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Isotonix® Vitamin D with K2

Price  $31.50
Makers of bone health supplements boast about the amount of vitamin D in their products. But only Isotonix delivers a bone health supplement that contains vitamin D with K2 - making it the best supplement to help maintain your bone health. Isotonix Vit...
Single Bottle (30 Servings)
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Isotonix® Vitamin D with K2

Makers of bone health supplements boast about the amount of vitamin D in their products. But only Isotonix delivers a bone health supplement that contains vitamin D with K2 - making it the best supplement to help maintain your bone health.

Isotonix Vitamin D with K2 contains vitamin D3, the metabolically active form of vitamin D, along with vitamin K2, a form of vitamin K which supports vascular health and calcium utilization. Vitamin K is included in Isotonix Vitamin D with K2 because of its unique partnership with vitamin D. Vitamins K and D work together to support calcium absorption and utilization. Vitamin K supports the normal delivery of calcium to the bones and promotes healthy arteries.

Despite the fact that there are many vitamin D and bone health supplements to choose from, Isotonix Vitamin D with K2 proves that all supplements are not created equal.

  • Knapen M et al. Vitamin K2 supplementation improves hip bone geometry and bone strength indices in postmenopausal women. Osteoporosis International. 18(7):963-72, 2007.
  • Shiraki, M., et al.  Vitamin K2 (menatetrenone) effectively prevents fractures and sustains lumbar bone mineral density in osteoporosis.  Journal of Bone & Mineral Research.  15:515-522, 2000.
  • Hiruma Y et al.  Vitamin K(2) and geranylgeraniol, its side chain component, inhibited osteoclast formation in a different manner.  Biochemical Biophysical Research Communications.  314(1):24-30, 2004.
  • Plaza S and Lamson D. Vitamin K2 in bone metabolism and osteoporosis. Alternative Medicine Reviews. 10(1):24-35, 2005. Review.
  • Kameda T et al.  Vitamin K2 inhibits osteoclastic bone resorption by inducing osteoclast apoptosis.  Biochemical and Biophysical Research Communications.  220(3):515-519, 1996.
  • Taira H et al.  Menatetrenone (vitamin K2) acts directly on circulating human osteoclast precursors.  Calcified Tissue International. 73(1):78-85, 2003.
  • Hidaka T et al.  Treatment for patients with postmenopausal osteoporosis who have been placed on HRT and show a decrease in bone mineral density: effects of concomitant administration of vitamin K(2).  Journal of Bone and Mineral Metabolism.  20(4):235-239, 2002.
  • Iwamoto J et al.  Effects of vitamin K2 on osteoporosis.  Current Pharmaceutical Design.  10(21):2557-2576, 2004.
  • Iwamoto J et al. Treatment with vitamin D3 and/or vitamin K2 for postmenopausal osteoporosis. The Keio Journal of Medicine. 2003 Sep;52(3):147-50. Review.
  • Neogi, T., et al.  Low vitamin K status is associated with osteoarthritis in the hand and knee.  Arthritis and Rheumatism.  54(4):1255-1261, 2006.
  • Price P.  Role of vitamin K-dependent proteins in bone metabolism.  Annual Review of Nutrition.  8:565-583, 1988.
  • Bekner K.  The vitamin K-dependent carboxylase.  Journal of Nutrition.  130(8):1877-1880, 2000.
  • Nelsestuen G et al.  Vitamin K-dependent proteins.  Vitamins and Hormones.  58:355-389, 2000.
  • Shearer M.  Role of vitamin K and Gla proteins in the pathophysiology of osteoporosis and vascular calcification.  Current Opinion in Clinical Nutrition and Metabolic Care.  3(6):433-438, 2000.
  • Gundberg C et al.  Vitamin K status and bone health:  an analysis of methods for determination under carboxylated osteocalcin.  Journal of Clinical Endocrinology and Metabolism.  83(9):3258-3266, 1998.
  • Weber P.  Management of osteoporosis: is there a role for vitamin K  International Journal for Vitamin and Nutrition Research.  67(5):350-6, 1997.
  • Garber, A. K., et al.  Comparison of phylloquinone bioavailability from food sources or a supplement in human subjects.  Journal of Nutrition.  129(6):1201-1203, 1999.
  • Binkley N et al.  Vitamin K nutrition and osteoporosis. Journal of Nutrition.  125(7):1812-1821, 1995.
  • Bischoff-Ferrari Het al.  Fracture prevention with vitamin D supplementation: a meta-analysis of randomized controlled trials.  JAMA.  293(18):2257-2264, 2005.
  • Guirguis-Blake J et al.  Oral vitamin D3 decreases fracture risk in the elderly.  Journal of Family Practice.  52(6):431-435, 2003.
  • Schaafsma, A., et al.  Vitamin D3 and vitamin K1 supplementation of Dutch postmenopausal women with normal and low bone mineral densities:  effects on serum 25-hydroxyvitamin D and carboxylated osteocalcin.  European Journal of Clinical Nutrition.  54:626-631, 2000.
  • Trivedi Det al.  Effect of four monthly oral vitamin D3 (cholecalciferol) supplementation on fractures and mortality in men and women living in the community: randomised double blind controlled trial.  British Medical Journal.  326(7387):469, 2003.
  • Van den Berghe G et al.  Bone turnover in prolonged critical illness: effect of vitamin D.  Journal of Clinical Endocrinology and Metabolism.  88(10):4623-4632, 2003.
  • Chapuy M et al.  Vitamin D3 and calcium to prevent hip fractures in the elderly women. New England Journal of Medicine. 327(23):1637-1642, 1992.
