Optimal Wellness Kit
What Makes the Optimal Wellness Kit Unique? Optimal health starts with a solid foundation. Start by ensuring your body gets the proper vitamins and nutrients it needs. The Optimal Wellness Kit contains three essential supplements – Isotonix® Multivitamin, Isotonix Activated B-Complex and Heart Health Essential Omega III with Vitamin E – that will help you promote long-term health and optimal nutrition. There is no substitute for a healthy, well-balanced diet; however, in today’s fast-paced lifestyles, it is important to ensure the body is getting the fuel it needs. Isotonix Multivitamin contains 100 percent or more of the daily value of most essential vitamins and minerals to complement your existing diet. Isotonix Multivitamin supplements dietary deficiencies and helps maintain normal metabolic functioning. Isotonix Multivitamin is a great supplement choice for all adults, growing teenagers and pre-menopausal women. And thanks to the revolutionary Isotonix delivery system, nutrients are allowed to pass directly into the small intestine and be rapidly absorbed into the bloodstream. With Isotonix products, little nutritive value is lost, making the absorption of nutrients highly efficient while delivering maximum results. The Optimal Wellness Kit also includes Isotonix Activated B Complex to keep your energy high and help promote your cardiovascular health. Isotonix Activated B Complex delivers metabolically active forms of several vitamins and minerals, which are important because traditional forms of vitamins B6, B12 and folic acid found in most other B complex products must undergo chemical changes in order to be utilized by the body. Several factors, including age and nutritional status, may decrease the body’s ability to activate these vitamins. By providing the metabolically active forms of these vitamins in isotonic form, you can be certain that your body is getting the vital nutrients it needs quickly and effectively.* A vitamin B complex is a mixture of the eight essential B vitamins that play a critical role in metabolism at the cellular level. B vitamins are important for hundreds of biochemical reactions in the body. B vitamin deficiency can lead to fatigue and lethargy, which is why B complex supplements are excellent energy boosters and anti-stress formulas.* Finally, Heart Health Essential Omega III Fish Oil with Vitamin E is a superior product due to a number of factors. The best fish are used to produce a clean and safe product that is rich in eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). It also contains 3,000 mg of fish oil where most other commercial products contain a third of the total fish oil contained in Heart Health Essential Omega III Fish Oil with Vitamin E. Heart Health Essential Omega III Fish Oil with Vitamin E comes from small fish where other competitive products use large fish which are more likely to accumulate toxins. Heart Health Essential Omega III Fish Oil with Vitamin E provides a high quality, high purity product with significant percentages of the health promoting EPA and DHA.
Primary Benefits of the Optimal Wellness Kit*
- Supports a healthy immune system
- Contains 100 percent or more of the recommended daily value of most essential vitamins and minerals
- Helps maintain normal blood pressure
- Supplements deficiencies in diet
Isotonix® Activated B Complex
- Increases energy
- Helps decrease stress and improve mood by helping to maintain healthy levels of serotonin
- Contains activated forms of select B vitamins to ensure optimal utilization by the body
- Meets need for B vitamins in a vegetarian diet
- May help support DNA integrity by protecting telomeres, markers of DNA stability
- May help in the maintenance of long term health
Heart Health™ Essential Omega 3 Fish Oil with Vitamin E
- Helps maintain normal cholesterol levels
- Promotes healthy blood pressure levels
- Helps maintain normal blood flow
- Helps maintain normal triglyceride levels in the blood
- Promotes overall cardiovascular health
- Helps maintain healthy levels of C-reactive protein
- Promotes a healthy complexion
- Helps enhance mood
Key Ingredients Found In Optimal Wellness Kit
Vitamin A (Beta-Carotene/Vitamin A pre-cursor) 10,000 IU
Vitamin A is a fat-soluble vitamin. Sources of vitamin A include organ meats (such as liver and kidney), egg yolks, butter, carrot juice, squash, sweet potatoes, spinach, peaches, fortified dairy products and cod liver oil. Vitamin A is also part of a family of compounds including retinol, retinal and beta-carotene. Beta-carotene, also known as pro-vitamin A, can be converted into vitamin A when additional levels are required. All the body’s tissues need Vitamin A for general growth and repair. Vitamin A helps to promote healthy night vision, support normal bone growth, and support an antioxidant defense and a healthy immune system.*
Vitamin C (Ascorbic Acid) 150 mg
Vitamin C is found in peppers (sweet, green, red, hot red and green chili), citrus fruits and brussels sprouts, cauliflower, cabbage, kale, collards, mustard greens, broccoli, spinach, guava, kiwi fruit, currants and strawberries. Nuts and grains contain small amounts of vitamin C. It is important to note that cooking destroys vitamin C activity.
Vitamin C is integral in supporting a healthy immune system, promoting cardiovascular health, helping to maintain healthy cholesterol levels and providing an antioxidant defense. The body does not manufacture vitamin C on its own, nor does it store it. Therefore, vitamin C must be acquired through diet and supplementation.*
Thiamin (Vitamin B1) 2.6 mg
Thiamin plays an important role in carbohydrate metabolism and nerve function. Thiamin is required for a healthy nervous system and assists in the production of the neurotransmitter acetylcholine and gamma-aminobutyric acid (GABA). It is used in the manufacture of hydrochloric acid and, therefore, plays a part in digestion, increases energy and helps promote mental clarity.*
Pantothenic Acid (Vitamin B5) 20 mg
Pantothenic acid (B5) is the transfer agent for choline to acetylcholine, which promotes proper neurotransmitter activity in the brain. Pantothenic acid is also known as the anti-stress vitamin because it detoxifies brain tissue, helps relieve physical and emotional stress and plays a very important role in the secretion of hormones.*
Niacin (Vitamin B3) 40 mg
Niacin is a water-soluble vitamin necessary for many aspects of health, growth and reproduction. Niacin supports the functioning of the digestive system, skin and nerves. It is also important for the conversion of food to energy. Niacin (also known as vitamin B-3) is found in dairy products, poultry, fish, lean meats, nuts, eggs, legumes, and enriched breads and cereals.*
Vitamin B12 (Cyanocobalamin) 75 mcg
Vitamin B12 is naturally found in meats, liver, beef, pork, eggs, whole milk, cheese, whole wheat bread and fish. Vitamin B12 can only be found in animal products, with small amounts derived from fermented soy products, such as miso and tempeh, and peanuts. It is essential that vegetarians consume a vitamin B12 supplement to maintain optimal health. Vitamin B12, when ingested, is stored in the liver and other tissues for later use. The synthetic form of vitamin B12, cyanocobalamin, is not derived from either plants or animals and is intrinsic in the maintenance of normal functioning body cells, especially those of the nervous system (protecting the sheaths of nerve cells), bone marrow and intestinal tract. These tissues are the first to exhibit signs of vitamin B12 depletion. Vitamin B12 itself is responsible for maintaining optimum energy levels, as it plays a vital role in the Krebs energy cycle. It is also a great anti-aging ingredient and helps increase concentration.*
Folic Acid 400 mcg
Folic acid is mainly found in fruits and vegetables. Dark, leafy greens, oranges, orange juice, beans and peas are the best sources as well as Brewer’s yeast, which supplies additional B-vitamins. Folic acid plays a key role by boosting the benefits of vitamin B12 supplementation. These two B-vitamins join forces and work together in maintaining normal red blood cells. Folic acid assists in the normal utilization of amino acids and proteins, as well as promoting the normal construction of the material for DNA and RNA synthesis. Scientific studies have found that when working in tandem with folic acid, vitamin B12 is capable of promoting a healthy cardiovascular and nervous system.*
Riboflavin 5-Phosphate (Vitamin B2) 3 mg
Vitamin B2 is found in liver, dairy products, dark green vegetables and some types of seafood. Vitamin B2 serves as a co-enzyme, working with other B vitamins. It promotes healthy blood, and supports both the nervous system and normal human growth. It supports healthy skin, nails, hair growth and helps maintain a healthy thyroid. Vitamin B2 plays a crucial role in turning food into energy as a part of the electron transport chain, driving cellular energy on the micro-level. Vitamin B2 aids in the breakdown of fats, while functioning as a cofactor or helper in activating B6 and folic acid. Vitamin B2 is water-soluble and cannot be stored by the body except in insignificant amounts; thus, it must be replenished daily. Under some conditions, vitamin B2 can act as an antioxidant. The riboflavin coenzymes are also important for the transformation of vitamin B6 and folic acid into their active forms, and for the conversion of tryptophan into niacin.*
Pyridoxine HCl (Vitamin B6) 4 mg
Poultry, fish, whole grains and bananas are the main dietary sources of vitamin B6. Vitamin B6 is a co-factor required for protein and amino acid metabolism, and helps maintain proper fluid balance. It also assists in the maintenance of healthy red and white blood cells. Vitamin B6 promotes normal hemoglobin synthesis. It is involved in the synthesis of neurotransmitters in brain and peripheral nerve cells, it has been recommended as a nutrient to support mental function, specifically mood, and it supports normal nerve conduction. Some athletic supplements include vitamin B6 because it promotes the conversion of glycogen to glucose for energy in muscle tissue. Vitamin B6, when taken with folic acid, has been shown to help maintain normal plasma levels of homocysteine, which promotes optimal cardiovascular health. Vitamin B6 should be administered as a part of a complex of other B-vitamins for best results.*
