- Helps promote delivery of healthy levels of LDL throughout the body
- Promotes a healthy rate of cholesterol production
- Helps maintain healthy levels of total cholesterol, LDL cholesterol and triglyceride levels
- Supports healthy synthesis of triglycerides in the liver
Heart Health™ Advanced LipiTrim® Ultra (Advanced Cholesterol Support Formula)
Poor cardiovascular health is one of the leading causes of death and illness in the United States, accounting for one out of every two deaths in both men and women. Poor cardiovascular health is becoming a worldwide epidemic. An unhealthy diet of processed, high-calorie, high-fat foods, pollution, smoking and sedentary lifestyles all contribute to poor heart health. Not smoking, maintaining a healthy weight, eating a diet rich in fruits, vegetables and whole grains, exercising regularly and taking the right supplements can all contribute to promoting cardiovascular health. Synthesis of cholesterol in the liver and other cells in the body is responsible for about 70 percent of our total cholesterol, with the other 30 percent from food. Maintaining healthy cholesterol and triglyceride levels is important to the overall health of the cardiovascular system.
Cholesterol is a soft, fat-like, waxy substance found in the bloodstream and in all your body's cells. It is normal to have cholesterol. Cholesterol is an important part of a healthy body because it is used for producing cell membranes and some hormones, and serves other needed bodily functions. Cholesterol cannot dissolve in the blood. It has to be transported to and from the cells by carriers called lipoproteins. Low-density lipoprotein, or LDL, is known as 'bad' cholesterol. High-density lipoprotein, or HDL, is known as 'good' cholesterol. Triglycerides are a form of fat made in the body.
Cholesterol comes from two sources, the body and food. The liver and other cells in the body make about 70 percent of blood cholesterol. The other 25 percent comes from food. The body produces LDL cholesterol (bad cholesterol) naturally, but many people inherit genes from their family that cause their body to create excess amounts of cholesterol. Eating saturated fat, trans fats and dietary cholesterol also increase the overall amount of cholesterol in the blood. Because high cholesterol levels can be dangerous, it is important to maintain healthy levels of cholesterol, both the good and the bad, in the body.
Heart Health Advanced LipiTrim Ultra is composed of Sytrinol®, a patented proprietary formula derived from natural citrus polymethoxylated flavones (PMFs) and palm tocotrienols, designed to promote overall cardiovascular health. Sytrinol works in the liver, without inhibiting the production of CoQ10. Advanced LipiTrim Ultra is a powerful antioxidant; it helps promote delivery of healthy levels of LDL throughout the body, promotes a normal rate of cholesterol production, helps maintain healthy levels of total cholesterol, LDL cholesterol and triglyceride levels, and promotes the normal synthesis of triglycerides in the liver.*
*These statements have not been evaluated by the Food and Drug Administration. This product(s) is not intended to diagnose, treat, cure or prevent any disease.
