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Isotonix OPC-3®

Isotonix OPC-3®

Price  $29.95 - $69.95
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Isotonix OPC-3 is one of the most revolutionary nutritional supplements available today. Between its unparalleled formula, including the clinically-studied ingredient Pycnogenol, and the revolutionary Isotonix Delivery System, there isn't a more effect...
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Isotonix OPC-3®

Isotonix OPC-3 is one of the most revolutionary nutritional supplements available today. Between its unparalleled formula, including the clinically-studied ingredient Pycnogenol, and the revolutionary Isotonix Delivery System, there isn't a more effective antioxidant supplement on the market today.

Isotonix OPC-3's list of benefits is substantial. From promoting your cardiovascular health by helping you maintain healthy blood vessels and showing anti-inflammatory activity, Isotonix OPC-3 provides complete antioxidant protection thanks to its unique formula.

The power behind this advanced nutritional supplement powder comes from its formula of OPCs, or oligomeric proanthocyanidins: complex organic plant compounds called bioflavonoids that provide exceptional nutritional benefits to the human body, including antioxidant protection.

Isotonix OPC-3 includes a combination of powerful bioflavonoids that protect against free radicals. This includes Pycnogenol, a super-antioxidant that is one of the most clinically-researched ingredients in the nutritional supplements industry.

Many nutritional supplements - including other nutritional supplement powders - claim Pycnogenol as an ingredient, but only Isotonix products - including Isotonix OPC-3 - have exclusive worldwide rights to the isotonic form of the super-antioxidant Pycnogenol.

The isotonic form of a nutrient - the defining characteristic of Isotonix nutritional supplements - is of vital importance. Traditional tablets and capsules can take hours for the body to digest; Isotonix nutritional supplements digest more quickly and are distributed throughout the body faster than pills.


