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Isotonix OPC-3®

Isotonix OPC-3®

Price  $29.95 - $69.95
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Isotonix OPC-3 is one of the most revolutionary nutritional supplements available today. Between its unparalleled formula, including the clinically-studied ingredient Pycnogenol, and the revolutionary Isotonix Delivery System, there isn't a more effect...
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Isotonix OPC-3®

Isotonix OPC-3 is one of the most revolutionary nutritional supplements available today. Between its unparalleled formula, including the clinically-studied ingredient Pycnogenol, and the revolutionary Isotonix Delivery System, there isn't a more effective antioxidant supplement on the market today.

Isotonix OPC-3's list of benefits is substantial. From promoting your cardiovascular health by helping you maintain healthy blood vessels and showing anti-inflammatory activity, Isotonix OPC-3 provides complete antioxidant protection thanks to its unique formula.

The power behind this advanced nutritional supplement powder comes from its formula of OPCs, or oligomeric proanthocyanidins: complex organic plant compounds called bioflavonoids that provide exceptional nutritional benefits to the human body, including antioxidant protection.

Isotonix OPC-3 includes a combination of powerful bioflavonoids that protect against free radicals. This includes Pycnogenol, a super-antioxidant that is one of the most clinically-researched ingredients in the nutritional supplements industry.

Many nutritional supplements - including other nutritional supplement powders - claim Pycnogenol as an ingredient, but only Isotonix products - including Isotonix OPC-3 - have exclusive worldwide rights to the isotonic form of the super-antioxidant Pycnogenol.

The isotonic form of a nutrient - the defining characteristic of Isotonix nutritional supplements - is of vital importance. Traditional tablets and capsules can take hours for the body to digest; Isotonix nutritional supplements digest more quickly and are distributed throughout the body faster than pills.


