Isotonix® Vitamin K2 with D3

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Isotonix® Vitamin K2 with D3

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Product Information

  • Helps in the development and maintenance of bones and teeth  
  • Helps in the absorption and use of calcium and phosphorus
  • Factor in the maintenance of good health

 

Product Information

Isotonix® Vitamin K2 with D3

Isotonix Vitamin K2 with D3 contains vitamin K2, a form of vitamin K which supports calcium utilization, along with vitamin D3, the metabolically active form of vitamin D. Vitamin K supports the normal delivery of calcium to the bones, while vitamin D plays an important role in bone health, working with vitamin K to support normal absorption of calcium. Isotonix Vitamin K2 is the first of its kind to deliver both of these powerful vitamins with isotonic delivery. Vitamin K2 and D3 are paired together in Isotonix Vitamin K2 with D3 so they can work synergistically together to support calcium absorption and utilization.

Two of the more common forms of vitamin K are K1 and K2. While there are many similarities between these two forms of vitamin K, they can be distinguished by their important differences, the most significant being their differing pharmacokinetic properties. Vitamin K1 disappears rapidly from the blood, while vitamin K2 persists in the blood’s circulation for a longer time.

Isotonic, which means “same pressure,” bears the same chemical resemblance of the body’s blood, plasma and tears. All fluids in the body have a certain concentration, referred to as osmotic pressure. The body’s common osmotic pressure, which is isotonic, allows a consistent maintenance of body tissues. In order for a substance to be absorbed and used in the body’s metabolism, it must be transported in an isotonic state.
 
Isotonix dietary supplements are delivered in an isotonic solution. This means that the body has less work to do to in obtaining great absorption. The isotonic state of the suspension allows nutrients to pass directly into the small intestine and be rapidly absorbed into the bloodstream. With Isotonix products, little nutritive value is lost, making the absorption of nutrients highly efficient while delivering maximum results.

Ingredients

Vitamin K2
Vitamin K is a fat-soluble vitamin found in meat, eggs, dairy and natto. Although a fat-soluble vitamin, the body stores very little vitamin K2, and its stores are rapidly depleted without regular dietary intake. Natural vitamin K2, also known as menaquinone-7 (MK-7), is the most bioavailable form of K2 and has the longest half-life in the blood of any form of vitamin K. The Japanese soy food natto is particularly rich in menaquinone-7 (MK-7). Studies of natto consumption in Japan have linked menaquinone-7 to bone and cardiovascular health. The correlation of vitamin K to cardiovascular and bone health directly focuses on supporting proper calcium utilization. Vitamin K2 promotes the synthesis of proteins involved with calcium utilization, thereby supporting bone retention and arterial health.

Vitamin D3 (Cholecalciferol)
Vitamin D is a fat-soluble vitamin that is found in some foods and produced when sunlight strikes the skin and activates vitamin D synthesis. Vitamin D promotes the efficient intestinal absorption of calcium, primarily in the duodenum and jejunum by supporting the synthesis of calcium-binding proteins to promote normal calcium absorption and retention. Vitamin D also promotes the normal formation of bone and normal bone growth, and bone remodeling by osteoblasts and osteoclasts. Vitamin D deficiency can be caused by factors, such as lack of exposure to sunlight, reduced skin synthesis of vitamin D, lower dietary intake, impaired intestinal absorption and reduced metabolism to active forms of vitamin D by the kidneys, all of which increase with aging. Deficiency has been linked to numerous health concerns, and insufficient levels of this vitamin are associated with frail bones and muscle weakness.

