- Helps to maintain vision, skin, membrane and immune functions
- Acts as an antioxidant for the maintenance of good health
- Helps the body to metabolize proteins, fats and carbohydrates
- Helps in the normal development of bones, cartilage, teeth and gums
- Helps in the function of the thyroid gland
- Helps to produce red blood cells and facilitate their proper function
- Provides support for healthy glucose metabolism
- Product Tested NO Detectable GMO
A good quality vitamin and mineral supplement creates a sound micronutrient foundation to accompany a balanced diet. According to the World Health Organisation (WHO), “Nutrition is the foundation for health and development. Better nutrition means stronger immune systems, less illness and better health. Healthy children learn better. Healthy people are stronger, are more productive and more able to create opportunities to gradually break the cycles of both poverty and hunger in a sustainable way. Better nutrition is a prime entry point to ending poverty and a milestone to achieving better quality of life.” There is no substitute for a healthy, well-balanced diet; however, in today’s fast-paced lifestyles, it is important to ensure the body is getting the fuel it needs. Isotonix Multi-Vitamin is an isotonic-capable food supplement containing 100 percent or more of most of the recommended daily allowances (RDA) of vitamins and minerals. There are wide varieties of vitamin and mineral supplements on the market today. Only Isotonix Multi-Vitamin contains a unique blend of complementary vitamins and minerals with the superior delivery of Isotonix. Isotonix Multi-Vitamin supplements dietary deficiencies and helps maintain normal metabolic functioning, helps maintain vision, skin, membrane, immune functions, and bone health, metabolism, and acts as an antioxidant for the maintenance of good health. Isotonix Multi-Vitamin is a great supplement choice for all adults and especially for athletes, growing teenagers and pre-menopausal women. This product should be taken daily in addition to your dietary regimen. Multivitamin will establish a sound micronutrient foundation. ""If a drop of prevention is worth a gallon of longevity, then preventative medicine, such as vitamins and minerals, are worth their weight in gold,"" said Dr. Linus Pauling in 1976. Good advice then and as we look to the future, vitamins and minerals will play an ever-increasing vital role to the well-being in every individual.
Isotonic, which means “same pressure,” bears the same chemical resemblance of the body’s blood, plasma and tears. All fluids in the body have a certain concentration, referred to as osmotic pressure. The body’s common osmotic pressure, which is isotonic, allows a consistent maintenance of body tissues. In order for a substance to be absorbed and used in the body’s metabolism, it must be transported in an isotonic state. Isotonix dietary supplements are delivered in an isotonic solution. This means that the body has less work to do in obtaining maximum absorption. The isotonic state of the suspension allows nutrients to pass directly into the small intestine and be rapidly absorbed into the bloodstream. With Isotonix products, little nutritive value is lost, making the absorption of nutrients highly efficient while delivering maximum results.
Certain products are considered essential for everyone because they help establish a foundation for optimal health. One of these products is a multivitamin, since it is important for helping provide vitamins and minerals that may be lacking in our diet. When adding a multivitamin, it is important to realize that a multivitamin should be delivered in a way where little nutritive value is lost, making the absorption of nutrients important. It is this reason why Isotonix Multivitamin sets itself apart from the competition. In addition to providing 100% or more of many of the daily recommended value of many vitamins and minerals, Isotonix Multivitamin includes the rapid absorption made possible by the Isotonix delivery system, eliminating the need to swallow a pill. Also, by removing binders and fillers, Isotonix multivitamin is a great tasting, all natural alternative to your everyday multivitamin.
First off, this product tastes AMAZING! And I don't have to take it with food = no nausea! And I was definitely low in iron - so much that they thought I was anemic. Thanks to this product, my iron is where it should be and I am getting the vitamins and minerals that I need daily.
Suprised I can take this
I have to be honest I have tried other multi-vitamins in the past and have not been able to take them. I would get the jitters, and or feel sick to my stomach. This is not a vitamin it is a supplement that absorbs in your system immediately. I cannot say enough how it is worth the money to invest in your inner, and outer health.
I felt the difference
I was taking pills and capsules from different places but when I started taking this vitamin. I felt the difference or not the difference. What I mean was it was so natural to my body it did not leave me feeling like something was stuck in my gut. I also had energy and actually felt better.
Isotonix mutivitamin great for those with MTHFR
MTHFR mutations are found in up to 40% of the population. People with this problem have trouble converting folic acid into active forms of folate useable by the body. People with MTHFR mutations, especially the more severe versions, should avoid folic acid and choose vitamins with activated forms of folate such as that found in this multivitamin. This multivitamin also contains other key B vitamins to support proper methylation which is the main function of the MTHFR gene.
Love this product!!
The best multivitamin I have ever tried! Love the delivery system, feel better and have more energy! Everyone should take a multivitamin and this one is the best!
