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Isotonix OPC-3®

Isotonix OPC-3®

Price  $29.95 - $69.95
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Isotonix OPC-3® is an isotonic-capable food supplement that is made from a combination of bilberry, grape seed, red wine and pine bark extracts, and citrus extract bioflavonoids, all found to be powerful antioxidants. Oligomeric proanthocyanidins (...
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Isotonix OPC-3®

Isotonix OPC-3® is an isotonic-capable food supplement that is made from a combination of bilberry, grape seed, red wine and pine bark extracts, and citrus extract bioflavonoids, all found to be powerful antioxidants. Oligomeric proanthocyanidins (OPCs) are bioflavonoids (complex organic plant compounds) found in fruits, vegetables and certain tree barks that provide exceptional nutritional benefits to the human body. Studies have shown OPCs to be up to 20 times more powerful than vitamin C and 50 times more powerful than vitamin E in neutralizing free radicals. Isotonix OPC-3 contains the only isotonic form of Pycnogenol® in the world. Pycnogenol is a natural plant extract from the bark of the French maritime pine tree and the most clinically researched and potent bioflavonoid.*

Isotonic, which means “same pressure,” bears the same chemical resemblance of the body’s blood, plasma and tears. All fluids in the body have a certain concentration, referred to as osmotic pressure. The body’s common osmotic pressure, which is isotonic, allows a consistent maintenance of body tissues. In order for a substance to be absorbed and used in the body’s metabolism, it must be transported in an isotonic state.

Isotonix® dietary supplements are delivered in an isotonic solution. This means that the body has less work to do to in obtaining maximum absorption. The isotonic state of the suspension allows nutrients to pass directly into the small intestine and be rapidly absorbed into the bloodstream. With Isotonix products, little nutritive value is lost, making the absorption of nutrients highly efficient while delivering maximum results.