Science

  • Adorini L.  Immunomodulatory effects of vitamin D receptor ligands in autoimmune diseases.  International Immunopharmacology. 2(7):1017-1028, 2002.
  • Argiles A et al.  Blood pressure is correlated with vitamin D(3) serum levels in dialysis patients.  Blood Purification.  20(4):370-375, 2002.
  • Bekner K.  The vitamin K-dependent carboxylase.  Journal of Nutrition.  130(8):1877-1880, 2000.
  • Binkley N et al.  Vitamin K nutrition and osteoporosis. Journal of Nutrition.  125(7):1812-1821, 1995.
  • Bischoff-Ferrari Het al.  Fracture prevention with vitamin D supplementation: a meta-analysis of randomized controlled trials.  JAMA. 293(18):2257-2264, 2005.
  • Blackmore K et al. Vitamin D from dietary intake and sunlight exposure and the risk of hormone-receptor-defined breast cancer. American Journal of Epidemiology. 168(8):915-24, 2008.
  • Cantorna M et al.  Mounting evidence for vitamin D as an environmental factor affecting autoimmune disease prevalence. Experimental Biology and Medicine (Maywood).  229(11):1136-1142, 2004.
  • Cantorna M. Vitamin D and autoimmunity: is vitamin D status an environmental factor affecting autoimmune disease prevalence? Society for Experimental Biology and Medicine. 223:230-233, 2000.
  • Chapuy M et al.  Vitamin D3 and calcium to prevent hip fractures in the elderly women. New England Journal of Medicine. 327(23):1637-1642, 1992.
  • Chlebowski R et al.  Vitamin K in the treatment of cancer.  Cancer Treatment Review.  12:49-63, 1985.
  • Deluca H et al.  Vitamin D: its role and uses in immunology.  FASEB Journal. 15(14):2579-2585, 2001.
  • Garber, A. K., et al.  Comparison of phylloquinone bioavailability from food sources or a supplement in human subjects.  Journal of Nutrition.  129(6):1201-1203, 1999.
  • Garland C et al.  The role of vitamin D in cancer prevention.  American Journal of Public Health.  96(2):252-61, 2006.
  • Giovannucci E et al.  Prospective study of predictors of vitamin D status and cancer incidence and mortality in men.  Journal of the National Cancer Institute.  98(7):451-459, 2006.
  • Gorham E et al.  Vitamin D and prevention of colorectal cancer.  Journal Steroid Biochemistry and Molecular Biology. 97(1-2):179-94, 2005.
  • Grant W and Holick M. Benefits and requirements of vitamin D for optimal health. Alternative Medicine Review. 10:94-111, 2005.
  • Grant W et al.  Reviews: A critical review of studies on vitamin D in relation to colorectal cancer.  Nutrition and Cancer.  48(2):115-123, 2004.
  • Guirguis-Blake J et al.  Oral vitamin D3 decreases fracture risk in the elderly.  Journal of Family Practice.  52(6):431-435, 2003.
  • Gundberg C et al.  Vitamin K status and bone health:  an analysis of methods for determination under carboxylated osteocalcin. Journal of Clinical Endocrinology and Metabolism.  83(9):3258-3266, 1998.
  • Habu D et al.  Role of vitamin K2 in the development of hepatocellular carcinoma in women with viral cirrhosis of the liver.  JAMA. 292(3):358-361, 2004.
  • Harris D et al.  Vitamin D and colon carcinogenesis.  Journal of Nutrition.  134(12):3463S-3471S, 2004.
  • Hayes C et al.  The immunological functions of the vitamin D endocrine system.  Cellular and Molecular Biology. 49(2):277-300, 2003.
  • Hidaka T et al.  Treatment for patients with postmenopausal osteoporosis who have been placed on HRT and show a decrease in bone mineral density: effects of concomitant administration of vitamin K(2).  Journal of Bone and Mineral Metabolism.  20(4):235-239, 2002.
  • Hiruma Y et al.  Vitamin K(2) and geranylgeraniol, its side chain component, inhibited osteoclast formation in a different manner. Biochemical Biophysical Research Communications.  314(1):24-30, 2004.
  • Hitomi M et al. Antitumor effects of vitamins K1, K2 and K3 on hepatocellular carcinoma in vitro and in vivo.  International Journal of Oncology.  26(3):713-720, 2005.
  • Holick, M.  Vitamin D:  Its role in cancer prevention and treatment.  Progress in Biophysics and Molecular Biology. 92(1):49-59, 2006.
  • Iwamoto J et al. Treatment with vitamin D3 and/or vitamin K2 for postmenopausal osteoporosis. The Keio Journal of Medicine. 2003 Sep;52(3):147-50. Review.
  • Iwamoto J et al.  Effects of vitamin K2 on osteoporosis.  Current Pharmaceutical Design.  10(21):2557-2576, 2004.
  • Kameda T et al.  Vitamin K2 inhibits osteoclastic bone resorption by inducing osteoclast apoptosis.  Biochemical and Biophysical Research Communications.  220(3):515-519, 1996.
  • Knapen M et al. Vitamin K2 supplementation improves hip bone geometry and bone strength indices in postmenopausal women. Osteoporosis International. 18(7):963-72, 2007.