Vitamin D3 (Cholecalciferol) 1,000 IU
Regular sunlight exposure is the main way that most humans get their vitamin D. Food sources of vitamin D are vitamin D-fortified milk (100 IU per cup), cod liver oil and fatty fish, such as salmon. Small amounts are found in egg yolks and liver. Vitamin D promotes the absorption of calcium and phosphorus, and supports the production of several proteins involved in calcium absorption and storage. Vitamin D works with calcium to promote hard, strong bones. It works to promote active transport of calcium out of the osteoblasts into the extra-cellular fluid and, in the kidneys, promotes calcium and phosphate uptake by renal tubules. Vitamin D also promotes the normal absorption of dietary calcium and phosphate uptake by the intestinal epithelium. It promotes healthy growth and repair of tissues, and supports overall skin health.*
Vitamin E (d-alpha-Tocopherol Succinate) 67 IU
The most valuable sources of dietary vitamin E include vegetable oils, margarine, nuts, seeds, avocados and wheat germ. Safflower oil contains large amounts of vitamin E (about two thirds of the RDA in ¼ cup) and there are trace amounts in corn oil and soybean oil. Vitamin E is actually a family of related compounds called tocopherols and tocotrienols. Vitamin E is available in a natural or synthetic form. In most cases, the natural and synthetic forms are identical except the natural form of vitamin E is better absorbed and retained in the body. The natural form of alpha-tocopherol is known as "d-alpha tocopherol." (The natural form is found in Isotonix® Multivitamin.) The synthetic "dl-" form is the most common form found in dietary supplements. For those individuals watching their dietary fat consumption, which is relatively common in the world of dieting, vitamin E intake is likely to be low, due to a reduced intake of foods with high fat content.*
The main health benefit of supplemental vitamin E comes from its immune-boosting antioxidant activity. It also supports normal healing and is known to promote cardiovascular health. Vitamin E is one of the most powerful fat-soluble antioxidants in the body. In turn, vitamin E protects cell membranes from free radical damage.*
Calcium (Lactate, Phosphate) 53.8 mg
Calcium is found in milk, cheese, yogurt, corn tortillas, Chinese cabbage (Napa), kale and broccoli. Calcium is an essential mineral with a wide range of biological roles. Calcium exists in bone primarily in the form of hydroxyapatite (Ca10 (PO4)6 (OH) 2). Hydroxyapatite comprises approximately 40 percent of the weight of bone. The skeleton has an obvious structural requisite for calcium. The skeleton also acts as a storehouse for calcium. Apart from being a major constituent of bones and teeth, calcium promotes normal muscle contraction, nerve conduction, cardiovascular health, the production of energy and helps maintain a healthy immune system.*
A sufficient daily calcium intake is necessary for maintaining bone density, and maintaining healthy teeth and bones. Calcium has been shown to reduce the symptoms of PMS in women. When the body does not obtain enough calcium each day, it draws calcium from the bones, causing them to thin, leading to osteoporosis. Osteoporosis is the age-related thinning of the bones, which can lead to a higher risk of broken hips, ribs, pelvis and other weakened bones. This is in addition to stooped posture associated with advanced age, which is caused by an accumulation of small fractures in the vertebrae.*
The PTH (parathyroid hormone) regulates the amount of calcium in the blood. High levels of calcium in the body have been associated with cardiovascular health in postmenopausal women and maintaining normal cholesterol levels. Low levels of calcium have been associated with reduced bone mass and osteoporosis.*
Chromium (Amino Nicotinate) 120 mcg
Chromium is found naturally in some cereals, meats, poultry, brewer’s yeast, broccoli, prunes mushrooms, fish and beer. Chromium is an essential trace mineral that promotes normal glucose metabolism and regulation of insulin levels, and helps the body maintain of healthy blood levels of cholesterol and other fats. Chromium combines to form something in the body called glucose tolerance factor, or GTF, which promotes normal insulin activity in regulating blood sugar levels. Chromium has been shown to help reduce overall body fat, control hunger and suppress appetite. Many people in the weight loss industry view chromium as an integral mineral in weight maintenance. Chromium may also contribute to an increase in lean body and muscle mass.*
Copper (Gluconate) 100 mcg
The richest sources of dietary copper derive from organ meats, seafood, nuts, seeds, wheat bran cereal, whole grain products and cocoa products. Copper may have some antioxidant properties and acts as a component of enzymes in iron metabolism. It is an essential trace mineral. Copper is needed in normal infant development, iron transport, bone strength, cholesterol metabolism, myocardial contractility, glucose metabolism, brain development and immune function.*
Iodine (Potassium Iodide) 150 mcg
Iodine is found in most seafood and in iodized salt. It is a necessary component of thyroid hormones, and helps regulate and maintain a properly functioning metabolism.*
Magnesium (Carbonate) 25 mg
Foods rich in magnesium include unpolished grains, nuts and green vegetables. Green, leafy vegetables are potent sources of magnesium because of their chlorophyll content. Meats, starches and milk are less rich sources of magnesium. Refined and processed foods are generally quite low in magnesium. The average daily magnesium intake in the U.S. for males nine years and older is estimated to be about 323 milligrams; for females nine years and older, it is estimated to be around 228 milligrams.
Magnesium is a component of the mineralized part of bone and is necessary for the metabolism of potassium and calcium in adults. It helps maintain normal levels of potassium, phosphorus, calcium, adrenaline and insulin. It is also important for the mobilization of calcium, transporting it inside the cell for further utilization. It plays a key role in the functioning of muscle and nervous tissue. Magnesium is necessary for the synthesis of all proteins, nucleic acids, nucleotides, cyclic adenosine monophosphate, lipids and carbohydrates.*
Magnesium is required for release of energy, it promotes the normal regulation of body temperature and proper nerve function, it helps the body handle stress, and it promotes a healthy metabolism. Magnesium works together with calcium to promote the normal regulation of the heart and blood pressure. Importantly, magnesium is also required by the body to build healthy bones and teeth, and promotes proper muscle development. It works together with calcium and vitamin D to help keep bones strong. Magnesium also promotes cardiovascular health by supporting normal platelet activity and helping to maintain normal cholesterol levels.*
Manganese (Gluconate) 2 mg
Manganese is a mineral found in large quantities in both plant and animal matter. The most valuable dietary sources of manganese include whole grains, nuts, leafy vegetables and teas. Manganese is concentrated in the bran of grains, which is often removed during processing. There are several forms of supplementary manganese, including manganese gluconate, manganese sulfate, manganese ascorbate and manganese amino acid chelates.
Only trace amounts of this element can be found in human tissue. Manganese is predominantly stored in the bones, liver, kidney and pancreas. It supports the normal formation of connective tissue, bones, blood-clotting factors and sex hormones. It promotes normal fat and carbohydrate metabolism, calcium absorption and blood sugar regulation. Manganese also promotes normal brain and nerve function.*
Potassium (Bicarbonate) 110 mg
Foods rich in potassium include fresh vegetables and fruits, such as bananas, oranges, cantaloupe, avocado, raw spinach, cabbage and celery. Potassium is an essential macromineral that helps to keep fluid balance. It also plays a role in a wide variety of biochemical and physiological processes. Among other things, it supports normal nerve impulses, cardiac, skeletal and smooth muscle contractions, energy production, synthesis of nucleic acids, and helps maintain intracellular tonicity and normal blood pressure. Potassium promotes normal muscle relaxation and insulin release. It also promotes glycogen and protein synthesis. Potassium is an electrolyte that promotes proper heartbeat. Potassium is important in releasing energy from protein, fat and carbohydrates during metabolism.*
Potassium also helps regulate water balance and assists recuperative powers. Potassium supports the normal elimination of wastes. Potassium promotes normal healing and generally contributes to a sense of well-being. Potassium is stored in the muscles.*
Selenium (Amino Acid Chelate) 55 mcg
The best dietary sources of selenium include nuts, unrefined grains, brown rice, wheat germ and seafood. In the body, selenium functions as part of an antioxidant enzyme called glutathione peroxidase, as well as promoting normal growth and proper usage of iodine in thyroid functioning. Selenium also supports the antioxidant effect of vitamin E and is often added to vitamin E supplements. As part of the antioxidant, glutathione peroxidase, selenium plays a direct role in the body’s ability to protect cells from damage by free radicals.*
Silicon (Dioxide) 13.2 mg
The richest sources of silicon are cereal products and unrefined grains with high fiber content. Most of the silicon in the body is located in connective tissues, bone, tendons, the trachea, the aorta, skin, hair and nails.