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FAQ
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  • Blazsó, G., et al. Anti-inflammatory and superoxide radical scavenging activities of a procyanidins containing extract from the bark of Pinus pinaster Sol. and its fractions. Pharm Pharmacol Lett 3: 217-20, 1994
  • Cesarone, M., et al. Improvement in Circulation and in Cardiovascular Risk Factors With a Proprietary Isotonic Bioflavanoid Formula OPC-3.  Journal Angiology 59: 408-414, 2008.
  • Cho, K., et al. Effect of bioflavonoids extracted from the bark of Pinus maritima on proinflammatory cytokine interlukin-1 production in lipopolysaccharide-stimulated RAW 264. 7.  Toxicology and Applied Pharmacology 168: 64-71, 2000.
  • Cho, K., et al. Inhibition mechanisms of bioflavonoids extracted from the bark of Pinus maritima on the expression of proinflammatory cytokines. Annals of the NYAcademy of Sciences 928: 141-156, 2001.
  • Devaraj, S., et al. Supplementation with a pine bark extract rich in polyphenols increases plasma antioxidant capacity and alters the plasma lipoprotein profile. Lipids 37:931-4, 2002.
  • Fine, AM, Oligomeric proanthocyanidin complexes: history, structure, and phytopharmaceutical applications. Altern Med Rev 5:144-51, 2000.
  • Fitzpatrick, D., et al. Endothelium-dependent vascular effects of Pycnogenol. Journal of Cardiovascular Pharmacology 32: 509-515, 1998.
  • Frankel, E., et al. Inhibition of oxidation of human low-density lipoprotein by phenolic substances in red wine. Lancet 341: 454-7, 1993.
  • Freedman, J., et al. Select flavonoids and whole juice from purple grapes inhibit platelet function and enhance nitric oxide release. Circulation 103:2792-8, 2001.
  • Frémont, L. Biological effects of resveratrol. Life Sciences 66: 663-673, 2000.
  • Gulati, O. Pycnogenol® in venous disorders: a review. European Bulletin of Drug Research 7: 1-13, 1999.
  • Hosseini, S., et al. Pycnogenol® in the management of asthma. Journal of Medicinal Food 4: 201-209, 2001. HHHh
  • Kohama, T., et al. The treatment of gynecological disorders with Pycnogenol®. European Bulletin of Drug Research 7: 30-32, 1999.
  • Kohama, T., et al. Analgesic efficacy of French maritime pine bark extract in dysmenorrhea. Journal of Reproductive Medicine 49: 828-32, 2004.
  • Liu, X., et al. Antidiabetic effect of Pycnogenol French maritime pine bark extract in patients with diabetes type II. Life Sci 75:2505-13, 2004.
  • Liu, X., et al. French maritime pine bark extract pycnogenol dose-dependently lowers glucose in type 2 diabetic patients. Diabetes Care 27: 839, 2004.
  • Manna, S., et al. Resveratrol suppresses TNF-Induced activation of nuclear transcription factors NF-kB, activator protein-1, and apoptosis: potential role of reactive oxygen intermediates and lipid peroxidation. The Journal of Immunology 164: 6509-19, 2000.
  • Maritim, A., et al. Effects of pycnogenol treatment on oxidative stress in streptozotocin-induced diabetic rats. J Biochem Mol Toxicol 17:193-9, 2003.
  • Miyagi, Y., et al. Inhibition of human low-density lipoprotein oxidation by flavonoids in red wine and grape juice. Am J Cardiol 0:1627-31, 1997.
  • Monograph. Vaccinium myrtillus (bilberry). Altern Med Rev 6:500-4, 2001.
  • Murias M., et al. Resveratrol analogues as selective cyclooxygenase-2 inhibitors: synthesis and structure-activity relationship. Bioorg Med Chem 12: 5571-8, 2004.
  • Nuttall SL, Kendall MJ, Bombardelli E, Morazzoni P. An evaluation of the antioxidant activity of a standardized grape seed extract, Leucoselect. J Clin Pharm Ther 23: 385-89, 1998.
  • Packer, L., et al. Antioxidant activity and biologic properties of a procyanidin-rich extract from pine (Pinus maritima) bark, pycnogenol. Free Radic Biol Med 27:704-24, 1999. Review.
  • Rohdewald, P. A review of the French maritime pine bark extract (Pycnogenol®), a herbal medication with a diverse clinical pharmacology. Int J Clin Pharmacol Ther 40:158-68, 2002. Review.
  • Rohdewald, P. Pycnogenol®. In "Flavonoids in Health and Disease". Ed. Catherine Rice-Evans and Lester Packer. New York:  Marcel Dekker, Inc., 1998. 405-19.
  • Roseff, S., et al. Improvement in sperm quality and function with French maritime pine tree bark extract. Journal Reproductive Medicine 47: 821-4, 2002.
  • Roseff, S., et al. Improvement of sperm quality by Pycnogenol®. European Bulletin of Drug Research 7: 33-6, 1999.
  • Saito, M., et al. Antiulcer activity of grape seed extract and procyanidins. J Agric  Food Chem 46: 1460-4, 1998.
  • Schönlau, F., et al. Pycnogenol® for diabetic retinopathy. International Ophthalmology 24: 161-171, 2002.
  • Schönlau, F., et al. The cosmeceutical Pycnogenol®. J Appl Cosmetology 20: 241-6, 2002.
  • Segger, D. and Schönlau, F. Supplementation with Evelle® improves skin smoothness and elasticity in a double blind, placebo-controlled study with 62 women. Journal of Dermatological Treatment 15:222-26, 2004.
  • Shi, J., et al. Polyphenolics in grape seeds-biochemistry and functionality. J Med Food 6:291-9, 2003. Review.
  • Sharma, S., et al. Pycnogenol® inhibits the release of histamine from mast cells. Phytotherapy Research 17: 66-69, 2003.
  • Spadea, L., et al. Treatment of vascular retinopathies with Pycnogenol®. Phytotherapy Research 15: 219-23, 2001.
  • Stein, J., et al. Purple grape juice improves endothelial function and reduces the susceptibility of LDL cholesterol to oxidation in patients with coronary artery disease. Circulation 100:1050-5, 1999.
  • Takada, Y., et al. Nonsteroidal anti-inflammatory agents differ in their ability to suppress NF-kappaB activation, inhibition of expression of cyclooxygenase-2 and cyclin D1, and abrogation of tumor cell proliferation. Oncogene 23: 9247-58, 2004.
  • Ueda, T., et al. Preventative effect of natural and synthetic antioxidants on lipid peroxidation in the mammalian eye. Ophthalmic Res 28: 184-92, 1996.
