- Contains DigeZyme® (a powerful blend of amylase, protease, cellulase, lactase and lipase)
- Contains the probiotic Lactospore® (Bacillus coagulans)
- One serving supplies over 100 mg of key digestive enzymes and 150 million CFUs of probiotic
Isotonix Digestive Enzymes with Probiotics
Isotonix Digestive Enzymes with Probiotics is an isotonic-capable food supplement made from a combination of DigeZyme®, a blend of amylase, protease, cellulase, lactase, and lipase, and Lactospore®, the probiotic Bacillus coagulans, with potassium, magnesium and sucrase, designed to replenish the body’s essential digestive enzymes and probiotics.
Enzymes are important for the body’s proper absorption and utilisation of food. Over time, the body’s ability to make certain enzymes reduces as part of the natural aging process. Many scientists now believe that maintaining normal levels of key enzymes is important to maintaining overall health. Enzymes are responsible for every activity of life. Digestive and metabolic are the two primary classifications of enzymes within the body. Proteases (aids in digesting protein), amylases (aids in digesting carbohydrates), and lipases (aids in digesting fats) are the three primary digestive enzymes, which function as the biological catalyst to breaking down food.
In today’s world of processed and fast foods, the body must work harder to break down food and absorb the nutrients. Poor eating habits, such as improper or inadequate chewing and eating on the run contribute to reduced levels of digestive enzymes. In addition to a reduction in essential enzymes, poor eating habits, some medications and illness deplete the body’s probiotics, which are necessary for maintaining a healthy digestive tract and promoting a healthy immune system.
DigeZyme is a multi-enzyme complex consisting mainly of amylase (starch hydrolysing enzyme), protease (protein hydrolysing enzyme) and lipase (fat hydrolysing enzymes). In addition to these, it also contains cellulase (that hydrolyses cellulose) and lactase (that hydrolyses lactose). The enzymes in this complex are of microbial origin (fungal amylase, lipase, lactase, cellulase; and a bacterial neutral protease). The product is, therefore, entirely of non-animal origin.
Isotonic, which means “same pressure,” bears the same chemical resemblance of the body’s blood, plasma and tears. All fluids in the body have a certain concentration, referred to as osmotic pressure. The body’s common osmotic pressure, which is isotonic, allows a consistent maintenance of body tissues. In order for a substance to be absorbed and used in the body’s metabolism, it must be transported in an isotonic state.
Isotonix dietary supplements are delivered in an isotonic solution. This means that the body has less work to do to in obtaining maximum absorption. The isotonic state of the suspension allows nutrients to pass directly into the small intestine and be rapidly absorbed into the bloodstream. With Isotonix products, little nutritive value is lost, making the absorption of nutrients highly efficient while delivering maximum results.
Amylases are enzymes that catalyse the hydrolysis of alpha-1, 4-glycosidic linkages of polysaccharides to yield dextrins, oligosaccharides, maltose and D-glucose. Amylases are derived from animal, fungal and plant sources. Pancreatin and pancrelipase contain amylase derived from the pancreas of animals, usually porcine pancreas. Amylase is also derived from barley malt and the fungus Aspergillus oryzae. There are a few different amylases. These enzymes are classified according to the manner in which the glysosidic bond is attacked. Alpha-amylases hydrolyse alpha-1, 4-glycosidic linkages, randomly yielding dextrins, oligosaccharides and monosaccharides. Alpha-amylases are endo-amylases. Exoamylases hydrolyse the alpha-1, 4-glycosidic linkage only from the non-reducing outer polysaccharide chain ends. Exoamylases include beta-amylases and glucoamylases (gamma-amylases, amyloglucosidases). Beta-amylases yield beta-limit dextrins and maltose. Gamma-amylases yield glucose. Amylases are used as digestants. Amylase activity is expressed as Dextrinising Units or DU.
Proteases (proteinases, peptidases or proteolytic enzymes) are enzymes that break peptide bonds between amino acids in proteins. The process is called proteolytic cleavage, a common mechanism of activation or inactivation of enzymes especially involved in blood coagulation or digestion. They use a molecule of water for this and are thus classified as hydrolases.