Zinc (Lactate) 7.5 mg
Zinc is largely found in fortified cereals, red meats, eggs, poultry and certain seafood, including oysters. It is a component of multiple enzymes and proteins. It is also involved in the regulation of gene expression. Zinc is an essential trace mineral that has functions in approximately 300 different enzyme reactions. Thus, zinc plays a part in almost all biochemical pathways and physiological processes. More than 90 percent of the body’s zinc is stored in the bones and muscles, but zinc is also found in virtually all body tissues. It has been claimed that zinc supports normal healing and the immune system, promotes a healthy prostate gland and supports healthy sperm quality. Because zinc is involved in such a great number of enzymatic processes, it has been found to support a large range of functions, including digestion, energy production, growth, cellular repair, collagen synthesis, bone strength, cognitive function and carbohydrate metabolism.*
Biotin (Vitamin B7) 300 mcg
Biotin can be found in food sources, such as egg yolks, peanuts, beef liver, milk (10 mcg/cup), cereals, almonds and Brewer’s yeast. Biotin is used in healthy cell growth, the production of fatty acids, metabolism of fats and amino acids. It plays a role in the Citric acid cycle, which is the process in which biochemical energy is generated during aerobic respiration. Biotin not only assists in various metabolic chemical conversions but also helps to transfer carbon dioxide. Biotin is also helpful in maintaining a steady blood sugar level. Biotin is often recommended for maintaining strong hair and nails.
Isotonix® Activated B Complex
Methylcobalamin (Vitamin B12) 120 mcg
Vitamin B12 (cobalamin) is a bacterial product naturally found in animal products, especially organ meats, such as liver, with small amounts derived from peanuts and fermented soy products, such as miso and tempeh. It is essential that vegetarians consume a vitamin B12 supplement to maintain optimal health. Vitamin B12, when ingested, is stored in the liver and other tissues for later use. It supports the maintenance of cells, especially those of the nervous system, bone marrow and intestinal tract. Vitamin B12 is important in homocysteine metabolism (homocysteine is an amino acid that is formed within the body). Normal homocysteine levels are important for maintaining cardiovascular health. Deficiencies of the vitamins folic acid, pyridoxine (B6) or cobalamin (B12) can result in elevated levels of homocysteine. Folate and B12, in their active coenzyme form, are both necessary cofactors for the conversion of homocysteine to methionine, thus helping to maintain healthy blood levels of homocysteine.*
Methylcobalamin is one of the naturally-occurring forms of vitamin B12 found in the human body. The liver must convert cyanocobalamin, the form of B12 most commonly used in supplements, into methylcobalamin before it can be properly utilized by the body; methylcobalamin is more effective than non-active forms of vitamin B12. Methylcobalamin also assists in the formation of SAMe (S-adenosylmethionine), a nutrient that has powerful mood-elevating properties.*
Folinic Acid (Calcium Folinate) 800 mcg
Folic acid is mainly found in fruits and vegetables. Dark, leafy greens, oranges, orange juice, beans, peas and Brewer’s yeast are the best sources. Folic acid plays a key role by boosting the benefits of B12 supplementation. These two B vitamins join forces and work together in maintaining normal red blood cells. Folic acid assists in the normal utilization of amino acids and proteins, as well as supporting the construction of the material for DNA and RNA synthesis, which is necessary for all bodily functions. Scientific studies have found that when working in tandem with folic acid, B12 is capable of promoting normal homocysteine levels. This works toward supporting a healthy cardiovascular and nervous system.*
Folic acid (folate) must go through a series of chemical conversions before it becomes metabolically active to be properly utilized. Folinic acid is the highly bioavailable, metabolically active derivative of folic acid. It does not require the action of the enzyme dihydrofolinate reductase to become active, so it’s not affected by medicines and herbs that inhibit this enzyme. Inhibition of this enzyme can result in folic acid deficiency. Some people have a genetic variation (in the MTHRF gene) that reduces the amount of activated folic acid in the body. Folinic acid, unlike folic acid, is not negatively impacted by this genetic variation.*
Riboflavin-5-Phosphate (Vitamin B2) 3 mg
Vitamin B2 is found in liver, dairy products, dark green vegetables and some types of seafood. Vitamin B2 serves as a coenzyme, working with other B vitamins. It promotes healthy red blood cell formation, supports the nervous system, respiration, antibody production and normal human growth. It supports healthy skin, nails, hair growth and promotes normal thyroid activity (a healthy thyroid is essential in maintaining a healthy weight, among other things). Vitamin B2 supports the body's ability to turn food into energy as a part of the electron transport chain, driving cellular energy on the micro-level. Riboflavin can be useful for pregnant or lactating women, as well as athletes due to their higher caloric needs. Vitamin B2 also aids in the breakdown of fats. Vitamin B2 is water-soluble and cannot be stored by the body except in insignificant amounts. It must be replenished daily.*
Pyridoxal-5-Phosphate (Vitamin B6) 6 mg
Poultry, fish, whole grains and bananas are the main dietary sources of vitamin B6. B6 is a co-factor required for protein and amino acid metabolism, and helps maintain proper fluid balance. It also assists in the maintenance of healthy red and white blood cells, which keeps our body healthy. Vitamin B6 is required for hemoglobin synthesis (hemoglobin is the protein portion of red blood cells which carries oxygen throughout the body). Because vitamin B6 is involved in the synthesis of neurotransmitters in the brain and nerve cells, it has been recommended as a nutrient to enhance mental function, specifically mood. Athletic supplements often include vitamin B6 because it promotes the conversion of glycogen to glucose for energy in muscle tissue. Vitamin B6, when taken with folic acid, has been shown to help maintain normal plasma levels of homocysteine, which promotes optimal cardiovascular health. Vitamin B6 should be administered as a part of a complex of other B-vitamins for best results.*
Magnesium (Carbonate) 40 mg
Foods rich in magnesium include unpolished grains, nuts and green vegetables. Green, leafy vegetables are potent sources of magnesium because of their chlorophyll content. Meats, starches, milk, refined and processed foods contain low amounts of magnesium. Recent research shows that many American diets are magnesium deficient.*
Magnesium is a component of the mineralized part of bone, and promotes the normal metabolism of potassium and calcium in adults. It helps maintain normal levels of potassium, phosphorus, calcium, adrenaline and insulin. It also supports the transportation of calcium inside the cell for utilization. Magnesium promotes the normal functioning of muscle and nervous tissue, and the synthesis of all proteins, nucleic acids, nucleotides, fats and carbohydrates.*
Magnesium is required for releasing energy from food during metabolism, regulation of body temperature, proper nerve function and helping the body handle stress. Importantly, magnesium is also required by the body to build healthy bones, teeth and normal muscle development. It works together with calcium and vitamin D to help keep bones strong. Magnesium, when combined with calcium, helps support the heart muscle in maintaining a regular heartbeat and promoting normal blood pressure.*
Potassium (Bicarbonate) 95 mg
Potassium is an electrolyte stored in the muscles. Foods rich in potassium include bananas, oranges, cantaloupe, avocado, raw spinach, cabbage and celery. Potassium is an essential macromineral that helps maintain fluid balance in the body. It also plays a role in a wide variety of biochemical and physiological processes. Among other things, potassium promotes the transmission of nerve impulses, the contraction of cardiac, skeletal and smooth muscle, the production of energy, the synthesis of nucleic acids and the maintenance of normal blood pressure.*
In 1928, it was first suggested that high potassium intake could help maintain cardiovascular health. Potassium promotes normal muscle relaxation and insulin release. It also promotes glycogen and protein synthesis. Potassium is an electrolyte that promotes normal heartbeat.Potassium is important in releasing energy from protein, fat and carbohydrates during metabolism. Potassium helps regulate water balance, aids in recovery from exercise and helps with the elimination of wastes. Sodium and potassium are two of the most important ions in maintaining the homeostatic equilibrium of the body fluids.*
Thiamin HCl (Vitamin B1) 2 mg
Thiamin promotes normal carbohydrate metabolism and nerve function. Thiamin is required for a healthy nervous system, and supports the production of certain neurotransmitters which have an important role in muscle function. It supports the digestive process, increases energy and helps promote mental clarity.*
D-Calcium Pantothenate (Vitamin B5) 20 mg
Pantothenic acid (B5) promotes proper neurotransmitter activity in the brain. Pantothenic acid is also known as the anti-stress vitamin because it detoxifies brain tissue, helps relieve physical and emotional stress, and promotes the secretion of hormones essential for optimal health.*
Niacinamide (Vitamin B3) 20 mg
Niacin is a water-soluble vitamin necessary for many aspects of health, growth and reproduction. Niacin supports the proper functioning of the digestive system, skin and nerves. It promotes the normal conversion of food to energy. Niacin is found in dairy products, poultry, fish, lean meats, nuts, eggs, legumes, and enriched breads and cereals.*