Sytrinol 300 mg (Polymethoxylated Flavones, Palm Tocotrienols)
Sytrinol is a patented proprietary formula derived from natural citrus polymethoxylated flavones (PMFs) and palm tocotrienols. This combination results in a synergistic effect for helping to maintain healthy cholesterol, LDL cholesterol and triglyceride levels. Sytrinol has also been shown to help maintain healthy HDL levels. Sytrinol is a powerful antioxidant with numerous heart health benefits. It promotes cardiovascular health, supports glycemic control and promotes normal blood platelet aggregation.*
Polymethoxylated Flavones (PMFs)
Polymethoxylated Flavones are extremely bioactive potent bioflavonoids found in citrus fruits. This is especially true for tangeretin and nobiletin, two of the most common flavonoids found in nutrient-rich foods. More than 25 years of documented research provides evidence that these particular bioflavonoids deliver heart health benefits. Specific PMFs, including nobiletin and tangeretin, have been found to help maintain normal levels of LDL cholesterol. Apolipoprotein B is considered the primary building block of LDL, making up almost 90 percent of the LDL cholesterol complex. Triglycerides are one of the key contributors to the formation of apolipoprotein B.*
Invitro, Sytrinol was shown to help maintain normal cytokine activity; cytokines such as interleukin-6 and interleukins 1-beta. Sytrinol was also shown to promote normal t-lymphocyte mitogenic response and thymidine uptake by activated lymphocytes.*
Palm tocotrienols, along with tocopherols, are members of the vitamin E family and are extracted from the fruit of the palm tree. Like vitamin E, palm tocotrienols help maintain a healthy level of HMG-CoA reductase, a key enzyme in our bodies used by the liver to produce cholesterol. New data on the biological activity of tocotrienols in cardiovascular health maintenance along with its antioxidant properties have raised tocotrienols to a new level of prominence in the scientific community.*
A completely new perspective has developed into the role tocotrienols play in heart health and their importance as a supplement to a healthy diet. Some of the key areas of interest have centered on its role in maintaining and support a healthy cardiovascular system by helping to maintain healthy cholesterol levels and supporting healthy blood platelet activity. In a recent study that was published in the Journal of Atherosclerosis, researchers at the Kyoto Prefectural University of Medicine in Japan found that tocotrienols were more effective than vitamin E in promoting heart health. The study revealed that tocotrienols accumulate at levels that are 25-95 times greater than alpha tocopherol in human aortic endothelial cells.*
Tocotrienols are also potent antioxidants. In human studies, researchers observed that alpha tocotrienols reduced the oxidation of LDL. The antioxidant properties of tocotrienols can mitigate the damage caused by free radicals while protecting cell membranes for better cellular communication.*
A clinical trial consisting of 60 adults showed that four weeks of treatment with 300 mg of patented Sytrinol daily promoted normal levels of total cholesterol, LDL cholesterol, and triglycerides. Follow up clinical studies have provided further support that Sytrinol promotes cardiovascular health.
- Ameer B, Weintraub RA, Johnson JV, Yost RA, Rouseff RL. Flavanone absorption after naringin, hesperidin, and citrus administration. Clin Pharmacol Ther. 1996 Jul; 60(1): 34-40.
- Bok SH, Lee SH, Park YB, Bae KH, Son KH, Jeong TS, Choi MS Plasma and hepatic cholesterol and hepatic activities of 3-hydroxy-3-methyl-glutaryl-CoA reductase and acyl CoA: cholesterol transferase are lower in rats fed citrus peel extract or a mixture of citrus bioflavonoids. J Nutr. 1999 Jun;129(6):1182-5.
- Borradaile NM, de Dreu LE, Barrett PH, Behrsin CD, Huff MW. Hepatocyte apoB-containing lipoprotein secretion is decreased by the grapefruit flavonoid, naringenin, via inhibition of MTP-mediated microsomal triglyceride accumulation. Biochemistry. 2003 Feb 11; 42(5) - 1283-91.
- Borradaile NM, de Dreu LE, Barrett PH, Huff MW. Inhibition of hepatocyte apoB secretion by naringenin - enhanced rapid intracellular degradation independent of reduced microsomal cholesteryl esters. J Lipid Res. 2002 Sep;43(9):1544-54.
- Borradaile, N.M., Carroll, K.K., and Kurowska, E.M., Regulation of HepG2 cell apolipoprotein B metabolism by the citrus flavones hesperitin and naringenin, Lipids, 34: 491-598, 1999
- Borradaile, N.M., Carroll, K.K. and Kurowska, E.M. Regulation of apo B metabolism in HepG2 cells by the citrus flavanones hesperetin and naringenin. Lipids 34 (1999) 591-598.
- Bors, W., Heller, W., Michel, C., and Saran, M., Flavonoids as antioxidants: determination of radical scavenging efficiencies, Method Enzymol., 186:343-355, 1990.
- Cheeke, P.R., Nutrition and nutritional disease, in The Biology of the Laboratory Rabbit, Manning, P.J., Ringler, D.H., and Newcomer, C.E., Eds., Academic Press, San Diego, CA, 1994.