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Science
FAQ
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  • Blazsó, G., et al. Anti-inflammatory and superoxide radical scavenging activities of a procyanidins containing extract from the bark of Pinus pinaster Sol. and its fractions. Pharm Pharmacol Lett 3: 217-20, 1994
  • Cesarone, M., et al. Improvement in Circulation and in Cardiovascular Risk Factors With a Proprietary Isotonic Bioflavanoid Formula OPC-3.  Journal Angiology 59: 408-414, 2008.
  • Cho, K., et al. Effect of bioflavonoids extracted from the bark of Pinus maritima on proinflammatory cytokine interlukin-1 production in lipopolysaccharide-stimulated RAW 264. 7.  Toxicology and Applied Pharmacology 168: 64-71, 2000.
  • Cho, K., et al. Inhibition mechanisms of bioflavonoids extracted from the bark of Pinus maritima on the expression of proinflammatory cytokines. Annals of the NYAcademy of Sciences 928: 141-156, 2001.
  • Devaraj, S., et al. Supplementation with a pine bark extract rich in polyphenols increases plasma antioxidant capacity and alters the plasma lipoprotein profile. Lipids 37:931-4, 2002.
  • Fine, AM, Oligomeric proanthocyanidin complexes: history, structure, and phytopharmaceutical applications. Altern Med Rev 5:144-51, 2000.
  • Fitzpatrick, D., et al. Endothelium-dependent vascular effects of Pycnogenol. Journal of Cardiovascular Pharmacology 32: 509-515, 1998.
  • Frankel, E., et al. Inhibition of oxidation of human low-density lipoprotein by phenolic substances in red wine. Lancet 341: 454-7, 1993.
  • Freedman, J., et al. Select flavonoids and whole juice from purple grapes inhibit platelet function and enhance nitric oxide release. Circulation 103:2792-8, 2001.
  • Frémont, L. Biological effects of resveratrol. Life Sciences 66: 663-673, 2000.
  • Gulati, O. Pycnogenol® in venous disorders: a review. European Bulletin of Drug Research 7: 1-13, 1999.
  • Hosseini, S., et al. Pycnogenol® in the management of asthma. Journal of Medicinal Food 4: 201-209, 2001. HHHh
  • Kohama, T., et al. The treatment of gynecological disorders with Pycnogenol®. European Bulletin of Drug Research 7: 30-32, 1999.
  • Kohama, T., et al. Analgesic efficacy of French maritime pine bark extract in dysmenorrhea. Journal of Reproductive Medicine 49: 828-32, 2004.
  • Liu, X., et al. Antidiabetic effect of Pycnogenol French maritime pine bark extract in patients with diabetes type II. Life Sci 75:2505-13, 2004.
  • Liu, X., et al. French maritime pine bark extract pycnogenol dose-dependently lowers glucose in type 2 diabetic patients. Diabetes Care 27: 839, 2004.
  • Manna, S., et al. Resveratrol suppresses TNF-Induced activation of nuclear transcription factors NF-kB, activator protein-1, and apoptosis: potential role of reactive oxygen intermediates and lipid peroxidation. The Journal of Immunology 164: 6509-19, 2000.
  • Maritim, A., et al. Effects of pycnogenol treatment on oxidative stress in streptozotocin-induced diabetic rats. J Biochem Mol Toxicol 17:193-9, 2003.
  • Miyagi, Y., et al. Inhibition of human low-density lipoprotein oxidation by flavonoids in red wine and grape juice. Am J Cardiol 0:1627-31, 1997.
  • Monograph. Vaccinium myrtillus (bilberry). Altern Med Rev 6:500-4, 2001.
  • Murias M., et al. Resveratrol analogues as selective cyclooxygenase-2 inhibitors: synthesis and structure-activity relationship. Bioorg Med Chem 12: 5571-8, 2004.
  • Nuttall SL, Kendall MJ, Bombardelli E, Morazzoni P. An evaluation of the antioxidant activity of a standardized grape seed extract, Leucoselect. J Clin Pharm Ther 23: 385-89, 1998.
  • Packer, L., et al. Antioxidant activity and biologic properties of a procyanidin-rich extract from pine (Pinus maritima) bark, pycnogenol. Free Radic Biol Med 27:704-24, 1999. Review.
  • Rohdewald, P. A review of the French maritime pine bark extract (Pycnogenol®), a herbal medication with a diverse clinical pharmacology. Int J Clin Pharmacol Ther 40:158-68, 2002. Review.
  • Rohdewald, P. Pycnogenol®. In "Flavonoids in Health and Disease". Ed. Catherine Rice-Evans and Lester Packer. New York:  Marcel Dekker, Inc., 1998. 405-19.
  • Roseff, S., et al. Improvement in sperm quality and function with French maritime pine tree bark extract. Journal Reproductive Medicine 47: 821-4, 2002.
  • Roseff, S., et al. Improvement of sperm quality by Pycnogenol®. European Bulletin of Drug Research 7: 33-6, 1999.
  • Saito, M., et al. Antiulcer activity of grape seed extract and procyanidins. J Agric  Food Chem 46: 1460-4, 1998.
  • Schönlau, F., et al. Pycnogenol® for diabetic retinopathy. International Ophthalmology 24: 161-171, 2002.
  • Schönlau, F., et al. The cosmeceutical Pycnogenol®. J Appl Cosmetology 20: 241-6, 2002.
  • Segger, D. and Schönlau, F. Supplementation with Evelle® improves skin smoothness and elasticity in a double blind, placebo-controlled study with 62 women. Journal of Dermatological Treatment 15:222-26, 2004.
  • Shi, J., et al. Polyphenolics in grape seeds-biochemistry and functionality. J Med Food 6:291-9, 2003. Review.
  • Sharma, S., et al. Pycnogenol® inhibits the release of histamine from mast cells. Phytotherapy Research 17: 66-69, 2003.
  • Spadea, L., et al. Treatment of vascular retinopathies with Pycnogenol®. Phytotherapy Research 15: 219-23, 2001.
  • Stein, J., et al. Purple grape juice improves endothelial function and reduces the susceptibility of LDL cholesterol to oxidation in patients with coronary artery disease. Circulation 100:1050-5, 1999.
  • Takada, Y., et al. Nonsteroidal anti-inflammatory agents differ in their ability to suppress NF-kappaB activation, inhibition of expression of cyclooxygenase-2 and cyclin D1, and abrogation of tumor cell proliferation. Oncogene 23: 9247-58, 2004.
  • Ueda, T., et al. Preventative effect of natural and synthetic antioxidants on lipid peroxidation in the mammalian eye. Ophthalmic Res 28: 184-92, 1996.