Biotin (Vitamin B7) 300 mcg
Biotin can be found in food sources, such as egg yolks, peanuts, beef liver, milk, cereals, almonds and Brewer’s yeast. Biotin promotes healthy cell growth, the production of fatty acids, metabolism of fats and amino acids. It supports the citric acid cycle, which is the process in which energy is generated during exercise. Biotin is also helpful in maintaining steady blood sugar levels. Biotin is often recommended for maintaining strong hair and nails.*
These 10 ingredients, combined with the superior delivery of Isotonix®, create a powerhouse B vitamin product superior to the rest on the market. Isotonix Activated B-Complex delivers all of the B vitamins, along with select minerals and electrolytes to help boost energy, decrease stress, improve mood and much more. The activated forms of select vitamins ensure maximal utilization by the body for optimal results.*
Heart Health™ Essential Omega 3 Fish Oil with Vitamin E
Fish Body Oils 3000 mg [EPA† 900 mg and DHA† 600 mg]
Fish oils or marine oils are lipids (fats) found in fish, particularly cold water fish like herring, kipper, mackerel, menhaden, pilchard, salmon, sardine and trout, and phytoplankton. The sources of fish oil in Heart Health™ Omega III Fish Oil are sardines and anchovies, tested by the manufacturer and an independent testing company to be virtually free of mercury lead, PCB and other heavy metals. Fish oils are rich sources of omega-3 long-chain polyunsaturated fatty acids. EPA (eicosapentaenoic acid) and DHA (docosahexanenoic acid) are the two most studied fish oils. DHA is a necessary component of the phospholipids in human cellular membranes, especially those found in the brain and retina. Clinical studies have shown omega-3 fatty acids to help maintain healthy triglyceride levels. A strong correlation has also been shown between fish oil consumption and the ability to maintain healthy levels of C-reactive protein. Fish oils are also important in the maintenance of normal blood flow, as they support normal fibrinogen levels (coagulation or blood clotting), which contributes to normal platelet activity.*
EPA and DHA have several mechanisms of action to help maintain normal triglyceride and cholesterol levels, help maintain normal blood flow and pressure, and support normal platelet activity. EPA and DHA help maintain normal triglyceride levels by promoting normal lipogenesis and supporting normal fatty acid oxidation in the liver. EPA and DHA promote the normal transcription of genes coding for lipogenesis enzymes and promote the normal transportation of the regulatory enzymes of fatty acid oxidation. Activating PPAR (peroxisome proliferator-activated receptor) - alpha, helps to support normal fatty acid oxidation. The promotion of normal lipogenesis is done through down-regulation of SREBP (sterol regulatory element binding protein) -1c messenger RNA.*
EPA is the precursor to series-3 prostaglandins (PG), the series-3 thrombaxanes (TX) and the series-5 leukotrienes (LT). More specifically, EPA is a precursor to eicosanoids (TXA3 and LTB5), which promote normal platelet activity and promote normal vasodilation. These effects demonstrate EPA’s potential ability to help maintain normal blood pressure and support normal blood clotting. Fish oils inhibit the arachidonic acid synthesis of thromboxane A2, which help to promote normal platelet activity and vasodilation. Fish oil may also contribute to the normal production of prostacyclin, a prostaglandin that promotes normal vasodilation and supports normal platelet activity.*
Omega-3 fatty acids compete metabolically with omega-6 fatty acids, found in higher amounts in typical western diets. Omega-6 fatty acids may inhibit the incorporation of omega-3 fatty acids into tissue lipids. Omega-3 fatty acids may inhibit the conversion of many omega-6 fatty acids into arachidonic acid. The consumption of omega-3 fatty acids DHA and EPA appears to result in a corresponding increase of these fatty acids in cell membranes and circulatory lipids, along with a simultaneous reduction in omega-6 fatty acids.*
Vitamin E (d-alpha tocopherol) 23 IU
The most valuable sources of dietary vitamin E include vegetable oils, margarine, nuts, seeds, avocados and wheat germ. Safflower oil contains large amounts of vitamin E (about two thirds of the RDA in ¼ cup) and there are trace amounts in corn oil and soybean oil. Vitamin E is actually a family of related compounds called tocopherols and tocotrienols. Vitamin E is available in a natural or synthetic form. In most cases, the natural and synthetic forms are identical except the natural form of vitamin E is better absorbed and retained in the body. The natural form of alpha-tocopherol is known as "d-alpha tocopherol." The synthetic "dl-" form is the most common form found in dietary supplements. For those individuals watching their dietary fat consumption, which is relatively common in the world of dieting, vitamin E intake is likely to be low, due to a reduced intake of foods with high fat content.
The main health benefit of supplemental vitamin E comes from its immune-boosting antioxidant activity. It supports a healthy cardiovascular system. Vitamin E is one of the most powerful fat-soluble antioxidants in the body. In turn, vitamin E protects cell membranes from free radical damage. Vitamin E is commonly added to fish oil supplements to provide antioxidant protection of DHA and EPA.*
†According to the FDA, supportive, but not conclusive, research shows that consumption of EPA and DHA omega-3 fatty acids may reduce the risk of coronary heart disease.
Scientific Studies Which Support the Optimal Wellness Kit
- Abbasi AA, Prasad AS, Rabbani P, DuMouchelle E. Experimental zinc deficiency in man. Effect on testicular function. J Lab Clin Med. 1980 Sep;96(3):544-50.
- Abid M, Billington CJ, Nuttall FQ. Thyroid function and energy intake during weight gain following treatment of hyperthyroidism. J Am Coll Nutr. 1999 Apr;18(2):189-93.
- Addison WLT, The use of sodium chloride, potassium chloride, sodium bromide and potassium bromide in cases of arterial hypertension which are amenable to potassium chloride. Can Med Assoc J. 1928; 18:281-285.
- Allende LM, Corell A, Madrono A, Gongora R, Rodriguez-Gallego C, Lopez-Goyanes A, Rosal M, Arnaiz-Villena A. Retinol (vitamin A) is a cofactor in CD3-induced human T-lymphocyte activation. Immunology. 1997 Mar;90(3):388-96
- Anderson RA. Effects of chromium on body composition and weight loss. Nutr Rev. 1998 Sep;56(9):266-70.
- Arthur JR. Functional indicators of iodine and selenium status. Proc Nutr Soc. 1999 May;58(2):507-12.
- Backstrom MC, Maki R, Kuusela AL, Sievanen H, Koivisto AM, Ikonen RS, Kouri T, Maki M. Randomised controlled trial of vitamin D supplementation on bone density and biochemical indices in preterm infants. Arch Dis Child Fetal Neonatal Ed. 1999 May;80(3):F161-6.
- Bahadori B, Wallner S, Schneider H, Wascher TC, Toplak H. Effect of chromium yeast and chromium picolinate on body composition of obese, non-diabetic patients during and after a formula diet. Acta Med Austriaca. 1997;24(5):185-7.
- Baly DL, Schneiderman JS, Garcia-Welsh AL. Effect of manganese deficiency on insulin binding, glucose transport and metabolism in rat adipocytes. J Nutr. 1990; 120:1075-1079.
- Baron JA, Beach M, Mandel JS, et al. Calcium supplements for the prevention of colorectal adenomas. N Engl J Med 1999;340:101-107.
- Baron JA, Tosteson TD, Wargovich MJ, et al. Calcium supplementation and rectal mucosal proliferation: a randomized controlled trial. J Natl Cancer Inst 1995;87:1303-1307.
- Bates CJ. Vitamin A. Lancet. 1995; 345:31-35.
- Baxter GF, Sumeray MS, Walker JM. Infant size and magnesium: insights into LIMIT-2 and ISIS-4 from experimental studies. Lancet. 1996; 348:1424-1426.
- Behl C. Vitamin E and other antioxidants in neuroprotection. Int J Vitam Nutr Res. 1999 May;69(3):213-9. 4. Botterweck AA, van den Brandt PA, Goldbohm RA. Vitamins, carotenoids, dietary fiber, and the risk of gastric carcinoma: results from a prospective study after 6.3 years of follow-up. Cancer. 2000 Feb 15;88(4):737-48.
- Bellamy MC, Gedney JA. Unrecognized iron deficiency in critical illness. Lancet. 1998; 352:1903.
- Beutler E, Larsh SE, Gurney CW. Iron therapy in chronically fatigued nonanemic women: a double-blind study. Ann Intern Med. 1960; 52:378-394.
- Bostick RM, Kushi LH, Wu Y, et al. Relation of calcium, vitamin D, and dairy food intake to ischemic heart disease mortality among postmenopausal women. Am J Epidemiol 1999;149:151-160.
- Britton J, Pavord I, Richards K, et al. Dietary magnesium, lung function, wheezing, and airway hyper-reactivity in a random adult population sample. Lancet. 1994; 344:357-362.
- Brown JE, Wahle KW Effect of fish-oil and vitamin E supplementation on lipid peroxidation and whole-blood aggregation in man. Clin Chim Acta. 1990 Dec 14;193(3):147-56.
- Brun JF, Dieu-Cambrezy C, Charpiat A, Fons C, Fedou C, Micallef JP, Fussellier M, Bardet L, Orsetti A. Serum zinc in highly trained adolescent gymnasts. Biol Trace Elem Res. 1995 Jan-Mar;47(1-3):273-8.
- Bruner AB, Joffe A, Duggan A, et al. Randomised study of cognitive effects of iron supplementation in non-anaemic iron-deficient adolescent girls. Lancet. 1996; 348:992-997.
- Buchinger W, Lorenz-Wawschinek O, Semlitsch G, Langsteger W, Binter G, Bonelli RM, Eber O. Thyrotropin and thyroglobulin as an index of optimal iodine intake: correlation with iodine excretion of 39,913 euthyroid patients. Thyroid. 1997 Aug;7(4):593-7.
- Butterfield DA, Koppal T, Subramaniam R, Yatin S. Vitamin E as an antioxidant/free radical scavenger against amyloid beta-peptide-induced oxidative stress in neocortical synaptosomal membranes and hippocampal neurons in culture: insights into Alzheimer's disease. Rev Neurosci. 1999;10(2):141-9
- Calomme MR, Vandem Berghe DA. Supplementation of calves with stabilized orthosilicic acid. Effect on the Si, Ca, Mg, and P concentrations in serum and the collagen concentration in skin and cartilage. Biol Trace Elem Res. 1997; 56:153-165.