Vitamin A (Beta-Carotene/Vitamin A pre-cursor & Palmitate) Vitamin A is a fat-soluble vitamin. Sources of vitamin A include organ meats (such as liver and kidney), egg yolks, butter, carrot juice, squash, sweet potatoes, spinach, peaches, fortified dairy products and cod liver oil. Vitamin A is also part of a family of compounds including retinol, retinal and beta-carotene. Beta-carotene, also known as pro-vitamin A, can be converted into vitamin A when additional levels are required. All the body’s tissues need vitamin A for general growth and repair. Vitamin A helps to promote healthy night vision, support normal bone growth, and support an antioxidant defense and a healthy immune system. Vitamin C (Ascorbic Acid) Vitamin C is found in peppers (sweet, green, red, hot red and green chili), citrus fruits and brussel sprouts, cauliflower, cabbage, kale, collards, mustard greens, broccoli, spinach, guava, kiwi fruit, currants and strawberries. Nuts and grains contain small amounts of vitamin C. It is important to note that cooking destroys vitamin C activity. Vitamin C is integral in supporting a healthy immune system and providing an antioxidant defense. The body does not manufacture vitamin C on its own, nor does it store it. Therefore, vitamin C must be acquired through diet and supplementation. Thiamin (Vitamin B1) Thiamin plays an important role in carbohydrate metabolism and nerve function. Thiamin is required for a healthy nervous system and assists in the production of the neurotransmitter acetylcholine and gamma-aminobutyric acid (GABA). It is used in the manufacture of hydrochloric acid and, therefore, plays a part in digestion and metabolism. Pantothenic Acid (Vitamin B5) Pantothenic acid (B5) is an important B vitamin with many roles in the body. It has roles in metabolism and also with cardiovascular support. Niacin (Vitamin B3) Niacin is a water-soluble vitamin necessary for many aspects of health, growth and reproduction. It is part of the vitamin B complex. Niacin supports the functioning of the digestive system, skin and nerves. It is also important for the conversion of food to energy by helping metabolize proteins, fats and carbohydrates in the body. Niacin (also known as vitamin B-3) is found in dairy products, poultry, fish, lean meats, nuts, eggs, legumes, and enriched breads and cereals. Vitamin B12 (Cyanocobalamin) Vitamin B12 is naturally found in meats, liver, beef, pork, eggs, whole milk, cheese, whole wheat bread and fish. Vitamin B12 can only be found in animal products, with small amounts derived from fermented soy products such as miso and tempeh, and peanuts. It is essential that vegetarians consume a vitamin B12 supplement to maintain optimal health. Vitamin B12, when ingested, is stored in the liver and other tissues for later use. The synthetic form of vitamin B12, cyanocobalamin, is not derived from either plants or animals and is intrinsic in the maintenance of normal functioning body cells. Folic Acid Folic acid is mainly found in fruits and vegetables. Dark, leafy greens, oranges, orange juice, beans and peas are the best sources, as well as Brewer’s yeast, which supplies additional B-vitamins. Folic acid plays a key role by boosting the benefits of vitamin B12 supplementation. These two B-vitamins join forces and work together in maintaining normal red blood cells. Folic acid assists in the normal utilization of amino acids. Scientific studies have found that when working in tandem with folic acid, vitamin B12 is capable of promoting a healthy cardiovascular and nervous system. Riboflavin 5-Phosphate (Vitamin B2) Vitamin B2 is found in liver, dairy products, dark green vegetables and some types of seafood. Vitamin B2 serves as a co-enzyme, working with other B vitamins. It promotes healthy blood and supports both the nervous system and normal human growth. It supports healthy skin, nails, hair growth and helps maintain a healthy thyroid. Vitamin B2 plays a crucial role in turning food into energy as a part of the electron transport chain, driving cellular energy on the micro-level. Vitamin B2 aids in the breakdown of fats while functioning as a cofactor or helper in activating B6 and folic acid. Vitamin B2 is water-soluble and cannot be stored by the body except in insignificant amounts; thus, it must be replenished daily. Under some conditions, vitamin B2 can act as an antioxidant. Pyridoxine HCl (Vitamin B6) Poultry, fish, whole grains and bananas are the main dietary sources of vitamin B6. Vitamin B6 is a co-factor required for protein and amino acid metabolism and helps maintain proper fluid balance. It also assists in the maintenance of healthy red and white blood cells. Vitamin B6 is required for hemoglobin synthesis. Vitamin B6 should be administered as a part of a complex of other B-vitamins for best results. Vitamin D3 (Cholecalciferol) Regular sunlight exposure is the main way that most humans get their vitamin D. Food sources of vitamin D are vitamin D-fortified milk (100 IU per cup), cod liver oil, and fatty fish such as salmon. Small amounts are found in egg yolks and liver. Vitamin D promotes the absorption of calcium and phosphorus and supports the production of several proteins involved in calcium absorption and storage. Vitamin D works with calcium to promote hard, strong bones. It works to promote active transport of calcium out of the osteoblasts into the extra-cellular fluid and in the kidneys, promotes calcium and phosphate uptake by renal tubules. Vitamin D also promotes the normal absorption of dietary calcium and phosphate uptake by the intestinal epithelium. It promotes healthy growth and repair of tissues, and supports overall skin health. Vitamin E (d-alpha-Tocopherol Acetate) The most valuable sources of dietary vitamin E include vegetable oils, margarine, nuts, seeds, avocados and wheat germ. Safflower oil contains large amounts of vitamin E (about two thirds of the RDA in ¼ cup) and there are trace amounts in corn oil and soybean oil. Vitamin E is actually a family of related compounds called tocopherols and tocotrienols. Vitamin E is available in a natural or synthetic form. In most cases, the natural and synthetic forms are identical except the natural form of vitamin E is better absorbed and retained in the body. The natural form of alpha-tocopherol is known as ""d-alpha tocopherol."" (The natural form is found in Isotonix Multivitamin.) The synthetic ""dl-"" form is the most common form found in dietary supplements. For those individuals watching their dietary fat consumption, which is relatively common in the world of dieting, vitamin E intake is likely to be low, due to a reduced intake of foods with high fat content. The main health benefit of supplemental vitamin E comes from its immune-boosting antioxidant activity. Vitamin E is one of the most powerful fat-soluble antioxidants in the body. In turn, vitamin E protects cell membranes from free radical damage. Chromium (Chelate) Chromium is found naturally in some cereals, meats, poultry, brewer’s yeast, broccoli, prunes mushrooms, fish and beer. Chromium is an essential trace mineral that promotes normal glucose metabolism and regulation of insulin levels, and helps the body maintain of healthy blood levels of cholesterol and other fats. Copper (Citrate) The richest sources of dietary copper derive from organ meats, seafood, nuts, seeds, wheat bran cereal, whole grain products and cocoa products. Copper may have some antioxidant properties and acts as a component of enzymes in iron metabolism. It is an essential trace mineral. Copper is needed in normal development, iron transport, bone strength and immune function. Iodine (Potassium Iodide) Iodine is found in most seafood and in iodized salt. It is a necessary component of thyroid hormones and helps regulate and maintain a properly functioning metabolism. Magnesium (Carbonate) Foods rich in magnesium include unpolished grains, nuts and green vegetables. Green leafy vegetables are potent