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Science
FAQ
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  • Blazsó, G., et al. Anti-inflammatory and superoxide radical scavenging activities of a procyanidins containing extract from the bark of Pinus pinaster Sol. and its fractions. Pharm Pharmacol Lett 3: 217-20, 1994
  • Cesarone, M., et al. Improvement in Circulation and in Cardiovascular Risk Factors With a Proprietary Isotonic Bioflavanoid Formula OPC-3.  Journal Angiology 59: 408-414, 2008.
  • Cho, K., et al. Effect of bioflavonoids extracted from the bark of Pinus maritima on proinflammatory cytokine interlukin-1 production in lipopolysaccharide-stimulated RAW 264. 7.  Toxicology and Applied Pharmacology 168: 64-71, 2000.
  • Cho, K., et al. Inhibition mechanisms of bioflavonoids extracted from the bark of Pinus maritima on the expression of proinflammatory cytokines. Annals of the NYAcademy of Sciences 928: 141-156, 2001.
  • Devaraj, S., et al. Supplementation with a pine bark extract rich in polyphenols increases plasma antioxidant capacity and alters the plasma lipoprotein profile. Lipids 37:931-4, 2002.
  • Fine, AM, Oligomeric proanthocyanidin complexes: history, structure, and phytopharmaceutical applications. Altern Med Rev 5:144-51, 2000.
  • Fitzpatrick, D., et al. Endothelium-dependent vascular effects of Pycnogenol. Journal of Cardiovascular Pharmacology 32: 509-515, 1998.
  • Frankel, E., et al. Inhibition of oxidation of human low-density lipoprotein by phenolic substances in red wine. Lancet 341: 454-7, 1993.
  • Freedman, J., et al. Select flavonoids and whole juice from purple grapes inhibit platelet function and enhance nitric oxide release. Circulation 103:2792-8, 2001.
  • Frémont, L. Biological effects of resveratrol. Life Sciences 66: 663-673, 2000.
  • Gulati, O. Pycnogenol® in venous disorders: a review. European Bulletin of Drug Research 7: 1-13, 1999.
  • Hosseini, S., et al. Pycnogenol® in the management of asthma. Journal of Medicinal Food 4: 201-209, 2001. HHHh
  • Kohama, T., et al. The treatment of gynecological disorders with Pycnogenol®. European Bulletin of Drug Research 7: 30-32, 1999.
  • Kohama, T., et al. Analgesic efficacy of French maritime pine bark extract in dysmenorrhea. Journal of Reproductive Medicine 49: 828-32, 2004.
  • Liu, X., et al. Antidiabetic effect of Pycnogenol French maritime pine bark extract in patients with diabetes type II. Life Sci 75:2505-13, 2004.
  • Liu, X., et al. French maritime pine bark extract pycnogenol dose-dependently lowers glucose in type 2 diabetic patients. Diabetes Care 27: 839, 2004.
  • Manna, S., et al. Resveratrol suppresses TNF-Induced activation of nuclear transcription factors NF-kB, activator protein-1, and apoptosis: potential role of reactive oxygen intermediates and lipid peroxidation. The Journal of Immunology 164: 6509-19, 2000.
  • Maritim, A., et al. Effects of pycnogenol treatment on oxidative stress in streptozotocin-induced diabetic rats. J Biochem Mol Toxicol 17:193-9, 2003.
  • Miyagi, Y., et al. Inhibition of human low-density lipoprotein oxidation by flavonoids in red wine and grape juice. Am J Cardiol 0:1627-31, 1997.
  • Monograph. Vaccinium myrtillus (bilberry). Altern Med Rev 6:500-4, 2001.
  • Murias M., et al. Resveratrol analogues as selective cyclooxygenase-2 inhibitors: synthesis and structure-activity relationship. Bioorg Med Chem 12: 5571-8, 2004.
  • Nuttall SL, Kendall MJ, Bombardelli E, Morazzoni P. An evaluation of the antioxidant activity of a standardized grape seed extract, Leucoselect. J Clin Pharm Ther 23: 385-89, 1998.
  • Packer, L., et al. Antioxidant activity and biologic properties of a procyanidin-rich extract from pine (Pinus maritima) bark, pycnogenol. Free Radic Biol Med 27:704-24, 1999. Review.
  • Rohdewald, P. A review of the French maritime pine bark extract (Pycnogenol®), a herbal medication with a diverse clinical pharmacology. Int J Clin Pharmacol Ther 40:158-68, 2002. Review.
  • Rohdewald, P. Pycnogenol®. In "Flavonoids in Health and Disease". Ed. Catherine Rice-Evans and Lester Packer. New York:  Marcel Dekker, Inc., 1998. 405-19.
  • Roseff, S., et al. Improvement in sperm quality and function with French maritime pine tree bark extract. Journal Reproductive Medicine 47: 821-4, 2002.
  • Roseff, S., et al. Improvement of sperm quality by Pycnogenol®. European Bulletin of Drug Research 7: 33-6, 1999.
  • Saito, M., et al. Antiulcer activity of grape seed extract and procyanidins. J Agric  Food Chem 46: 1460-4, 1998.
  • Schönlau, F., et al. Pycnogenol® for diabetic retinopathy. International Ophthalmology 24: 161-171, 2002.
  • Schönlau, F., et al. The cosmeceutical Pycnogenol®. J Appl Cosmetology 20: 241-6, 2002.
  • Segger, D. and Schönlau, F. Supplementation with Evelle® improves skin smoothness and elasticity in a double blind, placebo-controlled study with 62 women. Journal of Dermatological Treatment 15:222-26, 2004.
  • Shi, J., et al. Polyphenolics in grape seeds-biochemistry and functionality. J Med Food 6:291-9, 2003. Review.
  • Sharma, S., et al. Pycnogenol® inhibits the release of histamine from mast cells. Phytotherapy Research 17: 66-69, 2003.
  • Spadea, L., et al. Treatment of vascular retinopathies with Pycnogenol®. Phytotherapy Research 15: 219-23, 2001.
  • Stein, J., et al. Purple grape juice improves endothelial function and reduces the susceptibility of LDL cholesterol to oxidation in patients with coronary artery disease. Circulation 100:1050-5, 1999.
  • Takada, Y., et al. Nonsteroidal anti-inflammatory agents differ in their ability to suppress NF-kappaB activation, inhibition of expression of cyclooxygenase-2 and cyclin D1, and abrogation of tumor cell proliferation. Oncogene 23: 9247-58, 2004.
  • Ueda, T., et al. Preventative effect of natural and synthetic antioxidants on lipid peroxidation in the mammalian eye. Ophthalmic Res 28: 184-92, 1996.