- Cappuccio FP, MacGregor GA. Does potassium supplementation lower blood pressure? A meta-analysis of published trials. J Hypertens. 1991; 9:465-473.
- Carlisle EM. Silicon as a trace nutrient. Sci Total Environ. 1988; 73:95-106.
- Carlisle EM. The nutritional essentiality of silicon. Nutr Rev. 1982; 40:193-198.
- Casscells W. Magnesium and myocardial infarction. Lancet. 1994; 343:807-809.
- Christiansen CW, Rieder MA, Silverstein EL, Gencheff NE. Magnesium sulfate reduces myocardial infarct size when administered before but not after coronary reperfusion in a canine model. Circulation. 1995; 92:2617-2621.
- Comstock GW, Alberg AJ, Huang HY, Wu K, Burke AE, Hoffman SC, Norkus EP, Gross M, Cutler RG, Morris JS, Spate VL, Helzlsouer KJ. The risk of developing lung cancer associated with antioxidants in the blood: ascorbic acid, carotenoids, alpha-tocopherol, selenium, and total peroxyl radical absorbing capacity. Cancer Epidemiol Biomarkers Prev. 1997 Nov;6(11):907-16.
- Cooke MS, Evans MD, Podmore ID, et al. Novel repair action of vitamin C upon in vivo oxidative DNA damage. FEBS Lett. 1998; 439:363-367.
- Cooney RV, Franke AA, Hankin JH, Custer LJ, Wilkens LR, Harwood PJ, Le Marchand L. Seasonal variations in plasma micronutrients and antioxidants. Cancer Epidemiol Biomarkers Prev. 1995 Apr-May;4(3):207-15.
- Couzy F, Lafargue P, Guezennec CY. Zinc metabolism in the athlete: influence of training, nutrition and other factors. Int J Sports Med. 1990 Aug;11(4):263-6.
- Dallman PR. Iron deficiency and the immune response. Am J Clin Nutr. 1987; 46:329-334.
- Daudu PA, Kelley DS, Taylor PC, Burri BJ, Wu MM. Effect of a low beta-carotene diet on the immune functions of adult women. Am J Clin Nutr. 1994 Dec;60(6):969-72.
- Dawson-Hughes B. Vitamin D and calcium: recommended intake for bone health. Osteoporos Int. 1998;8 Suppl 2:S30-4. 6. Feit JM. Calcium and vitamin D supplements for elderly patients. J Fam Pract. 1997 Dec;45(6):471-2.
- de Lourdes Lima M, Cruz T, Carreiro Pousada J, et al. The effect of magnesium supplementation in increasing doses on the control of type 2 diabetes. Diabetes Care. 1998; 21:682-686.
- de Valk B, Marx JJM. Iron, atherosclerosis, and ischemic heart disease. Arch Int Med. 1999; 159:1542-1548.
- Dietary Reference Intakes for Calcium, Phosphorous, Magnesium, Vitamin D, and Fluoride. Washington, DC: National Academy Press; 1997.
- Dorgan JF, Schatzkin A. Antioxidant micronutrients in cancer prevention. Hematol Oncol Clin North Am. 1991 Feb;5(1):43-68.
- Dreon DM, Butterfield GE. Vitamin B6 utilization in active and inactive young men. Am J Clin Nutr. 1986 May;43(5):816-24.
- Duffy SJ, Gokce N, Holbrook M, et al. Treatment of hypertension with ascorbic acid. Lancet. 1999; 354:2048-2049.
- Durlach J, Durlach V, Bac P, et al. Magnesium and therapeutics. Magnes Res. 1994; 7:313-328.
- Elisaf M, Merkouropoulos M, Tsianos EV. Siamopoulos KC. Pathogenetic mechanisms of hypomagnesemia in alcoholic patients. J Trace Elem Med Biol. 1995; 9:210-214.
- Elitsur Y, Neace C, Liu X, Dosescu J, Moshier JA. Vitamin A and retinoic acids immunomodulation on human gut lymphocytes. Immunopharmacology. 1997 Jan;35(3):247-53.
- Enstrom JE, Kanim LE, Klein MA. Vitamin C intake and mortality among a sample of the United States population. Epidemiology. 1992; 3:194-202.
- Facchinetti F, Borella P, Sances G, et al. Oral magnesium successfully relieves premenstrual mood changes. Obstet Gynecol. 1991; 78:177-181.
- Facchinetti F, Borella P, Sances G, et al. Oral magnesium successfully relieves premenstrual mood changes. Obstet Gynecol. 1991; 78:177-181.
- Fairbanks VF. Iron in medicine and nutrition. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. Baltimore, MD: Williams and Wilkins; 1999:193-221.
- Fang J, Madhavan S, Alderman MH. Dietary potassium intake and stroke mortality. Stroke. 2000; 31:1532-1537.
- Fields M, Lewis CG. Starch diets high in iron can duplicate the severity of copper deficiency in rats fed fructose. J Med Food. 1998; 1:193-199.
- Finch CA, Huebers H. Perspectives in iron metabolism. N Engl J Med. 1982; 306:1520-1528.
- Flatt PR, Juntti-Berggren L, Berggren PO, Gould BJ, Swanston-Flatt SK. Failure of glucose tolerance factor-containing Brewer's yeast to ameliorate spontaneous diabetes in C57BL/KsJ DB/DB mice. Diabetes Res. 1989 Mar;10(3):147-51.
- Futoryan T, Gilchrest BA. Retinoids and the skin. Nutr Rev. 1994; 52:299-310.
- Gleeson M, Bishop NC. Elite athlete immunology: importance of nutrition. Int J Sports Med. 2000 May;21 Suppl 1:S44-50.
- Grant KE, Chandler RM, Castle AL, Ivy JL. Chromium and exercise training: effect on obese women. Med Sci Sports Exerc. 1997 Aug;29(8):992-8.
- Gullestad L, Dolva LO, Soyland E, et al. Oral magnesium supplementation improves metabolic variables and muscle strength in alcoholics. Alcohol Clin Exp Res. 1992; 16:986-990.
- Guo WD, Chow WH, Zheng W, Li JY, Blot WJ. Diet, serum markers and breast cancer mortality in China. Jpn J Cancer Res. 1994 Jun;85(6):572-7.
- Harris ED. Cellular copper transport and metabolism. Annu Rev Nutr. 2000; 20:291-310.
- Harrison MD, Jones CE. Solioz M, Dameron CT. Intracellular copper routing: the role of copper chaperones. Trends Biochem Sci. 2000; 25:29-32.
- Health & Medicine. (Statistical Data Included) American Fitness, July, 1999 Tannen RL. Effects of potassium on blood pressure control. Ann Intern Med. 1983; 98(part 2):773-780.
- Hemila H, Douglas RM. Vitamin C and acute respiratory infections. Int J Tuberc Lung Dis. 1999; 3:756-761.
- Hermans JJ, Fischer MA, Schiffers PM, Struijker-Boudier HA. High dietary potassium chloride intake augments rat renal mineralocorticoid receptor selectivity via 11beta-hydroxysteroid dehydrogenase. Biochim Biophys Acta. 1999; 1472:537-549.
- Hermansen K. Diet, blood pressure and hypertension. Br J Nutr. 2000; 83 Supp1:S113-S119.
- Hintze G, Kobberling J. Dietary iodine deficiency. Its consequences in the aged. Fortschr Med. 1992 Apr 10;110(10):163-6.
- Huebers HA, Beguin Y, Pootrakul P, et al. Intact transferrin receptors in human plasma and their relation to erythropoiesis. Blood. 1990; 75:102-107.
- Hughes K, Chua LH, Ong CN. Serum selenium in the general population of Singapore, 1993 to 1995. Ann Acad Med Singapore. 1998 Jul;27(4):520-3.
- Hunt CD, Johnson PE, Herbel J, Mullen LK. Effects of dietary zinc depletion on seminal volume and zinc loss, serum testosterone concentrations, and sperm morphology in young men. Am J Clin Nutr. 1992 Jul;56(1):148-57.
- Hwang J, Peterson H, Hodis HN, et al. Ascorbic acid enhances 17 beta-estradiol-mediated inhibition of oxidized low density lipoprotein formation. Atherosclerosis. 2000; 150:275-284.
- Ishimitsu T, Tobian L, Sugimoto K, Everson T. High potassium diets reduce vascular and plasma lipid peroxides in stroke-prone spontaneously hypertensive rats. Clin Exp Hypertens. 1996; 18:659-673
- Ishimitsu T, Tobian L, Sugimoto K, Lange JM. High potassium diets reduce macrophage adherence to vascular wall in stroke-prone spontaneously hypertensive rats. J Vasc Res. 1995; 32:406-412.
- Ishimitsu T, Tobian L, Uehara Y, et al. Effect of high potassium diets on the vascular and renal prostaglandin system in stroke-prone spontaneously hypertensive rats. Prostaglandins Leukot Essent Fatty Acids. 1995; 53:255-260.
- Ishimitsu T, Tobian L. High potassium diets reduce endothelial permeability in stroke-prone spontaneously hypertensive rats. Clin Exp Pharmacol Physiol. 1997; 23:241-245.
