Isotonix Daily Essentials Packets

Isotonix Daily Essentials Packets

Roll over image to zoom

  • View Larger Image
  • Single Box (30 Packets)
  • Label

Sold by Isotonix®

$69.95

$1.40 Cashback

Calculate Shipping

This product qualifies for free or reduced cost shipping Learn More

Free or reduced cost shipping

Get $5 flat-rate shipping on all Market America orders. Spend $99 or more, and get free shipping on Market America products! Conditions apply, see details.

Calculate

Standard Shipping:   More info



Single Box (30 Packets)
 

Save 5% by adding to AutoShip [details]

  • Select an AutoShip eligible item, and toggle the "Add to AutoShip" option on the right.
  • Add as many of your favorite items as you like. Create as many AutoShips (with different delivery dates) as you need.
  • Receive a 5% discount on your AutoShip order of Market America products every time!

Notify when the price is less than or equal to:

Price entered must be less than the current product price and greater than zero.

Your email address:

You already have an active alert for this item.

An eGift lets the recipient choose 1 gift from the list you create!

An email delivers this gift in seconds to your recipient and lets them choose any applicable product options such as size or color themselves. You can also send a personalized set of gift choices and let them choose which item they want. it's a unique and fun way to send a gift that shows you care.

This product has been saved

Isotonix Daily Essentials Packets

Sale $69.95

$1.40  Cashback  

We've successfully added your item!


This item has been added to

This item has been added to

Thanks! We'll email you if the price drops to your target price or lower. The alert will be in effect for 60 days.


To extend this price watch, create additional price watches, or to otherwise manage your alerts, please follow the instructions contained in the email that has been sent to the address you provided.

We've successfully added your egift!

This item has been added to

This item has been added to

This item has been added to



Product Information

  • Combats free radicals*
  • Demonstrates anti-inflammatory activity*
  • Helps maintain healthy cholesterol levels*
  • Supports healthy blood glucose levels*
  • Promotes sinus comfort*
  • Supports a healthy immune system*
  • Contains 100 percent or more of the recommended daily value of essential vitamins and minerals to help supplement deficiencies in diet*
  • Helps maintain normal blood pressure *
  • Contains vitamins that support the body’s ability to metabolize fats and carbohydrates and support a healthy body weight*
  • Increases energy*
  • Promotes cardiovascular health*
  • Helps decrease stress and improve mood*
  • Adequate calcium and vitamin D throughout life, as part of a well-balanced diet, may reduce the risk of osteoporosis*
  • Supports normal muscle use and performance*
  • Supports healthy teeth and gums*
  • Supports healthy body weight*






Product Information

Isotonix Daily Essentials Packets

There’s nothing more important than taking care of yourself on a daily basis. With the Isotonix Daily Essentials Packets, you can be sure that you’re giving your body the essential vitamins, minerals and nutrients it needs, thanks to four essential supplements – Isotonix OPC-3, Isotonix Multivitamin, Isotonix Activated B-Complex and Isotonix Calcium Plus – in one, convenient serving to promote long-term health and optimal nutrition.

Plus, by purchasing the Isotonix Daily Essentials Packets instead of buying a 30-day supply of these products individually, you save 27%  a $26.50 value!

Caring for your general health starts with Isotonix OPC-3, a powerful antioxidant that provides a variety of health benefits associated with general health and well-being. From helping maintain healthy cholesterol levels, joint flexibility, cardiovascular health and circulation, Isotonix OPC-3 helps the body function at its peak by combating free radicals throughout your body.

Next, Isotonix Multivitamin contains 100 percent or more of the recommended daily value of essential vitamins and minerals to complement your diet. With today’s fast-paced lifestyles, it is important to ensure the body is getting the fuel it needs. Isotonix® Multivitamin supplements dietary deficiencies and helps maintain normal metabolic functioning.

To provide the energy you need to function throughout the day, each packet includes Isotonix Activated B-Complex, which delivers metabolically active forms of several vitamins and minerals. Activated forms are important because traditional forms of vitamins B6, B12 and folic acid found in most other B-complex products must undergo chemical changes in order to be utilized by the body. Several factors, including age and nutritional status, may decrease the body’s ability to activate these vitamins.

By providing the metabolically active forms of these vitamins in isotonic form, you can be certain that your body is getting the vital nutrients it needs quickly and effectively. B-vitamin deficiency can lead to fatigue and lethargy, which is why B-complex supplements are excellent energy boosters and anti-stress formulas.*

Finally, Isotonix Calcium Plus delivers a potent package of calcium and complementary nutrients to keep your bones strong. While calcium supplements in tablet form can be difficult for the body to absorb, the unique Isotonix delivery system and the inclusion of beneficial vitamins and minerals – including vitamin D – make Isotonix Calcium Plus more readily available and easily absorbed by the body.

*These statements have not been evaluated by the Food and Drug Administration. This product(s) is not intended to diagnose, treat, cure or prevent any disease.

REVIEW SNAPSHOT®

by PowerReviews
Isotonix®Isotonix Daily Essentials Packets
 
5.0

(based on 11 reviews)

Ratings Distribution

  • 5 Stars

     

    (11)

  • 4 Stars

     

    (0)

  • 3 Stars

     

    (0)

  • 2 Stars

     

    (0)

  • 1 Stars

     

    (0)

100%

of respondents would recommend this to a friend.

Pros

  • Easy to take (8)
  • Nutritional (6)
  • Tastes good (6)
  • Effective (5)
  • Good value (5)

Cons

    Best Uses

    • Everyday use (7)
    • Men (3)
    • Women (3)
      • Reviewer Profile:
      • Work out regularly (6)

    Reviewed by 11 customers

    Sort by

    Displaying reviews 1-5

    Back to top

    Previous | Next »

    (1 of 1 customers found this review helpful)

     
    5.0

    Great for traveling

    By JadeRiver

    from Mt. Laurel, NJ

    About Me Health Enthusiast , Nutritionist, Work Out Regularly

    SHOP CONSULTANT

    Pros

    • Convenient
    • Easy To Take
    • Effective
    • Good Value
    • Nutritional
    • Tastes Good

    Cons

      Best Uses

      • Everyday Use
      • Men
      • Women

      Comments about Isotonix® Isotonix Daily Essentials Packets:

      These packets are great for traveling, no big bottles to carry. Each packet contains what you need for the day.
      It's also great for people who are in a hurry in the morning.
      Good for old folks who do not have steady hands to measure out each little cap of the supplements from the bottles.

      (3 of 3 customers found this review helpful)

       
      5.0

      Perfect Traveling Companion

      By Boomer who Travels

      from Maryland

      About Me Frequent Traveler, Health Enthusiast , Work Out Regularly

      SHOP CONSULTANT

      Pros

      • Easy To Pack
      • Easy To Take
      • Good Value
      • Tastes Good

      Cons

        Best Uses

        • Everyday Use

        Comments about Isotonix® Isotonix Daily Essentials Packets:

        Having my Isotonix vitamins at the ready while traveling is very important for me. I don't want to miss a day. So these travel packets make it super easy to stay on track no matter where I go.

        (2 of 2 customers found this review helpful)

         
        5.0

        i feel great! hooked for life!

        By ONE HAPPY MOM

        from Madisonville, Tx.

        About Me Rarely Work Out

        SHOP CONSULTANT

        Pros

        • Easy To Take
        • Effective
        • Nutritional

        Cons

          Best Uses

          • Everyday Use
          • Men
          • Weight Loss
          • Women

          Comments about Isotonix® Isotonix Daily Essentials Packets:

          well worth the price. easy to use. mix and match for maximum benefits. there is a combination for everyone. I now wake up free of back pain. I am back to living and loving life. LIFE CHANGING EXPERIENCE. TRY IT

          (1 of 1 customers found this review helpful)

           
          5.0

          I would buy this again.

          By Bob

          from Punta Gorda Fl.

          About Me Work Out Regularly

          Verified Buyer

          Pros

          • Easy To Take
          • Nutritional
          • Tastes Good

          Cons

            Best Uses

            • Everyday Use

            Comments about Isotonix® Isotonix Daily Essentials Packets:

            I feel better.

            (1 of 1 customers found this review helpful)

             
            5.0

            Superior Product & Packaging Convenience

            By Love Boxing Lady

            from Menomonee Falls, WI

            About Me Boxing Fitness 9-r, Fitness Boxing, Work Out Regularly

            Pros

            • Easy To Take
            • Effective
            • Good Value
            • Great For Traveling
            • Nutritional
            • Tastes Good

            Cons

              Best Uses

              • Everyday Use

              Comments about Isotonix® Isotonix Daily Essentials Packets:

              This is the easiest way to get all four supplements (vitamins) at once with very little thinking (something that is great for the early morning hours!!). It may be a little more expensive than purchasing the items separately in a larger quantity but takes the whole measuring out of the picture which I love!! Superior for traveling too!!

              Displaying reviews 1-5

              Back to top

              Previous | Next »

              Ingredients

              Grape Seed Extract  25 mg
              Grape seed extract is typically extracted from the seeds of red grapes (instead of white), which have a high content of compounds known as oligomeric proanthocyanidins (OPCs). Grape seed extract is extremely rich in polyphenols, compounds with high antioxidant activity. Grape seed extract has been found to maintain healthy cholesterol levels.* 

               
              Red Wine Extract 25 mg
              Red wine extract is a powerful antioxidant. This extract is found in grape vines, roots, seeds and stalks, with the highest concentration in the skins. The antioxidant properties of red wine extract contribute to maintaining healthy circulation by strengthening capillaries, arteries and veins, and promoting overall cardiovascular health.*

              In the late 1990s, scientists took note of a phenomenon among the French. There were very low rates of cardiovascular problems in the provinces where residents consistently ate high fat foods and drank red wine. Scientists concluded that the protective properties of red wine have helped the French maintain cardiovascular health for years and subsequent scientific studies have further shown that the OPCs found in red wine are particularly beneficial for protecting the heart and blood vessels.*     

              Pine Bark Extract (Pycnogenol®) 25 mg
              Pycnogenol is a natural plant extract from the bark of the maritime pine tree, which grows exclusively along the coast of southwest France in Les Landes de Gascogne. This unspoiled and natural forest environment is the unique source of pine bark. Pycnogenol is one of the most researched ingredients in the natural product marketplace. Published findings have demonstrated Pycnogenol’s wide array of beneficial effects on the body. Pine bark extract is an all natural combination of procyanidins, bioflavonoids and organic acids.

              The extract has three basic properties — it is a powerful antioxidant, selectively binds to collagen and elastin, and promotes the normal production of endothelial nitric oxide, which promotes the normal dilation of dilate blood vessels.*

              As one of the most potent natural scavenger of free radicals, Pycnogenol combats many aggressive free radicals before they cause oxidative stress to vital organs. Its super-antioxidant capabilities help support healthy blood platelet activity, support healthy blood glucose levels, reduce mild menstrual cramping and abdominal pain, maintain joint flexibility, promote cardiovascular health, promote healthy sperm quality, maintain healthy cholesterol levels and support a healthy complexion.*

              Bilberry Extract 25 mg
              Bilberry extract is derived from the leaves and berry-like fruit of a common European shrub closely related to the blueberry. Extracts of the ripe berry are known to contain flavonoid pigments known as anthocyanins, which are powerful antioxidants. Scientific studies confirm that bilberry extract supports healthy vision and venous circulation. Bilberry extract helps maintain healthy circulation by strengthening capillaries, arteries and veins.*

              Citrus Extract (Bioflavonoids) 25 mg
              Bioflavonoids are antioxidants found in certain plants that act as light filters, which protect delicate DNA chains and other important macromolecules by absorbing ultraviolet radiation. They have been found to promote cardiovascular health, help maintain healthy circulation by strengthening capillaries, arteries and veins, and demonstrate anti-inflammatory activity.*

              Vitamin A (Beta-Carotene/Vitamin A pre-cursor) 10,005 IU
              Vitamin A is a fat-soluble vitamin. Sources of vitamin A include organ meats (such as liver and kidney), egg yolks, butter, carrot juice, squash, sweet potatoes, spinach, peaches, fortified dairy products and cod liver oil. Vitamin A is also part of a family of compounds including retinol, retinal and beta-carotene. Beta-carotene, also known as pro-vitamin A, can be converted into vitamin A when additional levels are required. All the body’s tissues need Vitamin A for general growth and repair. Vitamin A helps to promote healthy night vision, support normal bone growth and support an antioxidant defense and a healthy immune system.*

              Vitamin C (Ascorbic Acid) 179 mg
              Vitamin C is found in peppers (sweet, green, red, hot red and green chili), citrus fruits and brussels sprouts, cauliflower, cabbage, kale, collards, mustard greens, broccoli, spinach, guava, kiwi fruit, currants and strawberries. Nuts and grains contain small amounts of vitamin C. It is important to note that cooking destroys vitamin C activity.