sources of magnesium because of their chlorophyll content. Meats, starches and milk are less rich sources of magnesium. Refined and processed foods are generally quite low in magnesium. The average daily magnesium intake in the U.S. for males nine years and older is estimated to be about 323 milligrams; for females nine years and older, it is estimated to be around 228 milligrams. Magnesium is a component of the mineralized part of bone and is necessary for the metabolism of potassium and calcium in adults. Magnesium is necessary for the synthesis of all proteins, nucleic acids, nucleotides, cyclic adenosine monophosphate, lipids and carbohydrates. Magnesium is required for release of energy and promotes a healthy metabolism. Importantly, magnesium is also required by the body to build healthy bones and teeth. It works together with calcium and vitamin D to help keep bones strong. Manganese (Gluconate) Manganese is a mineral found in large quantities in both plant and animal matter. The most valuable dietary sources of manganese include whole grains, nuts, leafy vegetables and teas. Manganese is concentrated in the bran of grains, which is often removed during processing. There are several forms of supplementary manganese, including manganese gluconate, manganese sulfate, manganese ascorbate, and manganese amino acid chelates. Only trace amounts of this element can be found in human tissue. Manganese is predominantly stored in the bones, liver, kidney and pancreas. It supports the normal formation of connective tissue and bones, and also promotes normal fat and carbohydrate metabolism. Potassium (Bicarbonate) Foods rich in potassium include fresh vegetables and fruits such as bananas, oranges, cantaloupe, avocado, raw spinach, cabbage and celery. Potassium is an essential macromineral that plays a role in a wide variety of biochemical and physiological processes. Potassium is important in releasing energy from protein, fat, and carbohydrates during metabolism. Selenium (Amino Acid Chelate) The best dietary sources of selenium include nuts, unrefined grains, brown rice, wheat germ, and seafood. In the body, selenium functions as part of an antioxidant enzyme called glutathione peroxidase as well as promoting normal growth and proper usage of iodine in thyroid functioning. Selenium also supports the antioxidant effect of vitamin E and is often added to vitamin E supplements. As part of the antioxidant, glutathione peroxidase, selenium plays a direct role in the body’s ability to protect cells from damage by free radicals. Zinc (Oxide) Zinc is largely found in fortified cereals, red meats, eggs, poultry and certain seafood, including oysters. It is a component of multiple enzymes and proteins. Zinc is an essential trace mineral that has functions in approximately 300 different enzyme reactions. Thus, zinc plays a part in almost all biochemical pathways and physiological processes. More than 90 percent of the body’s zinc is stored in the bones and muscles, but zinc is also found in virtually all body tissues. It has been claimed that zinc supports normal healing and the immune system. Because zinc is involved in such a great number of enzymatic processes, it has been found to support a large range of functions, including energy production, growth, cellular repair, bone strength and carbohydrate metabolism. Iron Phosphate (SunActive Fe) † Iron is mainly found in citrus fruits, tomatoes, beans, peas, fortified bread and grain products such as cereal (non-heme iron sources). Beef, liver, organ meats and poultry comprise the heme iron sources. The heme iron sources are more absorbable than the non-heme type of iron. Iron is an essential mineral. It is a component of hemoglobin, the protein that carries oxygen in the blood, and myoglobin, another protein that carries oxygen in muscle tissue. Iron is required in red blood cell formation. Iron plays a part in many imperative biochemical pathways and enzyme systems, including those involved with energy metabolism and immune system function. Young children, adult men and elderly women probably do not require supplemental iron in their diets and should consult their physician before taking iron supplements (due to the risk of excessive iron). Iron has been found to promote normal oxygen transport, thus improving exercise capacity, stimulate the immune system, increase energy levels and promote normal production of neurotransmitters and collagen. †SunActive Fe is a registered trademark of Taiyo International, Inc. Biotin (Vitamin B7) Biotin can be found in food sources, such as egg yolks, peanuts, beef liver, milk (10 mcg/cup), cereals, almonds and Brewer’s yeast. Biotin is used in healthy cell growth, metabolism of fats and amino acids.
- Abbasi AA, Prasad AS, Rabbani P, DuMouchelle E. Experimental zinc deficiency in man. Effect on testicular function. J Lab Clin Med. 1980 Sep;96(3):544-50.
- Abid M, Billington CJ, Nuttall FQ. Thyroid function and energy intake during weight gain following treatment of hyperthyroidism. J Am Coll Nutr. 1999 Apr;18(2):189-93.
- Addison WLT, The use of sodium chloride, potassium chloride, sodium bromide and potassium bromide in cases of arterial hypertension which are amenable to potassium chloride. Can Med Assoc J. 1928; 18:281-285.
- Allende LM, Corell A, Madrono A, Gongora R, Rodriguez-Gallego C, Lopez-Goyanes A, Rosal M, Arnaiz-Villena A. Retinol (vitamin A) is a cofactor in CD3-induced human T-lymphocyte activation. Immunology. 1997 Mar;90(3):388-96
- Anderson RA. Effects of chromium on body composition and weight loss. Nutr Rev. 1998 Sep;56(9):266-70.
- Arthur JR. Functional indicators of iodine and selenium status. Proc Nutr Soc. 1999 May;58(2):507-12.
- Backstrom MC, Maki R, Kuusela AL, Sievanen H, Koivisto AM, Ikonen RS, Kouri T, Maki M. Randomised controlled trial of vitamin D supplementation on bone density and biochemical indices in preterm infants. Arch Dis Child Fetal Neonatal Ed. 1999 May;80(3):F161-6.
- Bahadori B, Wallner S, Schneider H, Wascher TC, Toplak H. Effect of chromium yeast and chromium picolinate on body composition of obese, non-diabetic patients during and after a formula diet. Acta Med Austriaca. 1997;24(5):185-7.
- Baly DL, Schneiderman JS, Garcia-Welsh AL. Effect of manganese deficiency on insulin binding, glucose transport and metabolism in rat adipocytes. J Nutr. 1990; 120:1075-1079.
- Baron JA, Beach M, Mandel JS, et al. Calcium supplements for the prevention of colorectal adenomas. N Engl J Med 1999;340:101-107.
- Baron JA, Tosteson TD, Wargovich MJ, et al. Calcium supplementation and rectal mucosal proliferation: a randomized controlled trial. J Natl Cancer Inst 1995;87:1303-1307.
- Bates CJ. Vitamin A. Lancet. 1995; 345:31-35.
- Baxter GF, Sumeray MS, Walker JM. Infant size and magnesium: insights into LIMIT-2 and ISIS-4 from experimental studies. Lancet. 1996; 348:1424-1426.
- Behl C. Vitamin E and other antioxidants in neuroprotection. Int J Vitam Nutr Res. 1999 May;69(3):213-9. 4. Botterweck AA, van den Brandt PA, Goldbohm RA. Vitamins, carotenoids, dietary fiber, and the risk of gastric carcinoma: results from a prospective study after 6.3 years of follow-up. Cancer. 2000 Feb 15;88(4):737-48.
- Bellamy MC, Gedney JA. Unrecognized iron deficiency in critical illness. Lancet. 1998; 352:1903.
- Beutler E, Larsh SE, Gurney CW. Iron therapy in chronically fatigued nonanemic women: a double-blind study. Ann Intern Med. 1960; 52:378-394.
- Bostick RM, Kushi LH, Wu Y, et al. Relation of calcium, vitamin D, and dairy food intake to ischemic heart disease mortality among postmenopausal women. Am J Epidemiol 1999;149:151-160.
- Britton J, Pavord I, Richards K, et al. Dietary magnesium, lung function, wheezing, and airway hyper-reactivity in a random adult population sample. Lancet. 1994; 344:357-362.
- Brown JE, Wahle KW Effect of fish-oil and vitamin E supplementation on lipid peroxidation and whole-blood aggregation in man. Clin Chim Acta. 1990 Dec 14;193(3):147-56.