- ISIS-4 (Fourth International Study of Infarct Survival) Collaborative Group. ISIS-4: a randomised factorial trial assessing early oral captopril, oral mononitrate, and intravenous magnesium sulfate in 58,050 patients with suspected acute myocardial infarction. Lancet. 1995; 345:669-685.
- Jacobson SG, Cideciyan AV, Regunath G, et al. Night blindness in Sorsby's fundus dystrophy reversed by vitamin A. Nature Gen. 1995; 11:27-32.
- Jin L, ChaoL, Chao J. Potassium supplement upregulates the expression of renal kalikrein and bradykinin B2 receptor in SHR. Am J Physiol. 1999; 276:F476-F484.
- Johnson WT, Thomas AC. Copper deprivation potentiates oxidative stress in HL-60 cell mitochondria. Proc Soc Exp Biol Med. 1999; 221:147-152.
- Kao WHL, Folsom AR, Nieto J, et al. Serum and dietary magnesium and the risk for type 2 diabetes mellitus (editorial). Arch. Int Med. 1999; 159:2151-2159.
- Khaw K-T, Barrett-Conner E. Dietary potassium and stroke-associated mortality. N Engl J Med. 1987; 316:235-240.
- Klevay LM. Cardiovascular disease from copper deficiency — a history. J Nutr. 2000; 130:489S-492S.
- Klevay LM. Coronary heart disease: the zinc/copper hypothesis. Am J Clin Nutr. 1975; 28:764-774.
- Knekt P, Jarvinen R, Seppanen R, Rissanen A, Aromaa A, Heinonen OP, Albanes D, Heinonen M, Pukkala E, Teppo L. Dietary antioxidants and the risk of lung cancer. Am J Epidemiol. 1991 Sep 1;134(5):471-9.
- Krieger D, Krieger S, Jansen O, et al. Manganese and chronic hepatic encephalopathy. Lancet. 1995; 346:270-274.
- Krishna GG, Miller E, Kapoor S. Increased blood pressure during potassium depletion in normotensive men. N Eng J Med. 1989; 320:1177-1182.
- Krotkiewski M, Gudmundsson M, Backstrom P, Mandroukas K. Zinc and muscle strength and endurance. Acta Physiol Scand. 1982 Nov;116(3):309-11.
- Kung AW, Janus ED. Thyroid dysfunction in ambulatory elderly Chinese subjects in an area of borderline iodine intake. Thyroid. 1996 Apr;6(2):111-4.
- Lamberg L. Diet may affect skin cancer prevention. JAMA. 1998 May 13;279(18):1427-8.
- Lee M-O, Han S-Y, Jiang S, et al. Differential effects of retinoic acid on growth and apoptosis in human colon cancer cell lines associated with the induction of retinoic acid receptor beta. Biochem Pharmacol. 2000; 59:485-496.
- Lim R, Herzog WR. Magnesium for cardiac patients: is it a valuable treatment supplement? Contemp Int Med. 1998; 10:6-9.
- Lin H, Young DB. Interactions between plasma potassium and epinephrine in coronary thrombosis in dogs. Circulation. 1994; 89:331-338.
- Loeper J, Goy-Loeper J, Rozensztajn L, Fragny M. The antiatheromatous action of silicon. Atherosclerosis. 1979; 33:397-408.
- LoPresti JS, Gray D, Nicoloff JT. Influence of fasting and refeeding on 3,3',5'-triiodothyronine metabolism in man. J Clin Endocrinol Metab. 1991 Jan;72(1):130-6.
- Lucas MJ, Leveno KJ, Cunningham FG. A comparison of magnesium sulfate with phenytoin for the prevention of eclampsia. N Engl J Med. 1995; 333:201-205.
- Lukaski HC. Magnesium, zinc, and chromium nutriture and physical activity. Am J Clin Nutr. 2000 Aug;72(2 Suppl):585S-93S.
- Luoma P. Antioxidants, infections and environmental factors in health and disease in northern Finland. Int J Circumpolar Health. 1998 Jul;57(2-3):109-13.
- Ma G, Young DB, Clower BR. Inverse relationship between potassium intake and coronary artery disease in the cholesterol-fed rabbit. Am J Hypertens. 1999; 12:821-825.
- Manore MM. Effect of physical activity on thiamine, riboflavin, and vitamin B-6 requirements. Am J Clin Nutr. 2000 Aug;72(2 Suppl):598S-606S.
- Martini LA. Magnesium supplementation and bone turnover. Nutr Rev. 1999; 57:227-229.
- Mauskop A, Altura BM. Role of magnesium in the pathogenesis and treatment of migraines. Clin Neurosci. 1998; 5:24-27.
- McCabe RD, Backarich MA, Srivastava K, Young DB. Potassium inhibits free radical formation. Hypertension. 1994; 24:77-82.
- McCabe RD, Young DB. Potassium inhibits cultural vascular smooth muscle proliferation. Am J Hypertens. 1994; 7:346-350.
- McCarty MF. Chromium and other insulin sensitizers may enhance glucagon secretion: implications for hypoglycemia and weight control. Med Hypotheses. 1996 Feb;46(2):77-80.
- McDonald R, Keen CL. Iron, zinc and magnesium nutrition and athletic performance. Sports Med. 1988 Mar;5(3):171-84.
- Meunier PJ. Calcium, vitamin D and vitamin K in the prevention of fractures due to osteoporosis. Osteoporos Int. 1999;9 Suppl 2:S48-52.
- Miller ER 3rd, Appel LJ, Levander OA, Levine DM. The effect of antioxidant vitamin supplementation on traditional cardiovascular risk factors. J Cardiovasc Risk. 1997 Feb;4(1):19-24.
- Miller JW. Vitamin E and memory: is it vascular protection? Nutr Rev. 2000 Apr;58(4):109-11. Bell L, Halstenson CE, Halstenson CJ, et al. Cholesterol-lowering effects of calcium carbonate in patients with mild to moderate hypercholesterolemia. Arch Intern Med. 1992; 152:2441-2444.
- Morse AC, Beard JL, Jones BC. A genetic development model of iron deficiency: biological aspects. Proc Soc Exp Biol Med. 1999; 220:147-152.
- Ness AR, Chee D, Elliot P. Vitamin C and blood pressure—an overview. J Hum Hypertens. 1997; 11:343-350.
- Nielsen FH. Ultratrace minerals. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease, 9th ed. Baltimore, MD: Williams and Wilkins; 1999:283-303.
- Nielsen FH. Ultratrace minerals. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams and Wilkins; 199:283-303.
- Nishi Y. Anemia and zinc deficiency in the athlete. J Am Coll Nutr. 1996 Aug;15(4):323-4.
- Orchard TJ. Magnesium and type 2 diabetes mellitus (editorial). Arch Int Med. 1999; 159:2119-2120. Keen CL, Ensunsa JL, Watson MH, et al. Nutritional aspects of manganese from experimental studies. Neurotoxicol. 1999; 20:213-223.
- Paul T, Meyers B, Witorsch RJ, Pino S, Chipkin S, Ingbar SH, Braverman LE. The effect of small increases in dietary iodine on thyroid function in euthyroid subjects. Metabolism. 1988 Feb;37(2):121-4.
- Pauling L. Evolution and the need for ascorbic acid. Proc Natl Acad SciUSA. 1970; 67:1643-1648.
- Pauling L. The significance of the evidence about ascorbic acid and the common cold. Proc Natl Acad SciUSA. 1971; 68:2678-2681.
- Penn ND, Purkins L, Kelleher J, Heatley RV, Mascie-Taylor BH, Belfield PW. The effect of dietary supplementation with vitamins A, C and E on cell-mediated immune function in elderly long-stay patients: a randomized controlled trial. Age Ageing. 1991 May;20(3):169-74.
- Podmore ID, Griffiths HR, Herbert KE, et al. Vitamin C exhibits pro-oxidant effects. Nature. 1998; 392:559.
- Prasad AS, Cossack ZT. Neutrophil zinc: an indicator of zinc status in man. Trans Assoc Am Physicians. 1982;95:165-76.
- Prasad AS. Zinc deficiency in human subjects. Prog Clin Biol Res. 1983;129:1-33.
- Rayssiguier Y, Gueux E, Bussiere L, Mazur A. Copper deficiency increases the susceptibility of lipoproteins and tissues to peroxidation in rats. J Nutr. 1993; 123:1343-1348.
- Reading SA. Chromium picolinate. J Fla Med Assoc. 1996 Jan;83(1):29-31.
- Reinhardt W, Holtermann D, Benker G, Olbricht T, Jaspers C, Reinwein D. Effect of small doses of iodine on thyroid function during caloric restriction in normal subjects. Horm Res. 1993;39(3-4):132-7.
- Rico H, Gallego-Lago JL, Hernandez ER, at al. Effect of silicon supplement on osteopenia induced by ovariectomy in rats. Calcif Tissue Int. 2000; 66:53-55.
- Robuschi G, Emanuele R, Cavalli Sforza LT, Arsenio L, Strata A, Gnudi A, Roti E. Effect of iodine administration on thyroid function in diabetic patients. Acta Diabetol Lat. 1984 Oct-Dec;21(4):357-60.