              Vitamin C is integral in supporting a healthy immune system, promoting cardiovascular health, helping to maintain healthy cholesterol levels and providing an antioxidant defense. The body does not manufacture vitamin C on its own, nor does it store it. Therefore, vitamin C must be acquired through diet and supplementation.*

              Thiamin (Vitamin B1) 4.6 mg
              Thiamin plays an important role in carbohydrate metabolism and nerve function. Thiamin is required for a healthy nervous system and assists in the production of the neurotransmitter acetylcholine and gamma-aminobutyric acid (GABA). It is used in the manufacture of hydrochloric acid, and therefore plays a part in digestion, increases energy and helps promote mental clarity.*

              Pantothenic Acid (Vitamin B5) 40 mg
              Pantothenic acid (B5) is the transfer agent for choline to acetylcholine, which promotes proper neurotransmitter activity in the brain. Pantothenic acid is also known as the anti-stress vitamin because it detoxifies brain tissue, helps relieve physical and emotional stress and plays a very important role in the secretion of hormones.*

              Niacin (Vitamin B3) 60 mg
              Niacin is a water-soluble vitamin necessary for many aspects of health, growth and reproduction. It is part of the vitamin B complex. Niacin supports the functioning of the digestive system, skin and nerves. It is also important for the conversion of food to energy. Niacin (also known as vitamin B-3) is found in dairy products, poultry, fish, lean meats, nuts, eggs, legumes, and enriched breads and cereals.*

              Vitamin B12 (Cyanocobalamin & Methylcobalamin) 195 mcg
              Vitamin B12 is naturally found in meats, liver, beef, pork, eggs, whole milk, cheese, whole wheat bread and fish. Vitamin B12 can only be found in animal products, with small amounts derived from fermented soy products such as miso and tempeh, and peanuts. It is essential that vegetarians consume a vitamin B12 supplement to maintain optimal health. Vitamin B12, when ingested, is stored in the liver and other tissues for later use. The synthetic form of vitamin B12, cyanocobalamin, is not derived from either plants or animals and is intrinsic in the maintenance of normal functioning body cells, especially those of the nervous system (protecting the sheaths of nerve cells), bone marrow and intestinal tract. These tissues are the first to exhibit signs of vitamin B12 depletion. Vitamin B12 itself is responsible for maintaining optimum energy levels as it plays a vital role in the Krebs energy cycle. It is also a great anti-aging ingredient and helps increase concentration.*

              Folic Acid (Quatrefolic®) 648 mcg
              Folic acid is mainly found in fruits and vegetables. Dark, leafy greens, oranges, orange juice, beans, peas and Brewer’s yeast are the best sources. Folic acid plays a key role by boosting the benefits of B12 supplementation. These two B vitamins join forces and work together in maintaining normal red blood cells. Folic acid assists in the normal utilization of amino acids and proteins, as well as supporting the construction of the material for DNA and RNA synthesis, which is necessary for all bodily functions. Scientific studies have found that when working in tandem with folic acid, B12 is capable of promoting normal homocysteine levels. This works toward supporting a healthy cardiovascular and nervous system.* Quatrefolic® is the glucosamine salt of (6S)-5-methyltetrahydrofolate, the most active form of folate, as it is structurally analogous to the reduced and active form of folic acid. Because this form is naturally present in the body, it is much more bioavailable for its biological action without having to be metabolized in the body. This patented ingredient also provides greater stability and higher water solubility, perfect for Isotonix.*

              Riboflavin 5-Phosphate (Vitamin B2) 7.8 mg
              Vitamin B2 is found in liver, dairy products, dark green vegetables and some types of seafood. Vitamin B2 serves as a co-enzyme, working with other B vitamins. It promotes healthy blood and supports both the nervous system and normal human growth. It supports healthy skin, nails, hair growth and helps maintain a healthy thyroid. Vitamin B2 plays a crucial role in turning food into energy as a part of the electron transport chain, driving cellular energy on the micro-level. Vitamin B2 aids in the breakdown of fats while functioning as a cofactor or helper in activating B6 and folic acid. Vitamin B2 is water-soluble and cannot be stored by the body except in insignificant amounts; thus, it must be replenished daily. Under some conditions, vitamin B2 can act as an antioxidant. The riboflavin coenzymes are also important for the transformation of vitamin B6 and folic acid into their active forms and for the conversion of tryptophan into niacin.*

              Pyridoxine HCl (Vitamin B6) 10 mg
              Poultry, fish, whole grains and bananas are the main dietary sources of vitamin B6. Vitamin B6 is a co-factor required for protein and amino acid metabolism and helps maintain proper fluid balance. It also assists in the maintenance of healthy red and white blood cells. Vitamin B6 is required for hemoglobin synthesis. It is involved in the synthesis of neurotransmitters in brain and peripheral nerve cells, it has been recommended as a nutrient to enhance mental function, specifically mood, and it supports normal nerve conduction. Some athletic supplements include vitamin B6 because it promotes the conversion of glycogen to glucose, for energy in muscle tissue. Vitamin B6, when taken with folic acid, has been shown to help maintain normal plasma levels of homocysteine, which promotes optimal cardiovascular health. Vitamin B6 should be administered as a part of a complex of other B-vitamins for best results.*

              Vitamin D3 (Cholecalciferol) 1,500 IU
              Regular sunlight exposure is the main way that most humans get their vitamin D. Food sources of vitamin D are vitamin D-fortified milk (100 IU per cup), cod liver oil, and fatty fish such as salmon. Small amounts are found in egg yolks and liver. Vitamin D promotes the absorption of calcium and phosphorus and supports the production of several proteins involved in calcium absorption and storage. Vitamin D works with calcium to promote hard, strong bones. It works to promote active transport of calcium out of the osteoblasts into the extra-cellular fluid and in the kidneys, promotes calcium and phosphate uptake by renal tubules. Vitamin D also promotes the normal absorption of dietary calcium and phosphate uptake by the intestinal epithelium. It promotes healthy growth and repair of tissues, and supports overall skin health.* 

              Vitamin E (d-alpha-Tocopherol Succinate) 66 IU
              The most valuable sources of dietary vitamin E include vegetable oils, margarine, nuts, seeds, avocados and wheat germ. Safflower oil contains large amounts of vitamin E (about two thirds of the RDA in ¼ cup) and there are trace amounts in corn oil and soybean oil. Vitamin E is actually a family of related compounds called tocopherols and tocotrienols. Vitamin E is available in a natural or synthetic form. In most cases, the natural and synthetic forms are identical except the natural form of vitamin E is better absorbed and retained in the body. The natural form of alpha-tocopherol is known as "d-alpha tocopherol." (The natural form is found in Isotonix® Multivitamin.) The synthetic "dl-" form is the most common form found in dietary supplements. For those individuals watching their dietary fat consumption, which is relatively common in the world of dieting, vitamin E intake is likely to be low, due to a reduced intake of foods with high fat content.*

              The main health benefit of supplemental vitamin E comes from its immune-boosting antioxidant activity. It also supports normal healing and is known to promote cardiovascular health. Vitamin E is one of the most powerful fat-soluble antioxidants in the body. In turn, vitamin E protects cell membranes from free radical damage.*

              Calcium (Lactate, Phosphate) 467 mg
              Calcium is found in milk, cheese, yogurt, corn tortillas, Chinese cabbage (Napa), kale and broccoli. Calcium is an essential mineral with a wide range of biological roles. Calcium exists in bone primarily in the form of hydroxyapatite (Ca10 (PO4)6 (OH) 2). Hydroxyapatite comprises approximately 40 percent of the weight of bone. The skeleton has an obvious structural requisite for calcium. The skeleton also acts as a storehouse for calcium. Apart from being a major constituent of bones and teeth, calcium promotes normal muscle contraction, nerve conduction, cardiovascular health, the production of energy and helps maintain a healthy immune system.*

              A sufficient daily calcium intake is necessary for maintaining bone density and maintaining healthy teeth and bones. Calcium has been shown to reduce the symptoms of PMS in women. When the body does not obtain enough calcium each day, it draws calcium from the bones causing them to thin, leading to osteoporosis. Osteoporosis is the age-related thinning of the bones, which can lead to a higher risk of broken hips, ribs, pelvis and other weakened bones. This is in addition to stooped posture associated with advanced age, which is caused by an accumulation of small fractures in the vertebrae.*

              The PTH (parathyroid hormone) regulates the amount of calcium in the blood. High levels of calcium in the body have been associated with cardiovascular health in postmenopausal women and maintaining normal cholesterol levels. Low levels of calcium have been associated with reduced bone mass and osteoporosis.*

              Chromium (Nicotinate) 120 mcg
              Chromium is found naturally in some cereals, meats, poultry, brewer’s yeast, broccoli, prunes mushrooms, fish and beer. Chromium is an essential trace mineral that promotes normal glucose metabolism and regulation of insulin levels, and helps the body maintain of healthy blood levels of cholesterol and other fats. Chromium combines to form something in the body called glucose tolerance factor, or GTF, which promotes normal insulin activity in regulating blood sugar levels. Chromium has been shown to help reduce overall body fat, control hunger and suppress appetite. Many people in the weight-loss industry view chromium as an integral mineral in weight maintenance. Chromium may also contribute to an increase in lean body and muscle mass.*

              Copper (Gluconate) 100 mcg

              The richest sources of dietary copper derive from organ meats, seafood, nuts, seeds, wheat bran cereal, whole grain products and cocoa products. Copper may have some antioxidant properties and acts as a component of enzymes in iron metabolism. It is an essential trace mineral. Copper is needed in normal infant development, iron transport, bone strength, cholesterol metabolism, myocardial contractility, glucose metabolism, brain development and immune function.*

              Iodine (Potassium Iodide) 150 mcg
              Iodine is found in most seafood and in iodized salt. It is a necessary component of thyroid hormones and helps regulate and maintain a properly functioning metabolism.*

              Magnesium (Carbonate) 125 mg
              Foods rich in magnesium include unpolished grains, nuts and green vegetables. Green leafy vegetables are potent sources of magnesium because of their chlorophyll content. Meats, starches and milk are less rich sources of magnesium. Refined and processed foods are generally quite low in magnesium. The average daily magnesium intake in the U.S. for males nine years and older is estimated to be about 323 milligrams; for females nine years and older, it is estimated to be around 228 milligrams.

              Magnesium is a component of the mineralized part of bone, and is necessary for the metabolism of potassium and calcium in adults. It helps maintain normal levels of potassium, phosphorus, calcium, adrenaline and insulin. It is also important for the mobilization of calcium, transporting it inside the cell for further utilization. It plays a key role in the functioning of muscle and nervous tissue. Magnesium is necessary for the synthesis of all proteins, nucleic acids, nucleotides, cyclic adenosine monophosphate, lipids and carbohydrates.*

              Magnesium is required for release of energy and it promotes the normal regulation of body temperature and proper nerve function, it helps the body handle stress, and it promotes a healthy metabolism. Magnesium works together with calcium to promote the normal regulation of the heart and blood pressure. Importantly, magnesium is also required by the body to build healthy bones and teeth, and promotes proper muscle development. It works together with calcium and vitamin D to help keep bones strong. Magnesium also promotes cardiovascular health by supporting normal platelet activity and helping to maintain normal cholesterol levels.*

              Manganese (Gluconate) 2.5 mg
              Manganese is a mineral found in large quantities in both plant and animal matter. The most valuable dietary sources of manganese include whole grains, nuts, leafy vegetables and teas. Manganese is concentrated in the bran of grains, which is often removed during processing. There are several forms of supplementary manganese including manganese gluconate, manganese sulfate, manganese ascorbate, and manganese amino acid chelates.

