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Product Brochure

The most powerful antioxidant supplement on the market today! Provides complete antioxidant protection. 

  • Promotes cardiovascular health PLUS:
    • Helps maintain healthy cholesterol and blood glucose levels
    • Helps maintain healthy circulation by strengthening capillaries, arteries and veins
    • Promotes healthy blood vessel dilation
  • Demonstrates anti-inflammatory activity and promotes joint health

Additional Benefits

  • Combats free radicals
  • Helps maintain joint flexibility
  • Helps reduce mild menstrual cramping and abdominal pain
  • Helps support visual health/visual acuity
  • Potent free radical scavenger
  • Promotes healthy blood vessel dilation
  • Promotes healthy nitric oxide levels
  • Supports a healthy complexion
  • Supports healthy blood glucose levels
  • Supports healthy platelet activity
  • Supports healthy sperm quality
  • Promotes sinus comfort
  • Supports immune health

Gluten Free - Vegetarian - No Detectable GMO - Pycnogenol

Product Information

Isotonix OPC-3®

Isotonix OPC-3 is one of the most revolutionary nutritional supplements available today. Between its unparalleled formula, including the clinically-studied ingredient Pycnogenol, and the revolutionary Isotonix Delivery System, there isn't a more effective antioxidant supplement on the market today.

Isotonix OPC-3's list of benefits is substantial. From promoting your cardiovascular health by helping you maintain healthy blood vessels and showing anti-inflammatory activity, Isotonix OPC-3 provides complete antioxidant protection thanks to its unique formula.

The power behind this advanced nutritional supplement powder comes from its formula of OPCs, or oligomeric proanthocyanidins: complex organic plant compounds called bioflavonoids that provide exceptional nutritional benefits to the human body, including antioxidant protection.

Isotonix OPC-3 includes a combination of powerful bioflavonoids that protect against free radicals. This includes Pycnogenol, a super-antioxidant that is one of the most clinically-researched ingredients in the nutritional supplements industry.

Many nutritional supplements - including other nutritional supplement powders - claim Pycnogenol as an ingredient, but only Isotonix products - including Isotonix OPC-3 - have exclusive worldwide rights to the isotonic form of the super-antioxidant Pycnogenol.

The isotonic form of a nutrient - the defining characteristic of Isotonix nutritional supplements - is of vital importance. Traditional tablets and capsules can take hours for the body to digest; Isotonix nutritional supplements digest more quickly and are distributed throughout the body faster than pills.

*These statements have not been evaluated by the Food and Drug Administration. This product(s) is not intended to diagnose, treat, cure or prevent any disease.

A unique combination of five bioflavonoids, one of which is the most clinically researched pine bark extract, Pycnogenol®, Isotonix OPC-3 has been clinically studied proving its bioavailability and effectiveness. Many antioxidants claim Pycnogenol as an ingredient, but Isotonix OPC-3 has the only isotonic form of Pycnogenol in the world, adding to its antioxidant capabilities and free radical defense. In addition, Isotonix OPC-3 helps promote cardiovascular health by helping maintain healthy blood vessels and promoting healthy circulation. It also demonstrates anti-inflammatory activity and provides support for visual health.

SHOP.COM Reviews

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Everyone should take OPC-3

on 09/27/2015

I have simple question to ask anyone who takes supplements, if you stopped taking them for 3 days, would you notice anything? If the answer is no, they are probably not dong much. If I stop taking OPC-3 for 3 days, I would notice a huge difference (more fatigue, lousy mood, etc.)

Love the product but...

on 09/08/2015

I think this is a great product but it needs a packaging re-do. By the time I get 3/4 through the bottle it has become a gummy rock in the container. I have to cut container open and use my blender to pulverize the solid block of opc3. Happens to some others but not all. Please fix this. I hate to waste. I am very careful to open,pour and close quickly to prevent moisture in bottle but it doesn't help.

I can never run out of OPC3!!

Shop Consultant

on 08/25/2015

When I first tried this product I wasn't sure what it would do for me. 3 years later I am so glad I did! The anti inflammatory help I receive from this product has helped more than anything. I feel 20 years younger. I will never be without OPC3.

Feeling Great

Shop Consultant

on 08/23/2015

I have been taking OPC3 for a few years and I can't remember the last time I was sick. Great for your immune system.


Shop Consultant

on 07/13/2015

Great product give me a lot of energy.