  • Grant W and Holick M. Benefits and requirements of vitamin D for optimal health. Alternative Medicine Review. 10:94-111, 2005.
  • Plaza S and Lamson D. Vitamin K2 in bone metabolism and osteoporosis. Alternative Medicine Reviews. 10(1):24-35, 2005. Review.
  • Zitterman A et al.  Low vitamin D status: a contributing factor in the pathogenesis of congestive heart failure  Journal of the American College of Cardiology.  41(1):105-112, 2003.
  • Schleithoff S et al.  Vitamin D supplementation improves cytokine profiles in patients with congestive heart failure: a double-blind, randomized, placebo-controlled trial.  American Journal of Clinical Nutrition. 83(4):754-759, 2006.
  • Argiles A et al.  Blood pressure is correlated with vitamin D(3) serum levels in dialysis patients.  Blood Purification.  20(4):370-375, 2002.
  • Kristal-Boneh E et al.  Association of calcitriol and blood pressure in normotensive men.  Hypertension.  30(5):1289-1294, 1997.
  • Li Y et al.  1,25-Dihydroxyvitamin D(3) is a negative endocrine regulator of the renin-angiotensin system.  Journal of Clinical Investigation.  110(2):229-238, 2002.
  • Li Y et al.  Vitamin D regulation of the renin-angiotensin system.  Journal of Cell Biochemistry.  88(2):327-331, 2003.
  • Li Y et al.  Vitamin D: a negative endocrine regulator of the renin-angiotensin system and blood pressure.  Journal of Steroid Biochemistry and Molecular Biology.  89-90(1-5):387-392, 2004.
  • Pfeifer M et al.  Effects of a short-term vitamin D(3) and calcium supplementation on blood pressure and parathyroid hormone levels in elderly women.  Journal of Clinical Endocrinology and Metabolism.  86(4):1633-1637, 2001.
  • Sigmund C.  Regulation of renin expression and blood pressure by vitamin D(3).  Journal of Clinical Investigation.  110(2):155-156, 2002.
  • Vasquez A et al.  The clinical importance of vitamin D (cholecalciferol):  a paradigm shift with implications for all healthcare providers.  Alternative Therapies.  10(5):28-38, 2004.
  • Nimptsch K et al. Dietary intake of vitamin K and risk of prostate cancer in the Heidelberg cohort of the European Prospective Investigation into Cancer and Nutrition. American Journal of Clinical Nutrition. 87:985-992, 2008.
  • Habu D et al.  Role of vitamin K2 in the development of hepatocellular carcinoma in women with viral cirrhosis of the liver.  JAMA.  292(3):358-361, 2004.
  • Yoshida T et al.  Apoptosis induction of vitamin K2 in lung carcinoma cell lines: the possibility of vitamin K2 therapy for lung cancer.  International Journal of Oncology.  23(3):627-632, 2003.
  • Lamson D and Plaza S. The anticancer effects of vitamin K. Alternative Medicine Review. 8(3):303-18, 2003.
  • Yokoyama T et al.  Combination of vitamin K2 plus imatinib mesylate enhances induction of apoptosis in small cell lung cancer cell lines.  International Journal of Oncology.  26(1):33-40, 2005.
  • Chlebowski R et al.  Vitamin K in the treatment of cancer.  Cancer Treatment Review.  12:49-63, 1985.
  • Lamson D et al.  The anticancer effects of vitamin K.  Alternative Medicine Review.  8(3):303-318, 2003.
  • Hitomi M et al. Antitumor effects of vitamins K1, K2 and K3 on hepatocellular carcinoma in vitro and in vivo.  International Journal of Oncology.  26(3):713-720, 2005.
  • Nouso K et al.  Regression of hepatocellular carcinoma during vitamin K administration.  World Journal of Gastroenterology.  11(42):6722-6724, 2005.
  • Blackmore K et al. Vitamin D from dietary intake and sunlight exposure and the risk of hormone-receptor-defined breast cancer. American Journal of Epidemiology. 168(8):915-24, 2008.
  • Deluca H et al.  Vitamin D: its role and uses in immunology.  FASEB Journal. 15(14):2579-2585, 2001.
  • Adorini L.  Immunomodulatory effects of vitamin D receptor ligands in autoimmune diseases.  International Immunopharmacology.  2(7):1017-1028, 2002.
  • Cantorna M et al.  Mounting evidence for vitamin D as an environmental factor affecting autoimmune disease prevalence.  Experimental Biology and Medicine (Maywood).  229(11):1136-1142, 2004.
  • Cantorna M. Vitamin D and autoimmunity: is vitamin D status an environmental factor affecting autoimmune disease prevalence Society for Experimental Biology and Medicine. 223:230-233, 2000.
  • Garland C et al.  The role of vitamin D in cancer prevention.  American Journal of Public Health.  96(2):252-61, 2006.
  • Giovannucci E et al.  Prospective study of predictors of vitamin D status and cancer incidence and mortality in men.  Journal of the National Cancer Institute.  98(7):451-459, 2006.
  • Holick, M.  Vitamin D:  Its role in cancer prevention and treatment.  Progress in Biophysics and Molecular Biology. 92(1):49-59, 2006.
  • Gorham E et al.  Vitamin D and prevention of colorectal cancer.  Journal Steroid Biochemistry and Molecular Biology. 97(1-2):179-94, 2005.
  • Grant W et al.  Reviews: A critical review of studies on vitamin D in relation to colorectal cancer.  Nutrition and Cancer.  48(2):115-123, 2004.
  • Harris D et al.  Vitamin D and colon carcinogenesis.  Journal of Nutrition.  134(12):3463S-3471S, 2004.
  • Hayes C et al.  The immunological functions of the vitamin D endocrine system.  Cellular and Molecular Biology.  49(2):277-300, 2003.
*These statements have not been evaluated by the Food and Drug Administration. This product(s) is not intended to diagnose, treat, cure or prevent any disease.