- Chiba H, Uehara M, Wu J, Wang X, Masuyama R, Suzuki K, Kanazawa K, Ishimi Y. Hesperidin, a citrus flavonoid, inhibits bone loss and decreases serum and hepatic lipids in ovariectomized mice. J Nutr. 2003 Jun; 133(6): 1892-7.
- Choi, J.S., Yokozawa, T., and Oura, H., Antihyperlipidemic effect of flavonoids from Prunus davidiana, J. Nat. Prod., 54:218-224, 1991.
- Cook, N.C. and Samman, S., Flavonoids-chemistry, metabolism, cardioprotective effects, and dietary sources, J. Nutr. Biochem., 7:66-76, 1996.
- Dixon JL, Ginsberg HN Regulation of hepatic secretion of apolipoprotein B-containing lipoproteins: information obtained from cultured liver cells. J Lipid Res. 1993 Feb; 34(2):167-79. Review
- Erlund I, Silaste ML, Alfthan G, Rantala M, Kesaniemi YA, Aro A. Plasma concentrations of the flavonoids hesperetin, naringenin and quercetin in human subjects following their habitual diets, and diets high or low in fruit and vegetables. Eur J Clin Nutr. 2002 Sep; 56(9): 891-8.
- Hansen, M.B., Nielsen, S.E., and Berg, K. Re-examination and further development of a precise and rapid dye method for measuring cell growth/cell kill. J. Immunol. Meth., 119:203-210, 1989.
- Hayes, K.C., Pronczuk, A. and Liang, J.S. Differences in the plasma transport and tissue concentrations of tocopherols and tocotrienols: Observations in humans and hamsters. P. Soc. Exp. Biol. Med. 202 (1993) 353-359.
- Horowitz, R.M, Gentili, B. Flavonoid constituents of Citrus. In Citrus Science and Technology; Nagy, S., Shaw, P.E., Veldhuis, M.K., Eds.; Avi Publishing Company, Inc.; Westport, CT, 1977; Vol 1, pp 397-426
- Kamat JP, Sarma HD, Devasagayam TP, Naseratnam K and Basiron Y. Tocotrienols from palm oil as effective inhibitors of protein oxidation and lipid peroxidation in rat liver microsomes. Mol. Cell Biochem. 170:131-137, 1997.
- Kawaguchi, K., Mizuno, T., Aida, K., and Uchino, K. Hesperidin as an inhibitor of lipases from porcine pancreas and pseudomonas. Biosci. Biotech. Biochem., 61:102-104, 1997.
- Khor, H.T., Chieng D.Y., and Ong, K.K. Tocotrienols inhibit liver HMG-CoA reductase activity in the guinea pig. Nutr. Res., 15:537:544, 1995.
- Kurowska EM Determination of cholesterol-lowering potential of minor dietary components by measuring apolipoprotein B responses in HepG2 cells. Methods Enzymol. 2001; 335:398-404.
- Kurowska EM, Manthey JA, Casaschi A, Theriault AG. Modulation of HepG2 cell net apolipoprotein B secretion by the citrus polymethoxyflavone, tangeretin. Lipids. 2004 Feb; 39(2): 143-51.
- Kurowska, E.M. and Borradaile, N.M., Hypercholesterolemic effects of dietary citrus juices in rabbits, Nutr. Res., 20: 121-129, 2000.
- Kurowska, E.M., Hrabek-Smith, J.M., and Carroll, K.K., Compositional changes in serum lipoproteins during developing hypercholesterolemia induced in rabbits by cholesterol-free semipurified diets, Atherosclerosis, 78: 159-165, 1989.
- Kurowska EM, Manthey JA. Regulation of lipoprotein metabolism in HepG2 cells by citrus flavonoids. Adv Exp Med Biol. 2002; 505:173-9. Review.
- Kurowska EM, Manthey JA. Hypolipidemic effects and absorption of citrus polymethoxylated flavones in hamsters with diet-induced hypercholesterolemia. J Agric Food Chem. 2004 May 19;52(10):2879-86.
- Kurowska, E.M., Morley, K. and Gapor, A. Role of tocotrienols from palm oil in regulation of apo B metabolism in HepG2 cells. Experimental Biology 99, Washington, DC, April 17-21, 1999.