              Only trace amounts of this element can be found in human tissue. Manganese is predominantly stored in the bones, liver, kidney and pancreas. It supports the normal formation of connective tissue, bones, blood-clotting factors and sex hormones. It promotes normal fat and carbohydrate metabolism, calcium absorption and blood sugar regulation. Manganese also promotes normal brain and nerve function.*

              Potassium (Bicarbonate) 406 mg
              Foods rich in potassium include fresh vegetables and fruits such as bananas, oranges, cantaloupe, avocado, raw spinach, cabbage and celery. Potassium is an essential macromineral that helps to keep fluid balance. It also plays a role in a wide variety of biochemical and physiological processes. Among other things, it supports normal nerve impulses, cardiac, skeletal and smooth muscle contractions, energy production, synthesis of nucleic acids, and helps maintain intracellular tonicity and normal blood pressure. Potassium promotes normal muscle relaxation and insulin release. It also promotes glycogen and protein synthesis. Potassium is an electrolyte that promotes proper heartbeat. Potassium is important in releasing energy from protein, fat and carbohydrates during metabolism.*

              Potassium also helps regulate water balance and assists recuperative powers. Potassium supports the normal elimination of wastes. Potassium promotes normal healing and generally contributes to a sense of well-being. Potassium is stored in the muscles.*
               
              Selenium (Amino Acid Chelate) 55 mcg

              The best dietary sources of selenium include nuts, unrefined grains, brown rice, wheat germ, and seafood. In the body, selenium functions as part of an antioxidant enzyme called glutathione peroxidase, as well as promoting normal growth and proper usage of iodine in thyroid functioning. Selenium also supports the antioxidant effect of vitamin E and is often added to vitamin E supplements. As part of the antioxidant, glutathione peroxidase, selenium plays a direct role in the body’s ability to protect cells from damage by free radicals.*

              Zinc (Lactate) 7.5 mg
              Zinc is largely found in fortified cereals, red meats, eggs, poultry and certain seafood, including oysters. It is a component of multiple enzymes and proteins. It is also involved in the regulation of gene expression. Zinc is an essential trace mineral that has functions in approximately 300 different enzyme reactions. Thus, zinc plays a part in almost all biochemical pathways and physiological processes. More than 90 percent of the body’s zinc is stored in the bones and muscles, but zinc is also found in virtually all body tissues. It has been claimed that zinc supports normal healing and the immune system, promotes a healthy prostate gland and supports healthy sperm quality. Because zinc is involved in such a great number of enzymatic processe, it has been found to support a large range of functions, including digestion, energy production, growth, cellular repair, collagen synthesis, bone strength, cognitive function and carbohydrate metabolism.*

              Biotin (Vitamin B7) 600 mcg
              Biotin can be found in food sources, such as egg yolks, peanuts, beef liver, milk (10 mcg/cup), cereals, almonds and Brewer’s yeast. Biotin is used in healthy cell growth, the production of fatty acids, metabolism of fats and amino acids. It plays a role in the Citric acid cycle, which is the process in which biochemical energy is generated during aerobic respiration. Biotin not only assists in various metabolic chemical conversions but also helps to transfer carbon dioxide. Biotin is also helpful in maintaining a steady blood sugar level. Biotin is often recommended for strengthening hair and nails. 

              Boron .5 mg (Sodium Borate)
              Boron is a mineral found at high levels in plant foods such as dried fruits, nuts, dark green, leafy vegetables, applesauce, grape juice, and cooked dried beans and peas. Boron is found in most tissues, but mainly in the bone, spleen and thyroid. Boron supports normal bone and hormone metabolism.

              Boron supports the body’s ability to build and maintain healthy bones. It also helps retain adequate amounts of calcium and magnesium to promote proper bone mineralization. Boron is an essential cofactor for the converting vitamin D to its active form. It enhances the maintenance of healthy cell membranes, proper mental functioning and alertness, and supports normal serum estrogen levels and ionized calcium.

              Science

              Isotonix OPC-3®:

              • Bayeta, E., et al. Pycnogenol inhibits generation of inflammatory mediators in macrophages. Nutrition Research 20: 249-259, 2000.
              • Blazsó, G., et al. Anti-inflammatory and superoxide radical scavenging activities of a procyanidins containing extract from the bark of Pinus pinaster Sol. and its fractions. Pharm Pharmacol Lett 3: 217-20, 1994
              • Cesarone, M., et al. Improvement in Circulation and in Cardiovascular Risk Factors With a Proprietary Isotonic Bioflavanoid Formula OPC-3.  Journal Angiology 59: 408-414, 2008.
              • Cho, K., et al. Effect of bioflavonoids extracted from the bark of Pinus maritima on proinflammatory cytokine interlukin-1 production in lipopolysaccharide-stimulated RAW 264. 7.  Toxicology and Applied Pharmacology 168: 64-71, 2000.
              • Cho, K., et al. Inhibition mechanisms of bioflavonoids extracted from the bark of Pinus maritima on the expression of proinflammatory cytokines. Annals of the NYAcademy of Sciences 928: 141-156, 2001.
              • Devaraj, S., et al. Supplementation with a pine bark extract rich in polyphenols increases plasma antioxidant capacity and alters the plasma lipoprotein profile. Lipids 37:931-4, 2002.
              • Fine, AM, Oligomeric proanthocyanidin complexes: history, structure, and phytopharmaceutical applications. Altern Med Rev 5:144-51, 2000.
              • Fitzpatrick, D., et al. Endothelium-dependent vascular effects of Pycnogenol. Journal of Cardiovascular Pharmacology 32: 509-515, 1998.
              • Frankel, E., et al. Inhibition of oxidation of human low-density lipoprotein by phenolic substances in red wine. Lancet 341: 454-7, 1993.
              • Freedman, J., et al. Select flavonoids and whole juice from purple grapes inhibit platelet function and enhance nitric oxide release. Circulation 103:2792-8, 2001.
              • Frémont, L. Biological effects of resveratrol. Life Sciences 66: 663-673, 2000.
              • Gulati, O. Pycnogenol® in venous disorders: a review. European Bulletin of Drug Research 7: 1-13, 1999.
              • Hosseini, S., et al. Pycnogenol® in the management of asthma. Journal of Medicinal Food 4: 201-209, 2001. HHHh
              • Kohama, T., et al. The treatment of gynecological disorders with Pycnogenol®. European Bulletin of Drug Research 7: 30-32, 1999.
              • Kohama, T., et al. Analgesic efficacy of French maritime pine bark extract in dysmenorrhea. Journal of Reproductive Medicine 49: 828-32, 2004.
              • Liu, X., et al. Antidiabetic effect of Pycnogenol French maritime pine bark extract in patients with diabetes type II. Life Sci 75:2505-13, 2004.
              • Liu, X., et al. French maritime pine bark extract pycnogenol dose-dependently lowers glucose in type 2 diabetic patients. Diabetes Care 27: 839, 2004.
              • Manna, S., et al. Resveratrol suppresses TNF-Induced activation of nuclear transcription factors NF-kB, activator protein-1, and apoptosis: potential role of reactive oxygen intermediates and lipid peroxidation. The Journal of Immunology 164: 6509-19, 2000.
              • Maritim, A., et al. Effects of pycnogenol treatment on oxidative stress in streptozotocin-induced diabetic rats. J Biochem Mol Toxicol 17:193-9, 2003.
              • Miyagi, Y., et al. Inhibition of human low-density lipoprotein oxidation by flavonoids in red wine and grape juice. Am J Cardiol 0:1627-31, 1997.
              • Monograph. Vaccinium myrtillus (bilberry). Altern Med Rev 6:500-4, 2001.
              • Murias M., et al. Resveratrol analogues as selective cyclooxygenase-2 inhibitors: synthesis and structure-activity relationship. Bioorg Med Chem 12: 5571-8, 2004.
              • Nuttall SL, Kendall MJ, Bombardelli E, Morazzoni P. An evaluation of the antioxidant activity of a standardized grape seed extract, Leucoselect. J Clin Pharm Ther 23: 385-89, 1998.
              • Packer, L., et al. Antioxidant activity and biologic properties of a procyanidin-rich extract from pine (Pinus maritima) bark, pycnogenol. Free Radic Biol Med 27:704-24, 1999. Review.
              • Rohdewald, P. A review of the French maritime pine bark extract (Pycnogenol®), a herbal medication with a diverse clinical pharmacology. Int J Clin Pharmacol Ther 40:158-68, 2002. Review.
              • Rohdewald, P. Pycnogenol®. In "Flavonoids in Health and Disease". Ed. Catherine Rice-Evans and Lester Packer. New York:  Marcel Dekker, Inc., 1998. 405-19.
              • Roseff, S., et al. Improvement in sperm quality and function with French maritime pine tree bark extract. Journal Reproductive Medicine 47: 821-4, 2002.
              • Roseff, S., et al. Improvement of sperm quality by Pycnogenol®. European Bulletin of Drug Research 7: 33-6, 1999.
              • Saito, M., et al. Antiulcer activity of grape seed extract and procyanidins. J Agric  Food Chem 46: 1460-4, 1998.
              • Schönlau, F., et al. Pycnogenol® for diabetic retinopathy. International Ophthalmology 24: 161-171, 2002.
              • Schönlau, F., et al. The cosmeceutical Pycnogenol®. J Appl Cosmetology 20: 241-6, 2002.
              • Segger, D. and Schönlau, F. Supplementation with Evelle® improves skin smoothness and elasticity in a double blind, placebo-controlled study with 62 women. Journal of Dermatological Treatment 15:222-26, 2004.
              • Shi, J., et al. Polyphenolics in grape seeds-biochemistry and functionality. J Med Food 6:291-9, 2003. Review.
              • Sharma, S., et al. Pycnogenol® inhibits the release of histamine from mast cells. Phytotherapy Research 17: 66-69, 2003.
              • Spadea, L., et al. Treatment of vascular retinopathies with Pycnogenol®. Phytotherapy Research 15: 219-23, 2001.
              • Stein, J., et al. Purple grape juice improves endothelial function and reduces the susceptibility of LDL cholesterol to oxidation in patients with coronary artery disease. Circulation 100:1050-5, 1999.
              • Takada, Y., et al. Nonsteroidal anti-inflammatory agents differ in their ability to suppress NF-kappaB activation, inhibition of expression of cyclooxygenase-2 and cyclin D1, and abrogation of tumor cell proliferation. Oncogene 23: 9247-58, 2004.
              • Ueda, T., et al. Preventative effect of natural and synthetic antioxidants on lipid peroxidation in the mammalian eye. Ophthalmic Res 28: 184-92, 1996.
              • Wallerath, T., et al. Resveratrol, a polyphenolic phytoalexin present in red wine, enhances expression and activity of endothelial nitric oxide synthase. Circulation 106:1652-8, 2002.
              • Watson, R. Pycnogenol® and cardiovascular health. Evidence-Based Integrative Medicine 1: 27-32, 2003.
              • Wei, Z., et al. Pycnogenol enhances endothelial cell antioxidant defense. Redox Report 3: 219-24, 1997.
              • Yamakoshi, J., et al.  Proanthocyanidin-rich extract from grape seeds attenuates the development of aortic atherosclerosis in cholesterol-fed rabbits.  Atherosclerosis  142:139-149, 1999.
              • Ames, BN, et al.  Oxidants, antioxidants, and the degenerative diseases of aging.  Proc Natl Acad Sci USA 90:7915-7922, 1993.
              • Bagchi, D, et al.  Oxygen free radical scavenging abilities of vitamins C and E, and a grape seed proanthocyanidin extract in vitro.  Res Commun Mol Pathol Pharmacol 95:179-89, 1997.
              • Bagchi, D, et al.  Free radicals and grape seed proanthocyanidin extract: importance in human health and disease prevention.  Toxicology 148: 187-97, 2000.
              • Bagchi, D, et al.  Cellular protection with proanthocyanidins derived from grape seed.  Ann NY Acad Sci 957:260-70, 2002.
              • Cao G, Alessio H, Cultler R.  Oxygen-radical absorbance capacity assay for antioxidants.  Fre Rad Biol & Med 14:301-11, 1993.
              • Drew B, Leeuwenburgh C.  Aging and the role of reactive nitrogen species.  Ann NY Acad Sci 959:66-81, 2002.
              • Gibson, L, et al.  Effectiveness of cranberry juice in preventing urinary tract infections in long-term care facility patients.  J Naturopathic Med 2:45-47, 1991.
              • Graham DY, Smith JL, Bouvet, AA.  What happens to tablets in the stomach.  J Pharm Sci 79:420-24, 1990.
              • Havsteen B.  Flavonoids, a class of natural products of high pharmacological potency.  Biochem Pharm 32:1141-48, 1983.
              • Halpern, MJ, et al.  Red wine polyphenols and inhibition of platelet aggregation: possible mechanisms, and potential use in health promotion and disease prevention.  J Int Med Res 26:171-80, 1998.
              • Joseph JA, Shukitt-Hale B, Denisova NA, Bielinksi D, Martin A, McEwen JJ, Bickford PC.  Reversals of age-related declines in neuronal signal transduction, cognitive, and motor behavioral deficits with blueberry, spinach, or strawberry dietary supplementation.  J Neuroscience 19: 8114-21, 1999.
              • Kay CD, Holub BJ.  The effect of wild blueberry (Vaccinium angustifolium) on post-prandial serum antioxidant status in human subjects.  Br J Nutr 88: 389-98, 2002.
              • Kehrer JP.  Free radicals as mediators of tissue injury and disease.  Crit Rev Toxicol 23:21-48, 1993.
              • Koch R. Comparative study of Venostatin and Pycnogenol in chronic venous insufficiency.  Phytother Res 16:S1-5, 2002.
              • Koparker AD, Augsburger LL, Shangraw RF.  Intrinsic dissolution rates of tablet fillers and binders and their influence on the dissolution of drugs from tablet formulations.  Pharm Res 7:80-85, 1990.
              • Mazza G, Kay CD, Cottrell T, Holub BJ.  Absorption of anthocyanins from blueberries and serum antioxidant status in human subjects.  J Agric Food Chem 50:7731-37, 2002.
              • Nesaretnam K, et al.  Effect of tocotrienols on the growth of a human breast cancer cell line in culture.  Lipids 30:1139-43, 1995.
              • Ofek I, Goldhar J, Zafriri D, Lis H, Sharon N.  Anti-Escherichia coli adhesion activity of cranberry and blueberry juices. New England J Med 324:1599, 1991.
              • Qureshi, A, et al.  Response of hypercholesterolemic subjects to administration of tocotrienols.  Lipids 30:1171-77, 1995.
              • Rimbach G, Virgili F, Park YC, Packer L.  Effect of procyanidins from Pinus maritime on glutathione levels in endothelial cells challenged by 3-morpholinosydnonimine or activated macrophages.  Redox Rep 4:171-77, 1999. 
              • Sobota AE.  Inhibition of bacterial adherence by cranberry juice: potential use for the treatment of urinary tract infactions.  J Urology 131:1013-1016, 1984.
              • Soloway MS, Smith RA.  J Am Med Assoc 260:1465, 1988.
              • Tomco, A, et al.  Antioxidant effects of tocotrienol in patients with hyperlipidemia and carotid stenosis.  Lipids 30: 1179-83, 1995.
              • Zheng W, Wang SY.  Oxygen radical absorbing capacity of phenolics in blueberries, cranberries, chokeberries, and lingonberries.  J Agric Food Chem 51:502-9, 2003.
              • Wilson D et al. A randomized, double-blind, placebo-controlled exploratory study to evaluate the potential of pycnogenol for improving allergic rhinitis symptoms. Phytother Res. 24(8):1115-9, 2010.
              • Lau B et al. Pycnogenol as an adjunct in the management of childhood asthma. J Asthma. 41(8):825-32, 2004.
              • Choi YH, Yan GH. Pycnogenol® inhibits immunoglobulin E-mediated allergic response in mast cells. Phytother Res 23: 1691-1695, 2009.
              • Sharma SC, Sharma S, Gulati OP. Pycnogenol® inhibits the release of histamine from mast cells. Phytother Res, 17: 66-69, 2003.
              • Hosseini S, Pishnamazi S, Sadrzadeh MH, Farid F, Farid R, Watson RR.  Pycnogenol® in the management of asthma. J Med Food 4: 201-209, 2001.