- Rock E, Mazur A, O'Connor JM, et al. The effect of copper supplementation on red blood cell oxidizability and plasma antioxidants in Middle-aged healthy volunteers. Free Rad Biol Med. 2000; 28:324-329.
- Rokitzki L, Sagredos A, Keck E, Sauer B, Keul J. Assessment of vitamin B2 status in performance athletes of various types of sports. J Nutr Sci Vitaminol (Tokyo). 1994 Feb;40(1):11-22.
- Ross AC, Stephensen CB. Vitamin A and retinoids in antiviral responses. FASEB J. 1996; 10:979-985.
- Ross AC. Vitamin A and retinoids. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams and Wilkins; 1999:305-327.
- Saari JT, Sahuschke DA. Cardiovascular effects of dietary copper deficiency. Biofactors. 1999; 10:359-375.
- Schwarz K. A bound form of silicon in glycosaminoglycans and polyuronides. Proc Nat Acad Sci. 1973; 70:1608-1612.
- Schwarz K. Silicon, fibre, and atherosclerosis. Lancet. 1977; 1:454-457.
- Scrimshaw NS, San Giovanni JP. Synergism of nutrition, infection, and immunity: an overview. Am J Clin N. 1997; 66:464S-477S.
- Semba RD. The role of vitamin A and related retinoids in immune function. Nutr Rev. 1998 Jan;56(1 Pt 2):S38-48.
- Semba RD. Vitamin A and immunity to viral, bacterial and protozoan infections. Proc Nutr Soc. 1999 Aug;58(3):719-27.
- Semba RD. Vitamin A, immunity, and infection. Clin Infect Dis. 1994 Sep;19(3):489-99.
- Shephard RJ, Shek PN. Immunological hazards from nutritional imbalance in athletes. Exerc Immunol Rev. 1998;4:22-48.
- Silva JE. Effects of iodine and iodine-containing compounds on thyroid function. Med Clin North Am. 1985 Sep;69(5):881-98.
- Singh MA. Combined exercise and dietary intervention to optimize body composition in aging. Ann N Y Acad Sci. 1998 Nov 20;854:378-93.
- Skaper SD, Fabris M, Ferrari V, et al. quercetin protects cutaneous tissue-associated cell types including sensory neurons from oxidative stress induced by glutathione depletion: cooperative effects of ascorbic acid. Free Rad Biol Med. 1997; 22:669-678.
- Sohlenius-Sternbeck A-K, Appelkvist E-L, De Pierre JW. Effects of vitamin A deficiency on selected xenobiotic-metabolizing enzymes and defenses against oxidative stress in mouse liver. Biochem Pharmacol. 2000; 59:377-383.
- Stahelin HB. Critical reappraisal of vitamins and trace minerals in nutritional support of cancer patients. Support Care Cancer. 1993 Nov;1(6):295-7.
- Strause L, Saltman P, Glowacki J. The effect of deficiencies of manganese and copper on osteo-induction and on resorption of bone particles in rats. Calcif Tissue Int. 1987; 41:145-150
- Suboticanec K, Stavljenic A, Bilic-Pesic L, Gorajscan M, Gorajscan D, Brubacher G, Buzina R. Nutritional status, grip strength, and immune function in institutionalized elderly. Int J Vitam Nutr Res. 1989;59(1):20-8.
- Sugimoto K, Tobian L, Ishimutsu T, Lange JM. High potassium diets greatly increase growth-inhibiting agents in aortas of hypertensive rats. Hypertension. 1992; 19:749-752.
- Sugimoto T, Tobian L, Ganguli MC. High potassium diets protect against dysfunction of endothelial cells in stroke-prone spontaneously hypertensive rats. Hypertension. 1988:11:579-585.
- Suzuki M, Itokawa Y. Effects of thiamine supplementation on exercise-induced fatigue. Metab Brain Dis. 1996 Mar;11(1):95-106.
- Taddei S, Virdis A, Ghiadoni L, et al. Vitamin C improves endothelium-dependent vasodilation by restoring nitric oxide activity in essential hypertension. Circulation. 1998; 97:2222-2229.
- Takahashi T, Fujimori K, Simon SL, Bechtner G, Edwards R, Trott KR. Thyroid nodules, thyroid function and dietary iodine in the Marshall islands. Int J Epidemiol. 1999 Aug;28(4):742-9.
- Tannen RL. Effects of potassium on blood pressure control. Ann Intern Med. 1983; 98(part 2):773-780.
- Taylor PR, Li B, Dawsey SM, Li JY, Yang CS, Guo W, Blot WJ. Prevention of esophageal cancer: the nutrition intervention trials in Linxian, China. Linxian Nutrition Intervention Trials Study Group. Cancer Res. 1994 Apr 1;54(7 Suppl):2029s-2031s.
- Thilly CH, Swennen B, Bourdoux P, Ntambue K, Moreno-Reyes R, Gillies J, Vanderpas JB. The epidemiology of iodine-deficiency disorders in relation to goitrogenic factors and thyroid-stimulating-hormone regulation. Am J Clin Nutr. 1993 Feb;57(2 Suppl):267S-270S.
- Thurnham DI. Micronutrients and immune function: some recent developments. J Clin Pathol. 1997 Nov;50(11):887-91.
- Tobian L. Salt and hypertension. Lessons from animal models that relate to human hypertension. Hypertension. 1991; 17:152-158.
- Toyama T, Kubuki Y, Suzuki M. Tsubouchi H. [Copper deficiency anemia and neutropenia secondary to total gastrectomy]. [Article in Japanese]. Rinsho Ketsueki. 2000; 41:441-443.
- Trent LK, Thieding-Cancel D. Effects of chromium picolinate on body composition. J Sports Med Phys Fitness. 1995 Dec;35(4):273-80.
- Turnlund Jr. Copper. In: Shils ME, Olson JA, Shike M. Ross AC, eds. Modern Nutrition in health and Disease, 9th ed. Baltimore, MD: Williams and Wilkins; 1999:241-252.
- Underwood BA, Arthur P. The contribution of vitamin A to public health. FASEB J. 1996; 10:1040-1048
- Uusitupa MI, Mykkanen L, Siitonen O, Laakso M, Sarlund H, Kolehmainen P, Rasanen T, Kumpulainen J, Pyorala K. Chromium supplementation in impaired glucose tolerance of elderly: effects on blood glucose, plasma insulin, C-peptide and lipid levels. Br J Nutr. 1992 Jul;68(1):209-16.
- van den Brandt PA, Goldbohm RA, van 't Veer P, Bode P, Dorant E, Hermus RJ, Sturmans F. A prospective cohort study on selenium status and the risk of lung cancer. Cancer Res. 1993 Oct 15;53(20):4860-5.
- van der Heyden JT, Docter R, van Toor H, Wilson JH, Hennemann G, Krenning EP. Effects of caloric deprivation on thyroid hormone tissue uptake and generation of low-T3 syndrome. Am J Physiol. 1986 Aug;251(2 Pt 1):E156-63.
- Van Hooser JP, Aleman TS, He Y-G, et al. Rapid restoration of visual pigment and function with oral retinoid in a mouse model of childhood blindness. Proc Natl Acad Sci USA. 2000; 97:8623-8628.
- Vatassery GT, Bauer T, Dysken M. High doses of vitamin E in the treatment of disorders of the central nervous system in the aged. Am J Clin Nutr. 1999 Nov;70(5):793-801.
- Vatassery GT. Vitamin E and other endogenous antioxidants in the central nervous system. Geriatrics. 1998 Sep;53 Suppl 1:S25-7.
- Waggoner DJ, Bartnikas TB, Gitlin JD. The role of copper in neurodegenerative disease. Neurobiology of Disease. 1999; 6:221-230.
- Wahl R, Pilz-Mittenburg KW, Heer W, Kallee E. Iodine content in diet and excretion of iodine in urine. Z Ernahrungswiss. 1995 Dec;34(4):269-76.
- Walker LS, Bemben MG, Bemben DA, Knehans AW. Chromium picolinate effects on body composition and muscular performance in wrestlers. Med Sci Sports Exerc. 1998 Dec;30(12):1730-7.
- Wang Y, Mackenzie B, Tsukaguchi H, et al. Human vitamin C (L-ascorbic acid) transporter SVCT1. Biochem Biophys Res Commun. 2000; 267:488-494.
- Wargovich MJ, Eng VWS, Newmark HL. Calcium inhibits the damaging and compensatory proliferative effects of fatty acids on mouse colon epithelium. Cancer Lett. 1984; 23:253-258.\
- Weaver CM, Heaney RP. Calcium. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams and Wilkins; 1999:141-155.
- West KP Jr, Pokhrel RP, Katz J, et al. Efficacy of vitamin A in reducing preschool child mortality in Nepal. Lancet. 1991; 338:67-71.
- West SG, Light KC, Hinderliter AL, et al. Potassium supplementation induces beneficial cardiovascular changes during rest and stress in salt sensitive individuals. Health Psychol. 1999; 18:229-240.
- Whelton PK, He J, Cutler JA, et al. Effects of oral potassium on blood pressure. Meta-analysis of randomized controlled clinical triglyceride trials. JAMA. 1997; 277:1624-1632.
- Wolf RL, Cauley JA, Baker CE, et al. Factors associated with calcium absorption efficiency in pre- and perimenopausal women. Am J Clin Nutr. 2000; 72:466-471.
