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Poor cardiovascular health is one of the leading causes of death and illness in the United States , accounting for one out of every two deaths in both men and women. Poor cardiovascular health is becoming a worldwide epidemic. An unhealthy diet of processed, high-calorie, high-fat foods, pollution, smoking and sedentary lifestyles all contribute to poor heart health. Not smoking, maintaining a healthy weight, eating a diet rich in fruits, vegetables and whole grains, exercising regularly and taking the right supplements can all contribute to promoting cardiovascular health. Clinical studies have shown that supplementing with Coenzyme Q10 (CoQ10) may be beneficial in promoting cardiovascular health. CoQ10 is a coenzyme, meaning that it is essential to activating enzymes. Enzymes are produced by the body and are necessary for survival and healthy living. CoQ10 is known as a ubiquinone and is found in every cell in the body. Coenzyme Q10 is important for cellular energy production, promoting the strength of the heart muscle and providing antioxidant protection to the cardiovascular system.* All cellular functions depend upon the production of adenosine triphosphate (ATP). ATP is a molecule with three high-energy phosphate bonds, which exist in all of our cells. It is the primary energy source for many metabolic processes. Coenzyme Q10 is essential to the ATP production process, and the heart has a high metabolic demand, which is why normal levels of CoQ10 are associated with good cardiovascular health. As part of the energy production process CoQ10 exists in the inner mitochondrial membrane as part of the electron transport chain. CoQ10 transports the electrons and protons through the membranes to make the energy production process possible. The lysosomal membranes that separate digestive enzymes from the rest of the cell contain relatively high concentrations of Coenzyme Q10. Recent research suggests that Coenzyme Q10 plays an important role in the transport of protons across lysosomal membranes to maintain the optimal pH for cellular recycling. Within a cell, it serves as a carrier of electrons in the electron transport chain, neutralizes free radicals and helps maintain the integrity of the mitochondrial membrane. Throughout the aging process, the bodys ability to synthesize Coenzyme Q10 begins to decline. Sometimes this is due to stress or infections, but the main challenge is a poor diet. Heart Health Advanced Co-Q10 is a blend of CoQSol-CF and vitamin E, designed to promote overall cardiovascular health. CoQSol-CF is a unique, patent-pending formula of CoQ10, food grade d-limonene (which serves as a non-polar, organic solvent), and tocopherol (vitamin E). This combination creates a liquid, crystal-free solution of CoQ10 that provides enhanced bioavailability. By improving dissolution, absorption is enhanced. Heart Health Advanced Co-Q10 helps maintain normal blood pressure, helps maintain healthy cholesterol levels, provides antioxidant protection for the cardiovascular system, helps maintain heart muscle strength, helps maintain cognitive health and promotes cellular energy production.*
*These statements have not been evaluated by the Food and Drug Administration. This product(s) is not intended to diagnose, treat, cure or prevent any disease.
- CoQ10 concentrations naturally diminish with age and deficiency has been associated with certain health concerns; the bodys ability to synthesize normal amounts of CoQ10 is inhibited by one class of cholesterol-lowering drugs
- CoQ10 is a fat-soluble coenzyme, which is a substance that is necessary to, or supports the action of an enzyme
- CoQ10 is a potent antioxidant that is known to scavenge oxygen radicals in the mitochondria during oxidative phosphorylation
- CoQ10 is essential for the production of energy in every cell of the human body
- CoQ10 is a component of the electron-transport that is required to manufacture adenosine triphosphate (ATP)
- CoQ10 is known as ubiquinone, a substance that is similar in structure to a vitamin and is found mainly in mitochondria throughout the body
- CoQ10 resides in the membranes of the cells mitochondria
- Enhances traditional support of cardiovascular health
- Helps maintain healthy blood sugar levels
- Helps maintain heart muscle strength
- Helps maintain normal blood pressure
- Promotes/boosts the immune system
- Promotes cardiovascular health
- Promotes gum health
- Promotes head comfort
- Helps maintain healthy cholesterol levels
- Provides antioxidant protection for the cardiovascular system
- Studies have found CoQ10 deficiencies in overweight people
- Supports/Helps maintain brain health
- Vital for ATP production and supports muscle endurance
Coenzyme Q10 (CoQSol-CF) 102 mg
