69(3): 351-355, 2006.
  • Gao, X. and Talalay, P. Induction of phase 2 genes by sulforaphane protects retinal pigment epithelial cells against photooxidative damage. Proceedings of the National Academy of Sciences of the United States of America. 101(28): 10446-10451, 2004.
  • Garcia-Alloza, M., et al. Curcumin labels amyloid pathology in vivo, disrupts existing plaques, and partially restores distorted neurites in an Alzheimer mouse model. Journal of Neurochemistry. 102(4): 1095-1104, 2007.
  • Higdon, J., et al. Cruciferous vegetables and human cancer risk: epidemiologic evidence and mechanistic basis. Pharmacological Research. 55(3): 224-236, 2007.
  • Howells, L., et al. Comparison of oxaliplatin- and curcumin-mediated antiproliferative effects in colorectal cell lines. International Journal of Cancer. 121(1): 175-183, 2007.
  • Jagetia, G. and Aggarwal, B. "Spicing up" of the immune system by curcumin. Journal of Clinical Immunology. 27(1): 19-35, 2007.
  • Johnson, J., et al. Curcumin for chemoprevention of colon cancer. Cancer Letters. 255(2): 170-181, 2007.
  • Juge, N., et al. Molecular basis for chemoprevention by sulforaphane: a comprehensive review. Cellular and Molecular Life Sciences. 64(9): 1105-1127, 2007.
  • Kaur, G., et al. Inhibition of oxidative stress and cytokine activity by curcumin in amelioration of endotoxin-induced experimental hepatoxicity in rodents. Clinical and Experimental Immunology. 145(2): 313-321, 2006.
  • Kim, G., et al. Curcumin inhibits immunostimulatory function of dendritic cells: MAPKs and translocation of NF-kappa B as potential targets. Journal of Immunology. 174(12): 8116-8124, 2005.
  • Kurup, V., et al. Immune response modulation by curcumin in a latex allergy model. Clinical and Molecular Allergy. 5: 1, 2007.
  • Lim, G., et al. The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse. Journal of Neuroscience. 21(21): 8370-8377, 2001.
  • Lin, J. Molecular targets of curcumin. Advances in Experimental Medicine and Biology. 595: 227-243, 2007.
  • Magalska, A., et al. Curcumin induces cell death without oligonucleosomal DNA fragmentation in quiescent and proliferating human CD8+ cells. Acta Biochimica Polonica. 53(3): 531-538, 2006.
  • Maheshwari, R., et al. Multiple biological activities of curcumin: a short review. Life Sciences. 78(18): 2081-2087, 2006.
  • Mathuria, N. and Verma, R. Ameliorative effect of curcumin on aflatoxin-induced toxicity in DNA, RNA and protein in liver and kidney of mice. Acta Poloniae Pharmaceutica. 64(6): 497-502, 2007.
  • Monograph. Curcuma longa (turmeric). Alternative Medicine Review. 6(suppl): S62-S66, 2001.
  • Morimitsu, Y., et al. A sulforaphane analogue that potently activates the Nrf2-dependent detoxification pathway. Journal of Biological Chemistry. 277(5): 3456-3463, 2002.
  • Myzak, M. and Dashwood, R. Chemoprotection by sulforaphane: keep one eye beyond Keap1. Cancer Letters. 233(2): 208-218, 2006.
  • Myzak, M., et al. Sulforaphane inhibits histone deacetylase in vivo and suppresses tumorigenesis in Apc-minus mice. FASEB. 20(3): 506-508, 2006.
  • Naik, R., et al. Protection of liver cells from ethanol cytotoxicity by curcumin in liver slice culture in vitro. Journal of Ethnopharmacology. 95(1): 31-37, 2004.
  • Nanji, A., et al. Curcumin prevents alcohol-induced liver disease in rats by inhibiting the expression of NF-kappa B-dependent genes. American Journal of Physiology. 284(2): G321-G327, 2003.
  • Ng, T., et al. Curry consumption and cognitive function in the elderly. American Journal of Epidemiology. 164(9): 898-906, 2006.
  • Nishinaka, T., et al. Curcumin activates human glutathione S-transferase P1 expression through antioxidant response element. Toxicology Letters. 170(3): 238-247, 2007.
  • Noyan-Ashraf, M., et al. Dietary approach to decrease aging-related CNS inflammation. Nutritional Neuroscience. 8(2): 101-110, 2005.
  • O’Connell, M. and Rushworth, S. Curcumin: potential for hepatic fibrosis therapy? British Journal of Pharmacology. 153(3): 403-405, 2007.
  • Osawa, T. Nephroprotective and hepatoprotective effects of curcuminoids. Advances in Experimental Medicine and Biology. 595: 407-423, 2007.
  • Pal, S., et al. Amelioration of immune cell number depletion and potentiation of depressed detoxification system of tumor-bearing mice by curcumin. Cancer Detection and Prevention. 29(5): 470-478, 2005.
  • Pari, L. and Amali, D. Protective role of tetrahydrocurcumin (THC) an active principle of turmeric on chloroquine induced hepatotoxicity in rats. Journal of Pharmacy and Pharmaceutical Sciences. 8(1): 115-123, 2005.
  • Perkins, S., et al. Chemopreventive efficacy and pharmacokinetics of curcumin in the min/+ mouse, a model of familial adenomatous polyposis. Cancer Epidemiology, Biomarkers, and Prevention. 11(6): 535-540, 2002.
  • Rushworth, S., et al. Role of protein kinase C delta in curcumin-induced antioxidant response element-mediated gene expression in human monocytes. Biochemical and Biophysical Research Communications. 341(4): 1007-1016, 2006.