  • Wallerath, T., et al. Resveratrol, a polyphenolic phytoalexin present in red wine, enhances expression and activity of endothelial nitric oxide synthase. Circulation 106:1652-8, 2002.
  • Watson, R. Pycnogenol® and cardiovascular health. Evidence-Based Integrative Medicine 1: 27-32, 2003.
  • Wei, Z., et al. Pycnogenol enhances endothelial cell antioxidant defense. Redox Report 3: 219-24, 1997.
  • Yamakoshi, J., et al.  Proanthocyanidin-rich extract from grape seeds attenuates the development of aortic atherosclerosis in cholesterol-fed rabbits.  Atherosclerosis  142:139-149, 1999.
  • Ames, BN, et al.  Oxidants, antioxidants, and the degenerative diseases of aging.  Proc Natl Acad Sci USA 90:7915-7922, 1993.
  • Bagchi, D, et al.  Oxygen free radical scavenging abilities of vitamins C and E, and a grape seed proanthocyanidin extract in vitro.  Res Commun Mol Pathol Pharmacol 95:179-89, 1997.
  • Bagchi, D, et al.  Free radicals and grape seed proanthocyanidin extract: importance in human health and disease prevention.  Toxicology 148: 187-97, 2000.
  • Bagchi, D, et al.  Cellular protection with proanthocyanidins derived from grape seed.  Ann NY Acad Sci 957:260-70, 2002.
  • Cao G, Alessio H, Cultler R.  Oxygen-radical absorbance capacity assay for antioxidants.  Fre Rad Biol & Med 14:301-11, 1993.
  • Drew B, Leeuwenburgh C.  Aging and the role of reactive nitrogen species.  Ann NY Acad Sci 959:66-81, 2002.
  • Gibson, L, et al.  Effectiveness of cranberry juice in preventing urinary tract infections in long-term care facility patients.  J Naturopathic Med 2:45-47, 1991.
  • Graham DY, Smith JL, Bouvet, AA.  What happens to tablets in the stomach.  J Pharm Sci 79:420-24, 1990.
  • Havsteen B.  Flavonoids, a class of natural products of high pharmacological potency.  Biochem Pharm 32:1141-48, 1983.
  • Halpern, MJ, et al.  Red wine polyphenols and inhibition of platelet aggregation: possible mechanisms, and potential use in health promotion and disease prevention.  J Int Med Res 26:171-80, 1998.
  • Joseph JA, Shukitt-Hale B, Denisova NA, Bielinksi D, Martin A, McEwen JJ, Bickford PC.  Reversals of age-related declines in neuronal signal transduction, cognitive, and motor behavioral deficits with blueberry, spinach, or strawberry dietary supplementation.  J Neuroscience 19: 8114-21, 1999.
  • Kay CD, Holub BJ.  The effect of wild blueberry (Vaccinium angustifolium) on post-prandial serum antioxidant status in human subjects.  Br J Nutr 88: 389-98, 2002.
  • Kehrer JP.  Free radicals as mediators of tissue injury and disease.  Crit Rev Toxicol 23:21-48, 1993.
  • Koch R. Comparative study of Venostatin and Pycnogenol in chronic venous insufficiency.  Phytother Res 16:S1-5, 2002.
  • Koparker AD, Augsburger LL, Shangraw RF.  Intrinsic dissolution rates of tablet fillers and binders and their influence on the dissolution of drugs from tablet formulations.  Pharm Res 7:80-85, 1990.
  • Mazza G, Kay CD, Cottrell T, Holub BJ.  Absorption of anthocyanins from blueberries and serum antioxidant status in human subjects.  J Agric Food Chem 50:7731-37, 2002.
  • Nesaretnam K, et al.  Effect of tocotrienols on the growth of a human breast cancer cell line in culture.  Lipids 30:1139-43, 1995.
  • Ofek I, Goldhar J, Zafriri D, Lis H, Sharon N.  Anti-Escherichia coli adhesion activity of cranberry and blueberry juices. New England J Med 324:1599, 1991.
  • Qureshi, A, et al.  Response of hypercholesterolemic subjects to administration of tocotrienols.  Lipids 30:1171-77, 1995.
  • Rimbach G, Virgili F, Park YC, Packer L.  Effect of procyanidins from Pinus maritime on glutathione levels in endothelial cells challenged by 3-morpholinosydnonimine or activated macrophages.  Redox Rep 4:171-77, 1999. 
  • Sobota AE.  Inhibition of bacterial adherence by cranberry juice: potential use for the treatment of urinary tract infactions.  J Urology 131:1013-1016, 1984.
  • Soloway MS, Smith RA.  J Am Med Assoc 260:1465, 1988.
  • Tomco, A, et al.  Antioxidant effects of tocotrienol in patients with hyperlipidemia and carotid stenosis.  Lipids 30: 1179-83, 1995.
  • Zheng W, Wang SY.  Oxygen radical absorbing capacity of phenolics in blueberries, cranberries, chokeberries, and lingonberries.  J Agric Food Chem 51:502-9, 2003.
  • Wilson D et al. A randomized, double-blind, placebo-controlled exploratory study to evaluate the potential of pycnogenol for improving allergic rhinitis symptoms. Phytother Res. 24(8):1115-9, 2010.
  • Lau B et al. Pycnogenol as an adjunct in the management of childhood asthma. J Asthma. 41(8):825-32, 2004.
  • Choi YH, Yan GH. Pycnogenol® inhibits immunoglobulin E-mediated allergic response in mast cells. Phytother Res 23: 1691-1695, 2009.
  • Sharma SC, Sharma S, Gulati OP. Pycnogenol® inhibits the release of histamine from mast cells. Phytother Res, 17: 66-69, 2003.
  • Hosseini S, Pishnamazi S, Sadrzadeh MH, Farid F, Farid R, Watson RR.  Pycnogenol® in the management of asthma. J Med Food 4: 201-209, 2001.
  • Cheshier, J.E et al. Immunomodulation by Pycnogenol® in retro-virus infected or ethanol-fed mice. Life Sci., 58(5): 87-96, 1996.
  • Park, Y.C., Rimbach, G., Saliou, C., Valacchi, G. and Packer, L. Activity of monomeric, dimeric, and trimeric flavonoids on NO production, TNF-alpha secretion, and NF-kappaB-dependent gene expression in RAW 264.7 macrophages. FEBS Letters, 465: 93-97, 2000.
  • Rice-Evans CA, Packer L, eds. Flavonoids in Health and Disease. Manhattan, NY: Marcel Dekker, Inc., 1998.
  • Liu, F.J., Zhang, Y.X. and Lau B.H.S. Pycnogenol® enhances immune and haemopoietic functions in senescence-accelerated mice.CMLS, Cell. Mol. Life. Sci., 54: 1168-1172, 1998.
*These statements have not been evaluated by the Food and Drug Administration. This product(s) is not intended to diagnose, treat, cure or prevent any disease.