- Brun JF, Dieu-Cambrezy C, Charpiat A, Fons C, Fedou C, Micallef JP, Fussellier M, Bardet L, Orsetti A. Serum zinc in highly trained adolescent gymnasts. Biol Trace Elem Res. 1995 Jan-Mar;47(1-3):273-8.
- Bruner AB, Joffe A, Duggan A, et al. Randomised study of cognitive effects of iron supplementation in non-anaemic iron-deficient adolescent girls. Lancet. 1996; 348:992-997.
- Buchinger W, Lorenz-Wawschinek O, Semlitsch G, Langsteger W, Binter G, Bonelli RM, Eber O. Thyrotropin and thyroglobulin as an index of optimal iodine intake: correlation with iodine excretion of 39,913 euthyroid patients. Thyroid. 1997 Aug;7(4):593-7.
- Butterfield DA, Koppal T, Subramaniam R, Yatin S. Vitamin E as an antioxidant/free radical scavenger against amyloid beta-peptide-induced oxidative stress in neocortical synaptosomal membranes and hippocampal neurons in culture: insights into Alzheimer's disease. Rev Neurosci. 1999;10(2):141-9
- Calomme MR, Vandem Berghe DA. Supplementation of calves with stabilized orthosilicic acid. Effect on the Si, Ca, Mg, and P concentrations in serum and the collagen concentration in skin and cartilage. Biol Trace Elem Res. 1997; 56:153-165.
- Cappuccio FP, MacGregor GA. Does potassium supplementation lower blood pressure? A meta-analysis of published trials. J Hypertens. 1991; 9:465-473.
- Carlisle EM. Silicon as a trace nutrient. Sci Total Environ. 1988; 73:95-106.
- Carlisle EM. The nutritional essentiality of silicon. Nutr Rev. 1982; 40:193-198.
- Casscells W. Magnesium and myocardial infarction. Lancet. 1994; 343:807-809.
- Christiansen CW, Rieder MA, Silverstein EL, Gencheff NE. Magnesium sulfate reduces myocardial infarct size when administered before but not after coronary reperfusion in a canine model. Circulation. 1995; 92:2617-2621.
- Comstock GW, Alberg AJ, Huang HY, Wu K, Burke AE, Hoffman SC, Norkus EP, Gross M, Cutler RG, Morris JS, Spate VL, Helzlsouer KJ. The risk of developing lung cancer associated with antioxidants in the blood: ascorbic acid, carotenoids, alpha-tocopherol, selenium, and total peroxyl radical absorbing capacity. Cancer Epidemiol Biomarkers Prev. 1997 Nov;6(11):907-16.
- Cooke MS, Evans MD, Podmore ID, et al. Novel repair action of vitamin C upon in vivo oxidative DNA damage. FEBS Lett. 1998; 439:363-367.
- Cooney RV, Franke AA, Hankin JH, Custer LJ, Wilkens LR, Harwood PJ, Le Marchand L. Seasonal variations in plasma micronutrients and antioxidants. Cancer Epidemiol Biomarkers Prev. 1995 Apr-May;4(3):207-15.
- Couzy F, Lafargue P, Guezennec CY. Zinc metabolism in the athlete: influence of training, nutrition and other factors. Int J Sports Med. 1990 Aug;11(4):263-6.
- Dallman PR. Iron deficiency and the immune response. Am J Clin Nutr. 1987; 46:329-334.
- Daudu PA, Kelley DS, Taylor PC, Burri BJ, Wu MM. Effect of a low beta-carotene diet on the immune functions of adult women. Am J Clin Nutr. 1994 Dec;60(6):969-72.
- Dawson-Hughes B. Vitamin D and calcium: recommended intake for bone health. Osteoporos Int. 1998;8 Suppl 2:S30-4. 6. Feit JM. Calcium and vitamin D supplements for elderly patients. J Fam Pract. 1997 Dec;45(6):471-2.
- de Lourdes Lima M, Cruz T, Carreiro Pousada J, et al. The effect of magnesium supplementation in increasing doses on the control of type 2 diabetes. Diabetes Care. 1998; 21:682-686.
- de Valk B, Marx JJM. Iron, atherosclerosis, and ischemic heart disease. Arch Int Med. 1999; 159:1542-1548.
- Dietary Reference Intakes for Calcium, Phosphorous, Magnesium, Vitamin D, and Fluoride. Washington, DC: National Academy Press; 1997.
- Dorgan JF, Schatzkin A. Antioxidant micronutrients in cancer prevention. Hematol Oncol Clin North Am. 1991 Feb;5(1):43-68.
- Dreon DM, Butterfield GE. Vitamin B6 utilization in active and inactive young men. Am J Clin Nutr. 1986 May;43(5):816-24.
- Duffy SJ, Gokce N, Holbrook M, et al. Treatment of hypertension with ascorbic acid. Lancet. 1999; 354:2048-2049.
- Durlach J, Durlach V, Bac P, et al. Magnesium and therapeutics. Magnes Res. 1994; 7:313-328.
- Elisaf M, Merkouropoulos M, Tsianos EV. Siamopoulos KC. Pathogenetic mechanisms of hypomagnesemia in alcoholic patients. J Trace Elem Med Biol. 1995; 9:210-214.
- Elitsur Y, Neace C, Liu X, Dosescu J, Moshier JA. Vitamin A and retinoic acids immunomodulation on human gut lymphocytes. Immunopharmacology. 1997 Jan;35(3):247-53.
- Enstrom JE, Kanim LE, Klein MA. Vitamin C intake and mortality among a sample of the United States population. Epidemiology. 1992; 3:194-202.
- Facchinetti F, Borella P, Sances G, et al. Oral magnesium successfully relieves premenstrual mood changes. Obstet Gynecol. 1991; 78:177-181.
- Facchinetti F, Borella P, Sances G, et al. Oral magnesium successfully relieves premenstrual mood changes. Obstet Gynecol. 1991; 78:177-181.
- Fairbanks VF. Iron in medicine and nutrition. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. Baltimore, MD: Williams and Wilkins; 1999:193-221.
- Fang J, Madhavan S, Alderman MH. Dietary potassium intake and stroke mortality. Stroke. 2000; 31:1532-1537.
- Fields M, Lewis CG. Starch diets high in iron can duplicate the severity of copper deficiency in rats fed fructose. J Med Food. 1998; 1:193-199.
- Finch CA, Huebers H. Perspectives in iron metabolism. N Engl J Med. 1982; 306:1520-1528.
