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Isotonix® Vitamin D with K2

Price  $31.50
Makers of bone health supplements boast about the amount of vitamin D in their products. But only Isotonix delivers a bone health supplement that contains vitamin D with K2 - making it the best supplement to help maintain your bone health. Isotonix Vit...
Single Bottle (30 Servings)
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Isotonix® Vitamin D with K2

Makers of bone health supplements boast about the amount of vitamin D in their products. But only Isotonix delivers a bone health supplement that contains vitamin D with K2 - making it the best supplement to help maintain your bone health.

Isotonix Vitamin D with K2 contains vitamin D3, the metabolically active form of vitamin D, along with vitamin K2, a form of vitamin K which supports vascular health and calcium utilization. Vitamin K is included in Isotonix Vitamin D with K2 because of its unique partnership with vitamin D. Vitamins K and D work together to support calcium absorption and utilization. Vitamin K supports the normal delivery of calcium to the bones and promotes healthy arteries.

Despite the fact that there are many vitamin D and bone health supplements to choose from, Isotonix Vitamin D with K2 proves that all supplements are not created equal.


Vitamin D3 (Cholecalciferol) (5000 IU)
Vitamin D is a fat-soluble vitamin that is found in some foods and endogenously produced when sunlight strikes the skin and activates vitamin D synthesis. Vitamin D promotes the efficient intestinal absorption of calcium, primarily in the duodenum and jejunum by supporting the synthesis of calcium-binding proteins to promote normal calcium absorption and retention. Vitamin D also promotes the normal formation of bone and normal bone growth and bone remodeling by osteoblasts and osteoclasts. Vitamin D deficiency can be caused by factors such as lack of exposure to sunlight, reduced skin synthesis of vitamin D, lower dietary intake, impaired intestinal absorption, and reduced metabolism to active forms of vitamin D by the kidneys, all of which increase with aging. Deficiency has been linked to numerous health concerns, and insufficient levels of this vitamin are associated with weak bones and muscle weakness. In addition to promoting strong bones, vitamin D also has other roles in health, including supporting the body's normal modulation of neuromuscular function and immune function. Vitamin D has been shown to support immune-modulation, and it is thought that supplementation promotes immune health by promoting the body's normal regulation of T-cell function. In reference to cellular health, Vitamin D supports the modulation of many genes that are responsible for encoding proteins that regulate normal cell cycle activity. Vitamin D levels have been strongly correlated to healthy cells. Lastly, through its interaction with VDR (vitamin D receptor), vitamin D supports the healthy expression of the gene encoding renin, thus helping to maintain healthy blood pressure.*

Vitamin K2 (45 mcg)
Vitamin K is a fat-soluble vitamin found meat, eggs, dairy and natto. Although a fat-soluble vitamin, the body stores very little K2, and its stores are rapidly depleted without regular dietary intake.Natural vitamin K2, also known as menaquinone-7 (MK-7), is the most bioavailable form of K2 and has the longest half-life in the blood of any form of vitamin K. The Japanese soy food natto is particularly rich in menaquinone-7 (MK-7). Studies of natto consumption in Japan have linked menaquinone-7 to bone and cardiovascular health. The correlation of vitamin K to cardiovascular and bone health directly focuses on supporting proper calcium utilization, whereby adequate metabolism of calcium supports arterial and bone health. This is often referred to as the calcium paradox. The calcium paradox is explained simply as getting calcium in the right place (i.e., into the bone structures instead of the arterial vessel walls). These events are dependent upon the synthesis of the vitamin K-dependent proteins osteocalcin and matrix Gla protein in a process called carboxylation. The carboxylation of these proteins is a post-translational step; that is, osteocalcin and matrix Gla protein are translated from their respective messenger RNA and then modified by enzymes to the active forms. These carboxylated forms support the healthy binding and releasing of calcium. This reaction is essential for optimal and healthy utilization of calcium. Vitamin K2 promotes the synthesis of proteins involved with calcium utilization, thereby supporting bone retention and arterial health. While vitamin D supports the healthy regulation and synthesis of osteocalcin, the mineral-binding capacity of this protein requires vitamin K-dependent carboxylation and is thought to be related to bone mineralization. Gas6 is a vitamin K-dependent protein found throughout the nervous system, as well in the heart, lungs, stomach, kidneys and cartilage. Although the exact mechanism of its action has not been determined, Gas6 appears to be a cellular growth regulator involved in cellular activities such as cell adhesion, cell proliferation and protection against apoptosis.*

*These statements have not been evaluated by the Food and Drug Administration. This product(s) is not intended to diagnose, treat, cure or prevent any disease.


by PowerReviews
Isotonix® Vitamin D with K2

(based on 86 reviews)

Ratings Distribution

  • 5 Stars



  • 4 Stars



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  • 1 Stars




of respondents would recommend this to a friend.


  • No side effects (40)
  • Good value (30)
  • Works quickly (27)
  • Natural-feeling results (24)
  • Relieves stress (10)


    Best Uses

    • Morning (35)
    • Daily use (27)
    • Afternoon (5)
    • Before sleep (5)
      • Reviewer Profile:
      • First time user (30), Regular user (27), Health conscious (18), Medical professional (3)

    Reviewed by 86 customers

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    Re: "Wasted 1/4 of Product"

    By Yana and KenR

    from USA


    Comments about Isotonix® Vitamin D with K2:

    Maria, I hope that you read this! The "Cap" that you measure the powder into is NOT the cap that you fill with water! Your product should have come with an "overcap" that is used to measure the right amound of water (2 ounces) for every bottlecap of powder. THAT cap is the one that is right on the bottle. If you use them correctly, you should not have water getting into the bottle. That having been said, if you live in a humid environment, you can actually just refrigerate the bottle to make sure that it stays fresh and dry.


    Wasted 1/4 of Product

    By MariaS

    from USA

    Comments about Isotonix® Vitamin D with K2:

    Somehow water got inside the bottle and wasted the 1/4 of remaining powder. I think a different mechanism is needed, since the bottle top is used to administer the product with water. I'm going to try again and use without the bottle top to see if it makes a difference.


    Tastes great!

    By DanielP

    from USA

    Comments about Isotonix® Vitamin D with K2:

    Tastes like kool aid and boosts immunity while protecting against a myraid of afflictions. Everyone needs Vit D and this is the best!


    very good

    By pat

    from seffner fl.

    Verified Buyer

    Comments about Isotonix® Vitamin D with K2:

    its so easy to takee


    I will buy this time and time again

    By SBrown

    from Atlanta, Ga

    Verified Buyer

    Comments about Isotonix® Vitamin D with K2:

    I started using Isotonix Vitamin D after the doctor said that my vitamin D level was low and the "over the counter" products I was using weren't helping to raise my level. So far I have enjoyed taking it. Even if is has only been about three weeks now. I have already ordered the next bottle. I am looking forward to seeing the face of the doctor when we recheck my levels in a couple of months.

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