| Item 9783642240065N$49.99 - $64.95 up to $3.50  Cashback This book focuses on the analysis of dose-response microarray data in pharmaceutical settings, the goal being to cover this important topic for early drug development experiments and to provide user-friendly R packages that can be used to analyze this ... | $49.99
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This book focuses on the analysis of dose-response microarray data in pharmaceutical settings, the goal being to cover this important topic for early drug development experiments and to provide user-friendly R packages that can be used to analyze this data. It is intended for biostatisticians and bioinformaticians in the pharmaceutical industry, biologists, and biostatistics/bioinformatics graduate students.Part I of the book is an introduction, in which we discuss the dose-response setting and the problem of estimating normal means under order restrictions. In particular, we discuss the pooled-adjacent-violator (PAV) algorithm and isotonic regression, as well as inference under order restrictions and non-linear parametric models, which are used in the second part of the book.Part II is the core of the book, in which we focus on the analysis of dose-response microarray data. Methodological topics discussed include:• Multiplicity adjustment• Test statistics and procedures for the analysis of dose-response microarray data• Resampling-based inference and use of the SAM method for small-variance genes in the data• Identification and classification of dose-response curve shapes• Clustering of order-restricted (but not necessarily monotone) dose-response profiles• Gene set analysis to facilitate the interpretation of microarray results• Hierarchical Bayesian models and Bayesian variable selection• Non-linear models for dose-response microarray data• Multiple contrast tests• Multiple confidence intervals for selected parameters adjusted for the false coverage-statement rateAll methodological issues in the book are illustrated using real-world examples of dose-response microarray datasets from early drug development experiments.
Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R : Order Restricted Analysis of Microarray Data General
| ISBN | 9783642240065 |
| Fiction/Non-Fiction | Non-Fiction |
| Publisher | Springer Verlag |
| Pages | 282 |
| List Price | $64.95 |
| Publication Date | 08/26/2012 |
| Release Status | In Print |
| Format | Paperback |
| Language | English |
| Measurements | Height: 9 Inches (US)Width: 6 Inches (US)Thickness: 0.5 Inches (US)Unit Weight: 0.95 Pounds (US) |
| Series | Use R! |
| Editor | Amaratunga, DhammikaBijnens, LucLin, DanShkedy, ZivYekutieli, Daniel |
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