  • Kristal-Boneh E et al.  Association of calcitriol and blood pressure in normotensive men.  Hypertension.  30(5):1289-1294, 1997.
  • Lamson D and Plaza S. The anticancer effects of vitamin K. Alternative Medicine Review. 8(3):303-18, 2003.
  • Li Y et al.  1,25-Dihydroxyvitamin D(3) is a negative endocrine regulator of the renin-angiotensin system.  Journal of Clinical Investigation.  110(2):229-238, 2002.
  • Li Y et al.  Vitamin D regulation of the renin-angiotensin system.  Journal of Cell Biochemistry.  88(2):327-331, 2003.
  • Li Y et al.  Vitamin D: a negative endocrine regulator of the renin-angiotensin system and blood pressure.  Journal of Steroid Biochemistry and Molecular Biology.  89-90(1-5):387-392, 2004.
  • Nelsestuen G et al.  Vitamin K-dependent proteins.  Vitamins and Hormones.  58:355-389, 2000.
  • Neogi, T., et al.  Low vitamin K status is associated with osteoarthritis in the hand and knee.  Arthritis and Rheumatism. 54(4):1255-1261, 2006.
  • Nimptsch K et al. Dietary intake of vitamin K and risk of prostate cancer in the Heidelberg cohort of the European Prospective Investigation into Cancer and Nutrition. American Journal of Clinical Nutrition. 87:985-992, 2008.
  • Nouso K et al.  Regression of hepatocellular carcinoma during vitamin K administration.  World Journal of Gastroenterology. 11(42):6722-6724, 2005.
  • Pfeifer M et al.  Effects of a short-term vitamin D(3) and calcium supplementation on blood pressure and parathyroid hormone levels in elderly women.  Journal of Clinical Endocrinology and Metabolism.  86(4):1633-1637, 2001.
  • Plaza S and Lamson D. Vitamin K2 in bone metabolism and osteoporosis. Alternative Medicine Reviews. 10(1):24-35, 2005. Review.
  • Plaza S and Lamson D. Vitamin K2 in bone metabolism and osteoporosis. Alternative Medicine Reviews. 10(1):24-35, 2005. Review.
  • Price P.  Role of vitamin K-dependent proteins in bone metabolism.  Annual Review of Nutrition.  8:565-583, 1988.
  • Schaafsma, A., et al.  Vitamin D3 and vitamin K1 supplementation of Dutch postmenopausal women with normal and low bone mineral densities:  effects on serum 25-hydroxyvitamin D and carboxylated osteocalcin.  European Journal of Clinical Nutrition.  54:626-631, 2000.
  • Schleithoff S et al.  Vitamin D supplementation improves cytokine profiles in patients with congestive heart failure: a double-blind, randomized, placebo-controlled trial.  American Journal of Clinical Nutrition. 83(4):754-759, 2006.
  • Shearer M.  Role of vitamin K and Gla proteins in the pathophysiology of osteoporosis and vascular calcification.  Current Opinion in Clinical Nutrition and Metabolic Care.  3(6):433-438, 2000.
  • Shiraki, M., et al.  Vitamin K2 (menatetrenone) effectively prevents fractures and sustains lumbar bone mineral density in osteoporosis.  Journal of Bone & Mineral Research.  15:515-522, 2000.
  • Sigmund C.  Regulation of renin expression and blood pressure by vitamin D(3).  Journal of Clinical Investigation.  110(2):155-156, 2002.
  • Taira H et al.  Menatetrenone (vitamin K2) acts directly on circulating human osteoclast precursors.  Calcified Tissue International. 73(1):78-85, 2003.
  • Trivedi Det al.  Effect of four monthly oral vitamin D3 (cholecalciferol) supplementation on fractures and mortality in men and women living in the community: randomised double blind controlled trial.  British Medical Journal.  326(7387):469, 2003.
  • Van den Berghe G et al.  Bone turnover in prolonged critical illness: effect of vitamin D.  Journal of Clinical Endocrinology and Metabolism.  88(10):4623-4632, 2003.
  • Vasquez A et al.  The clinical importance of vitamin D (cholecalciferol):  a paradigm shift with implications for all healthcare providers.  Alternative Therapies.  10(5):28-38, 2004.
  • Weber P.  Management of osteoporosis: is there a role for vitamin K?  International Journal for Vitamin and Nutrition Research. 67(5):350-6, 1997.
  • Yokoyama T et al.  Combination of vitamin K2 plus imatinib mesylate enhances induction of apoptosis in small cell lung cancer cell lines.  International Journal of Oncology.  26(1):33-40, 2005.
  • Yoshida T et al.  Apoptosis induction of vitamin K2 in lung carcinoma cell lines: the possibility of vitamin K2 therapy for lung cancer. International Journal of Oncology.  23(3):627-632, 2003.
  • Zitterman A et al.  Low vitamin D status: a contributing factor in the pathogenesis of congestive heart failure?  Journal of the American College of Cardiology.  41(1):105-112, 2003.