Grape Seed Extract (25 mg)
Grape seed extract is typically extracted from the seeds of red grapes (instead of white), which have a high content of compounds known as oligomeric proanthocyanidins (OPCs). Grape seed extract is extremely rich in polyphenols, compounds with high antioxidant activity. Grape seed extract has been found to maintain healthy cholesterol levels.* 
Red Wine Extract (25 mg)
Red wine extract is a powerful antioxidant. This extract is found in grape vines, roots, seeds and stalks, with the highest concentration in the skins. The antioxidant properties of red wine extract contribute to maintaining healthy circulation by strengthening capillaries, arteries and veins, and promoting overall cardiovascular health.*

In the late 1990s, scientists took note of a phenomenon among the French. There were very low rates of cardiovascular problems in the provinces where residents consistently ate high fat foods and drank red wine. Scientists concluded that the protective properties of red wine have helped the French maintain cardiovascular health for years and subsequent scientific studies have further shown that the OPCs found in red wine are particularly beneficial for protecting the heart and blood vessels.*     

Pine Bark Extract (Pycnogenol®) (25 mg)
Pycnogenol is a natural plant extract from the bark of the maritime pine tree, which grows exclusively along the coast of southwest France in Les Landes de Gascogne. This unspoiled and natural forest environment is the unique source of pine bark. Pycnogenol is one of the most researched ingredients in the natural product marketplace. Published findings have demonstrated Pycnogenol’s wide array of beneficial effects on the body. Pine bark extract is an all natural combination of procyanidins, bioflavonoids and organic acids.

The extract has three basic properties — it is a powerful antioxidant, selectively binds to collagen and elastin, and promotes the normal production of endothelial nitric oxide, which promotes the normal dilation of blood vessels.*

As one of the most potent natural scavenger of free radicals, Pycnogenol combats many aggressive free radicals before they cause oxidative stress to vital organs. Its super-antioxidant capabilities help support healthy blood platelet activity, support healthy blood glucose levels, reduce mild menstrual cramping and abdominal pain, maintain joint flexibility, promote cardiovascular health, promote healthy sperm quality, maintain healthy cholesterol levels and support a healthy complexion.*

Bilberry Extract (25 mg)
Bilberry extract is derived from the leaves and berry-like fruit of a common European shrub closely related to the blueberry. Extracts of the ripe berry are known to contain flavonoid pigments known as anthocyanins, which are powerful antioxidants. Scientific studies confirm that bilberry extract supports healthy vision and venous circulation. Bilberry extract helps maintain healthy circulation by strengthening capillaries, arteries and veins.*

Citrus Extract (Bioflavonoids) (25 mg)
Bioflavonoids are antioxidants found in certain plants that act as light filters, which protect delicate DNA chains and other important macromolecules by absorbing ultraviolet radiation. They have been found to promote cardiovascular health, help maintain healthy circulation by strengthening capillaries, arteries and veins, and demonstrate anti-inflammatory activity.*


What is Isotonix OPC-3®?
Isotonix OPC-3 is a dietary supplement that bears some of the most powerful bioflavonoids currently known to research scientists. These bioflavonoids are scientifically termed oligomeric proanthocyanidins, commonly abbreviated OPCs. The purest and best-researched OPCs chosen for OPC-3 are prepared from grape seed, red wine, bilberries, Pycnogenol from pine bark and citrus fruit. This combination of powerful OPCs is unique to OPC-3, as is the Isotonix® delivery system, which enables rapid and highly efficient absorption of the OPCs. Isotonix OPC-3 has been shown to provide a variety of health benefits including, but not limited to, combating free radicals, demonstrating anti-inflammatory activity, helping maintain healthy cholesterol levels, helping maintain healthy circulation by strengthening capillaries, arteries and veins, helping maintain joint flexibility, helping promote/support cardiovascular health, helping reduce mild menstrual cramping, helping support visual health/visual acuity, scavenging free radicals, promoting healthy blood vessel dilation, promoting healthy nitric oxide levels, supporting a healthy complexion, supporting healthy blood glucose levels, supporting healthy platelet activity and supporting healthy sperm quality.*
What is a bioflavonoid?
Bioflavonoids are complex organic plant compounds. Plants and fruits differ in colors based on the specific bioflavonoids they contain. An increasing number of clinical studies have shown how bioflavonoids support health. Bioflavonoids found in OPCs play a key role in cardiovascular health and maintaining vascular integrity. Bioflavonoids have been shown to demonstrate support for healthy circulation and cell vitality. Normal collagen renewal is promoted, which supports firmness of the skin, joint cartilage and connective tissue. 