by PowerReviews
Isotonix® Vitamin D with K2

(based on 86 reviews)

Ratings Distribution

  • 5 Stars



  • 4 Stars



  • 3 Stars



  • 2 Stars



  • 1 Stars




of respondents would recommend this to a friend.


  • No side effects (40)
  • Good value (30)
  • Works quickly (27)
  • Natural-feeling results (24)
  • Relieves stress (10)


    Best Uses

    • Morning (35)
    • Daily use (27)
    • Afternoon (5)
    • Before sleep (5)
      • Reviewer Profile:
      • First time user (30), Regular user (27), Health conscious (18), Medical professional (3)

    Reviewed by 86 customers

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    Displaying reviews 1-5

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    Re: "Wasted 1/4 of Product"

    By Yana and KenR

    from USA


    Comments about Isotonix® Vitamin D with K2:

    Maria, I hope that you read this! The "Cap" that you measure the powder into is NOT the cap that you fill with water! Your product should have come with an "overcap" that is used to measure the right amound of water (2 ounces) for every bottlecap of powder. THAT cap is the one that is right on the bottle. If you use them correctly, you should not have water getting into the bottle. That having been said, if you live in a humid environment, you can actually just refrigerate the bottle to make sure that it stays fresh and dry.


    Wasted 1/4 of Product

    By MariaS

    from USA

    Comments about Isotonix® Vitamin D with K2:

    Somehow water got inside the bottle and wasted the 1/4 of remaining powder. I think a different mechanism is needed, since the bottle top is used to administer the product with water. I'm going to try again and use without the bottle top to see if it makes a difference.


    Tastes great!

    By DanielP

    from USA

    Comments about Isotonix® Vitamin D with K2:

    Tastes like kool aid and boosts immunity while protecting against a myraid of afflictions. Everyone needs Vit D and this is the best!


    very good

    By pat

    from seffner fl.

    Verified Buyer

    Comments about Isotonix® Vitamin D with K2:

    its so easy to takee


    I will buy this time and time again

    By SBrown

    from Atlanta, Ga

    Verified Buyer

    Comments about Isotonix® Vitamin D with K2:

    I started using Isotonix Vitamin D after the doctor said that my vitamin D level was low and the "over the counter" products I was using weren't helping to raise my level. So far I have enjoyed taking it. Even if is has only been about three weeks now. I have already ordered the next bottle. I am looking forward to seeing the face of the doctor when we recheck my levels in a couple of months.

    Displaying reviews 1-5

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