- Kurowska, E.M., Morley, K., and Gapor, A. Regulation of apo B production in HepG2 cells by tocotrienols from palm oil. Proceedings, PORIM International Palm Oil Congress, Kuala Lumpur, Malaysia, 212-219, 1999.
- Kurowska EM, Spence JD, Jordan J, Wetmore S, Freeman DJ, Piche LA, Serratore P. HDL-cholesterol-raising effect of orange juice in subjects with hypercholesterolemia. Am J Clin Nutr. 2000 Nov;72(5):1095-100.
- Manach C, Morand C, Gil-Izquierdo A, Bouteloup-Demange C, Remesy C. Bioavailability in humans of the flavanones hesperidin and narirutin after the ingestion of two doses of orange juice. Eur J Clin Nutr. 2003 Feb;57(2):235-42.
- Manthey JA, Grohmann K, Guthrie N. Biological properties of citrus flavonoids pertaining to cancer and inflammation. Curr Med Chem. 2001 Feb;8(2):135-53. Review.
- Mensink, R.P., van Houwelingen, A.C., Kromhout, D., and Hornstra, G. A vitamin E concentrate rich in tocotrienols had no effect on serum lipids, lipoproteins, or platelet function in men with mildly elevated serum lipid concentrations. Am. J. Clin. Nutr., 69:213-219, 1999.
- Monforte, M.T., Trovato, A., Kirjavainen, S., Forestieri, A.M., and Galati, E.M. Biological effects of hesperidin, a citrus flavonoid. (note II): hypolipidemic activity on experimental hypercholesterolemia in rat. Farmaco 50:595-599, 1995.
- Murakami A, Koshimizu K, Ohigashi H, Kuwahara S, Kuki W, Takahashi Y, Hosotani K, Kawahara S, Matsuoka Y. Characteristic rat tissue accumulation of nobiletin, a chemopreventive polymethoxyflavonoid, in comparison with luteolin. Biofactors. 2002; 16(3-4): 73-82.
- Murakami A, Kuwahara, S., Takahashi Y , Ito, C., Furukawa, H., Ju-Ichi, M. In Vitro absorption and metabolism of nobiletin, a chemopreventive polymethoxyflavonoid in citrus fruits. Biosci., Biotechnol., Biochem. 2001. 65. 194-197.
- Nielsen SE, Breinholt V, Cornett C, Dragsted LO Biotransformation of the citrus flavone tangeretin in rats. Identification of metabolites with intact flavane nucleus. Food Chem Toxicol. 2000 Sep;38(9):739-46.
- Nielsen SE, Breinholt V, Justesen U, Cornett C, Dragsted LO. In vitro biotransformation of flavonoids by rat liver microsomes. Xenobiotica. 1998 Apr;28(4):389-401.
- Parker, R.A., Pearce, B.C., Clark, R.W., Gordon, D.A., and Wright J.J.K. Tocotrienols regulate cholesterol production in mammalian cells by post-transcriptional suppression of 3-hydroxy-3-methylglutaryl-coenzyme A reductase. J. Biol. Chem., 268:11230-11238, 1993.
- Pearce, B.C., Parker, R.A., Deason, M.E., Quereshi, A.A., and Wright J.J.K. Hypercholesterolemic activity of synthetic and natural tocotrienols. J. Med. Chem., 35:3595-3606, 1992.
- Quereshi, A.A., Bradlow, B.A., Brace, L. et al. Response of hypercholesterolemic subjects to administration of tocotrienols. Lipids 30 (1995) 1171-1177.
- Quereshi, A.A., Bradlow, B.A., Salser, W.A., and Brace, L.D. Novel tocotrienols of rice bran modulate cardiovascular disease risk parameters of hypercholesterolemic humans. J. Nutr. Biochem., 8:290-298, 1997.
- Quereshi, A.A., Pearce, B.C., Nor, R.M., Gapor, A., Peterson, D.M. and Elson. C.E. Dietary a-tocopherol attenuates the impact of g-tocotrienol on hepatic 3-hydroxy-3-methylglutaryl coenzyme a reductase activity in chickens. J. Nutr., 126:389-394, 1996.