- Flatt PR, Juntti-Berggren L, Berggren PO, Gould BJ, Swanston-Flatt SK. Failure of glucose tolerance factor-containing Brewer's yeast to ameliorate spontaneous diabetes in C57BL/KsJ DB/DB mice. Diabetes Res. 1989 Mar;10(3):147-51.
- Futoryan T, Gilchrest BA. Retinoids and the skin. Nutr Rev. 1994; 52:299-310.
- Gleeson M, Bishop NC. Elite athlete immunology: importance of nutrition. Int J Sports Med. 2000 May;21 Suppl 1:S44-50.
- Grant KE, Chandler RM, Castle AL, Ivy JL. Chromium and exercise training: effect on obese women. Med Sci Sports Exerc. 1997 Aug;29(8):992-8.
- Gullestad L, Dolva LO, Soyland E, et al. Oral magnesium supplementation improves metabolic variables and muscle strength in alcoholics. Alcohol Clin Exp Res. 1992; 16:986-990.
- Guo WD, Chow WH, Zheng W, Li JY, Blot WJ. Diet, serum markers and breast cancer mortality in China. Jpn J Cancer Res. 1994 Jun;85(6):572-7.
- Harris ED. Cellular copper transport and metabolism. Annu Rev Nutr. 2000; 20:291-310.
- Harrison MD, Jones CE. Solioz M, Dameron CT. Intracellular copper routing: the role of copper chaperones. Trends Biochem Sci. 2000; 25:29-32.
- Health & Medicine. (Statistical Data Included) American Fitness, July, 1999 Tannen RL. Effects of potassium on blood pressure control. Ann Intern Med. 1983; 98(part 2):773-780.
- Hemila H, Douglas RM. Vitamin C and acute respiratory infections. Int J Tuberc Lung Dis. 1999; 3:756-761.
- Hermans JJ, Fischer MA, Schiffers PM, Struijker-Boudier HA. High dietary potassium chloride intake augments rat renal mineralocorticoid receptor selectivity via 11beta-hydroxysteroid dehydrogenase. Biochim Biophys Acta. 1999; 1472:537-549.
- Hermansen K. Diet, blood pressure and hypertension. Br J Nutr. 2000; 83 Supp1:S113-S119.
- Hintze G, Kobberling J. Dietary iodine deficiency. Its consequences in the aged. Fortschr Med. 1992 Apr 10;110(10):163-6.
- Huebers HA, Beguin Y, Pootrakul P, et al. Intact transferrin receptors in human plasma and their relation to erythropoiesis. Blood. 1990; 75:102-107.
- Hughes K, Chua LH, Ong CN. Serum selenium in the general population of Singapore, 1993 to 1995. Ann Acad Med Singapore. 1998 Jul;27(4):520-3.
- Hunt CD, Johnson PE, Herbel J, Mullen LK. Effects of dietary zinc depletion on seminal volume and zinc loss, serum testosterone concentrations, and sperm morphology in young men. Am J Clin Nutr. 1992 Jul;56(1):148-57.
- Hwang J, Peterson H, Hodis HN, et al. Ascorbic acid enhances 17 beta-estradiol-mediated inhibition of oxidized low density lipoprotein formation. Atherosclerosis. 2000; 150:275-284.
- Ishimitsu T, Tobian L, Sugimoto K, Everson T. High potassium diets reduce vascular and plasma lipid peroxides in stroke-prone spontaneously hypertensive rats. Clin Exp Hypertens. 1996; 18:659-673
- Ishimitsu T, Tobian L, Sugimoto K, Lange JM. High potassium diets reduce macrophage adherence to vascular wall in stroke-prone spontaneously hypertensive rats. J Vasc Res. 1995; 32:406-412.
- Ishimitsu T, Tobian L, Uehara Y, et al. Effect of high potassium diets on the vascular and renal prostaglandin system in stroke-prone spontaneously hypertensive rats. Prostaglandins Leukot Essent Fatty Acids. 1995; 53:255-260.
- Ishimitsu T, Tobian L. High potassium diets reduce endothelial permeability in stroke-prone spontaneously hypertensive rats. Clin Exp Pharmacol Physiol. 1997; 23:241-245.
- ISIS-4 (Fourth International Study of Infarct Survival) Collaborative Group. ISIS-4: a randomised factorial trial assessing early oral captopril, oral mononitrate, and intravenous magnesium sulfate in 58,050 patients with suspected acute myocardial infarction. Lancet. 1995; 345:669-685.
- Jacobson SG, Cideciyan AV, Regunath G, et al. Night blindness in Sorsby's fundus dystrophy reversed by vitamin A. Nature Gen. 1995; 11:27-32.
- Jin L, ChaoL, Chao J. Potassium supplement upregulates the expression of renal kalikrein and bradykinin B2 receptor in SHR. Am J Physiol. 1999; 276:F476-F484.
- Johnson WT, Thomas AC. Copper deprivation potentiates oxidative stress in HL-60 cell mitochondria. Proc Soc Exp Biol Med. 1999; 221:147-152.
- Kao WHL, Folsom AR, Nieto J, et al. Serum and dietary magnesium and the risk for type 2 diabetes mellitus (editorial). Arch. Int Med. 1999; 159:2151-2159.
- Khaw K-T, Barrett-Conner E. Dietary potassium and stroke-associated mortality. N Engl J Med. 1987; 316:235-240.
- Klevay LM. Cardiovascular disease from copper deficiency — a history. J Nutr. 2000; 130:489S-492S.
- Klevay LM. Coronary heart disease: the zinc/copper hypothesis. Am J Clin Nutr. 1975; 28:764-774.
- Knekt P, Jarvinen R, Seppanen R, Rissanen A, Aromaa A, Heinonen OP, Albanes D, Heinonen M, Pukkala E, Teppo L. Dietary antioxidants and the risk of lung cancer. Am J Epidemiol. 1991 Sep 1;134(5):471-9.
- Krieger D, Krieger S, Jansen O, et al. Manganese and chronic hepatic encephalopathy. Lancet. 1995; 346:270-274.
- Krishna GG, Miller E, Kapoor S. Increased blood pressure during potassium depletion in normotensive men. N Eng J Med. 1989; 320:1177-1182.
- Krotkiewski M, Gudmundsson M, Backstrom P, Mandroukas K. Zinc and muscle strength and endurance. Acta Physiol Scand. 1982 Nov;116(3):309-11.
- Kung AW, Janus ED. Thyroid dysfunction in ambulatory elderly Chinese subjects in an area of borderline iodine intake. Thyroid. 1996 Apr;6(2):111-4.
- Lamberg L. Diet may affect skin cancer prevention. JAMA. 1998 May 13;279(18):1427-8.