  • Wallerath, T., et al. Resveratrol, a polyphenolic phytoalexin present in red wine, enhances expression and activity of endothelial nitric oxide synthase. Circulation 106:1652-8, 2002.
  • Watson, R. Pycnogenol® and cardiovascular health. Evidence-Based Integrative Medicine 1: 27-32, 2003.
  • Wei, Z., et al. Pycnogenol enhances endothelial cell antioxidant defense. Redox Report 3: 219-24, 1997.
  • Yamakoshi, J., et al.  Proanthocyanidin-rich extract from grape seeds attenuates the development of aortic atherosclerosis in cholesterol-fed rabbits.  Atherosclerosis  142:139-149, 1999.
  • Ames, BN, et al.  Oxidants, antioxidants, and the degenerative diseases of aging.  Proc Natl Acad Sci USA 90:7915-7922, 1993.
  • Bagchi, D, et al.  Oxygen free radical scavenging abilities of vitamins C and E, and a grape seed proanthocyanidin extract in vitro.  Res Commun Mol Pathol Pharmacol 95:179-89, 1997.
  • Bagchi, D, et al.  Free radicals and grape seed proanthocyanidin extract: importance in human health and disease prevention.  Toxicology 148: 187-97, 2000.
  • Bagchi, D, et al.  Cellular protection with proanthocyanidins derived from grape seed.  Ann NY Acad Sci 957:260-70, 2002.
  • Cao G, Alessio H, Cultler R.  Oxygen-radical absorbance capacity assay for antioxidants.  Fre Rad Biol & Med 14:301-11, 1993.
  • Drew B, Leeuwenburgh C.  Aging and the role of reactive nitrogen species.  Ann NY Acad Sci 959:66-81, 2002.
  • Gibson, L, et al.  Effectiveness of cranberry juice in preventing urinary tract infections in long-term care facility patients.  J Naturopathic Med 2:45-47, 1991.
  • Graham DY, Smith JL, Bouvet, AA.  What happens to tablets in the stomach.  J Pharm Sci 79:420-24, 1990.
  • Havsteen B.  Flavonoids, a class of natural products of high pharmacological potency.  Biochem Pharm 32:1141-48, 1983.
  • Halpern, MJ, et al.  Red wine polyphenols and inhibition of platelet aggregation: possible mechanisms, and potential use in health promotion and disease prevention.  J Int Med Res 26:171-80, 1998.
  • Joseph JA, Shukitt-Hale B, Denisova NA, Bielinksi D, Martin A, McEwen JJ, Bickford PC.  Reversals of age-related declines in neuronal signal transduction, cognitive, and motor behavioral deficits with blueberry, spinach, or strawberry dietary supplementation.  J Neuroscience 19: 8114-21, 1999.
  • Kay CD, Holub BJ.  The effect of wild blueberry (Vaccinium angustifolium) on post-prandial serum antioxidant status in human subjects.  Br J Nutr 88: 389-98, 2002.
  • Kehrer JP.  Free radicals as mediators of tissue injury and disease.  Crit Rev Toxicol 23:21-48, 1993.
  • Koch R. Comparative study of Venostatin and Pycnogenol in chronic venous insufficiency.  Phytother Res 16:S1-5, 2002.
  • Koparker AD, Augsburger LL, Shangraw RF.  Intrinsic dissolution rates of tablet fillers and binders and their influence on the dissolution of drugs from tablet formulations.  Pharm Res 7:80-85, 1990.
  • Mazza G, Kay CD, Cottrell T, Holub BJ.  Absorption of anthocyanins from blueberries and serum antioxidant status in human subjects.  J Agric Food Chem 50:7731-37, 2002.
  • Nesaretnam K, et al.  Effect of tocotrienols on the growth of a human breast cancer cell line in culture.  Lipids 30:1139-43, 1995.
  • Ofek I, Goldhar J, Zafriri D, Lis H, Sharon N.  Anti-Escherichia coli adhesion activity of cranberry and blueberry juices. New England J Med 324:1599, 1991.
  • Qureshi, A, et al.  Response of hypercholesterolemic subjects to administration of tocotrienols.  Lipids 30:1171-77, 1995.
  • Rimbach G, Virgili F, Park YC, Packer L.  Effect of procyanidins from Pinus maritime on glutathione levels in endothelial cells challenged by 3-morpholinosydnonimine or activated macrophages.  Redox Rep 4:171-77, 1999. 
  • Sobota AE.  Inhibition of bacterial adherence by cranberry juice: potential use for the treatment of urinary tract infactions.  J Urology 131:1013-1016, 1984.
  • Soloway MS, Smith RA.  J Am Med Assoc 260:1465, 1988.
  • Tomco, A, et al.  Antioxidant effects of tocotrienol in patients with hyperlipidemia and carotid stenosis.  Lipids 30: 1179-83, 1995.
  • Zheng W, Wang SY.  Oxygen radical absorbing capacity of phenolics in blueberries, cranberries, chokeberries, and lingonberries.  J Agric Food Chem 51:502-9, 2003.
  • Wilson D et al. A randomized, double-blind, placebo-controlled exploratory study to evaluate the potential of pycnogenol for improving allergic rhinitis symptoms. Phytother Res. 24(8):1115-9, 2010.
  • Lau B et al. Pycnogenol as an adjunct in the management of childhood asthma. J Asthma. 41(8):825-32, 2004.
  • Choi YH, Yan GH. Pycnogenol® inhibits immunoglobulin E-mediated allergic response in mast cells. Phytother Res 23: 1691-1695, 2009.
  • Sharma SC, Sharma S, Gulati OP. Pycnogenol® inhibits the release of histamine from mast cells. Phytother Res, 17: 66-69, 2003.
  • Hosseini S, Pishnamazi S, Sadrzadeh MH, Farid F, Farid R, Watson RR.  Pycnogenol® in the management of asthma. J Med Food 4: 201-209, 2001.
  • Cheshier, J.E et al. Immunomodulation by Pycnogenol® in retro-virus infected or ethanol-fed mice. Life Sci., 58(5): 87-96, 1996.
  • Park, Y.C., Rimbach, G., Saliou, C., Valacchi, G. and Packer, L. Activity of monomeric, dimeric, and trimeric flavonoids on NO production, TNF-alpha secretion, and NF-kappaB-dependent gene expression in RAW 264.7 macrophages. FEBS Letters, 465: 93-97, 2000.
  • Rice-Evans CA, Packer L, eds. Flavonoids in Health and Disease. Manhattan, NY: Marcel Dekker, Inc., 1998.
  • Liu, F.J., Zhang, Y.X. and Lau B.H.S. Pycnogenol® enhances immune and haemopoietic functions in senescence-accelerated mice.CMLS, Cell. Mol. Life. Sci., 54: 1168-1172, 1998.
*These statements have not been evaluated by the Food and Drug Administration. This product(s) is not intended to diagnose, treat, cure or prevent any disease.