- Quereshi, A.A., Quereshi, N., Hasler-Rapacz, J.O. et al. Dietary tocotrienols reduce concentrations of plasma cholesterol, apolipoprotein B, tromboxane B2, and platelet factor 4 in pigs with inherited hyperlipidemias. Am. J. Clin. Nutr. 53 (1991) 1042S-1046S.
- Quereshi, A.A., Quereshi, N., Wright J.J.K., Shen, Z., Kramer, G., Gapor, A., Chong, Y.H., DeWitt, G., Ong, A.S.H., Peterson, D.M., and Bradlow, B.A. Lowering of serum cholesterol in hypercholesterolemic humans by tocotrienols (palmvitee). Am. J. Clin. Nutr., 53:1021S-1026S, 1991.
- Quereshi, N. and Quereshi, A.A. Tocotrienols: Novel hypocholesterolemic agents with antioxidant properties. In: Vitamin E in Health and Disease, Packer L. and Fuchs, J. (eds.) Marcel Dekker, Inc., New York 1993, 247-267.
- Shin, Y.W., Bok, S.H., Jeong, T.S., Bae, K.H., Jeoung, N.H., Choi, M.S., Lee, S.H. and Park, Y.B. Hypocholesterolemic effect of naringin associated with hepatic cholesterol regulating enzyme changes in rats. Int. J. Vitam. Nutr. Res. 69 (1999) 341-347.
- Spencer JP, Chowrimootoo G, Choudhury R, Debnam ES, Srai SK, Rice-Evans C. The small intestine can both absorb and glucuronidate luminal flavonoids. FEBS Lett. 1999 Sep 17;458(2):224-30
- Theriault, A., Chao, J.T., Wang, Q., Gapor, A. and Adeli, K. Tocotrienol: A review of its therapeutic potential. Clin. Biochem 32 (1999) 309-319.
- Theriault, A., Wang, Q., Gapor, A., and Adeli, K. Effects of g-tocotrienol on apoB synthesis, degradation, and secretion in HepG2 cells. Arterioscler. Tromb. Vac. Biol., 19:714-712, 1999.
- Theriault, A., Wang, Q., Gapor, A., and Adeli, K. Effects of g-tocotrienol on apoB synthesis, degradation, and secretion in HepG2 cells. Arterioscler. Tromb. Vac. Biol., 19:714-712, 1999.
- Thrift, R.N., Forte, T.M., Cahoon, B.E., and Shore, V.G., Characterization of lipoprotein produced by the human liver cell line HepG2, under defined conditions, J. Lipid Res., 27: 236-250, 1986.
- Tomeo AC, Geller M, Watkins TR, Gapor A and Bierenbaum ML. Antioxidant effects of tocotrienols in patients with hyperlipidemia and carotid stenosis. Lipids 30:1179-1183, 1995.
- Watkins, T., Lenz, P., Gapor, A., Struck, M., Tomeo, A., and Bierenbaum, M. g-Tocotrienol as a hypocholesterolemic and antioxidant agent in rats fed atherogenic diet. Lipids 28:1113-1118, 1993.
- Wilcox, L.J., Borradaile, N.M. and Huff, M.W. Antiatherogenic properties of naringenin, a citrus flavonoid. Cardiovasc. Drug Rev. 17 (1999) 160-178.
- Wilcox LJ, Borradaile NM, de Dreu LE, Huff MW. Secretion of hepatocyte apoB is inhibited by the flavonoids, naringenin and hesperetin, via reduced activity and expression of ACAT2 and MTP. J Lipid Res. 2001 May; 42(5): 725-34.
- Wilcox, L.J., Borradaile, N.M., Kurowska, E.M. Telford, D.E., and Huff, M.W., Naringenin, a citrus flavonoids, markedly decreases apoB secretion in HepG2 cells and inhibits acyl CoA: cholesterol acyltransferase, Circulation, 98: 1-537, 1998.