What sets Isotonix OPC-3 apart from other bioflavonoid products?
Isotonix OPC-3 offers scientifically supported OPCs, found to be the most powerful antioxidants for human health. In addition to being powerful antioxidants, these individual OPCs have been shown to provide a myriad of specific health benefits. This science-driven selection of OPCs is unique to OPC-3, as is the Isotonix delivery system, which enables rapid and highly efficient absorption of the OPCs. The potent nutrients, in combination with the highly effective delivery system, makes OPC-3 the most powerful free radical scavenging product available.*      

Is Isotonix OPC-3 safe?
Yes. OPCs are among the most valuable constituents of a healthy human diet. OPCs have been researched and used for over 30 years throughout Europe. OPC-3 contains pure OPCs in combination with carefully balanced quantities of potassium and fructose/glucose, which set up the isotonic delivery system. OPC-3 is free of harmful chemicals, preservatives and alcohol. OPC-3 should be taken as directed.

How long does it take to benefit from Isotonix OPC-3?
Many effects of OPC-3 start to work after a single serving. Studies with human volunteers have found that the health benefits of OPCs may take a while to occur.  This may be the case for health concerns resulting from everyday wear and tear, where time simply has taken its toll. Taking Isotonix OPC-3 daily enables the body to sustain a consistent antioxidant defense.

What is the advantage of taking Isotonix OPC-3 regularly?
OPC-3 not only provides the most potent OPCs available, the unique Isotonix delivery system ensures that the small intestine rapidly absorbs the OPCs, which are available in the blood stream within minutes. This is because the OPCs are delivered in liquid form. The liquid is isotonic, which means it duplicates the environment in our cells and blood stream regarding pH, electrolytes, etc. This enables the OPCs to enter the body easily and with a high level of bioavailability. Because of the rapid absorbability, the body should benefit from Isotonix OPC-3 almost immediately.

Why should everyone take Isotonix OPC-3?
Everyone is subject to free radical damage and oxidative stress. Free radicals develop as byproducts of physiological processes that occur within the body. This damage does not cause noticeable harm at first, yet may add up over the years. This process is largely responsible for the aging process. Free radicals have been linked directly to premature aging, poor circulation, poor heart health and poor immune health. OPCs are the most powerful natural free radical neutralizers and you get the best of all OPCs by taking Isotonix OPC-3. Regular use every day is vital for keeping free radicals in check and a long, healthy life. Laboratory studies have shown that OPCs are more powerful antioxidants than vitamin C and vitamin E.

Can you take Isotonix OPC-3 in soda, juice, coffee, etc., rather than water?
It is possible but not recommended. This product should only be taken as directed. In order to keep the product in an isotonic form and to achieve the maximum delivery speed, it needs to be taken on an empty stomach with 2 oz. of water per capful. Mixing the products with anything else besides other Isotonix products and water slows down the delivery time and may affect the percentage of uptake.

I am healthy and athletic; why should I take Isotonix OPC-3?
Everyone is vulnerable to the aging process caused by continuous free radical damage. Athletes tend to be exposed to elevated levels of oxidative stress. Free radicals develop as byproducts during metabolism when calories are processed with oxygen. Athletes inhale 10 to 20 times more oxygen during physical activity over rest periods. The increase in activity creates additional free radicals. In fact, these free radicals are known to limit performance, as free radicals appear to take their toll on muscle tissue. Studies on recreational athletes have shown a 20 percent endurance increase with OPCs, as compared to a control group receiving a placebo. Another study has shown that athletes using OPCs suffered significantly less muscle cramping during and after performing. Isotonix OPC-3 helps to maintain healthy blood flow and this supports oxygen supply to muscles.* 

Does OPC-3 have visible benefits?
As OPCs support collagen production in the skin, an increase of smoothness and support of elasticity is the natural result. Such an effect was objectively measured in women aged 40 years and older. Skin smoothness was increased after three months as measured by 3-dimensional topography. It requires patience to show visible effects. It is essential to continuously take OPC-3 to keep skin cells at their peak vitality. On a short-term basis, many people notice a fresher-looking skin complexion. This is a result of healthy blood microcirculation, which helps detoxify the skin and improves the nutrient supply. Regular use of OPC-3 helps defy photo-aging of the skin. 