  • Wallerath, T., et al. Resveratrol, a polyphenolic phytoalexin present in red wine, enhances expression and activity of endothelial nitric oxide synthase. Circulation 106:1652-8, 2002.
  • Watson, R. Pycnogenol® and cardiovascular health. Evidence-Based Integrative Medicine 1: 27-32, 2003.
  • Wei, Z., et al. Pycnogenol enhances endothelial cell antioxidant defense. Redox Report 3: 219-24, 1997.
  • Yamakoshi, J., et al.  Proanthocyanidin-rich extract from grape seeds attenuates the development of aortic atherosclerosis in cholesterol-fed rabbits.  Atherosclerosis  142:139-149, 1999.
  • Ames, BN, et al.  Oxidants, antioxidants, and the degenerative diseases of aging.  Proc Natl Acad Sci USA 90:7915-7922, 1993.
  • Bagchi, D, et al.  Oxygen free radical scavenging abilities of vitamins C and E, and a grape seed proanthocyanidin extract in vitro.  Res Commun Mol Pathol Pharmacol 95:179-89, 1997.
  • Bagchi, D, et al.  Free radicals and grape seed proanthocyanidin extract: importance in human health and disease prevention.  Toxicology 148: 187-97, 2000.
  • Bagchi, D, et al.  Cellular protection with proanthocyanidins derived from grape seed.  Ann NY Acad Sci 957:260-70, 2002.
  • Cao G, Alessio H, Cultler R.  Oxygen-radical absorbance capacity assay for antioxidants.  Fre Rad Biol & Med 14:301-11, 1993.
  • Drew B, Leeuwenburgh C.  Aging and the role of reactive nitrogen species.  Ann NY Acad Sci 959:66-81, 2002.
  • Gibson, L, et al.  Effectiveness of cranberry juice in preventing urinary tract infections in long-term care facility patients.  J Naturopathic Med 2:45-47, 1991.
  • Graham DY, Smith JL, Bouvet, AA.  What happens to tablets in the stomach.  J Pharm Sci 79:420-24, 1990.
  • Havsteen B.  Flavonoids, a class of natural products of high pharmacological potency.  Biochem Pharm 32:1141-48, 1983.
  • Halpern, MJ, et al.  Red wine polyphenols and inhibition of platelet aggregation: possible mechanisms, and potential use in health promotion and disease prevention.  J Int Med Res 26:171-80, 1998.
  • Joseph JA, Shukitt-Hale B, Denisova NA, Bielinksi D, Martin A, McEwen JJ, Bickford PC.  Reversals of age-related declines in neuronal signal transduction, cognitive, and motor behavioral deficits with blueberry, spinach, or strawberry dietary supplementation.  J Neuroscience 19: 8114-21, 1999.
  • Kay CD, Holub BJ.  The effect of wild blueberry (Vaccinium angustifolium) on post-prandial serum antioxidant status in human subjects.  Br J Nutr 88: 389-98, 2002.
  • Kehrer JP.  Free radicals as mediators of tissue injury and disease.  Crit Rev Toxicol 23:21-48, 1993.
  • Koch R. Comparative study of Venostatin and Pycnogenol in chronic venous insufficiency.  Phytother Res 16:S1-5, 2002.
  • Koparker AD, Augsburger LL, Shangraw RF.  Intrinsic dissolution rates of tablet fillers and binders and their influence on the dissolution of drugs from tablet formulations.  Pharm Res 7:80-85, 1990.
  • Mazza G, Kay CD, Cottrell T, Holub BJ.  Absorption of anthocyanins from blueberries and serum antioxidant status in human subjects.  J Agric Food Chem 50:7731-37, 2002.
  • Nesaretnam K, et al.  Effect of tocotrienols on the growth of a human breast cancer cell line in culture.  Lipids 30:1139-43, 1995.
  • Ofek I, Goldhar J, Zafriri D, Lis H, Sharon N.  Anti-Escherichia coli adhesion activity of cranberry and blueberry juices. New England J Med 324:1599, 1991.
  • Qureshi, A, et al.  Response of hypercholesterolemic subjects to administration of tocotrienols.  Lipids 30:1171-77, 1995.
  • Rimbach G, Virgili F, Park YC, Packer L.  Effect of procyanidins from Pinus maritime on glutathione levels in endothelial cells challenged by 3-morpholinosydnonimine or activated macrophages.  Redox Rep 4:171-77, 1999. 
  • Sobota AE.  Inhibition of bacterial adherence by cranberry juice: potential use for the treatment of urinary tract infactions.  J Urology 131:1013-1016, 1984.
  • Soloway MS, Smith RA.  J Am Med Assoc 260:1465, 1988.
  • Tomco, A, et al.  Antioxidant effects of tocotrienol in patients with hyperlipidemia and carotid stenosis.  Lipids 30: 1179-83, 1995.
  • Zheng W, Wang SY.  Oxygen radical absorbing capacity of phenolics in blueberries, cranberries, chokeberries, and lingonberries.  J Agric Food Chem 51:502-9, 2003.
  • Wilson D et al. A randomized, double-blind, placebo-controlled exploratory study to evaluate the potential of pycnogenol for improving allergic rhinitis symptoms. Phytother Res. 24(8):1115-9, 2010.
  • Lau B et al. Pycnogenol as an adjunct in the management of childhood asthma. J Asthma. 41(8):825-32, 2004.
  • Choi YH, Yan GH. Pycnogenol® inhibits immunoglobulin E-mediated allergic response in mast cells. Phytother Res 23: 1691-1695, 2009.
  • Sharma SC, Sharma S, Gulati OP. Pycnogenol® inhibits the release of histamine from mast cells. Phytother Res, 17: 66-69, 2003.
  • Hosseini S, Pishnamazi S, Sadrzadeh MH, Farid F, Farid R, Watson RR.  Pycnogenol® in the management of asthma. J Med Food 4: 201-209, 2001.
  • Cheshier, J.E et al. Immunomodulation by Pycnogenol® in retro-virus infected or ethanol-fed mice. Life Sci., 58(5): 87-96, 1996.
  • Park, Y.C., Rimbach, G., Saliou, C., Valacchi, G. and Packer, L. Activity of monomeric, dimeric, and trimeric flavonoids on NO production, TNF-alpha secretion, and NF-kappaB-dependent gene expression in RAW 264.7 macrophages. FEBS Letters, 465: 93-97, 2000.
  • Rice-Evans CA, Packer L, eds. Flavonoids in Health and Disease. Manhattan, NY: Marcel Dekker, Inc., 1998.
  • Liu, F.J., Zhang, Y.X. and Lau B.H.S. Pycnogenol® enhances immune and haemopoietic functions in senescence-accelerated mice.CMLS, Cell. Mol. Life. Sci., 54: 1168-1172, 1998.
*These statements have not been evaluated by the Food and Drug Administration. This product(s) is not intended to diagnose, treat, cure or prevent any disease.