REVIEW SNAPSHOT®

by PowerReviews
Isotonix®Isotonix OPC-3®
 
4.5

(based on 707 reviews)

Ratings Distribution

  • 5 Stars

     

    (450)

  • 4 Stars

     

    (189)

  • 3 Stars

     

    (34)

  • 2 Stars

     

    (12)

  • 1 Stars

     

    (22)

94%

of respondents would recommend this to a friend.

Pros

  • Good taste (353)
  • Simple to take (244)
  • Produces results (236)
  • Acts quickly (204)
  • Effective (138)

Cons

  • Complicated to take (30)
  • No results (20)
  • Not effective (10)
  • Bad flavor (9)
  • Causes side effects (4)

Best Uses

  • Daily use (451)
  • Women (167)
  • Men (123)
  • Older people (101)
  • Good supplement (96)
    • Reviewer Profile:
    • First time user (280), Health conscious (251), Regular user (123), Medical professional (33)

Reviewed by 707 customers

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Displaying reviews 1-5

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5.0

I use this product every day

By KDB

from Bozeman,Mt

About Me Health Enthusiast , Work Out Regularly

SHOP CONSULTANT

Pros

  • Easy To Take
  • Effective
  • Nutritional
  • Tastes Good

Cons

    Best Uses

    • Everyday Use
    • Men
    • Women

    Comments about Isotonix® Isotonix OPC-3®:

    I use this product for my allergies, high cholesterol, and bad joints

     
    5.0

    I can't Live without it

    By Happy Person

    from Poughkeepsie, NY

    SHOP CONSULTANT

    Comments about Isotonix® Isotonix OPC-3®:

    OPC-3 is easy to take, great for my joint pain, allergies, acid reflux and increased my energy. I was on medication for all these conditions, but no more and I feel great.

    (1 of 1 customers found this review helpful)

     
    4.0

    JUST TRY IT !!!

    By getmikeyhecandoit

    from poughkeepsie new york

    SHOP CONSULTANT

    Comments about Isotonix® Isotonix OPC-3®:

    I have had trouble with my sciatic nerve for about 3 years before I found OPC3 or it found me. It was so bad I would have to crawl to the bathroom on my hands and knees. So, after 2 years of using OPC3 I can say that at the age of 53, I will every go another day without it.

    OPC3 iiiisssSS GREAT!!!

     
    5.0

    All the vitamin I need!

    By Mich the Rollerblader

    from New Jersey

    SHOP CONSULTANT

    Comments about Isotonix® Isotonix OPC-3®:

    I have been taking capfuls of this product for years, sometimes I boost it up to 2 or 3 if I feel a cold coming on. I haven't gotten a cold in YEARS! My skin is clearer, my energy is at it's highest and I feel and look younger than my age. I absolutely Love, Love my OPC3.

     
    5.0

    Absolutely Amazing Product

    By Stephen "The U-CAN Man" Underwood

    from Washington, DC

    SHOP CONSULTANT

    Comments about Isotonix® Isotonix OPC-3®:

    This product is absolutely amazing product to have in any one regiment of dietary supplements on a regular basis. It simply flat out works great. You will see results in a couple of days of taking it. I would recommend this product to anyone.

    Displaying reviews 1-5

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