              Isotonix® Multivitamin

              • Abbasi AA, Prasad AS, Rabbani P, DuMouchelle E. Experimental zinc deficiency in man. Effect on testicular function. J Lab Clin Med. 1980 Sep;96(3):544-50.
              • Abid M, Billington CJ, Nuttall FQ. Thyroid function and energy intake during weight gain following treatment of hyperthyroidism. J Am Coll Nutr. 1999 Apr;18(2):189-93.
              • Addison WLT, The use of sodium chloride, potassium chloride, sodium bromide and potassium bromide in cases of arterial hypertension which are amenable to potassium chloride. Can Med Assoc J. 1928; 18:281-285.
              • Allende LM, Corell A, Madrono A, Gongora R, Rodriguez-Gallego C, Lopez-Goyanes A, Rosal M, Arnaiz-Villena A. Retinol (vitamin A) is a cofactor in CD3-induced human T-lymphocyte activation. Immunology. 1997 Mar;90(3):388-96
              • Anderson RA. Effects of chromium on body composition and weight loss. Nutr Rev. 1998 Sep;56(9):266-70.
              • Arthur JR. Functional indicators of iodine and selenium status. Proc Nutr Soc. 1999 May;58(2):507-12.
              • Backstrom MC, Maki R, Kuusela AL, Sievanen H, Koivisto AM, Ikonen RS, Kouri T, Maki M. Randomised controlled trial of vitamin D supplementation on bone density and biochemical indices in preterm infants. Arch Dis Child Fetal Neonatal Ed. 1999 May;80(3):F161-6.
              • Bahadori B, Wallner S, Schneider H, Wascher TC, Toplak H. Effect of chromium yeast and chromium picolinate on body composition of obese, non-diabetic patients during and after a formula diet. Acta Med Austriaca. 1997;24(5):185-7.
              • Baly DL, Schneiderman JS, Garcia-Welsh AL. Effect of manganese deficiency on insulin binding, glucose transport and metabolism in rat adipocytes. J Nutr. 1990; 120:1075-1079.
              • Baron JA, Beach M, Mandel JS, et al. Calcium supplements for the prevention of colorectal adenomas. N Engl J Med 1999;340:101-107.
              • Baron JA, Tosteson TD, Wargovich MJ, et al. Calcium supplementation and rectal mucosal proliferation: a randomized controlled trial. J Natl Cancer Inst 1995;87:1303-1307.
              • Bates CJ. Vitamin A. Lancet. 1995; 345:31-35.
              • Baxter GF, Sumeray MS, Walker JM. Infant size and magnesium: insights into LIMIT-2 and ISIS-4 from experimental studies. Lancet. 1996; 348:1424-1426.
              • Behl C. Vitamin E and other antioxidants in neuroprotection. Int J Vitam Nutr Res. 1999 May;69(3):213-9. 4. Botterweck AA, van den Brandt PA, Goldbohm RA. Vitamins, carotenoids, dietary fiber, and the risk of gastric carcinoma: results from a prospective study after 6.3 years of follow-up. Cancer. 2000 Feb 15;88(4):737-48.
              • Bellamy MC, Gedney JA. Unrecognized iron deficiency in critical illness. Lancet. 1998; 352:1903.
              • Beutler E, Larsh SE, Gurney CW. Iron therapy in chronically fatigued nonanemic women: a double-blind study. Ann Intern Med. 1960; 52:378-394.
              • Bostick RM, Kushi LH, Wu Y, et al. Relation of calcium, vitamin D, and dairy food intake to ischemic heart disease mortality among postmenopausal women. Am J Epidemiol 1999;149:151-160.
              • Britton J, Pavord I, Richards K, et al. Dietary magnesium, lung function, wheezing, and airway hyper-reactivity in a random adult population sample. Lancet. 1994; 344:357-362.
              • Brown JE, Wahle KW Effect of fish-oil and vitamin E supplementation on lipid peroxidation and whole-blood aggregation in man. Clin Chim Acta. 1990 Dec 14;193(3):147-56.
              • Brun JF, Dieu-Cambrezy C, Charpiat A, Fons C, Fedou C, Micallef JP, Fussellier M, Bardet L, Orsetti A. Serum zinc in highly trained adolescent gymnasts. Biol Trace Elem Res. 1995 Jan-Mar;47(1-3):273-8.
              • Bruner AB, Joffe A, Duggan A, et al. Randomised study of cognitive effects of iron supplementation in non-anaemic iron-deficient adolescent girls. Lancet. 1996; 348:992-997.
              • Buchinger W, Lorenz-Wawschinek O, Semlitsch G, Langsteger W, Binter G, Bonelli RM, Eber O. Thyrotropin and thyroglobulin as an index of optimal iodine intake: correlation with iodine excretion of 39,913 euthyroid patients. Thyroid. 1997 Aug;7(4):593-7.
              • Butterfield DA, Koppal T, Subramaniam R, Yatin S. Vitamin E as an antioxidant/free radical scavenger against amyloid beta-peptide-induced oxidative stress in neocortical synaptosomal membranes and hippocampal neurons in culture: insights into Alzheimer's disease. Rev Neurosci. 1999;10(2):141-9
              • Calomme MR, Vandem Berghe DA. Supplementation of calves with stabilized orthosilicic acid. Effect on the Si, Ca, Mg, and P concentrations in serum and the collagen concentration in skin and cartilage. Biol Trace Elem Res. 1997; 56:153-165.
              • Cappuccio FP, MacGregor GA. Does potassium supplementation lower blood pressure? A meta-analysis of published trials. J Hypertens. 1991; 9:465-473.
              • Carlisle EM. Silicon as a trace nutrient. Sci Total Environ. 1988; 73:95-106.
              • Carlisle EM. The nutritional essentiality of silicon. Nutr Rev. 1982; 40:193-198.
              • Casscells W. Magnesium and myocardial infarction. Lancet. 1994; 343:807-809.
              • Christiansen CW, Rieder MA, Silverstein EL, Gencheff NE. Magnesium sulfate reduces myocardial infarct size when administered before but not after coronary reperfusion in a canine model. Circulation. 1995; 92:2617-2621.
              • Comstock GW, Alberg AJ, Huang HY, Wu K, Burke AE, Hoffman SC, Norkus EP, Gross M, Cutler RG, Morris JS, Spate VL, Helzlsouer KJ. The risk of developing lung cancer associated with antioxidants in the blood: ascorbic acid, carotenoids, alpha-tocopherol, selenium, and total peroxyl radical absorbing capacity. Cancer Epidemiol Biomarkers Prev. 1997 Nov;6(11):907-16.
              • Cooke MS, Evans MD, Podmore ID, et al. Novel repair action of vitamin C upon in vivo oxidative DNA damage. FEBS Lett. 1998; 439:363-367.
              • Cooney RV, Franke AA, Hankin JH, Custer LJ, Wilkens LR, Harwood PJ, Le Marchand L. Seasonal variations in plasma micronutrients and antioxidants. Cancer Epidemiol Biomarkers Prev. 1995 Apr-May;4(3):207-15.
              • Couzy F, Lafargue P, Guezennec CY. Zinc metabolism in the athlete: influence of training, nutrition and other factors. Int J Sports Med. 1990 Aug;11(4):263-6.
              • Dallman PR. Iron deficiency and the immune response. Am J Clin Nutr. 1987; 46:329-334.
              • Daudu PA, Kelley DS, Taylor PC, Burri BJ, Wu MM. Effect of a low beta-carotene diet on the immune functions of adult women. Am J Clin Nutr. 1994 Dec;60(6):969-72.
              • Dawson-Hughes B. Vitamin D and calcium: recommended intake for bone health. Osteoporos Int. 1998;8 Suppl 2:S30-4. 6. Feit JM. Calcium and vitamin D supplements for elderly patients. J Fam Pract. 1997 Dec;45(6):471-2.
              • de Lourdes Lima M, Cruz T, Carreiro Pousada J, et al. The effect of magnesium supplementation in increasing doses on the control of type 2 diabetes. Diabetes Care. 1998; 21:682-686.
              • de Valk B, Marx JJM. Iron, atherosclerosis, and ischemic heart disease. Arch Int Med. 1999; 159:1542-1548.
              • Dietary Reference Intakes for Calcium, Phosphorous, Magnesium, Vitamin D, and Fluoride. Washington, DC: National Academy Press; 1997.
              • Dorgan JF, Schatzkin A. Antioxidant micronutrients in cancer prevention. Hematol Oncol Clin North Am. 1991 Feb;5(1):43-68.
              • Dreon DM, Butterfield GE. Vitamin B6 utilization in active and inactive young men. Am J Clin Nutr. 1986 May;43(5):816-24.
              • Duffy SJ, Gokce N, Holbrook M, et al. Treatment of hypertension with ascorbic acid. Lancet. 1999; 354:2048-2049.
              • Durlach J, Durlach V, Bac P, et al. Magnesium and therapeutics. Magnes Res. 1994; 7:313-328.
              • Elisaf M, Merkouropoulos M, Tsianos EV. Siamopoulos KC. Pathogenetic mechanisms of hypomagnesemia in alcoholic patients. J Trace Elem Med Biol. 1995; 9:210-214.
              • Elitsur Y, Neace C, Liu X, Dosescu J, Moshier JA. Vitamin A and retinoic acids immunomodulation on human gut lymphocytes. Immunopharmacology. 1997 Jan;35(3):247-53.
              • Enstrom JE, Kanim LE, Klein MA. Vitamin C intake and mortality among a sample of the United States population. Epidemiology. 1992; 3:194-202.
              • Facchinetti F, Borella P, Sances G, et al. Oral magnesium successfully relieves premenstrual mood changes. Obstet Gynecol. 1991; 78:177-181.
              • Facchinetti F, Borella P, Sances G, et al. Oral magnesium successfully relieves premenstrual mood changes. Obstet Gynecol. 1991; 78:177-181.
              • Fairbanks VF. Iron in medicine and nutrition. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. Baltimore, MD: Williams and Wilkins; 1999:193-221.
              • Fang J, Madhavan S, Alderman MH. Dietary potassium intake and stroke mortality. Stroke. 2000; 31:1532-1537.
              • Fields M, Lewis CG. Starch diets high in iron can duplicate the severity of copper deficiency in rats fed fructose. J Med Food. 1998; 1:193-199.
              • Finch CA, Huebers H. Perspectives in iron metabolism. N Engl J Med. 1982; 306:1520-1528.
              • Flatt PR, Juntti-Berggren L, Berggren PO, Gould BJ, Swanston-Flatt SK. Failure of glucose tolerance factor-containing Brewer's yeast to ameliorate spontaneous diabetes in C57BL/KsJ DB/DB mice. Diabetes Res. 1989 Mar;10(3):147-51.
              • Futoryan T, Gilchrest BA. Retinoids and the skin. Nutr Rev. 1994; 52:299-310.
              • Gleeson M, Bishop NC. Elite athlete immunology: importance of nutrition. Int J Sports Med. 2000 May;21 Suppl 1:S44-50.
              • Grant KE, Chandler RM, Castle AL, Ivy JL. Chromium and exercise training: effect on obese women. Med Sci Sports Exerc. 1997 Aug;29(8):992-8.
              • Gullestad L, Dolva LO, Soyland E, et al. Oral magnesium supplementation improves metabolic variables and muscle strength in alcoholics. Alcohol Clin Exp Res. 1992; 16:986-990.
