Curcumin Extreme

(13)
Curcumin Extreme
  • View Larger Image
  • Single Bottle (30 Servings)
  • Label
View Larger Image
Single Bottle (30 Servings)
Label

Sold by Market America

This item is no longer in stock.

$43.19

$0.86 Cashback




Product Information

  • A factor in the maintenance of good health
  • An antioxidant
  • Helps relieve joint inflammation and associated symptoms such as joint pain when used in conjunction with conventional treatment
  • Helps to promote joint comfort when used in conjunction with conventional treatment

Curcumin Extreme helps relieve and promote your joints’ comfort and relief from inflammation symptoms thanks to its unique formula that includes Meriva, a curcumin complex scientifically proven to have superior bioavailability and absorption rates compared to other curcumin products on the market. In conjunction with conventional treatments, Curcumin Extreme can play a key role in the maintenance of your overall health – especially the health of your joints.

Ingredients

Turmeric Extract (Meriva)
Meriva is a complexation of turmeric and soy phospholipids in a ratio of 1:4. This complexation allows for improved absorption and bioavailability of curcumin. Soy phospholipids, when in the water medium of the digestive tract, form a micelle type structure which encircles and protects the curcumin, and allows for absorption through passive diffusion in the same fashion as fat is absorbed. Research showed up to a 20-fold improvement in bioavailablity of curcumin versus standard extracts.

For centuries turmeric has been revered by Ayurvedic medicine (traditional form of medicine in India) for its diverse and powerful healing properties. Studies have shown that curcumin has antioxidant, anti-inflammatory, immune-stimulating, and neuroprotective properties. Preliminary research in people with arthritis found curcumin to be helpful in reducing inflammation and symptoms, such as pain and stiffness, possibly through the inhibition of the pro-inflammatory markers such as NF-kappaB, cyclooxygenase-2 (COX-2), prostaglandins, and leukotrienes.

Further research indicates curcumin may be an effective tool for the prevention and inhibition of malignant cell growth due to its ability to inhibit these inflammatory cytokines which can stimulate cell production. Preliminary research shows that curcumin might inhibit activation of carcinogens that are metabolized by CYP enzymes, thereby helping to normalize the body’s ability to metabolize and eliminate toxins. Curcumin appears to increase glutathione S-transferase (GST) activity which also plays an important role in detoxifying harmful compounds within the body.

Selenium
Selenium is a required cofactor for selenoproteins, such as glutathione peroxidase.  Selenomethionine is incorporated directly into proteins because selenomethionine cannot be distinguished from methionine during the translation of mRNA into protein.  This serves as a storage form of selenium and is liberated upon protein catabolism. 