Coenzyme Q10 belongs to a family of substances called ubiquinones and is a water-insoluble, wax-like substance that is part of the respiratory chain. Since it is a coenzyme, it is necessary to support the action of an enzyme, and it has a similar structure to vitamin K. CoQ10 is found in each of the 50-75 trillion cells throughout the body, except for mature red blood cells. It has a multitude of health benefits at the cellular level, in the cardiovascular system and with the bodys metabolism. It serves to revitalize and energize the bodys cells and immune system and contributes to increases in stamina and endurance by fueling the bodys energy production (ATP) cycle. It is beneficial to the cardiovascular system because it helps to protect the heart, maintain normal blood pressure, and promotes mental alertness and brain activity.* The mechanism of action of supplemental coenzyme Q10 has yet to be clarified and is a matter of much speculation. However, much is known about the biochemistry of CoQ10. Coenzyme Q10 is a two-part compound that is composed of a long, fat-soluble isoprenoid tail that anchors the molecule in the inner membrane of the mitochondria, and quinine that is capable of accepting and transferring electrons through a portion of the respiratory chain. The Q stands for quinine and the 10 stands for the number of isoprenoid units in the tail portion of the molecule. It is synthesized in the cells, and is involved in electron transport and energy production in mitochondria. In the cellular system, it functions to generate energy from oxygen, in the form of ATP, for bodily processes. It serves as a free radical scavenger and an antioxidant. The antioxidant activity in the mitochondria and cell membranes promotes the stability and health of lipid membranes. Combining CoQ10 with vitamin E generates a synergistic antioxidant effect on lipoprotein and spares the vitamin E.* Coenzyme Q10 can be found in spinach, broccoli, nuts, soy, organ and muscle meats, and fish. In 1977, a Japanese company succeeded in synthesizing coenzyme Q10, which made the nutrient available to the world. CoQ10 is absorbed in the small intestine and a steady-state concentration can be attained in the body in five to six weeks. In the body, it is found in the highest concentration in the cells of the heart, liver, kidney and pancreas. The liver produces small amounts of CoQ10, and then it is distributed to the rest of the body.
Vitamin E (d-alpha-Tocopherol): 200 IU
The most valuable sources of dietary vitamin E include vegetable oils, margarine, nuts, seeds, avocados and wheat germ. Safflower oil contains large amounts of vitamin E (about two thirds of the RDA in ¼ cup) and there are trace amounts in corn oil and soybean oil. Vitamin E is actually a family of related compounds called tocopherols and tocotrienols. Vitamin E is available in a natural or synthetic form. In most cases, the natural and synthetic forms are identical except the natural form of vitamin E is better absorbed and retained in the body. The natural form of alpha-tocopherol is known as "d-alpha tocopherol." The synthetic "dl-" form is the most common form found in dietary supplements. For those individuals watching their dietary fat consumption, which is relatively common in the world of dieting, vitamin E intake is likely to be low, due to a reduced intake of foods with high fat content.* The main health benefit of supplemental vitamin E comes from its immune-boosting antioxidant activity. It also promotes the normal healing of wounds and is known to promote cardiovascular health. Vitamin E is one of the most powerful fat-soluble antioxidants in the body. Vitamin E protects cell membranes from free radical damage.*
What type of vitamin E is in Advanced Coenzyme Q10?
The natural form of vitamin E, d-Alpha-Tocopherol, is in Advance Coenzyme Q10. It is far superior to synthetic in terms of retention in the body and absorption.
If my body makes CoQ10, why should I take a supplement?
When you are young, your body can produce adequate levels of CoQ10. However, as you get older, your cells do not produce enough of the energy they need to function well. Supplementation of CoQ10 has been shown to raise blood levels of this co-enzyme when the bodys ability to synthesize it begins to decrease.
What is the recommended serving size of Coenzyme Q10?
Coenzyme Q10 has been used in maintenance servings of 30-60 mg, but can go up to 100 mg or more.
Is there a certain time I should take CoQ10?
Coenzyme Q10 should be taken with a meal containing some fat. However, taking it in combination with soy or vegetable oil substantially enhances it absorption.
Is it okay to take a CoQ10 supplement while pregnant or nursing?
No. The safety of coenzyme Q10 has not been established in pregnancy and lactation.
Is it safe to take CoQ10?
Yes, it is safe to take CoQ10; it does not produce any toxic side effects when ingested by humans or animals. It is listed in the 42nd edition of the Physicians Desk Reference as replacement therapy for a nutrient, and no adverse reactions are listed.
- Kagan, V, et al. Coenzyme Q: Its role in scavenging and generation of radicals in membranes. In Handbook of Antioxidants, eds. Enrique Cadenas and Lester Packer, New York, Marcel Dekker, Inc., 1996, pp. 157-201.
- Littarru, G.P. et al. Clinical aspects of coenzyme Q: Improvement of cellular bioenergetics or antioxidant protection? In Handbook of Antioxidants, eds. E. Cadenas and L. Packer: New York, Marcel Dekker, Inc., 1996, pp. 203-239.
- Greenberg, S. and Frishman, W.H. Coenzyme Q10: A new drug for cardiovascular disease. Journal of Clinical Pharmacology 30: 596-608, 1990.