- Delaney B, Phillips K, Vasquez C, Wilson A, Cox D, Wang HB, Manthey J.Genetic toxicity of a standardized mixture of citrus polymethoxylated flavones. Food Chem Toxicol. 2002 May;40(5):617-24.
- Delaney B, Phillips K, Buswell D, Mowry B, Nickels D, Cox D, Wang HB, Manthey J. Immunotoxicity of a standardized citrus polymethoxylated flavone extract. Food Chem Toxicol. 2001 Nov; 39(11): 1087-94.
- Kawaii S, Tomono Y, Katase E, Ogawa K, Yano M. Antiproliferative activity of flavonoids on several cancer cell lines. Biosci Biotechnol Biochem. 1999 May; 63(5):896-9.
- Manthey JA, Guthrie N. Antiproliferative activities of citrus flavonoids against six human cancer cell lines. J Agric Food Chem. 2002 Oct 9; 50(21): 5837-43.
- Manthey JA, Grohmann K. Phenols in citrus peel byproducts. Concentrations of hydroxycinnamates and polymethoxylated flavones in citrus peel molasses. J Agric Food Chem. 2001 Jul; 49(7): 3268-73.
- Manthey JA, Grohmann K, Montanari A, Ash K, Manthey CL. Polymethoxylated flavones derived from citrus suppress tumor necrosis factor-alpha expression by human monocytes. J Nat Prod. 1999 Mar; 62(3): 441-4.
- Mora A, Paya M, Rios JL, Alcaraz MJ. Structure-activity relationships of polymethoxyflavones and other flavonoids as inhibitors of non-enzymic lipid peroxidation. Biochem Pharmacol. 1990 Aug 15; 40(4): 793-7.
- Takanaga H, Ohnishi A, Yamada S, Matsuo H, Morimoto S, Shoyama Y, Ohtani H, Sawada Y. Polymethoxylated flavones in orange juice are inhibitors of P-glycoprotein but not cytochrome P450 3A4. J Pharmacol Exp Ther. 2000 Apr; 293(1):230-6.
What does lifestyle have to do with maintaining a healthy heart?
There are simple, everyday things you can do to help maintain proper heart heath. Among these are:
- Not smoking
- Maintaining a healthy height-to-weight ratio
- Eating a diet rich in fruits, vegetable and whole grains
- Limiting the consumption of total and saturated fat
- Exercising regularly
- Working with your physician to monitor cholesterol, blood pressure, homocysteine and C-reactive protein levels
- Starting a complete nutritional supplementation program designed to help maintain proper cardiovascular health
Why is LDL cholesterol considered bad?
When too much LDL cholesterol circulates in the blood, it can slowly build up in the inner walls of the arteries that feed the heart and brain. Together with other substances it can form plaque, a thick, hard deposit that can clog those arteries. If a clot forms and blocks a narrowed artery, it can cause serious heart problems.
Why is HDL cholesterol considered good?
About one-third to one-fourth of blood cholesterol is carried by high-density lipoprotein (HDL). HDL cholesterol is known as the good cholesterol because a high level of it seems to protect against heart problems. Medical experts think that HDL tends to carry cholesterol away from the arteries and back to the liver, where it's passed from the body. Some experts believe that HDL removes excess cholesterol from plaque in arteries, thus slowing the buildup.
What are triglycerides and how are they related to HDL and LDL?
A triglyceride is a form of fat. It comes from food and is also made in your body. People with high triglyceride levels often have high overall cholesterol, which is high LDL and low HDL cholesterol levels.
With numerous heart health benefits including healthy cholesterol maintenance and promoting the accumulation of normal blood platelets, sytrinol is a pivotal ingredient in the quest for improved heart health. Studies have shown that in order to achieve maximum results with sytrinol, 300mg is the recommended dosage. While other products contain this ingredient, most contain only 150mg. In contrast, Heart Health Advanced Lipitrim Ultra contains 300mg, (twice the amount of other leading brands).This increased dosage helps promote healthy levels of LDL throughout the body while helping to maintain healthy cholesterol levels.