Science

  • Araujo, C. and Leon, L. Biological activities of Curcuma longa L. Memorias do Instituto Oswaldo Cruz. 96(5): 723-728, 2001.
  • Biswas, S., et al. Curcumin induces glutathione biosynthesis and inhibits NF-kappaB activation and interleukin-8 release in alveolar epithelial cells: mechanism of free radical scavenging activity. Antioxidants and Redox Signaling. 7(1-2): 32-41, 2005.
  • Funk, J., et al. Turmeric extracts containing curcuminoids prevent experimental rheumatoid arthritis. Journal of Natural Products. 69(3): 351-355, 2006.
  • Jagetia, G. and Aggarwal, B. "Spicing up" of the immune system by curcumin. Journal of Clinical Immunology. 27(1): 19-35, 2007.
  • Juge, N., et al. Molecular basis for chemoprevention by sulforaphane: a comprehensive review. Cellular and Molecular Life Sciences. 64(9): 1105-1127, 2007.
  • Kim, G., et al. Curcumin inhibits immunostimulatory function of dendritic cells: MAPKs and translocation of NF-kappa B as potential targets. Journal of Immunology. 174(12): 8116-8124, 2005.
  • Lim, G., et al. The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse. Journal of Neuroscience. 21(21): 8370-8377, 2001.
  • Lin, J. Molecular targets of curcumin. Advances in Experimental Medicine and Biology. 595: 227-243, 2007.
  • Maheshwari, R., et al. Multiple biological activities of curcumin: a short review. Life Sciences. 78(18): 2081-2087, 2006.
  • Salvioli, S., et al. Curcumin in cell death processes: A challenge for CAM of age-related pathologies. Evidence-based Complementary and Alternative Medicine. 4(2): 181-190, 2007.
  • Shishodia, S., et al. Curcumin: getting back to the roots. Annals of the New York Academy of Sciences. 1056: 206-217, 2005.
  • Thangapazham, R., et al. Multiple molecular targets in cancer chemoprevention by curcumin. AAPS Journal. 8(3): E443-E449, 2006.
  • Yadav, V., et al. Immunomodulatory effects of curcumin. Immunopharmacology and Immunotoxicology. 27(3): 485-497, 2005.
  • Cheng, Y., et al. Effects of curcumin on peroxisome proliferator-activated receptor gamma expression and nuclear translocation/redistribution in culture-activated rat hepatic stellate cells. Chinese Medical Journal. 120(9): 794-801, 2007.
  • Farombi, E., et al. Curcumin attenuates dimethylnitrosamine-induced liver injury in rats through Nrf2-mediated induction of heme oxygenase-1. Food and Chemical Toxicology. 46(4): 1279-1287, 2008.
  • Kaur, G., et al. Inhibition of oxidative stress and cytokine activity by curcumin in amelioration of endotoxin-induced experimental hepatoxicity in rodents. Clinical and Experimental Immunology. 145(2): 313-321, 2006.
  • Mathuria, N. and Verma, R. Ameliorative effect of curcumin on aflatoxin-induced toxicity in DNA, RNA and protein in liver and kidney of mice. Acta Poloniae Pharmaceutica. 64(6): 497-502, 2007.
  • Naik, R., et al. Protection of liver cells from ethanol cytotoxicity by curcumin in liver slice culture in vitro. Journal of Ethnopharmacology. 95(1): 31-37, 2004.
  • Nanji, A., et al. Curcumin prevents alcohol-induced liver disease in rats by inhibiting the expression of NF-kappa B-dependent genes. American Journal of Physiology. 284(2): G321-G327, 2003.
  • O’Connell, M. and Rushworth, S. Curcumin: potential for hepatic fibrosis therapy? British Journal of Pharmacology. 153(3): 403-405, 2007.
  • Osawa, T. Nephroprotective and hepatoprotective effects of curcuminoids. Advances in Experimental Medicine and Biology. 595: 407-423, 2007.
  • Pari, L. and Amali, D. Protective role of tetrahydrocurcumin (THC) an active principle of turmeric on chloroquine induced hepatotoxicity in rats. Journal of Pharmacy and Pharmaceutical Sciences. 8(1): 115-123, 2005.
  • Shen, G., et al. Modulation of nuclear factor E2-related factor 2-mediated gene expression in mice liver and small intestine by cancer chemopreventive agent curcumin. Molecular and Cancer Therapeutics. 5(1): 39-51, 2006.
  • Shen, S., et al. Protective effect of curcumin against liver warm ischemia/reperfusion injury in rat model is associated with regulation of heat shock protein and antioxidant enzymes. World Journal of Gastroenterology. 13(13): 1953-1961, 2007.
  • Shu, J., et al. The study of therapeutic effects of curcumin on hepatic fibrosis and variation of correlated cytokine. Journal of Chinese Medicinal Materials. 30(11): 1421-1425, 2007.
  • Shu, J., et al. Therapeutic effects of curcumin treatment on hepatic fibrosis. Chinese Journal of Hepatology. 15(10): 753-757, 2007.
  • Wei, Q., et al. Inhibition of lipid peroxidation and protein oxidation in rat liver mitochondria by curcumin and its analogues. Biochimica et Biophysica Acta. 1760(1): 70-77, 2006.
  • Zheng, S. and Chen, A. Disruption of transforming growth factor-beta signaling by curcumin induces gene expression of peroxisome proliferator-activated receptor-gamma in rat hepatic stellate cells. American Journal of Physiology. 292(1): G113-G123, 2007.