- Chello, M, et al. Protection of coenzyme Q10 from myocardial reperfusion injury during coronary artery bypass grafting. Annals of Thoracic Surgery 58: 1427-1432, 1994.
- Lansjoen, P.H. et al. Response of patients in classes III and IV of cardiomyopathy to therapy in a blind crossover trial with coenzyme Q10. Proceedings of the National Academy of Sciences USA 82: 4240, 1985.
- Stryer, L. Biochemistry, 2nd ed. New York, W.H. Freeman and Company, 1981.
- Firstein, R. The Nutraceutical Revolution. New York , Riverhead Books, 1998.
- Frei, B, et al. Ubiquinol-10 is an effective lipid-soluble antioxidant at physiological concentrations. Proceedings of the National Academy of Sciences USA 87: 4879-4883, 1990.
- Hanaki, Y. et al. Ratio of low-density lipoprotein cholesterol to ubiquinone as a coronary risk factor: New England Journal of Medicine, 325: 814-815, 1991.
- Singh R.B. and Singh M.M. Effects of coenzyme Q10 in new indications with antioxidant vitamin deficiency. Journal of Nutritional and Environmental Medicine 9: 223-228, 1999.
- Greenburg S. and Frishman W. Coenzyme Q10: A new drug from myocardial ischemia? Medical Clinics of North America 72: 243-58, 1998.
- Langsjoen, P.H. et al. Pronounced increase of survival of patients with cardiomyopathy when treated with coenzyme Q10 and conventional therapy. International Journal of Tissue Reactions 12: 163-168, 1990.
- Digiesi, V. et al. Mechanism of action of coenzyme Q10 in essential hypertension. Current Therapy and Research 51: 668-672, 1992.
- Sunamori, M. et al. Clinical experience of coenzyme Q10 to enhance intraoperative myocardial protection in coronary artery revascularization. Cardiovascular Drugs and Therapy 5: 297-300, 1991.
- Langsjoen, P.H. et al. A six-year clinical study of therapy of cardiomyopathy with coenzyme Q10. International Journal of Tissue Reactions 12: 169-71, 199.
- Stocker, R. et al. Ubiquinol-10 protects human low density lipoprotein more efficiently against lipid peroxidation than does alpha-tocopherol. Proceedings of the National Academy of Sciences USA 88: 1646-1650, 1991.
- Shi, H. and Noguchi, N. Dynamics of antioxidant action of ubiquinol: A reappraisal. Biofactors 9: 141-148, 1999.
- Folkers, K. et al. Effect of coenzyme Q10 on serum levels of creatine phosphokinase in preclinical muscular dystrophy. Proceedings of the National Academy of Sciences USA 71: 2098, 1974.
- Folkers, K. et al. Biochemical rationale and the cardiac response of patients with muscle disease to therapy with coenzyme Q10. Proceedings of the National Academy of Sciences USA 82: 4513, 1985.
- Chen Y.F., Lin Y.T. and Wu S.C. Effectiveness of coenzyme Q10 on myocardial preservation during hypothermic cardioplegic arrest. Journal of Thoracic and Cardiovascular Surgery 107: 242-247, 1994.
- Murray, M.T. Encyclopedia of Natural Medicine, Rocklin , CA , Prima Publishing, 1998.
- Folkers, K et al. The activities of coenzyme and vitamin B6 for immune responses. Biochemical and Biophysical Research Communications 193: 88-92, 1993.
- Folkers, K et al. Coenzyme Q10 increases T4/T8 ratios of lymphocytes in ordinary subjects and relevance to patients having the AIDS-related complex. Biochemical and Biophysical Research Communications 176: 25.
- Lockwood, K. et al. Partial and complete regression of breast cancer in patients in relation to dosage of Coenzyme Q10. Biomedical and Biophysical Research Communications 199: 1504-1508, 1994.
- Nakamura, R. et al. Study of Co Q10-enzymes in gingival tissues from patients with periodontal disease and evidence for a deficiency of coenzyme Q10. Proceedings of the National Academy of Sciences USA 71: 1456, 1974.
- Littarru, G.P. et al. Deficiency of coenzyme Q10 in gingival tissue from patients with periodontal disease. Proceedings of National Academy of Sciences USA 68: 2332, 1971.
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on Monday, October 14, 2002 More support for CoQ10's benefits for heart health
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By Stephen Daniells 07/06/2006 Nutraingredients.com Coenzyme Q10: It May Just Be the Miracle Vitamin of the 1990s 12/04/96 - www.thenutritionreporter.com Coenzyme Q10 American Academy of Family Physicians 2005 - www.aafp.org CoQ10 boosts vitamin E's anti-inflammatory action 08/09/2004 -
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