Proteases occur naturally in all organisms and constitute one to five percent of the gene content. These enzymes are involved in a multitude of physiological reactions from simple digestion of food proteins to highly regulated cascades. Peptidases can break either specific peptide bonds (limited proteolysis), depending on the amino acid sequence of a protein, or break down a complete peptide to amino acids (unlimited proteolysis). The activity can be a destructive change abolishing a protein's function or digesting it to its principal components, an activation of a function or a signal in a signaling pathway.
Lactase (LCT), a member of the β-galactosidase family of enzyme, is involved in the hydrolysis of the disaccharide lactose into constituent galactose and glucose monomers. In humans, lactase is present predominantly along the brush border membrane of the differentiated enterocytes lining the villi of the small intestine.
Lactase is essential for digestive hydrolysis of lactose in milk. Deficiency of the enzyme causes lactose intolerance; most humans become lactose intolerant as adults.
A lipase is a water-soluble enzyme that catalyses the hydrolysis of ester bonds in water–insoluble, lipid substrates. Most lipases act at a specific position on the glycerol backbone of a lipid substrate (A1, A2 or A3). In the example of human pancreatic lipase (HPL), which is the main enzyme responsible for breaking down fats in the human digestive system, a lipase acts to convert triglyceride substrates found in oils from food to monoglycerides and free fatty acids. A myriad of other lipase activities exist in nature, especially when the phospholipases and sphingomyelinases are considered.
Lipases are ubiquitous throughout living organisms, and genes encoding lipases are even present in certain viruses. While a diverse array of genetically distinct lipase enzymes are found in nature, most are built on an alpha/beta hydrolase fold and employ a chymotrypsin-like hydrolysis mechanism involving a serine nucleophile, an acid residue (usually aspartic acid), and a histidine.
Some lipases work within the interior spaces of living cells to degrade lipids. In the example of lysosomal lipase, the enzyme is confined within an organelle called the lysosome. Other lipase enzymes, such as pancreatic lipases, are found in the spaces outside of cells and have roles in the metabolism, absorption and transport of lipids throughout the body. As biological membranes are integral to living cells and are largely composed of phospholipids, lipases play important roles in cell biology. Furthermore, lipases are involved in diverse biological processes ranging from routine metabolism of dietary triglycerides to cell signalling and inflammation. Several different types of lipases are found in the human body, including pancreatic lipase, hepatic lipase, lysosomal lipase, gastric lipase, endothelial lipase and as various phospholipases.
Cellulase is an enzyme complex which breaks down cellulose to beta-glucose. It is produced mainly by symbiotic bacteria in the ruminating chambers of herbivores. Aside from ruminants, most animals (including humans) do not produce cellulase in their bodies and are, therefore, unable to use most of the energy contained in plant material.
Enzymes which hydrolyse Hemicellulose are usually referred to as hemicellulase and are usually classified under cellulase in general. Enzymes that cleave lignin are occasionally classified as cellulase, but this is usually considered erroneous.
Cellulase is an enzyme derived from the fungi Aspergillus niger and Trichoderma longbrachiatum or other sources. Cellulose is an indigestible plant polysaccharide. It is the principal constituent of the cell wall of plants. Cellulase has cellulolytic activity, meaning that it hydrolyses cellulose. Cellulase hydrolyses the beta-D-1, 4-glycosidic bonds of cellulose. Cellulase derived from Trichoderma longbrachiatum is comprised of an enzyme complex consisting of cellulase, a glucosidase, cellobiohydrolase and a glucanase. This complex converts cellulose to beta-dextrins and ultimately to D-glucose. Cellulase is used as a digestive aid, particularly in animals, and for the management of flatulence. The activity of cellulase is expressed in cellulose units or CU.
Cellulase is used for commercial food processing in coffee. It performs hydrolysis of cellulose during drying of beans. Cellulase is used in the fermentation of biomass into bio fuels, although this process is relatively experimental at present. Cellulase is used to address Phytobezoars, a form of cellulose bezoar found in the human stomach.