  • Zheng, S. and Chen, A. Curcumin suppresses the expression of extracellular matrix genes in activated hepatic stellate cells by inhibiting gene expression of connective tissue growth factor. American Journal of Physiology. 290(5): G883-G893, 2006.
  • Bhattacharyya, S., et al. Curcumin prevents tumor-induced T cell apoptosis through Stat-5a-mediated Bcl-2 induction. Journal of Biological Chemistry. 282(22): 15954-15964.
  • Howells, L., et al. Comparison of oxaliplatin- and curcumin-mediated antiproliferative effects in colorectal cell lines. International Journal of Cancer. 121(1): 175-183, 2007.
  • Johnson, J., et al. Curcumin for chemoprevention of colon cancer. Cancer Letters. 255(2): 170-181, 2007.
  • Magalska, A., et al. Curcumin induces cell death without oligonucleosomal DNA fragmentation in quiescent and proliferating human CD8+ cells. Acta Biochimica Polonica. 53(3): 531-538, 2006.
  • Pal, S., et al. Amelioration of immune cell number depletion and potentiation of depressed detoxification system of tumor-bearing mice by curcumin. Cancer Detection and Prevention. 29(5): 470-478, 2005.
  • Perkins, S., et al. Chemopreventive efficacy and pharmacokinetics of curcumin in the min/+ mouse, a model of familial adenomatous polyposis. Cancer Epidemiology, Biomarkers, and Prevention. 11(6): 535-540, 2002.
  • Dairam, A., et al. Curcuminoids, curcumin, and demethoxycurcumin reduce lead-induced memory deficits in male Wistar rats. Journal of Agricultural and Food Chemistry. 55(3): 1039-1044, 2007.
  • Dickinson, D., et al. Curcumin alters EpRE and AP-1 binding complexes and elevates glutamate-cysteine ligase gene expression. FASEB. 17(3): 473-475, 2003.
  • Nishinaka, T., et al. Curcumin activates human glutathione S-transferase P1 expression through antioxidant response element. Toxicology Letters. 170(3): 238-247, 2007.
  • Rushworth, S., et al. Role of protein kinase C delta in curcumin-induced antioxidant response element-mediated gene expression in human monocytes. Biochemical and Biophysical Research Communications. 341(4): 1007-1016, 2006.
  • Scapagnini, G., et al. Curcumin activates defensive genes and protects neurons against oxidative stress. Antioxidants and Redox Signaling. 8(3-4): 395-403, 2006.
  • Shukla, P., et al. Protective effect of curcumin against lead neurotoxicity in rat. Human and Experimental Toxicology. 22(12): 653-658, 2003.
  • Ye, S., et al. Effect of curcumin on the induction of glutathione S-transferases and NADP(H):quinone oxidoreductase and its possible mechanism of action. Acta Pharmaceutica Sinica. 42(4): 376-380, 2007.
  • Zheng, S., et al. De novo synthesis of glutathione is a prerequisite for curcumin to inhibit hepatic stellate cell (HSC) activation. Free Radical Biology and Medicine. 43(3): 444-453, 2007.
  • Garcia-Alloza, M., et al. Curcumin labels amyloid pathology in vivo, disrupts existing plaques, and partially restores distorted neurites in an Alzheimer mouse model. Journal of Neurochemistry. 102(4): 1095-1104, 2007.
  • Ng, T., et al. Curry consumption and cognitive function in the elderly. American Journal of Epidemiology. 164(9): 898-906, 2006.
  • Wu, A., et al. Dietary curcumin counteracts the outcome of traumatic brain injury on oxidative stress, synaptic plasticity, and cognition. 197(2): 309-317, 2006.
  • Xu, Y., et al. Curcumin reverses the effects of chronic stress on behavior, the HPA axis, BDNF expression and phosphorylation of CREB. Brain Research. 1122(1): 56-64, 2006.
  • Yang, F., et al. Curcumin inhibits formation of amyloid beta oligomers and fibrils, binds plaques, and reduces amyloid in vivo. Journal of Biological Chemistry. 280(7): 5892-5901, 2005.
  • Zhang, L., et al. Curcuminoids enhance amyloid-beta uptake by macrophages of Alzheimer's disease patients. Journal of Alzheimer’s Disease. 10(1): 1-7, 2006.
  • Biswas, S., et al. Curcumin induces glutathione biosynthesis and inhibits NF-kappaB activation and interleukin-8 release in alveolar epithelial cells: mechanism of free radical scavenging activity. Antioxidants and Redox Signaling. 7(1-2): 32-41, 2005.
  • Monograph. Curcuma longa (turmeric). Alternative Medicine Review. 6(suppl): S62-S66, 2001.
  • Thangapazham, R., et al. Multiple molecular targets in cancer chemoprevention by curcumin. AAPS Journal. 8(3): E443-E449, 2006.
  • Churchill, M., et al. Inhibition of intestinal tumors by curcumin is associated with changes in the intestinal immune cell profile. Journal of Surgical Research. 89(2): 169-175, 2000.
  • Kurup, V., et al. Immune response modulation by curcumin in a latex allergy model. Clinical and Molecular Allergy. 5: 1, 2007.
  • Srinivasan, M., et al. Protective effect of curcumin on gamma-radiation induced DNA damage and lipid peroxidation in cultured human lymphocytes. Mutation Research. 611(1-2): 96-103, 2006.