Does OPC-3 have a rejuvenating effect?
The damage caused by free radicals adds up with time. A cause for more worry is the fact that your body's own mechanisms to keep free radicals in check decline with increasing age — when you need them the most. Suddenly, we find ourselves confronted with some typical age-related problems. Some cells of our body are more vulnerable to free radicals than others. OPC-3 has the ability to go in and do a knockout job, cleaning and scavenging the free radicals that feast on cellular energy, and take it away from vital processes.*

What are the cardiovascular health benefits of OPCs?
Scientist Albert Szent-Gyorgyi, who received the Nobel Prize for the discovery of vitamin C, discovered OPCs. Szent-Györgyi found that OPCs work in a similar fashion. They strengthen the walls of arteries, veins and capillaries.*

In the past 20 years scientists discovered that OPCs bear a lot more benefits for the cardiovascular system. Epidemiological studies have shown that regular intake of powerful OPC antioxidants supports a healthy cardiovascular system. OPCs appear to be particularly helpful in maintaining healthy cholesterol levels and healthy arteries. Pycnogenol® in Isotonix OPC-3 plays a key role, as it promotes healthy nitric oxide (NO) levels. NO is a tiny molecule which serves as a key messenger molecule in the blood stream. It promotes relaxation of smooth muscle-surrounding arteries and supports normal artery diameter and blood flow. Healthy NO levels help maintain normal blood pressure. This benefit has been explicitly demonstrated with Pycnogenol in two clinical studies. NO also promotes healthy blood platelet activity thus preserving a normal, fluid environment. OPCs are especially helpful for smokers. OPC-3 packs a powerful punch when it comes to maintaining excellent cardiovascular health.*  

How can OPC-3 help my eyes?
Loss of eyesight is the disability people fear more than all others. Isotonix OPC-3 contains specific OPCs successfully tested for eye health. Pycnogenol has been shown to support healthy capillaries in the eye. Isotonix OPC-3 helps maintain visual health and supports visual acuity.

Does OPC-3 have benefits specifically for women?
Some OPCs were shown in clinical trials to help women who suffer from mild pain and cramping during the menstrual period. When women were supplemented with OPCs, starting at least a week before their menstrual period, pain values were found to be significantly lowered.

What exactly is Pycnogenol?
Pycnogenol is the registered trademark of Horphag Research (UK) Ltd. for a standardized extract of bark of the French maritime pine tree. Pycnogenol is particularly renowned for its extensive clinical research with more than 120 studies published in peer-reviewed medical journals. The flavonoids in Pycnogenol not only act as powerful antioxidants, they also appear to promote the normal generation of nitric oxide (NO). NO plays a key role in regulating cardiovascular health. Nitric oxide promotes the normal relaxation of arteries, supports normal diameter of blood vessels and helps maintain healthy blood pressure and circulation. NO promotes normal platelet activity allowing the blood to maintain a normal, fluid viscosity. Pycnogenol has been awarded various patents for its ability to support healthy platelet activity.*   

How do I take OPC-3?
Each capful of Isotonix OPC-3 contains 125 milligrams of bioflavonoids, of which 75 milligrams are oligomeric proanthocyanidins in an isotonic-capable base. That means that the OPC-3 active ingredients will be delivered in the highest concentration to the small intestine, where most absorption of nutrients occurs.

To start using Isotonix OPC-3 for its benefit as an antioxidant and free radical scavenger, take two level capfuls for every 150 pounds of body weight for the first seven days. This is referred to as the saturation serving. Then, switch to a daily serving of one capful, per 150 lbs. of body weight, as a maintenance dose. For example, if you weigh 190 pounds, you would take three servings of Isotonix OPC-3 per day for seven days, and then switch to two servings per day for long-term health maintenance. This product should be taken on an empty stomach for the fastest, most effective delivery of the active ingredient. 

What is the history of OPCs?
In 1534, French explorer Jacques Cartier was leading an expedition up the St. Lawrence River. Trapped by bad weather, Cartier and his crew were forced to survive on a ration of salted meat and biscuits. Cartier's crew began to suffer from severe deficiency of vitamin C and showed symptoms of scurvy. Many crew members died before the surviving members encountered a friendly Native American who saved most of their lives. He told them to make a tea from the bark and needles of the pine tree to cure their malady. They complied and, as a result, Cartier and many crew members survived.

Some 400 years later, Professor Jacques Masquelier of the University of Bordeaux, France, read a book by Cartier detailing their expedition. He concluded that pine bark not only contained some vitamin C, but obviously was a good source of bioflavonoids, whose effects are similar to those of vitamin C. Further studies and research revealed that the pine bark contained an array of proanthocyanidins complexes. These compounds were also found in a variety of plants, including grape seeds, cranberries, peanut skin, lemon tree bark and citrus rinds. Masquelier termed the active ingredients of the pine bark "pycnogenols", which today are referred to in the scientific community as oligomeric proanthocyanidins, or OPCs.