Sucrase is the enzyme involved in the hydrolysis of sucrose to fructose and glucose. It is secreted by the tips of the villi of the epithelium in the small intestines. Its levels are reduced in response to villi blunting events such as coeliac sprue. Sucrase increases during pregnancy and lactation as villi hypertrophy.
Foods rich in magnesium include unpolished grains, nuts and green vegetables. Green, leafy vegetables are good sources of magnesium because of their chlorophyll content. Meats, starches and milk are less rich sources of magnesium. Refined and processed foods are generally quite low in magnesium.
Magnesium is a component of the mineralised part of bone and is necessary for the metabolism of potassium and calcium in adults. It helps maintain normal levels of potassium, phosphorus, calcium, adrenaline and insulin. It plays a key role in the functioning of muscle and nervous tissue. Magnesium is necessary for the synthesis of all proteins.
Foods rich in potassium include fresh vegetables and fruits, such as bananas, oranges, cantaloupe, avocado, raw spinach, cabbage and celery.
Potassium is an essential macromineral that helps to maintain fluid balance. It also plays a role in a wide variety of biochemical and physiological processes. Among other things, it is important in the transmission of nerve impulses, normal muscle function and the maintenance of normal blood pressure.
Bacillus coagulans - Lactospore®
Bacillus coagulans is a lactic acid bacillus preparation manufactured and distributed by the Sabinsa Corporation. Fermented milks have been a part of the human diet since ancient times. Their efficacy in alleviating gastrointestinal disorders has been exploited in systems of traditional medicine the world over. Lactic acid bacteria, the indigenous microbial flora in fermented milks and natural inhabitants of the human gastrointestinal tract were thought to be responsible for the longevity of their hosts through their curative and prophylactic actions.
The role of lactic acid bacteria in gastrointestinal microecology has been the subject of extensive research. It is widely believed that these bacteria prevent the growth of putrefactive microorganisms responsible for ill health by competitive inhibition, the generation of a non-conducive acidic environment and/or by the production of bacteriocins. Their metabolites may include B group vitamins.
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What are digestive enzymes?
Digestive enzymes are special catalytic proteins that help your body break down food to utilise the complete spectrum of nutrients in the food we eat. Unfortunately, food enzymes, which are sensitive to heat, are usually inactivated when food is cooked to serve. This leaves your body with the challenge of trying to break down foods for absorption into your system with no help from the natural enzymes that would otherwise be present in many of the foods we eat. While your body can break down foods with no help, it may put additional strain on your system. Isotonix Digestive Enzymes with Probiotics acts to supplement and maximise the activity of the body’s own enzymes and the "friendly" bacteria our bodies need in an easy-to-take, pleasant-tasting drink.
Our lifestyles and diets are constantly changing. If the last 25 years are any indication, these changes are not usually for the best. Foods that would otherwise offer us their own added enzymes to help our bodies absorb more nutrients are increasingly processed, heated for extended shelf life and stripped of vital elements. The problem is that in making increasing numbers of foods "safe" for ingestion, we are in some cases making foods less healthy for our systems. This means our bodies now need to work harder to absorb the same nutritional content as they may have just a few years ago. Isotonix Digestive Enzymes with Probiotics helps your body replenish all the essential enzymes and "good" bacteria necessary for maximum absorption of nutrients from the food we eat.
What are enzymes?
Enzymes are the workhorses of our cells. They are proteins that catalyse many thousands of biochemical reactions in the body. While most enzymes work inside our cells, digestive enzymes operate outside the cells in the gastrointestinal tract.
The start of digestion begins with digestive enzymes secreted by salivary gland cells into our mouths. Cells lining the gastrointestinal tract also contribute enzymes such as pepsin in the stomach. In addition, digestive enzymes are produced in the pancreas and are emptied into the upper part of the small intestine.
These enzymes help to break apart proteins, allowing the body to optimise its effort to digest proteins from plant and animal sources as well as break down starch, lactose, fats, and nucleic acids (DNA and RNA). The result is a more complete digestive process, resulting in better nutritional absorption.
Isotonix Digestive Enzymes with Probiotics supplies natural plant enzymes that are not inactivated by stomach acid. What this means is that the supplemental enzymes mix with and work in concert with the ingested food and begin to work with the body’s own digestive enzymes to release as many of the nutrients as possible.