- Lee M-O, Han S-Y, Jiang S, et al. Differential effects of retinoic acid on growth and apoptosis in human colon cancer cell lines associated with the induction of retinoic acid receptor beta. Biochem Pharmacol. 2000; 59:485-496.
- Lim R, Herzog WR. Magnesium for cardiac patients: is it a valuable treatment supplement? Contemp Int Med. 1998; 10:6-9.
- Lin H, Young DB. Interactions between plasma potassium and epinephrine in coronary thrombosis in dogs. Circulation. 1994; 89:331-338.
- Loeper J, Goy-Loeper J, Rozensztajn L, Fragny M. The antiatheromatous action of silicon. Atherosclerosis. 1979; 33:397-408.
- LoPresti JS, Gray D, Nicoloff JT. Influence of fasting and refeeding on 3,3',5'-triiodothyronine metabolism in man. J Clin Endocrinol Metab. 1991 Jan;72(1):130-6.
- Lucas MJ, Leveno KJ, Cunningham FG. A comparison of magnesium sulfate with phenytoin for the prevention of eclampsia. N Engl J Med. 1995; 333:201-205.
- Lukaski HC. Magnesium, zinc, and chromium nutriture and physical activity. Am J Clin Nutr. 2000 Aug;72(2 Suppl):585S-93S.
- Luoma P. Antioxidants, infections and environmental factors in health and disease in northern Finland. Int J Circumpolar Health. 1998 Jul;57(2-3):109-13.
- Ma G, Young DB, Clower BR. Inverse relationship between potassium intake and coronary artery disease in the cholesterol-fed rabbit. Am J Hypertens. 1999; 12:821-825.
- Manore MM. Effect of physical activity on thiamine, riboflavin, and vitamin B-6 requirements. Am J Clin Nutr. 2000 Aug;72(2 Suppl):598S-606S.
- Martini LA. Magnesium supplementation and bone turnover. Nutr Rev. 1999; 57:227-229.
- Mauskop A, Altura BM. Role of magnesium in the pathogenesis and treatment of migraines. Clin Neurosci. 1998; 5:24-27.
- McCabe RD, Backarich MA, Srivastava K, Young DB. Potassium inhibits free radical formation. Hypertension. 1994; 24:77-82.
- McCabe RD, Young DB. Potassium inhibits cultural vascular smooth muscle proliferation. Am J Hypertens. 1994; 7:346-350.
- McCarty MF. Chromium and other insulin sensitizers may enhance glucagon secretion: implications for hypoglycemia and weight control. Med Hypotheses. 1996 Feb;46(2):77-80.
- McDonald R, Keen CL. Iron, zinc and magnesium nutrition and athletic performance. Sports Med. 1988 Mar;5(3):171-84.
- Meunier PJ. Calcium, vitamin D and vitamin K in the prevention of fractures due to osteoporosis. Osteoporos Int. 1999;9 Suppl 2:S48-52.
- Miller ER 3rd, Appel LJ, Levander OA, Levine DM. The effect of antioxidant vitamin supplementation on traditional cardiovascular risk factors. J Cardiovasc Risk. 1997 Feb;4(1):19-24.
- Miller JW. Vitamin E and memory: is it vascular protection? Nutr Rev. 2000 Apr;58(4):109-11. Bell L, Halstenson CE, Halstenson CJ, et al. Cholesterol-lowering effects of calcium carbonate in patients with mild to moderate hypercholesterolemia. Arch Intern Med. 1992; 152:2441-2444.
- Morse AC, Beard JL, Jones BC. A genetic development model of iron deficiency: biological aspects. Proc Soc Exp Biol Med. 1999; 220:147-152.
- Ness AR, Chee D, Elliot P. Vitamin C and blood pressure—an overview. J Hum Hypertens. 1997; 11:343-350.
- Nielsen FH. Ultratrace minerals. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease, 9th ed. Baltimore, MD: Williams and Wilkins; 1999:283-303.
- Nielsen FH. Ultratrace minerals. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams and Wilkins; 199:283-303.
- Nishi Y. Anemia and zinc deficiency in the athlete. J Am Coll Nutr. 1996 Aug;15(4):323-4.
- Orchard TJ. Magnesium and type 2 diabetes mellitus (editorial). Arch Int Med. 1999; 159:2119-2120. Keen CL, Ensunsa JL, Watson MH, et al. Nutritional aspects of manganese from experimental studies. Neurotoxicol. 1999; 20:213-223.
- Paul T, Meyers B, Witorsch RJ, Pino S, Chipkin S, Ingbar SH, Braverman LE. The effect of small increases in dietary iodine on thyroid function in euthyroid subjects. Metabolism. 1988 Feb;37(2):121-4.
- Pauling L. Evolution and the need for ascorbic acid. Proc Natl Acad SciUSA. 1970; 67:1643-1648.
- Pauling L. The significance of the evidence about ascorbic acid and the common cold. Proc Natl Acad SciUSA. 1971; 68:2678-2681.
- Penn ND, Purkins L, Kelleher J, Heatley RV, Mascie-Taylor BH, Belfield PW. The effect of dietary supplementation with vitamins A, C and E on cell-mediated immune function in elderly long-stay patients: a randomized controlled trial. Age Ageing. 1991 May;20(3):169-74.
- Podmore ID, Griffiths HR, Herbert KE, et al. Vitamin C exhibits pro-oxidant effects. Nature. 1998; 392:559.
- Prasad AS, Cossack ZT. Neutrophil zinc: an indicator of zinc status in man. Trans Assoc Am Physicians. 1982;95:165-76.
- Prasad AS. Zinc deficiency in human subjects. Prog Clin Biol Res. 1983;129:1-33.
- Rayssiguier Y, Gueux E, Bussiere L, Mazur A. Copper deficiency increases the susceptibility of lipoproteins and tissues to peroxidation in rats. J Nutr. 1993; 123:1343-1348.
- Reading SA. Chromium picolinate. J Fla Med Assoc. 1996 Jan;83(1):29-31.
- Reinhardt W, Holtermann D, Benker G, Olbricht T, Jaspers C, Reinwein D. Effect of small doses of iodine on thyroid function during caloric restriction in normal subjects. Horm Res. 1993;39(3-4):132-7.
- Rico H, Gallego-Lago JL, Hernandez ER, at al. Effect of silicon supplement on osteopenia induced by ovariectomy in rats. Calcif Tissue Int. 2000; 66:53-55.
- Robuschi G, Emanuele R, Cavalli Sforza LT, Arsenio L, Strata A, Gnudi A, Roti E. Effect of iodine administration on thyroid function in diabetic patients. Acta Diabetol Lat. 1984 Oct-Dec;21(4):357-60.