  • Salvioli, S., et al. Curcumin in cell death processes: A challenge for CAM of age-related pathologies. Evidence-based Complementary and Alternative Medicine. 4(2): 181-190, 2007.
  • Scapagnini, G., et al. Curcumin activates defensive genes and protects neurons against oxidative stress. Antioxidants and Redox Signaling. 8(3-4): 395-403, 2006.
  • Shen, G., et al. Modulation of nuclear factor E2-related factor 2-mediated gene expression in mice liver and small intestine by cancer chemopreventive agent curcumin. Molecular and Cancer Therapeutics. 5(1): 39-51, 2006.
  • Shen, S., et al. Protective effect of curcumin against liver warm ischemia/reperfusion injury in rat model is associated with regulation of heat shock protein and antioxidant enzymes. World Journal of Gastroenterology. 13(13): 1953-1961, 2007.
  • Shishodia, S., et al. Curcumin: getting back to the roots. Annals of the New York Academy of Sciences. 1056: 206-217, 2005.
  • Shu, J., et al. The study of therapeutic effects of curcumin on hepatic fibrosis and variation of correlated cytokine. Journal of Chinese Medicinal Materials. 30(11): 1421-1425, 2007.
  • Shu, J., et al. Therapeutic effects of curcumin treatment on hepatic fibrosis. Chinese Journal of Hepatology. 15(10): 753-757, 2007.
  • Shukla, P., et al. Protective effect of curcumin against lead neurotoxicity in rat. Human and Experimental Toxicology. 22(12): 653-658, 2003.
  • Smith, T., et al. Allyl-isothiocyanate causes mitotic block, loss of cell adhesion and disrupted cytoskeletal structure in HT29 cells. Carcinogenesis. 25(8): 1409-1415, 2004.
  • Srinivasan, M., et al. Protective effect of curcumin on gamma-radiation induced DNA damage and lipid peroxidation in cultured human lymphocytes. Mutation Research. 611(1-2): 96-103, 2006.
  • Tang, L., et al. Potent activation of mitochondria-mediated apoptosis and arrest in S and M phases of cancer cells by a broccoli sprout extract. Molecular Cancer Therapeutics. 5(4): 935-944, 2006.
  • Thangapazham, R., et al. Multiple molecular targets in cancer chemoprevention by curcumin. AAPS Journal. 8(3): E443-E449, 2006.
  • Thejass, P. and Kuttan, G. Antimetastatic activity of Sulforaphane. Life Sciences. 78(26): 3043-3050, 2006.
  • Thejass, P. and Kuttan, G. Augmentation of natural killer cell and antibody-dependent cellular cytotoxicity in BALB/c mice by sulforaphane, a naturally occurring isothiocyanate from broccoli through enhanced production of cytokines IL-2 and IFN-gamma. Immunopharmacology and Immunotoxicology. 28(3): 443-457, 2006.
  • Thejass, P. and Kuttan, G. Immunomodulatory activity of Sulforaphane, a naturally occurring isothiocyanate from broccoli (Brassica oleracea). Phytomedicine. 14(7-8): 538-545, 2007.
  • Wakabayashi, N., et al. Protection against electrophile and oxidant stress by induction of the phase 2 response: fate of cysteines of the Keap1 sensor modified by inducers. Proceedings of the National Academy of Sciences of the United States of America. 101(7): 2040-2045, 2004.
  • Wei, Q., et al. Inhibition of lipid peroxidation and protein oxidation in rat liver mitochondria by curcumin and its analogues. Biochimica et Biophysica Acta. 1760(1): 70-77, 2006.
  • Wu, A., et al. Dietary curcumin counteracts the outcome of traumatic brain injury on oxidative stress, synaptic plasticity, and cognition. 197(2): 309-317, 2006.
  • Xu, Y., et al. Curcumin reverses the effects of chronic stress on behavior, the HPA axis, BDNF expression and phosphorylation of CREB. Brain Research. 1122(1): 56-64, 2006.
  • Yadav, V., et al. Immunomodulatory effects of curcumin. Immunopharmacology and Immunotoxicology. 27(3): 485-497, 2005.
  • Yang, F., et al. Curcumin inhibits formation of amyloid beta oligomers and fibrils, binds plaques, and reduces amyloid in vivo. Journal of Biological Chemistry. 280(7): 5892-5901, 2005.
  • Ye, S., et al. Effect of curcumin on the induction of glutathione S-transferases and NADP(H):quinone oxidoreductase and its possible mechanism of action. Acta Pharmaceutica Sinica. 42(4): 376-380, 2007.
  • Zhang, L., et al. Curcuminoids enhance amyloid-beta uptake by macrophages of Alzheimer's disease patients. Journal of Alzheimer’s Disease. 10(1): 1-7, 2006.
  • Zheng, S. and Chen, A. Curcumin suppresses the expression of extracellular matrix genes in activated hepatic stellate cells by inhibiting gene expression of connective tissue growth factor. American Journal of Physiology. 290(5): G883-G893, 2006.
  • Zheng, S. and Chen, A. Disruption of transforming growth factor-beta signaling by curcumin induces gene expression of peroxisome proliferator-activated receptor-gamma in rat hepatic stellate cells. American Journal of Physiology. 292(1): G113-G123, 2007.
  • Zheng, S., et al. De novo synthesis of glutathione is a prerequisite for curcumin to inhibit hepatic stellate cell (HSC) activation. Free Radical Biology and Medicine. 43(3): 444-453, 2007.