FAQ

What is curcumin?
Curcumin is present in the spice turmeric, frequently used in Indian food. Its chemical makeup is responsible for the yellow colouring of turmeric, and is often used specifically to give colour to foods. However, it may serve a more important purpose to humans.

Are any side effects associated with Curcumin Extreme?
Side effects are uncommon and are generally limited to mild stomach distress.

Are there any warnings associated with taking Curcumin Extreme?
If you are currently using Warfarin (Coumadin) or other antiplatelet/anticoagulant medications, you should not take this product. If you are taking any prescription medications or have an ongoing medical condition, you should consult your healthcare practitioner before using this product. Consult a healthcare practitioner prior to use if you have gallstones or a bile duct obstruction, or stomach ulcers or excess stomach acid. Women who are pregnant or breastfeeding should not take this product. Consult a healthcare practitioner if symptoms persist or worsen.

What is the recommended daily serving for Curcumin Extreme?
Take two capsules daily, with or without a meal.

Are there any human clinical trials done with curcumin?
There have been clinical trials performed with curcumin in patients with different diseases.

Can men and women take this product?
Yes.  However, women who are pregnant or nursing should not take this product.

Does Curcumin Extreme contain any allergens?
Yes, Curcumin Extreme contains soy. Anyone who is allergic to soy and soy-based products should not take this product.

Curcumin Extreme was created to promote joint comfort and to provide relief from inflammation symptoms. Curcumin Extreme also offers antioxidant protection and helps you to maintain overall health when used in combination with conventional treatments.

Curcumin Extreme was created to promote joint comfort and to provide relief from inflammation symptoms. Curcumin Extreme also offers antioxidant protection and helps you to maintain overall health when used in combination with conventional treatments.

Curcumin Extreme’s unique formula contains Meriva®, a trademarked, scientifically proven form of curcumin. Meriva® utilizes a patented Phytosome® delivery system, meaning that it is a blend of curcumin, derived from the herb turmeric, with soy phospholipids in order to improve bioavailability. In vivo (human) studies, Meriva® is shown to be absorbed approximately 2x’s faster and has  a 29-fold improvement in the bioavailablity over other forms of curcumin. In addition to Meriva®, Curcumin Extreme also contains selenium, an essential trace mineral that has antioxidant properties and may help protect cells from damage. Selenium promotes the production of glutathione peroxidase, the body's master antioxidant.

So the benefits of Curcumin Extreme with Meriva® are clear:

  • Supported efficacy and safety
  • High bioavailability
  • Fast absorption

REVIEW SNAPSHOT®

by PowerReviews
NutriPhysicalCurcumin Extreme
 
4.8

(based on 13 reviews)

Ratings Distribution

  • 5 Stars

     

    (11)

  • 4 Stars

     

    (2)

  • 3 Stars

     

    (0)

  • 2 Stars

     

    (0)

  • 1 Stars

     

    (0)

100%

of respondents would recommend this to a friend.

Pros

  • Simple to take (8)
  • Acts quickly (3)
  • Boosts energy (3)
  • Produces results (3)

Cons

    Best Uses

    • Daily use (5)
      • Reviewer Profile:
      • Health conscious (5), First time user (4), Regular user (4)

    Reviewed by 13 customers

    Sort by

    Displaying reviews 1-5

    Back to top

    Previous | Next »

    (4 of 4 customers found this review helpful)

     
    5.0

    This solved my skin problem!

    By GaryN

    from USA

    Comments about NutriPhysical Curcumin Extreme:

    I have had eczema for most of my life. About 2 years ago, I noticed my skin getting itchy and bumps starting to form first on my arm the spreaading to my face and body. I went to my doctor and they gave me a steroid shot and it worked for a week then it came back. I used topical steroids and it seemed to get worse. The doctor suggested to go to UCSF or Stanford to visit a dermatology specialist. I went to a acupuncturist and that did not work. I took a GeneSNP analysis and found that my body could not detox. So, I self diagnosed myself and read about Curcumin Extreme it says it detoxes the liver. So, I ordered a bottle and started to take 2 capsules a day. Almost immediately I had relief! My itching stopped and my skin started to clear up in a week. Now it has been 6 months and I have not used any topical steroids! I am taking this for the rest of my life! This works!

    (1 of 1 customers found this review helpful)

     
    5.0

    I will buy this product again.

    By I have beef

    from New York, NY

    Comments about NutriPhysical Curcumin Extreme:

    Use daily and feeling great!

    (2 of 2 customers found this review helpful)

     
    5.0

    Detox Your Liver

    By AlanL

    from USA

    Comments about NutriPhysical Curcumin Extreme:

    I love this product because it helps detox my liver. We live in a chemical world and need a product like this to help our liver out.

    (1 of 1 customers found this review helpful)

     
    5.0

    LOVE THIS PRODUCT!

    By AdamB

    from USA

    SHOP CONSULTANT

    Comments about NutriPhysical Curcumin Extreme:

    The main ingredient in this turmeric is wonderful and powerful antioxidant! Helped me with my skin issues I was going to light therapy for and no longer have to! Would recommend this for anyone even for general maintenance and overall good health!

    (1 of 1 customers found this review helpful)

     
    5.0

    Great Product

    By Ella

    from Whitesboro New York

    About Me Health Conscious, Medical Professional, Regular User

    Pros

    • Boosts Energy
    • Good Value
    • Helps Recovery
    • Simple To Take

    Cons

      Best Uses

      • Great morale booster

      Comments about NutriPhysical Curcumin Extreme:

      Take one capsule every day.

      Displaying reviews 1-5

      Back to top

      Previous | Next »