- Rock E, Mazur A, O'Connor JM, et al. The effect of copper supplementation on red blood cell oxidizability and plasma antioxidants in Middle-aged healthy volunteers. Free Rad Biol Med. 2000; 28:324-329.
- Rokitzki L, Sagredos A, Keck E, Sauer B, Keul J. Assessment of vitamin B2 status in performance athletes of various types of sports. J Nutr Sci Vitaminol (Tokyo). 1994 Feb;40(1):11-22.
- Ross AC, Stephensen CB. Vitamin A and retinoids in antiviral responses. FASEB J. 1996; 10:979-985.
- Ross AC. Vitamin A and retinoids. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams and Wilkins; 1999:305-327.
- Saari JT, Sahuschke DA. Cardiovascular effects of dietary copper deficiency. Biofactors. 1999; 10:359-375.
- Schwarz K. A bound form of silicon in glycosaminoglycans and polyuronides. Proc Nat Acad Sci. 1973; 70:1608-1612.
- Schwarz K. Silicon, fibre, and atherosclerosis. Lancet. 1977; 1:454-457.
- Scrimshaw NS, San Giovanni JP. Synergism of nutrition, infection, and immunity: an overview. Am J Clin N. 1997; 66:464S-477S.
- Semba RD. The role of vitamin A and related retinoids in immune function. Nutr Rev. 1998 Jan;56(1 Pt 2):S38-48.
- Semba RD. Vitamin A and immunity to viral, bacterial and protozoan infections. Proc Nutr Soc. 1999 Aug;58(3):719-27.
- Semba RD. Vitamin A, immunity, and infection. Clin Infect Dis. 1994 Sep;19(3):489-99.
- Shephard RJ, Shek PN. Immunological hazards from nutritional imbalance in athletes. Exerc Immunol Rev. 1998;4:22-48.
- Silva JE. Effects of iodine and iodine-containing compounds on thyroid function. Med Clin North Am. 1985 Sep;69(5):881-98.
- Singh MA. Combined exercise and dietary intervention to optimize body composition in aging. Ann N Y Acad Sci. 1998 Nov 20;854:378-93.
- Skaper SD, Fabris M, Ferrari V, et al. quercetin protects cutaneous tissue-associated cell types including sensory neurons from oxidative stress induced by glutathione depletion: cooperative effects of ascorbic acid. Free Rad Biol Med. 1997; 22:669-678.
- Sohlenius-Sternbeck A-K, Appelkvist E-L, De Pierre JW. Effects of vitamin A deficiency on selected xenobiotic-metabolizing enzymes and defenses against oxidative stress in mouse liver. Biochem Pharmacol. 2000; 59:377-383.
- Stahelin HB. Critical reappraisal of vitamins and trace minerals in nutritional support of cancer patients. Support Care Cancer. 1993 Nov;1(6):295-7.
- Strause L, Saltman P, Glowacki J. The effect of deficiencies of manganese and copper on osteo-induction and on resorption of bone particles in rats. Calcif Tissue Int. 1987; 41:145-150
- Suboticanec K, Stavljenic A, Bilic-Pesic L, Gorajscan M, Gorajscan D, Brubacher G, Buzina R. Nutritional status, grip strength, and immune function in institutionalized elderly. Int J Vitam Nutr Res. 1989;59(1):20-8.
- Sugimoto K, Tobian L, Ishimutsu T, Lange JM. High potassium diets greatly increase growth-inhibiting agents in aortas of hypertensive rats. Hypertension. 1992; 19:749-752.
- Sugimoto T, Tobian L, Ganguli MC. High potassium diets protect against dysfunction of endothelial cells in stroke-prone spontaneously hypertensive rats. Hypertension. 1988:11:579-585.
- Suzuki M, Itokawa Y. Effects of thiamine supplementation on exercise-induced fatigue. Metab Brain Dis. 1996 Mar;11(1):95-106.
- Taddei S, Virdis A, Ghiadoni L, et al. Vitamin C improves endothelium-dependent vasodilation by restoring nitric oxide activity in essential hypertension. Circulation. 1998; 97:2222-2229.
- Takahashi T, Fujimori K, Simon SL, Bechtner G, Edwards R, Trott KR. Thyroid nodules, thyroid function and dietary iodine in the Marshall islands. Int J Epidemiol. 1999 Aug;28(4):742-9.
- Tannen RL. Effects of potassium on blood pressure control. Ann Intern Med. 1983; 98(part 2):773-780.
- Taylor PR, Li B, Dawsey SM, Li JY, Yang CS, Guo W, Blot WJ. Prevention of esophageal cancer: the nutrition intervention trials in Linxian, China. Linxian Nutrition Intervention Trials Study Group. Cancer Res. 1994 Apr 1;54(7 Suppl):2029s-2031s.
- Thilly CH, Swennen B, Bourdoux P, Ntambue K, Moreno-Reyes R, Gillies J, Vanderpas JB. The epidemiology of iodine-deficiency disorders in relation to goitrogenic factors and thyroid-stimulating-hormone regulation. Am J Clin Nutr. 1993 Feb;57(2 Suppl):267S-270S.
- Thurnham DI. Micronutrients and immune function: some recent developments. J Clin Pathol. 1997 Nov;50(11):887-91.
- Tobian L. Salt and hypertension. Lessons from animal models that relate to human hypertension. Hypertension. 1991; 17:152-158.
- Toyama T, Kubuki Y, Suzuki M. Tsubouchi H. [Copper deficiency anemia and neutropenia secondary to total gastrectomy]. [Article in Japanese]. Rinsho Ketsueki. 2000; 41:441-443.
- Trent LK, Thieding-Cancel D. Effects of chromium picolinate on body composition. J Sports Med Phys Fitness. 1995 Dec;35(4):273-80.
- Turnlund Jr. Copper. In: Shils ME, Olson JA, Shike M. Ross AC, eds. Modern Nutrition in health and Disease, 9th ed. Baltimore, MD: Williams and Wilkins; 1999:241-252.
- Underwood BA, Arthur P. The contribution of vitamin A to public health. FASEB J. 1996; 10:1040-1048
- Uusitupa MI, Mykkanen L, Siitonen O, Laakso M, Sarlund H, Kolehmainen P, Rasanen T, Kumpulainen J, Pyorala K. Chromium supplementation in impaired glucose tolerance of elderly: effects on blood glucose, plasma insulin, C-peptide and lipid levels. Br J Nutr. 1992 Jul;68(1):209-16.