NutriClean® HepatoCleanse:

  • Varghese, L., et al. Silibinin Efficacy against Human Hepatocellular Carcinoma. Clinical Cancer Research.  11: 8441-8448, 2005.
  • Rainone, F.  Milk Thistle.  American Family Physician.  72(7): 1285-1288,2005.
  • Kidd, P. and Head, K.  A Review of the Bioavailability and Clinical Efficacy of Milk Thistle Phytosome: a Silybin-Phosphatidylcholine Complex (Siliphos). .  Alternative Medicine Review.  10(3): 193-203, 2005.
  • Luper, S. A Review of Plants Used in the Treatment of Liver Disease: Part Two.  Alternative Medicine Review.  4(3): 178-188, 1999.
  • Cetinkaya, A., et al.  N-Acetylcysteine Ameliorates Methotrexate-Induced Oxidative Liver Damage in Rats. Medical Science Monitor. 12(8): 274-278, 2006.
  • Pal, R., et al. Effect of Garlic on Isoniazid and Rifampicin-Induced Hepatic Injury in Rats.  World Journal of Gastroenterology. 12(4); 636-639, 2006.
  • Kidd, P. and Head, K.  A Review of the Bioavailability and Clinical Efficacy of Milk Thistle Phytosome: a Silybin-Phosphatidylcholine Complex (Siliphos). Alternative Medical Review.  10(3): 193-203, 2005.
  • Luper, S. A Review of Plants Used in the Treatment of Liver Disease: Part One.  Alternative Medicine Review.  3(6): 410-421, 1998.
  • Pal, R., et al. Effect of Garlic on Isoniazid and Rifampicin-Induced Hepatic Injury in Rats.  World Journal of Gastroenterology. 12(4); 636-639, 2006.
  • Cetinkaya, A., et al.  N-Acetylcysteine Ameliorates Methotrexate-Induced Oxidative Liver Damage in Rats. Medical Science Monitor. 12(8): 274-278, 2006.
  • Pal, R., et al. Effect of Garlic on Isoniazid and Rifampicin-Induced Hepatic Injury in Rats.  World Journal of Gastroenterology. 12(4); 636-639, 2006.
  • Kren, V. and Walterova, D.  Silybin and Silymarin--New Effects and Applications. Biomedical papers of the Medical Faculty of the University Palack.