REVIEW SNAPSHOT®

by PowerReviews
Isotonix®Isotonix OPC-3®
 
4.5

(based on 713 reviews)

Ratings Distribution

  • 5 Stars

     

    (454)

  • 4 Stars

     

    (190)

  • 3 Stars

     

    (34)

  • 2 Stars

     

    (12)

  • 1 Stars

     

    (23)

94%

of respondents would recommend this to a friend.

Pros

  • Good taste (353)
  • Simple to take (244)
  • Produces results (236)
  • Acts quickly (204)
  • Effective (145)

Cons

  • Complicated to take (30)
  • No results (20)
  • Not effective (10)
  • Bad flavor (9)
  • Causes side effects (4)

Best Uses

  • Daily use (451)
  • Women (168)
  • Men (124)
  • Older people (101)
  • Good supplement (96)
    • Reviewer Profile:
    • First time user (280), Health conscious (251), Regular user (123), Medical professional (33), Health enthusiast (5)

Reviewed by 713 customers

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Displaying reviews 1-5

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5.0

Miracle worker

By Phil the fanatic tennis enthusiast

from Naples Fl

About Me Health Enthusiast , Push The Envelop Every Da, Work Out Regularly

Verified Buyer

Pros

  • Easy To Take
  • Effective
  • Good Value
  • It Helps Me Stay Active
  • Keeps Me Painfree
  • Makes Me Feel Confident
  • Nutritional
  • Reduces Need For Aspirin
  • Reduces The Need For Advi
  • Tastes Good

Cons

    Best Uses

    • Everyday Use

    Comments about Isotonix® Isotonix OPC-3®:

    I take it every morning as directed on an empty stomach. I hardly ever need advil or another aspirin type pill which tend to effect
    other parts of the body. I play tennis four or five times per week
    painfree. Most all senior tennis players I know take advil before and after. My daughter Aimee Wilson got me to try this product about 7 or 8 years ago and I thank her every day. I really
    believe in the product and recommend it regulary to others!

     
    5.0

    Excellent service and quality product.

    By Frankie

    from Bethlehem,PA,

    Verified Buyer

    Comments about Isotonix® Isotonix OPC-3®:

    I take this every mornng.

     
    5.0

    It does what I needed it for!!

    By Murph's Magic

    from West Springfield, Ma.

    About Me Health Enthusiast , Nutritionist, Training 12 Marathon, Training Half Marathon, Work Out Regularly

    Verified Buyer

    Pros

    • Easy To Take
    • Effective
    • Good Value
    • It Works
    • Nutritional
    • Tastes Good

    Cons

      Best Uses

      • After A Run
      • Everyday Use
      • In The Morning And After
      • Men

      Comments about Isotonix® Isotonix OPC-3®:

      I take it first thing in the morning and after an afternoon run

       
      1.0

      Wrong Size

      By Nurse Mark

      from Ocala, Fl

      Verified Buyer

      Pros

        Cons

        • Poor Value

        Best Uses

          Comments about Isotonix® Isotonix OPC-3®:

          Paid the same price as before, but received a smaller, 3.5 oz bottle. I will not purchase again

           
          4.0

          Making a difference

          By Sandy

          from Bradford, PA

          About Me Rarely Work Out

          Verified Buyer

          Pros

          • Easy To Take
          • Effective
          • Takes No Time To Prepare

          Cons

            Best Uses

            • Everyday Use

            Comments about Isotonix® Isotonix OPC-3®:

            I take it every morning and have noticed a difference in my energy level. I am happy with how easy it is to prepare and that it is just a liquid - not a horse pill!

            Displaying reviews 1-5

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            Previous | Next »

             
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