              • Guo WD, Chow WH, Zheng W, Li JY, Blot WJ. Diet, serum markers and breast cancer mortality in China. Jpn J Cancer Res. 1994 Jun;85(6):572-7.
              • Harris ED. Cellular copper transport and metabolism. Annu Rev Nutr. 2000; 20:291-310.
              • Harrison MD, Jones CE. Solioz M, Dameron CT. Intracellular copper routing: the role of copper chaperones. Trends Biochem Sci. 2000; 25:29-32.
              • Health & Medicine. (Statistical Data Included) American Fitness, July, 1999 Tannen RL. Effects of potassium on blood pressure control. Ann Intern Med. 1983; 98(part 2):773-780.
              • Hemila H, Douglas RM. Vitamin C and acute respiratory infections. Int J Tuberc Lung Dis. 1999; 3:756-761.
              • Hermans JJ, Fischer MA, Schiffers PM, Struijker-Boudier HA. High dietary potassium chloride intake augments rat renal mineralocorticoid receptor selectivity via 11beta-hydroxysteroid dehydrogenase. Biochim Biophys Acta. 1999; 1472:537-549.
              • Hermansen K. Diet, blood pressure and hypertension. Br J Nutr. 2000; 83 Supp1:S113-S119.
              • Hintze G, Kobberling J. Dietary iodine deficiency. Its consequences in the aged. Fortschr Med. 1992 Apr 10;110(10):163-6.
              • Huebers HA, Beguin Y, Pootrakul P, et al. Intact transferrin receptors in human plasma and their relation to erythropoiesis. Blood. 1990; 75:102-107.
              • Hughes K, Chua LH, Ong CN. Serum selenium in the general population of Singapore, 1993 to 1995. Ann Acad Med Singapore. 1998 Jul;27(4):520-3.
              • Hunt CD, Johnson PE, Herbel J, Mullen LK. Effects of dietary zinc depletion on seminal volume and zinc loss, serum testosterone concentrations, and sperm morphology in young men. Am J Clin Nutr. 1992 Jul;56(1):148-57.
              • Hwang J, Peterson H, Hodis HN, et al. Ascorbic acid enhances 17 beta-estradiol-mediated inhibition of oxidized low density lipoprotein formation. Atherosclerosis. 2000; 150:275-284.
              • Ishimitsu T, Tobian L, Sugimoto K, Everson T. High potassium diets reduce vascular and plasma lipid peroxides in stroke-prone spontaneously hypertensive rats. Clin Exp Hypertens. 1996; 18:659-673
              • Ishimitsu T, Tobian L, Sugimoto K, Lange JM. High potassium diets reduce macrophage adherence to vascular wall in stroke-prone spontaneously hypertensive rats. J Vasc Res. 1995; 32:406-412.
              • Ishimitsu T, Tobian L, Uehara Y, et al. Effect of high potassium diets on the vascular and renal prostaglandin system in stroke-prone spontaneously hypertensive rats. Prostaglandins Leukot Essent Fatty Acids. 1995; 53:255-260.
              • Ishimitsu T, Tobian L. High potassium diets reduce endothelial permeability in stroke-prone spontaneously hypertensive rats. Clin Exp Pharmacol Physiol. 1997; 23:241-245.
              • ISIS-4 (Fourth International Study of Infarct Survival) Collaborative Group. ISIS-4: a randomised factorial trial assessing early oral captopril, oral mononitrate, and intravenous magnesium sulfate in 58,050 patients with suspected acute myocardial infarction. Lancet. 1995; 345:669-685.
              • Jacobson SG, Cideciyan AV, Regunath G, et al. Night blindness in Sorsby's fundus dystrophy reversed by vitamin A. Nature Gen. 1995; 11:27-32.
              • Jin L, ChaoL, Chao J. Potassium supplement upregulates the expression of renal kalikrein and bradykinin B2 receptor in SHR. Am J Physiol. 1999; 276:F476-F484.
              • Johnson WT, Thomas AC. Copper deprivation potentiates oxidative stress in HL-60 cell mitochondria. Proc Soc Exp Biol Med. 1999; 221:147-152.
              • Kao WHL, Folsom AR, Nieto J, et al. Serum and dietary magnesium and the risk for type 2 diabetes mellitus (editorial). Arch. Int Med. 1999; 159:2151-2159.
              • Khaw K-T, Barrett-Conner E. Dietary potassium and stroke-associated mortality. N Engl J Med. 1987; 316:235-240.
              • Klevay LM. Cardiovascular disease from copper deficiency — a history. J Nutr. 2000; 130:489S-492S.
              • Klevay LM. Coronary heart disease: the zinc/copper hypothesis. Am J Clin Nutr. 1975; 28:764-774.
              • Knekt P, Jarvinen R, Seppanen R, Rissanen A, Aromaa A, Heinonen OP, Albanes D, Heinonen M, Pukkala E, Teppo L. Dietary antioxidants and the risk of lung cancer. Am J Epidemiol. 1991 Sep 1;134(5):471-9.
              • Krieger D, Krieger S, Jansen O, et al. Manganese and chronic hepatic encephalopathy. Lancet. 1995; 346:270-274.
              • Krishna GG, Miller E, Kapoor S. Increased blood pressure during potassium depletion in normotensive men. N Eng J Med. 1989; 320:1177-1182.
              • Krotkiewski M, Gudmundsson M, Backstrom P, Mandroukas K. Zinc and muscle strength and endurance. Acta Physiol Scand. 1982 Nov;116(3):309-11.
              • Kung AW, Janus ED. Thyroid dysfunction in ambulatory elderly Chinese subjects in an area of borderline iodine intake. Thyroid. 1996 Apr;6(2):111-4.
              • Lamberg L. Diet may affect skin cancer prevention. JAMA. 1998 May 13;279(18):1427-8.
              • Lee M-O, Han S-Y, Jiang S, et al. Differential effects of retinoic acid on growth and apoptosis in human colon cancer cell lines associated with the induction of retinoic acid receptor beta. Biochem Pharmacol. 2000; 59:485-496.
              • Lim R, Herzog WR. Magnesium for cardiac patients: is it a valuable treatment supplement? Contemp Int Med. 1998; 10:6-9.
              • Lin H, Young DB. Interactions between plasma potassium and epinephrine in coronary thrombosis in dogs. Circulation. 1994; 89:331-338.
              • Loeper J, Goy-Loeper J, Rozensztajn L, Fragny M. The antiatheromatous action of silicon. Atherosclerosis. 1979; 33:397-408.
              • LoPresti JS, Gray D, Nicoloff JT. Influence of fasting and refeeding on 3,3',5'-triiodothyronine metabolism in man. J Clin Endocrinol Metab. 1991 Jan;72(1):130-6.
              • Lucas MJ, Leveno KJ, Cunningham FG. A comparison of magnesium sulfate with phenytoin for the prevention of eclampsia. N Engl J Med. 1995; 333:201-205.
              • Lukaski HC. Magnesium, zinc, and chromium nutriture and physical activity. Am J Clin Nutr. 2000 Aug;72(2 Suppl):585S-93S.
              • Luoma P. Antioxidants, infections and environmental factors in health and disease in northern Finland. Int J Circumpolar Health. 1998 Jul;57(2-3):109-13.
              • Ma G, Young DB, Clower BR. Inverse relationship between potassium intake and coronary artery disease in the cholesterol-fed rabbit. Am J Hypertens. 1999; 12:821-825.
              • Manore MM. Effect of physical activity on thiamine, riboflavin, and vitamin B-6 requirements. Am J Clin Nutr. 2000 Aug;72(2 Suppl):598S-606S.
              • Martini LA. Magnesium supplementation and bone turnover. Nutr Rev. 1999; 57:227-229.
              • Mauskop A, Altura BM. Role of magnesium in the pathogenesis and treatment of migraines. Clin Neurosci. 1998; 5:24-27.
              • McCabe RD, Backarich MA, Srivastava K, Young DB. Potassium inhibits free radical formation. Hypertension. 1994; 24:77-82.
              • McCabe RD, Young DB. Potassium inhibits cultural vascular smooth muscle proliferation. Am J Hypertens. 1994; 7:346-350.
              • McCarty MF. Chromium and other insulin sensitizers may enhance glucagon secretion: implications for hypoglycemia and weight control. Med Hypotheses. 1996 Feb;46(2):77-80.
              • McDonald R, Keen CL. Iron, zinc and magnesium nutrition and athletic performance. Sports Med. 1988 Mar;5(3):171-84.
              • Meunier PJ. Calcium, vitamin D and vitamin K in the prevention of fractures due to osteoporosis. Osteoporos Int. 1999;9 Suppl 2:S48-52.
              • Miller ER 3rd, Appel LJ, Levander OA, Levine DM. The effect of antioxidant vitamin supplementation on traditional cardiovascular risk factors. J Cardiovasc Risk. 1997 Feb;4(1):19-24.
              • Miller JW. Vitamin E and memory: is it vascular protection? Nutr Rev. 2000 Apr;58(4):109-11. Bell L, Halstenson CE, Halstenson CJ, et al. Cholesterol-lowering effects of calcium carbonate in patients with mild to moderate hypercholesterolemia. Arch Intern Med. 1992; 152:2441-2444.
              • Morse AC, Beard JL, Jones BC. A genetic development model of iron deficiency: biological aspects. Proc Soc Exp Biol Med. 1999; 220:147-152.
              • Ness AR, Chee D, Elliot P. Vitamin C and blood pressure—an overview. J Hum Hypertens. 1997; 11:343-350.
              • Nielsen FH. Ultratrace minerals. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease, 9th ed. Baltimore, MD: Williams and Wilkins; 1999:283-303.
              • Nielsen FH. Ultratrace minerals. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams and Wilkins; 199:283-303.
              • Nishi Y. Anemia and zinc deficiency in the athlete. J Am Coll Nutr. 1996 Aug;15(4):323-4.
              • Orchard TJ. Magnesium and type 2 diabetes mellitus (editorial). Arch Int Med. 1999; 159:2119-2120. Keen CL, Ensunsa JL, Watson MH, et al. Nutritional aspects of manganese from experimental studies. Neurotoxicol. 1999; 20:213-223.
              • Paul T, Meyers B, Witorsch RJ, Pino S, Chipkin S, Ingbar SH, Braverman LE. The effect of small increases in dietary iodine on thyroid function in euthyroid subjects. Metabolism. 1988 Feb;37(2):121-4.
              • Pauling L. Evolution and the need for ascorbic acid. Proc Natl Acad SciUSA. 1970; 67:1643-1648.
              • Pauling L. The significance of the evidence about ascorbic acid and the common cold. Proc Natl Acad SciUSA. 1971; 68:2678-2681.
              • Penn ND, Purkins L, Kelleher J, Heatley RV, Mascie-Taylor BH, Belfield PW. The effect of dietary supplementation with vitamins A, C and E on cell-mediated immune function in elderly long-stay patients: a randomized controlled trial. Age Ageing. 1991 May;20(3):169-74.
              • Podmore ID, Griffiths HR, Herbert KE, et al. Vitamin C exhibits pro-oxidant effects. Nature. 1998; 392:559.
              • Prasad AS, Cossack ZT. Neutrophil zinc: an indicator of zinc status in man. Trans Assoc Am Physicians. 1982;95:165-76.
              • Prasad AS. Zinc deficiency in human subjects. Prog Clin Biol Res. 1983;129:1-33.