FAQ

Who should purchase the Complete Detoxification Kit?
Anyone over 18 years old or over can take the products contained in the Complete Detoxification Kit, especially those who want to support normal liver detoxification activity, help maintain healthy glutathione levels and provide the body with strong antioxidant protection to fight the negative effects of free radicals.


What is glutathione, and why is it important in the detoxification process?
Glutathione performs two tasks in the detoxification process. First, it quenches free radicals created when the liver neutralizes toxins in Phase 1 of detoxification. Second, it combines with toxic chemicals, such as those found in cigarette smoke, auto exhaust and the deadly PCBs, in Phase 2 of detoxification so they can be safely excreted.


Glutathione also detoxifies substances in the intestines before they can be absorbed into your bloodstream. It is also thought to protect your stomach lining from the free radical effects of the high amounts of acid it produces. High glutathione levels are good for the immune system, enabling the body to produce more white blood cells to fight off infection and rid the body of harmful toxins.

The products contained in the Complete Detoxification Kit have been shown to help the body generate glutathione, which is necessary to the enzymatic reactions that must take place in order for proper filtration and elimination of bodily toxins. Glutathione is also known as a Phase II enzyme in that it bonds with separate Phase I enzymes in making the filtered toxins more soluble for elimination through the bile or the kidneys.

What’s the difference between a liver detox and a weight loss detox?
Many people hear “detox” and immediately think of “weight loss.” While it is common for those starting a weight loss program to go through a period of detoxification, they do so for different reasons.


A weight loss detox, which is recommended once or twice a year, usually lasts for periods between three and seven days and involves eating only certain foods, in addition to using products such as NutriClean® 7-Day Cleaning System — a colon and liver cleansing system — to detoxify and cleanse the digestive tract and liver to support the body’s natural processes of restoration and cleansing.    

The Complete Detoxification Kit is meant to be used to support the body’s normal detoxification process and does not require the types of restrictions common with a periodic detox system. This includes scavenging free radicals on an ongoing basis to rid the body of toxins that build up, providing a strong, lasting antioxidant defense to keep toxins from accumulating, and maintaining your liver health, which helps cleanse the body on a regular basis and not just for a short period of time.

Why is the liver so important?
The liver is one of the most important organs in the body. It is the way the body eliminates many unnatural, detrimental substances that enter the body on a consistent basis. Maintaining optimal liver health is a must in modern times where free radicals, toxins and harmful chemicals bombard the body daily. The liver's function is to sort out and eliminate all of these harmful substances, removing them from the body. The body regularly does this to stay healthy and, more importantly, alive. Internally, the liver must break down compounds, such as excess hormones and other byproducts of a healthy metabolism. Externally, the liver must filter and eliminate foods, food preservatives and added chemicals, pollutants, pathogenic toxins and excessive alcohol. Lifestyle factors that we may or may not be able to control, such as genetics, diet, environment and stress can influence the proper functioning of the liver, resulting in less than optimal elimination and filtering of subsequent toxins.