REVIEW SNAPSHOT®

by PowerReviews
Isotonix®Isotonix OPC-3®
 
4.5

(based on 708 reviews)

Ratings Distribution

  • 5 Stars

     

    (451)

  • 4 Stars

     

    (189)

  • 3 Stars

     

    (34)

  • 2 Stars

     

    (12)

  • 1 Stars

     

    (22)

94%

of respondents would recommend this to a friend.

Pros

  • Good taste (353)
  • Simple to take (244)
  • Produces results (236)
  • Acts quickly (204)
  • Effective (142)

Cons

  • Complicated to take (30)
  • No results (20)
  • Not effective (10)
  • Bad flavor (9)
  • Causes side effects (4)

Best Uses

  • Daily use (451)
  • Women (168)
  • Men (123)
  • Older people (101)
  • Good supplement (96)
    • Reviewer Profile:
    • First time user (280), Health conscious (251), Regular user (123), Medical professional (33), Health enthusiast (3)

Reviewed by 708 customers

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Displaying reviews 1-5

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(1 of 2 customers found this review helpful)

 
5.0

OPC-3 Is the best antioxidant ever

By Radical man

from New York

About Me Health Enthusiast , Returning To Old Form, Work Out Regularly

Pros

  • Easy To Take
  • Effective
  • Good Value
  • Nutritional
  • Tastes Good

Cons

    Best Uses

    • Everyday Use
    • Men
    • Weight Loss

    Comments about Isotonix® Isotonix OPC-3®:

    OPC-3 Is the best anitoxidant ever developed by any company, anywhere....And Market America through SHOP.COM has it exclusively....HALLELUJAH

    (2 of 2 customers found this review helpful)

     
    5.0

    Great product

    By Clare

    from San Ramon

    Pros

    • Effective

    Cons

      Best Uses

      • Everyday Use

      Comments about Isotonix® Isotonix OPC-3®:

      All I complain is the shipping. This product is free shipping but takes too long. Last order, the shipped date was 1 week later than the the date the credit card charged. Yesterday I tried to order again, but I don't see any chance to upgrade the shippment. The free shipping just not acceptable. If you can suggest the faster shipping method that would be great. Thank you!

      (2 of 2 customers found this review helpful)

       
      5.0

      Great item

      By TC

      from Milwaukee, WI

      About Me Health Enthusiast

      Pros

      • Easy To Take
      • Effective
      • Great For Allergies

      Cons

      • Not The Best Tasting
      • Tastes Bad

      Best Uses

      • Allergies
      • Everyday Use

      Comments about Isotonix® Isotonix OPC-3®:

      My husband is a health enthusiast and was toughing out his allergies when my consultant had mentioned to use OPC3. He loves the results. this is the first time in years he hasn't had to deal with his allergies. My son-in-law just tried it and he forgot he had to take medication for it. He also is a health enthusiast and loves this product..

      (1 of 1 customers found this review helpful)

       
      5.0

      LOVE IT

      By Beth S

      from Franklin WI

      Verified Buyer

      Comments about Isotonix® Isotonix OPC-3®:

      I truly wish that the OPC for women was in the Daily Essentials pack - please consider making that an option!

      (2 of 2 customers found this review helpful)

       
      5.0

      I have used OPC-3 for many years.

      By Esther

      from Syracuse, NY

      Verified Buyer

      Pros

      • Easy To Take
      • Nutritional
      • Tastes Good

      Cons

        Best Uses

        • Everyday Use

        Comments about Isotonix® Isotonix OPC-3®:

        I use this product daily, and have for many years.
        I am 82 years old and I am in reasonably good health.

        I list this as one of the products taken daily, when I visit Health Care Physicians. No one has ever told me not to use it and one did tell me that OPC-3 was very good.

        Displaying reviews 1-5

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