              • Rayssiguier Y, Gueux E, Bussiere L, Mazur A. Copper deficiency increases the susceptibility of lipoproteins and tissues to peroxidation in rats. J Nutr. 1993; 123:1343-1348.
              • Reading SA. Chromium picolinate. J Fla Med Assoc. 1996 Jan;83(1):29-31.
              • Reinhardt W, Holtermann D, Benker G, Olbricht T, Jaspers C, Reinwein D. Effect of small doses of iodine on thyroid function during caloric restriction in normal subjects. Horm Res. 1993;39(3-4):132-7.
              • Rico H, Gallego-Lago JL, Hernandez ER, at al. Effect of silicon supplement on osteopenia induced by ovariectomy in rats. Calcif Tissue Int. 2000; 66:53-55.
              • Robuschi G, Emanuele R, Cavalli Sforza LT, Arsenio L, Strata A, Gnudi A, Roti E. Effect of iodine administration on thyroid function in diabetic patients. Acta Diabetol Lat. 1984 Oct-Dec;21(4):357-60.
              • Rock E, Mazur A, O'Connor JM, et al. The effect of copper supplementation on red blood cell oxidizability and plasma antioxidants in Middle-aged healthy volunteers. Free Rad Biol Med. 2000; 28:324-329.
              • Rokitzki L, Sagredos A, Keck E, Sauer B, Keul J. Assessment of vitamin B2 status in performance athletes of various types of sports. J Nutr Sci Vitaminol (Tokyo). 1994 Feb;40(1):11-22.
              • Ross AC, Stephensen CB. Vitamin A and retinoids in antiviral responses. FASEB J. 1996; 10:979-985.
              • Ross AC. Vitamin A and retinoids. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams and Wilkins; 1999:305-327.
              • Saari JT, Sahuschke DA. Cardiovascular effects of dietary copper deficiency. Biofactors. 1999; 10:359-375.
              • Schwarz K. A bound form of silicon in glycosaminoglycans and polyuronides. Proc Nat Acad Sci. 1973; 70:1608-1612.
              • Schwarz K. Silicon, fibre, and atherosclerosis. Lancet. 1977; 1:454-457.
              • Scrimshaw NS, San Giovanni JP. Synergism of nutrition, infection, and immunity: an overview. Am J Clin N. 1997; 66:464S-477S.
              • Semba RD. The role of vitamin A and related retinoids in immune function. Nutr Rev. 1998 Jan;56(1 Pt 2):S38-48.
              • Semba RD. Vitamin A and immunity to viral, bacterial and protozoan infections. Proc Nutr Soc. 1999 Aug;58(3):719-27.
              • Semba RD. Vitamin A, immunity, and infection. Clin Infect Dis. 1994 Sep;19(3):489-99.
              • Shephard RJ, Shek PN. Immunological hazards from nutritional imbalance in athletes. Exerc Immunol Rev. 1998;4:22-48.
              • Silva JE. Effects of iodine and iodine-containing compounds on thyroid function. Med Clin North Am. 1985 Sep;69(5):881-98.
              • Singh MA. Combined exercise and dietary intervention to optimize body composition in aging. Ann N Y Acad Sci. 1998 Nov 20;854:378-93.
              • Skaper SD, Fabris M, Ferrari V, et al. quercetin protects cutaneous tissue-associated cell types including sensory neurons from oxidative stress induced by glutathione depletion: cooperative effects of ascorbic acid. Free Rad Biol Med. 1997; 22:669-678.
              • Sohlenius-Sternbeck A-K, Appelkvist E-L, De Pierre JW. Effects of vitamin A deficiency on selected xenobiotic-metabolizing enzymes and defenses against oxidative stress in mouse liver. Biochem Pharmacol. 2000; 59:377-383.
              • Stahelin HB. Critical reappraisal of vitamins and trace minerals in nutritional support of cancer patients. Support Care Cancer. 1993 Nov;1(6):295-7.
              • Strause L, Saltman P, Glowacki J. The effect of deficiencies of manganese and copper on osteo-induction and on resorption of bone particles in rats. Calcif Tissue Int. 1987; 41:145-150
              • Suboticanec K, Stavljenic A, Bilic-Pesic L, Gorajscan M, Gorajscan D, Brubacher G, Buzina R. Nutritional status, grip strength, and immune function in institutionalized elderly. Int J Vitam Nutr Res. 1989;59(1):20-8.
              • Sugimoto K, Tobian L, Ishimutsu T, Lange JM. High potassium diets greatly increase growth-inhibiting agents in aortas of hypertensive rats. Hypertension. 1992; 19:749-752.
              • Sugimoto T, Tobian L, Ganguli MC. High potassium diets protect against dysfunction of endothelial cells in stroke-prone spontaneously hypertensive rats. Hypertension. 1988:11:579-585.
              • Suzuki M, Itokawa Y. Effects of thiamine supplementation on exercise-induced fatigue. Metab Brain Dis. 1996 Mar;11(1):95-106.
              • Taddei S, Virdis A, Ghiadoni L, et al. Vitamin C improves endothelium-dependent vasodilation by restoring nitric oxide activity in essential hypertension. Circulation. 1998; 97:2222-2229.
              • Takahashi T, Fujimori K, Simon SL, Bechtner G, Edwards R, Trott KR. Thyroid nodules, thyroid function and dietary iodine in the Marshall islands. Int J Epidemiol. 1999 Aug;28(4):742-9.
              • Tannen RL. Effects of potassium on blood pressure control. Ann Intern Med. 1983; 98(part 2):773-780.
              • Taylor PR, Li B, Dawsey SM, Li JY, Yang CS, Guo W, Blot WJ. Prevention of esophageal cancer: the nutrition intervention trials in Linxian, China. Linxian Nutrition Intervention Trials Study Group. Cancer Res. 1994 Apr 1;54(7 Suppl):2029s-2031s.
              • Thilly CH, Swennen B, Bourdoux P, Ntambue K, Moreno-Reyes R, Gillies J, Vanderpas JB. The epidemiology of iodine-deficiency disorders in relation to goitrogenic factors and thyroid-stimulating-hormone regulation. Am J Clin Nutr. 1993 Feb;57(2 Suppl):267S-270S.
              • Thurnham DI. Micronutrients and immune function: some recent developments. J Clin Pathol. 1997 Nov;50(11):887-91.
              • Tobian L. Salt and hypertension. Lessons from animal models that relate to human hypertension. Hypertension. 1991; 17:152-158.
              • Toyama T, Kubuki Y, Suzuki M. Tsubouchi H. [Copper deficiency anemia and neutropenia secondary to total gastrectomy]. [Article in Japanese]. Rinsho Ketsueki. 2000; 41:441-443.
              • Trent LK, Thieding-Cancel D. Effects of chromium picolinate on body composition. J Sports Med Phys Fitness. 1995 Dec;35(4):273-80.
              • Turnlund Jr. Copper. In: Shils ME, Olson JA, Shike M. Ross AC, eds. Modern Nutrition in health and Disease, 9th ed. Baltimore, MD: Williams and Wilkins; 1999:241-252.
              • Underwood BA, Arthur P. The contribution of vitamin A to public health. FASEB J. 1996; 10:1040-1048
              • Uusitupa MI, Mykkanen L, Siitonen O, Laakso M, Sarlund H, Kolehmainen P, Rasanen T, Kumpulainen J, Pyorala K. Chromium supplementation in impaired glucose tolerance of elderly: effects on blood glucose, plasma insulin, C-peptide and lipid levels. Br J Nutr. 1992 Jul;68(1):209-16.
              • van den Brandt PA, Goldbohm RA, van 't Veer P, Bode P, Dorant E, Hermus RJ, Sturmans F. A prospective cohort study on selenium status and the risk of lung cancer. Cancer Res. 1993 Oct 15;53(20):4860-5.
              • van der Heyden JT, Docter R, van Toor H, Wilson JH, Hennemann G, Krenning EP. Effects of caloric deprivation on thyroid hormone tissue uptake and generation of low-T3 syndrome. Am J Physiol. 1986 Aug;251(2 Pt 1):E156-63.
              • Van Hooser JP, Aleman TS, He Y-G, et al. Rapid restoration of visual pigment and function with oral retinoid in a mouse model of childhood blindness. Proc Natl Acad Sci USA. 2000; 97:8623-8628.
              • Vatassery GT, Bauer T, Dysken M. High doses of vitamin E in the treatment of disorders of the central nervous system in the aged. Am J Clin Nutr. 1999 Nov;70(5):793-801.
              • Vatassery GT. Vitamin E and other endogenous antioxidants in the central nervous system. Geriatrics. 1998 Sep;53 Suppl 1:S25-7.
              • Waggoner DJ, Bartnikas TB, Gitlin JD. The role of copper in neurodegenerative disease. Neurobiology of Disease. 1999; 6:221-230.
              • Wahl R, Pilz-Mittenburg KW, Heer W, Kallee E. Iodine content in diet and excretion of iodine in urine. Z Ernahrungswiss. 1995 Dec;34(4):269-76.
              • Walker LS, Bemben MG, Bemben DA, Knehans AW. Chromium picolinate effects on body composition and muscular performance in wrestlers. Med Sci Sports Exerc. 1998 Dec;30(12):1730-7.
              • Wang Y, Mackenzie B, Tsukaguchi H, et al. Human vitamin C (L-ascorbic acid) transporter SVCT1. Biochem Biophys Res Commun. 2000; 267:488-494.
              • Wargovich MJ, Eng VWS, Newmark HL. Calcium inhibits the damaging and compensatory proliferative effects of fatty acids on mouse colon epithelium. Cancer Lett. 1984; 23:253-258.\
              • Weaver CM, Heaney RP. Calcium. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams and Wilkins; 1999:141-155.
              • West KP Jr, Pokhrel RP, Katz J, et al. Efficacy of vitamin A in reducing preschool child mortality in Nepal. Lancet. 1991; 338:67-71.
              • West SG, Light KC, Hinderliter AL, et al. Potassium supplementation induces beneficial cardiovascular changes during rest and stress in salt sensitive individuals. Health Psychol. 1999; 18:229-240.
              • Whelton PK, He J, Cutler JA, et al. Effects of oral potassium on blood pressure. Meta-analysis of randomized controlled clinical triglyceride trials. JAMA. 1997; 277:1624-1632.
              • Wolf RL, Cauley JA, Baker CE, et al. Factors associated with calcium absorption efficiency in pre- and perimenopausal women. Am J Clin Nutr. 2000; 72:466-471.
              • Young DB, Lin H, McCabe RD. Potassium's cardiovascular protective mechanisms. Am J Physiol. 1995; 268:R825-R837.
              • Young DB, Ma G. Vascular protective effects of potassium. Semin Nephrol. 1999; 19:477-486.
              • Zemel MB, Shi H, Greer B, et al. Regulation of adiposity by dietary calcium. FASEB J. 2000; 14:1132-1138.
              • Zhou B, Wang T, Sun G, Guan P, Wu JM. A case-control study of the relationship between dietary factors and risk of lung cancer in women of Shenyang, China. Oncol Rep. 1999 Jan-Feb;6(1):139-43.
              • Zhou MS, Nishida Y, Yoneyama H, et al. Potassium supplementation increases sodium excretion in hypertensive Dahl rats. Clin Exp Hypertens.