FAQ

Why are vitamins K and D included in Isotonix Vitamin K2 with D3?
Vitamins K and D are paired together due to their unique partnership. Vitamins K and D work together to promote healthy calcium absorption and utilization. 

Is Isotonix Vitamin K2 with D3 safe for people on anti-coagulant medications?
Most products containing vitamin K (including K1 and/or K2) warn users taking anticoagulants not to take the product. If you are currently taking warfarin or another anticoagulant medication, you should consult your physician before taking any product containing vitamin K1 or K2.

How do I take Isotonix Vitamin K2 with D3?
Mix one capful of Isotonix Vitamin K2 with D3 with 60 ml of water. Take one serving daily.

Is it safe to take more than one serving of this product daily?
One serving daily of Isotonix Vitamin K2 with D3 is recommended. Check with your health care practitioner before taking additional daily servings of this product.

What are dietary sources of vitamin D?
Foods rich in vitamin D include cod liver oil, salmon, mackerel and tuna.


Isotonix Vitamin K2 with D3 contains vitamin K2, a form of vitamin K which supports vascular health and calcium utilization along with vitamin D3, the metabolically active form of vitamin D. Vitamin K supports the normal delivery of calcium to the bones, while vitamin D plays an important role in bone health, working with vitamin K to support normal absorption of calcium. Isotonix Vitamin K2 is the first of its kind to deliver both of these powerful vitamins with isotonic delivery.

REVIEW SNAPSHOT®

by PowerReviews
Isotonix® Vitamin D with K2
 
4.6

(based on 87 reviews)

Ratings Distribution

  • 5 Stars

     

    (62)

  • 4 Stars

     

    (18)

  • 3 Stars

     

    (4)

  • 2 Stars

     

    (2)

  • 1 Stars

     

    (1)

96%

of respondents would recommend this to a friend.

Pros

  • No side effects (40)
  • Good value (30)
  • Works quickly (27)
  • Natural-feeling results (24)
  • Relieves stress (10)

Cons

    Best Uses

    • Morning (35)
    • Daily use (27)
    • Afternoon (5)
    • Before sleep (5)
      • Reviewer Profile:
      • First time user (30), Regular user (27), Health conscious (18), Medical professional (3)

    Reviewed by 87 customers

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    Displaying reviews 1-5

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    5.0

    Love the taste

    By Sheba

    from Rochester, New York

    Pros

    • Easy To Take
    • Tastes Good

    Cons

    • Day Size
    • I Wish That You Offered A
    • Larger Sized Bottle-90

    Best Uses

    • Everyday Use

    Comments about Isotonix® Vitamin D with K2:

    I take it first thing in the mornings that I do not plan to be in the sun. I live in an area that is cloudy for much of the winter & and often in the spring and fall, too.

     
    5.0

    Re: "Wasted 1/4 of Product"

    By Yana and KenR

    from USA

    SHOP CONSULTANT

    Comments about Isotonix® Vitamin D with K2:

    Maria, I hope that you read this! The "Cap" that you measure the powder into is NOT the cap that you fill with water! Your product should have come with an "overcap" that is used to measure the right amound of water (2 ounces) for every bottlecap of powder. THAT cap is the one that is right on the bottle. If you use them correctly, you should not have water getting into the bottle. That having been said, if you live in a humid environment, you can actually just refrigerate the bottle to make sure that it stays fresh and dry.

     
    2.0

    Wasted 1/4 of Product

    By MariaS

    from USA

    Comments about Isotonix® Vitamin D with K2:

    Somehow water got inside the bottle and wasted the 1/4 of remaining powder. I think a different mechanism is needed, since the bottle top is used to administer the product with water. I'm going to try again and use without the bottle top to see if it makes a difference.

    (0 of 1 customers found this review helpful)

     
    5.0

    Tastes great!

    By DanielP

    from USA

    Comments about Isotonix® Vitamin D with K2:

    Tastes like kool aid and boosts immunity while protecting against a myraid of afflictions. Everyone needs Vit D and this is the best!

     
    4.0

    very good

    By pat

    from seffner fl.

    Verified Buyer

    Comments about Isotonix® Vitamin D with K2:

    its so easy to takee

    Displaying reviews 1-5

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