What are probiotics?
Probiotics are beneficial organisms that promote a healthy intestinal tract environment. Probiotics can help support the body in maintaining proper digestive functions and improving emotional health. Bacillus coagulans bacteria reside mostly in the large intestine and help break down undigested food. These "friendly" bacteria can help the absorption of vitamins and minerals and can actually synthesise some vitamins, such as biotin and vitamin K. In addition, these beneficial bacteria contribute to the breaking down of fibres and undigested starch into simple sugars. These simple sugars then function as fuel for the cells that line the large intestine.
What happens when we eat?
Even before we eat our body‘s digestive action begins to take place. Simply smelling food activates our salivary glands ("mouth watering"). As the food enters the stomach, the stomach acid and pepsin work together to begin breaking the food down into material the small intestine (where most nutrients are absorbed) can use. Enzymes specific to each of the three nutrient groups are released at this stage, further breaking down the food and contributing to the digestive and absorption processes. These processes continue into the large intestine until the food’s nutritional content is extracted by the body.
What are the basic and specialty enzymes in this product?
There are three basic food enzymes that help us digest our food. Each has a specific function and purpose, and each is necessary for the releasing of nutrients into our bodies. They are: protease (which digests proteins), amylase (which digests starch) and lipase (which digests fats). The specialty enzymes are: lactase (for the sugar lactose in dairy products), sucrase (for table sugar and fruit), and cellulase (which helps us digest cellulose fibres). Each of these enzymes plays a significant part in the body’s overall health by helping to release specific and necessary nutrients into our bodies.
What are the "good" bacteria?
We all know that chlorine in our water supply kills bacteria, making water safe to drink. That’s good, but all bacteria are not harmful. In fact, if it weren’t for "good" bacteria, we would be unable to digest food. Many people, especially women, know the importance of having "good" bacteria in their system, and many actually take supplements like Lactobacillus acidophilus to keep healthy. Isotonix Digestive Enzyme Formula with Probiotics contains probiotic bacteria called Bacillus coagulans, designed to help replenish the "good" bacteria that can be harmed by things like the ingestion of chlorinated water and antibiotics. These "friendly" bacteria help to repopulate the colon, displacing harmful bacteria, and promote an appropriate pH balance.
How do I take Isotonix Digestive Enzymes with Probiotics?
Pour one level, white bottle capful of powder into the overcap. Add water to the line on the overcap (60 ml/2 fl. oz.) and stir. As a food supplement, take once daily. Maximum absorption occurs when taken with a meal or immediately following a meal. Additional servings may be taken if necessary. This product is isotonic only if the specified amounts of powder and water are used.
Are there any warnings or contraindications for Isotonix Digestive Enzymes with Probiotics?
If you are currently using prescription drugs, have an ongoing medical condition, or if you are pregnant or breastfeeding, consult your healthcare provider before using this product.
Are there any allergen warnings for Isotonix Digestive Enzymes?
Isotonix Digestive Enzymes is a vegetarian product and contains no added wheat, soy, yeast, gluten, artificial flavour, starch, salt, preservatives or milk.
Isotonix Digestive Enzymes with Probiotics is an isotonic-capable food supplement that is made from a unique blend of digestive enzymes and probiotics. By including patented ingredients Digezyme® (a powerful blend of amylase, protease, cellulase, lactase and lipase) and Lactospore®, the probiotic Lactobacillus sporogenes all designed to replenish essential digestive enzymes and probiotics. Enzymes are important for the body's proper absorption and utilization of food. One serving supplies over 100 mg of key digestive enzymes and 150 million CFUs of probiotic. Over time, the body's ability to make certain enzymes decreases as part of the natural ageing process. Isotonix Digestive Enzymes with Probiotics promotes digestion and absorption of nutrients which can support a healthy digestive tract. Lactospore® is a lactic acid bacillus preparation manufactured and distributed by the SABINSA CORPORATION.
*These products are not manufactured or distributed by Market (United Kingdom) Ltd and all associated trademarks are the property of their respective owners.