              Isotonix® Activated B-Complex

              • Benton D., et al.  Thiamine supplementation for mood and cognitive functioning.  Psychopharmacology. 129(1):66-71, 1997.
              • Benton, D., et al.  The effects of nutrients on mood.  Public Health Nutr.  2(3A):403-409, 1999.
              • Bhagavan, H. N., et al.  The effect of pyridoxine hydrochloride on blood serotonin and pyridoxal phosphate contents in hyperactive children.  Pediatrics.  55(3):437-441, 1975.
              • Bronstrup A, Hages M, Prinz-Langenohl R, Pietrzik K. Effects of folic acid and
              • Bryan, J., et al.  Associations between dietary intake of folate and vitamins B-12 and B-6 and self-reported cognitive function and psychological well-being in Australian men and women in midlife.  J Nutr Health Aging.  8(4):226-232, 2004.
              • Bryan, J., et al.  Short-term folate, vitamin B-12 or vitamin B-6 supplementation slightly affects memory performance but not mood in women of various ages.  Journal of Nutrition.  132(6):1345-1356, 2002.
              • combinations of folic acid and vitamin B12 on plasma homocysteine concentrations in healthy young women. Am J Clin Nutr 68:1104-10, 1998.
              • Coppen, A., et al.  Plasma folate and affective morbidity during long-term lithium therapy.  Br J Psychiatry.  141:87-89, 1982.
              • Cummings, P. M., et al.  Effect of folic acid and antioxidant vitamins on endothelial dysfunction in patients with coronary artery disease.  J Am Coll Cardiol.  36:758-765, 2000.
              • Dharmarajan, T. S., et al.  Vitamin B12 deficiency. Recognizing subtle symptoms in older adults.  Geriatrics.  58(3):30-34, 2003.
              • Doshi, S. N., et al.  Folic acid improves endothelial function in coronary artery disease via mechanisms largely independent of homocysteine lowering.  Circulation.  105(1):22-26, 2002.
              • Duthie, S. J., et al.  Homocysteine, B vitamin status, and cognitive function in the elderly.  American Journal of Clinical Nutrition.  75(5):908-913, 2002.
              • Friso, S., et al.  Low plasma vitamin B-6 concentrations and modulation of coronary artery disease risk.  Am J Clin Nutr.  79(6):992-998, 2004.
              • Grant, J. E., et al.  Analysis of dietary intake and selected nutrient concentrations in patients with chronic fatigue syndrome.  J Am Diet Assoc.  96(4):383-386, 1996.
              • Hartvig, P., et al.  Pyridoxine effect on synthesis rate of serotonin in the monkey brain measured with position emission tomography.  Neural Trans.  102:91-97, 1995.
              • Heap, L. C., et al.  Vitamin B status in patients with chronic fatigue syndrome.  J R Soc Med.  92(4):183-185, 1999.
              • Heseker, H., et al.  Psychological disorders as early symptoms of a mild-to-moderate vitamin deficiency.  Ann N Y Acad Sci.  669:352-357, 1992.
              • Jacobson, W., et al.  Serum folate and chronic fatigue syndrome.  Neurology.  43:2645-2647, 1993.
              • Kelly, G. S.  Nutritional and botanical interventions to assist with the adaptation to stress.  Alternative Medicine Review.4(4):249-265, 1999.
              • Litoff, D., et al.  Effects of pantothenic acid supplementation on human exercise.  Med Sci Sport Exercise., 17(Supplement):287, 1985.
              • Osada, K., et al.  Experimental study of fatigue provoked by biotin deficiency in mice.  Int J Vitam Nutr Res.  74(5):334-340, 2004.
              • Quadri, P., et al.  Homocysteine, folate, and vitamin B-12 in mild cognitive impairment, Alzheimer disease, and vascular dementia.  Am J Clin Nutr.  80(1):114-122, 2004.
              • Riggs, K. M., et al.  Relations of vitamin B-12, vitamin B-6, folate, and homocysteine to cognitive performance in the Normative Aging Study.  American Journal of Clinical Nutrition.  63(3):306-314, 1996.
              • Van den Berg M., et al.  Combined vitamin B-6 plus folic acid therapy in young patients with arteriosclerosis and hyperhomocysteinemia.  Journal Vascular Surgery.  20(6):933-940, 1994.
              • van Oort FV, Melse-Boonstra A, Brouwer IA, et al. Folic acid and reduction of plasma homocysteine concentrations in older adults: a dose-response study. 77:1318-23, 2003.
              • Vargiu, R., et al.  Enhancement of muscular performance by a coformulation of propionyl-L-carnitine, coenzyme Q(10), nicotinamide, riboflavin and pantothenic acid in the rat.  Physiol Behav.  76(2):257-63, 2002.
              • Wald DS, Bishop L, Wald NJ, et al. Randomized trial of folic acid supplementation and serum homocysteine levels. Arch Intern Med 61:695-700, 2001.
              • Werbach, M. R.  Nutritional strategies for treating chronic fatigue syndrome.  Alternative Medicine Review.  5(2):93-108, 2000.
              • Woo, K. S., et al.  Long-term improvement in homocysteine levels and arterial endothelial function after 1-year folic acid supplementation.  American Journal of Medicine.  112(7):535-539, 2002.

              Isotonix® Calcium Plus:

              •  Allender PS, Cutler JA, Follman D, et al. Dietary calcium and blood pressure: meta—analysis of randomized clinical trials. Ann Intern Med. 1996; 124:825-831.
              • Altura BM, Altura BT. Role of magnesium and calcium in alcohol-induced hypertension and strokes as probed by in vivo television microscopy, digital image microscopy, optical spectroscopy, 31P-NMR, spectroscopy and a unique magnesium ion-selective electrode. Alcohol Clin Exp Res. 1994; 18:1057-1068.
              • Baly DL, Schneiderman JS, Garcia-Welsh AL. Effect of manganese deficiency on insulin binding, glucose transport and metabolism in rat adipocytes. J Nutr. 1990; 120:1075-1079.
              • Baron JA, Beach M, Mandel JS, et al. Calcium supplements for the prevention of colorectal adenomas. N Engl J Med 1999;340:101-107.
              • Baron JA, Tosteson TD, Wargovich MJ, et al. Calcium supplementation and rectal mucosal proliferation: a randomized controlled trial. J Natl Cancer Inst 1995;87:1303-1307.
              • Baxter GF, Sumeray MS, Walker JM. Infant size and magnesium: insights into LIMIT-2 and ISIS-4 from experimental studies. Lancet. 1996; 348:1424-1426.
              • Beattie JH, Peace HS. The influence of a low-boron diet and boron supplementation on bone, major mineral and sex steroid metabolism in postmenopausal women. Br J Nutr. 1993 May;69(3):871-84. 
              • Bell L, Halstenson CE, Halstenson CJ, et al. Cholesterol-lowering effects of calcium carbonate in patients with mild to moderate hypercholesterolemia. Arch Intern Med. 1992; 152:2441-2444.
              • Bostick RM, Kushi LH, Wu Y, et al. Relation of calcium, vitamin D, and dairy food intake to ischemic heart disease mortality among postmenopausal women. Am J Epidemiol 1999;149:151-160.
              • Britton J, Pavord I, Richards K, et al. Dietary magnesium, lung function, wheezing, and airway hyper-reactivity in a random adult population sample. Lancet. 1994; 344:357-362.
              • Buckley LM, Leib ES, Cartularo KS, et al. Calcium and vitamin D3 supplementation prevents bone loss in the spine secondary to low-dose corticosteroids in patients with rheumatoid arthritis. Ann Intern Med. 1996; 125:961-968.
              • Casscells W. Magnesium and myocardial infarction. Lancet. 1994; 343:807-809.
              • Christiansen CW, Rieder MA, Silverstein EL, Gencheff NE. Magnesium sulfate reduces myocardial infarct size when administered before but not after coronary reperfusion in a canine model. Circulation. 1995; 92:2617-2621.
              • Christin Marandino, Vegetarian Times, August 1998
              • Curhan GC, Willett WC, Speizer FE, et al. Comparison of dietary calcium with supplemental calcium and other nutrients as factors affecting the risk of kidney stones in women. Ann Intern Med. 1997; 126:497-504.
              • Dawson-Hughes B, Harris SS, Krall EA, Dallal GE. Effect of calcium and vitamin D supplementation on bone density on men and women 65 years of age and older. N Engl J Med. 1997; 337:670-676.
              • de Lourdes Lima M, Cruz T, Carreiro Pousada J, et al. The effect of magnesium supplementation in increasing doses on the control of type 2 diabetes. Diabetes Care. 1998; 21:682-686.
              • Dietary Reference Intakes for Calcium, Phosphorous, Magnesium, Vitamin D, and Fluoride. Washington, DC: National Academy Press; 1997.
              • Durlach J, Durlach V, Bac P, et al. Magnesium and therapeutics. Magnes Res. 1994; 7:313-328.
              • Elisaf M, Merkouropoulos M, Tsianos EV. Siamopoulos KC. Pathogenetic mechanisms of hypomagnesemia in alcoholic patients. J Trace Elem Med Biol. 1995; 9:210-214.
              • Facchinetti F, Borella P, Sances G, et al. Oral magnesium successfully relieves premenstrual mood changes. Obstet Gynecol. 1991; 78:177-181.
              • Garland CF, Garland FC, Gorham ED. Calcium and vitamin D. Their potential roles in colon and breast cancer prevention. Ann NY Acad Sci. 1999; 889:107-119.
              • Gong H, Amemiya T. Optic nerve changes in manganese-deficient rats. Exp Eye Res. 1999; 68:313-320.
              • Gullestad L, Dolva LO, Soyland E, et al. Oral magnesium supplementation improves metabolic variables and muscle strength in alcoholics. Alcohol Clin Exp Res. 1992; 16:986-990.
              • Health & Medicine. (Statistical Data Included) American Fitness, July, 1999 Tannen RL. Effects of potassium on blood pressure control. Ann Intern Med. 1983; 98(part 2):773-780.
              • Heaney RP. Calcium, dairy products and osteoporosis. J Am Coll Nutr. 2000; 19(2 Suppl):83S-99S.
              • Hussain S, Ali SF. Manganese scavenges superoxide and hydroxyl radicals: an in vitro study in rats. Neuroscience Letters. 1999; 261:21-24.
              • ISIS-4 (Fourth International Study of Infarct Survival) Collaborative Group. ISIS-4: a randomised factorial trial assessing early oral captopril, oral mononitrate, and intravenous magnesium sulfate in 58,050 patients with suspected acute myocardial infarction. Lancet. 1995; 345:669-685.
              • Jorde R, Sundsfjord J, Haug E, et al. Relation between low calcium intake, parathyroid hormone, and blood pressure. Hypertension 2000;35:1154-1159.
              • Kao WHL, Folsom AR, Nieto J, et al. Serum and dietary magnesium and the risk for type 2 diabetes mellitus (editorial). Arch. Int Med. 1999; 159:2151-2159.
              • Keen CL, Ensunsa JL, Watson MH, et al. Nutritional aspects of manganese from experimental studies. Neurotoxicol. 1999; 20:213-223.
              • Krieger D, Krieger S, Jansen O, et al. Manganese and chronic hepatic encephalopathy. Lancet. 1995; 346:270-274.
              • Lim R, Herzog WR. Magnesium for cardiac patients: is it a valuable treatment supplement? Contemp Int Med. 1998; 10:6-9.
              • Lipkin M, Newmark H. Effect of added dietary calcium on colonic epithelial-cell proliferation in subjects at high risk for familial colonic cancer. N Engl J Med. 1985; 313:1381-1384.
              • Lucas MJ, Leveno KJ, Cunningham FG. A comparison of magnesium sulfate with phenytoin for the prevention of eclampsia. N Engl J Med. 1995; 333:201-205.
              • Martini LA. Magnesium supplementation and bone turnover. Nutr Rev. 1999; 57:227-229.
              • Mauskop A, Altura BM. Role of magnesium in the pathogenesis and treatment of migraines. Clin Neurosci. 1998; 5:24-27.
              • Naghii MR, Wall PM, Samman S. The boron content of selected foods and the estimation of its daily intake among free-living subjects. J Am Coll Nutr. 1996 Dec;15(6):614-9.
              • Newnham RE. Essentiality of boron for healthy bones and joints. Environ Health Perspect. 1994;102:83-85
              • Nielsen FH. Studies on the relationship between boron and magnesium which possibly affects the formation and maintenance of bones. Magnes Trace Elem. 1990;9:61-69
              • Nielsen FH. Ultratrace minerals. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease, 9th ed. Baltimore, MD: Williams and Wilkins; 1999:283-303.
              • Oginni LM, Sharp CA, Worsfold M, et al. Healing of rickets after calcium supplementation. Lancet. 1999; 353:296-297.
              • Orchard TJ. Magnesium and type 2 diabetes mellitus (editorial). Arch Int Med. 1999; 159:2119-2120.
              • Paolisso G, Sgamabato S, Pizza G, et al. Improved insulin response and action by chronic magnesium administration in aged NIDDM. Diabetes Care. 1989; 12:265-269.
              • Peikert A, Wilimzig C, Kohne-Volland R. Prophylaxis of migraine with oral magnesium: results from a prospective, multi-center, placebo-controlled and double-blind randomized study. Cephalalgia. 1996; 16:257-263.
              • Penland J.G. The importance of boron nutrition for brain and psychological function. Biol Trace Elem Res. 1998; 66:299-317.
              • Recker RR. Calcium absorption and achlorhydria. N Engl J Med. 1985; 313:70-73. Reid IR, Ames RW, Evans MC, et al. Effect of calcium supplementation on bone loss in postmenopausal women. N Engl J Med. 1993; 328:460-464.
              • Rivlin RS. Magnesium deficiency and alcohol intake: mechanisms, clinical significance and possible relation to cancer development (a review). J Am Coll Nutr. 1994; 13:416-423.
              • Roberts JM. Magnesium for preeclampsia and eclampsia. N Engl J Med. 1995; 333:250-251.
              • Roffe C, Fletcher S, Woods KL. Investigation of the effects of intravenous magnesium sulphate on cardiac rhythm in acute myocardial infarction. Br Heart J. 1994; 71:141-145.
              • Saris N-EL, Mervaala E, Karppanen H, et al. Magnesium. An update on physiological, clinical and analytical aspects (review). Clinica Chimica Acta. 2000; 294:1-26.
              • Shils ME. Magnesium. In: Shils M, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams and Wilkins; 1999:169-192.
              • Singh MA. Combined exercise and dietary intervention to optimize body composition in aging. Ann N Y Acad Sci. 1998 Nov 20;854:378-93.
              • Singh N, Singh PN, Hershman JM. Effect of calcium carbonate on the absorption of levothyroxine. JAMA. 2000; 283:2822-2825.
              • Sojka JE. Magnesium supplementation and osteoporosis. Nutr Rev. 1995; 53:71-80.
              • Strause L, Saltman P, Glowacki J. The effect of deficiencies of manganese and copper on osteo-induction and on resorption of bone particles in rats. Calcif Tissue Int. 1987; 41:145-150
              • Strause L, Saltman P, Smith KT, et al. Spinal bone loss in postmenopausal women supplemented with calcium and trace minerals. J Nutr. 1994; 124:1060-1064.
              • Sutherland B, Strong P, King JC. Determining human dietary requirements for boron. Biol Trace Elem Res. 1998 Winter;66(1-3):193-204.
              • Talbot JR, Guardo P, Seccia S, et al. Calcium bioavailability and parathyroid hormone acute changes after oral intake of dairy and nondairy products in healthy volunteers. Osteoporosis Int. 1999; 10:137-142.
              • Tobian L. Salt and hypertension. Lessons from animal models that relate to human hypertension. Hypertension. 1991; 17:152-158.
              • Tosiello L. Hypomagnesemia and diabetes mellitus. A review of clinical implications. Arch Intern Med. 1998; 156:1143-1148.
              • Volpe SL, Taper LJ, Meacham S. The relationship between boron and magnesium status and bone mineral density in the human: a review. Magnes Res. 1993;6:291-296
              • Wargovich MJ, Eng VWS, Newmark HL. Calcium inhibits the damaging and compensatory proliferative effects of fatty acids on mouse colon epithelium. Cancer Lett. 1984; 23:253-258.
              • Weaver CM, Heaney RP. Calcium. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams and Wilkins; 1999:141-155.
              • Wolf RL, Cauley JA, Baker CE, et al. Factors associated with calcium absorption efficiency in pre- and perimenopausal women. Am J Clin Nutr. 2000; 72:466-471.
              • Woods KL, Fletcher S. Long-term outcome after intravenous magnesium sulphate in suspected acute myocardial infarction: the second Leicester Intravenous Magnesium Intervention Trial (LIMIT-2). Lancet. 1994; 343:816-819.
              • Zemel MB, Shi H, Greer B, et al. Regulation of adiposity by dietary calcium. FASEB J. 2000; 14:1132-1138. 

              FAQ

              What is included in each packet of the Isotonix Daily Essentials Packets?
              Each packet contains one capful each of Isotonix OPC-3, Isotonix Multivitamin, Isotonix Activated B-Complex, and Isotonix Calcium Plus.

              Why are Isotonix® supplements better than standard supplements?
              Isotonix formulas are more effective than standard supplement formulas because they offer the best way to get the maximum delivery of vitamins and minerals into the bloodstream. Isotonix formulas are also the fastest and most effective way to receive vitamins, minerals and nutrients. The stomach has very little work to do because the pH and tonicity are carefully designed to allow the stomach to quickly release all the nutrients into the small intestine. With the Isotonix formulas, this process takes about five minutes, whereas a standard vitamin tablet can take up to four hours.

              What sets Isotonix OPC-3 apart from other bioflavonoid products?
              Isotonix OPC-3 offers scientifically-supported oligomeric proanthocyanidins, or OPCs, found to be the most powerful antioxidants for human health. In addition to being powerful antioxidants, these individual OPCs have been shown to provide a myriad of specific health benefits. This science-driven selection of OPCs is unique to OPC-3, as is the Isotonix delivery system, which enables rapid and highly efficient absorption of the OPCs. The potent nutrients, in combination with the highly effective delivery system, makes OPC-3 the most powerful, free radical-scavenging product available.*      

              Why do I need to take a multivitamin?
              A good quality vitamin and mineral supplement creates a sound micronutrient foundation to accompany a balanced diet. Vitamins and minerals help to support a healthy immune system, promote the conversion of food into energy, support a healthy cardiovascular system, support strong bones, promote mental clarity, maintain normal metabolic functioning, promote healthy growth and repair of tissues, help maintain normal blood pressure, and help maintain water and electrolyte balance in the body.

              What does “Activated” refer to in Isotonix Activated B-Complex?
              Activated refers to the active forms of vitamins B6, B12 and folic acid. Using forms other than these activated forms requires that the vitamins be enzymatically activated prior to utilization by the body. Not only does this take time and energy within the body, there are circumstances in which this reaction is either slowed or inhibited.

              Why should I take calcium?
              According to the Surgeon General, taking a calcium supplement daily is key to preventing and treating calcium deficiency and to helping reduce the risk of osteoporosis. Currently, osteoporosis affects over one-third of postmenopausal women in this country. Recent clinical statistics also indicate that aging men are also likely to become susceptible to osteoporosis.* 

              Everyone needs calcium. Practically no one ingests enough calcium in their daily diet. Besides being helpful in supporting and maintaining bone integrity, calcium serves a dynamic role as a mineral. It's very important in supporting the activity of many bodily enzymes and maintaining proper fluid balance. Isotonix Calcium Plus also promotes the normal contraction of skeletal and muscle.  

              I am healthy and athletic; why should I take Isotonix OPC-3?
              Everyone is vulnerable to the aging process caused by continuous free radical damage. Athletes tend to be exposed to elevated levels of oxidative stress. Free radicals develop as byproducts during metabolism when calories are processed with oxygen. Athletes inhale 10 to 20 times more oxygen during physical activity over rest periods. The increase in activity creates additional free radicals. In fact, these free radicals are known to limit performance, as free radicals appear to take their toll on muscle tissue. Studies on recreational athletes have shown a 20 percent endurance increase with OPCs, as compared to a control group receiving a placebo. Another study has shown that athletes using OPCs suffered significantly less muscle cramping during and after performing. Isotonix OPC-3 helps to maintain healthy blood flow and this supports oxygen supply to muscles.* 

              Are there any warnings or contraindications for the products in the Isotonix Daily Essentials Packets?
              Isotonix OPC-3, Isotonix Multivitamin, Isotonix Activated B-Complex and Isotonix Calcium Plus are vegetarian products and contain no wheat, gluten, soy, yeast, artificial flavor, starch, salt, preservatives or milk.

              If you are currently using any prescription drugs, have ongoing medical condition, or if you are pregnant or breastfeeding, you should consult your healthcare provider before using these product.