- van den Brandt PA, Goldbohm RA, van 't Veer P, Bode P, Dorant E, Hermus RJ, Sturmans F. A prospective cohort study on selenium status and the risk of lung cancer. Cancer Res. 1993 Oct 15;53(20):4860-5.
- van der Heyden JT, Docter R, van Toor H, Wilson JH, Hennemann G, Krenning EP. Effects of caloric deprivation on thyroid hormone tissue uptake and generation of low-T3 syndrome. Am J Physiol. 1986 Aug;251(2 Pt 1):E156-63.
- Van Hooser JP, Aleman TS, He Y-G, et al. Rapid restoration of visual pigment and function with oral retinoid in a mouse model of childhood blindness. Proc Natl Acad Sci USA. 2000; 97:8623-8628.
- Vatassery GT, Bauer T, Dysken M. High doses of vitamin E in the treatment of disorders of the central nervous system in the aged. Am J Clin Nutr. 1999 Nov;70(5):793-801.
- Vatassery GT. Vitamin E and other endogenous antioxidants in the central nervous system. Geriatrics. 1998 Sep;53 Suppl 1:S25-7.
- Waggoner DJ, Bartnikas TB, Gitlin JD. The role of copper in neurodegenerative disease. Neurobiology of Disease. 1999; 6:221-230.
- Wahl R, Pilz-Mittenburg KW, Heer W, Kallee E. Iodine content in diet and excretion of iodine in urine. Z Ernahrungswiss. 1995 Dec;34(4):269-76.
- Walker LS, Bemben MG, Bemben DA, Knehans AW. Chromium picolinate effects on body composition and muscular performance in wrestlers. Med Sci Sports Exerc. 1998 Dec;30(12):1730-7.
- Wang Y, Mackenzie B, Tsukaguchi H, et al. Human vitamin C (L-ascorbic acid) transporter SVCT1. Biochem Biophys Res Commun. 2000; 267:488-494.
- Wargovich MJ, Eng VWS, Newmark HL. Calcium inhibits the damaging and compensatory proliferative effects of fatty acids on mouse colon epithelium. Cancer Lett. 1984; 23:253-258.\
- Weaver CM, Heaney RP. Calcium. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams and Wilkins; 1999:141-155.
- West KP Jr, Pokhrel RP, Katz J, et al. Efficacy of vitamin A in reducing preschool child mortality in Nepal. Lancet. 1991; 338:67-71.
- West SG, Light KC, Hinderliter AL, et al. Potassium supplementation induces beneficial cardiovascular changes during rest and stress in salt sensitive individuals. Health Psychol. 1999; 18:229-240.
- Whelton PK, He J, Cutler JA, et al. Effects of oral potassium on blood pressure. Meta-analysis of randomized controlled clinical triglyceride trials. JAMA. 1997; 277:1624-1632.
- Wolf RL, Cauley JA, Baker CE, et al. Factors associated with calcium absorption efficiency in pre- and perimenopausal women. Am J Clin Nutr. 2000; 72:466-471.
- Young DB, Lin H, McCabe RD. Potassium's cardiovascular protective mechanisms. Am J Physiol. 1995; 268:R825-R837.
- Young DB, Ma G. Vascular protective effects of potassium. Semin Nephrol. 1999; 19:477-486.
- Zemel MB, Shi H, Greer B, et al. Regulation of adiposity by dietary calcium. FASEB J. 2000; 14:1132-1138.
- Zhou B, Wang T, Sun G, Guan P, Wu JM. A case-control study of the relationship between dietary factors and risk of lung cancer in women of Shenyang, China. Oncol Rep. 1999 Jan-Feb;6(1):139-43.
- Zhou MS, Nishida Y, Yoneyama H, et al. Potassium supplementation increases sodium excretion in hypertensive Dahl rats. Clin Exp Hypertens.
What are vitamins? A vitamin may be broadly defined as a substance that is essential for the maintenance of normal metabolic function, but which is not produced in the body and therefore must be consumed from sources outside the body. They are necessary components in the process of converting food to energy, and in the growth and repair of body tissue. Reduction of vitamin levels over extended periods can result in vitamin deficiency. These shortages may lead to symptoms, which can include loss of appetite, loss of body weight, increased irritability, and sleeplessness or constant drowsiness. Deficiencies of this nature can easily be reversed by adequate vitamin intake. What type of vitamin E is in the Multivitamin formula? The vitamin E in the Multivitamin formula is the natural, high activity d, 1-alpha-tocopherol. It has been converted to the acetate form to aid water solubility. Why is there vitamin D3 in the Calcium Plus and the Multivitamin formulas? Vitamin D3 has been added to the Calcium Plus and the Multivitamin formulas to facilitate the uptake of calcium. Vitamin D3 is initially activated further in the skin in the presence of sunlight, and then it is activated further in the kidney and liver. Vitamin D3 is a hormone that can stimulate the production of calcium-binding proteins, which aid in transporting this essential mineral through cells. The 1,25-dihydroxy-vitamin D3 is then transported to critical sites in the body to facilitate calcium uptake. The intestine and bone cells are two of these critical sites. There are groups of people who are not out in the sun for significant lengths of time. Certain racial groups have significant problems in the higher latitudes, especially during the winter, in producing substantial amounts of vitamin D3 and subsequently taking up enough calcium. Even with intense phototherapy for those people requiring significant calcium nutriture, the blood levels of 1,25-OH-vitamin D3 are highly regulated. The daily doses of vitamin D3 are highly regulated. The daily doses of vitamin D3 thought to be toxic are greater than 1000 IU — reports concerning inappropriate calcium deposition in soft tissues occur at 3000-4000 IU/day. How many of us sit down at home to three complete and balanced meals a day? Very few! Fast-food restaurants, food fads, weight-loss diets and an ever-increasing use of unfortified convenience foods have heavily influenced today’s eating habits. Modern processing and preparation techniques often rob foods of vitamin content, as can growth, harvest and storage conditions. We often come up short. It is up to us to make up the difference with supplements. Life cannot be sustained without all the essential vitamins. How important are minerals? As important as vitamins are, without minerals, they become largely ineffective in the absence of mineral catlysts. Minerals provide a vital role in nutrition. Although there is rarely much discussion about the benefits they provide, minerals are considered the ""unsung"" heroes of nutrition. Virtually no nutritional benefit from the various vitamins would be possible without the assistance of one or more key minerals. There are a number of vital roles that minerals play in the body. It is their non-organic components that initiate the metabolism of protein, carbohydrates and lipids. In addition to their assistance in the metabolic process, minerals aid the regulation of water and electrolyte balance. Minerals are also pivotal in providing a sound skeleton, and regulating the functions of our muscles and nerves. Minerals are essential for sustaining good health and life.