- Young DB, Lin H, McCabe RD. Potassium's cardiovascular protective mechanisms. Am J Physiol. 1995; 268:R825-R837.
- Young DB, Ma G. Vascular protective effects of potassium. Semin Nephrol. 1999; 19:477-486.
- Zemel MB, Shi H, Greer B, et al. Regulation of adiposity by dietary calcium. FASEB J. 2000; 14:1132-1138.
- Zhou B, Wang T, Sun G, Guan P, Wu JM. A case-control study of the relationship between dietary factors and risk of lung cancer in women of Shenyang, China. Oncol Rep. 1999 Jan-Feb;6(1):139-43.
- Zhou MS, Nishida Y, Yoneyama H, et al. Potassium supplementation increases sodium excretion in hypertensive Dahl rats. Clin Exp Hypertens.
Isotonix® Activated B Complex
- Benton D., et al. Thiamine supplementation for mood and cognitive functioning. Psychopharmacology. 129(1):66-71, 1997.
- Benton, D., et al. The effects of nutrients on mood. Public Health Nutr. 2(3A):403-409, 1999.
- Bhagavan, H. N., et al. The effect of pyridoxine hydrochloride on blood serotonin and pyridoxal phosphate contents in hyperactive children. Pediatrics. 55(3):437-441, 1975.
- Bronstrup A, Hages M, Prinz-Langenohl R, Pietrzik K. Effects of folic acid and
- Bryan, J., et al. Associations between dietary intake of folate and vitamins B-12 and B-6 and self-reported cognitive function and psychological well-being in Australian men and women in midlife. J Nutr Health Aging. 8(4):226-232, 2004.
- Bryan, J., et al. Short-term folate, vitamin B-12 or vitamin B-6 supplementation slightly affects memory performance but not mood in women of various ages. Journal of Nutrition. 132(6):1345-1356, 2002.
- combinations of folic acid and vitamin B12 on plasma homocysteine concentrations in healthy young women. Am J Clin Nutr 68:1104-10, 1998.
- Coppen, A., et al. Plasma folate and affective morbidity during long-term lithium therapy. Br J Psychiatry. 141:87-89, 1982.
- Cummings, P. M., et al. Effect of folic acid and antioxidant vitamins on endothelial dysfunction in patients with coronary artery disease. J Am Coll Cardiol. 36:758-765, 2000.
- Dharmarajan, T. S., et al. Vitamin B12 deficiency. Recognizing subtle symptoms in older adults. Geriatrics. 58(3):30-34, 2003.
- Doshi, S. N., et al. Folic acid improves endothelial function in coronary artery disease via mechanisms largely independent of homocysteine lowering. Circulation. 105(1):22-26, 2002.
- Duthie, S. J., et al. Homocysteine, B vitamin status, and cognitive function in the elderly. American Journal of Clinical Nutrition. 75(5):908-913, 2002.
- Friso, S., et al. Low plasma vitamin B-6 concentrations and modulation of coronary artery disease risk. Am J Clin Nutr. 79(6):992-998, 2004.
- Grant, J. E., et al. Analysis of dietary intake and selected nutrient concentrations in patients with chronic fatigue syndrome. J Am Diet Assoc. 96(4):383-386, 1996.
- Hartvig, P., et al. Pyridoxine effect on synthesis rate of serotonin in the monkey brain measured with position emission tomography. Neural Trans. 102:91-97, 1995.
- Heap, L. C., et al. Vitamin B status in patients with chronic fatigue syndrome. J R Soc Med. 92(4):183-185, 1999.
- Heseker, H., et al. Psychological disorders as early symptoms of a mild-to-moderate vitamin deficiency. Ann N Y Acad Sci. 669:352-357, 1992.
- Jacobson, W., et al. Serum folate and chronic fatigue syndrome. Neurology. 43:2645-2647, 1993.
- Kelly, G. S. Nutritional and botanical interventions to assist with the adaptation to stress. Alternative Medicine Review.4(4):249-265, 1999.
- Litoff, D., et al. Effects of pantothenic acid supplementation on human exercise. Med Sci Sport Exercise., 17(Supplement):287, 1985.
- Osada, K., et al. Experimental study of fatigue provoked by biotin deficiency in mice. Int J Vitam Nutr Res. 74(5):334-340, 2004.
- Quadri, P., et al. Homocysteine, folate, and vitamin B-12 in mild cognitive impairment, Alzheimer disease, and vascular dementia. Am J Clin Nutr. 80(1):114-122, 2004.
- Riggs, K. M., et al. Relations of vitamin B-12, vitamin B-6, folate, and homocysteine to cognitive performance in the Normative Aging Study. American Journal of Clinical Nutrition. 63(3):306-314, 1996.
- Van den Berg M., et al. Combined vitamin B-6 plus folic acid therapy in young patients with arteriosclerosis and hyperhomocysteinemia. Journal Vascular Surgery. 20(6):933-940, 1994.
- van Oort FV, Melse-Boonstra A, Brouwer IA, et al. Folic acid and reduction of plasma homocysteine concentrations in older adults: a dose-response study. 77:1318-23, 2003.
- Vargiu, R., et al. Enhancement of muscular performance by a coformulation of propionyl-L-carnitine, coenzyme Q(10), nicotinamide, riboflavin and pantothenic acid in the rat. Physiol Behav. 76(2):257-63, 2002.
- Wald DS, Bishop L, Wald NJ, et al. Randomized trial of folic acid supplementation and serum homocysteine levels. Arch Intern Med 61:695-700, 2001.
- Werbach, M. R. Nutritional strategies for treating chronic fatigue syndrome. Alternative Medicine Review. 5(2):93-108, 2000.
- Woo, K. S., et al. Long-term improvement in homocysteine levels and arterial endothelial function after 1-year folic acid supplementation. American Journal of Medicine. 112(7):535-539, 2002.
Heart Health™ Essential Omega 3 Fish Oil with Vitamin E
- Madsen T, Skou HA, et al, C-reactive protein, dietary n-3 fatty acids, and the extent of coronary artery disease. Am J Cardiol 88:1139-42 (2001)
- Rigelsky, JM, et al, Hawthorn: pharmacology and therapeutic uses. Am J Health Syst Pharm 59:417-22 (2002)
- Kris-Etherton PM, et al, fish consumption, fish oil, omega-3 fatty acids, and cardiovascular disease. Arterioscler Thromb Vasc Biol 23(2):e20-e30 (2003)
- Morris, MC, Sacks F, Rosner B. Does fish oil lower blood pressure? A meta-analysis of controlled trials. Circulation 88(2):523-533 (19930
- Howe PR. Dietary fats and hypertension. Focus on fish oil. Ann NY Acad Sci 827:339-352 (1997)
- Morris MC, et al, The effect of fish oil on blood pressure in mild hypertensive subjects: a randomized crossover trial. Am J Clin Nutr 57(1):59-64 (1993)
- Knapp HR, FitzGerald GA. The antihypertensive effects of fish oil. A controlled study of polyunsaturated fatty acid supplements in essential hypertension. J Engl J Med 320(16):1037-1043 (1989)
- Bonaa, KH, et al, Effect of eicosapentaenoic and docosahexaenoic acids on blood pressure in hypertension. A population-based intervention trial from the Tromso study. N Engl J Med 322(12):795-801 (1990)
- Chan JK, et al, Dietary alpha-linolenic acid is as effective as oleic acid and linoleic acid in lowering blood cholesterol in normolipidemic men. Am J Clin Nutr 53(5):1230-1234 (1991)
- Harris WS, et al, Dietary omega-3 fatty acids prevent carbohydrate-induced hypertriglyceridemia. Metabolism 33(11):1016-1019 (1984)
- Nestel PJ. Fish oil attenuates the cholesterol induced rise in lipoprotein cholesterol. Am J Clin Nutr 43(5):752-757 (1986)
- Tsai PJ, Lu SC. Fish oil lowers plasma lipid concentrations and increases the susceptibility of low density lipoprotein to oxidative modification in healthy men. J Formos Med Assoc 96(9):718-726 (1997)
- Garrido A, et al, Ingestion of high doses of fish oil increases the susceptibility of cellular membranes to the induction of oxidative stress. Lipids 24(9):833-835 (1989)
Frequently Asked Questions About the Optimal Wellness Kit
Can the Optimal Wellness Kit products be taken at the same time?
Yes. The Optimal Wellness Kit products can safely be taken at the same time, provided that one follows the recommended serving size for each product.
Why are Isotonix® supplements better than standard supplements?
Isotonix formulas are more effective than standard formulas because they offer the best way to get the maximum delivery of actives into the bloodstream. Isotonix formulas are also the fastest and most effective way to receive vitamins and minerals. The stomach has very little work to do because the pH and tonicity are carefully designed to allow the stomach to quickly release all the nutrients into the small intestine. With the Isotonix formulas, this process takes about five minutes, whereas a standard vitamin tablet can take up to four hours.
Why do I need to take a multivitamin?
A good quality vitamin and mineral supplement creates a sound micronutrient foundation to accompany a balanced diet. Vitamins and minerals help to support a healthy immune system, promote the conversion of food into energy, support a healthy cardiovascular system, support strong bones, promote mental clarity, maintain normal metabolic functioning, promote healthy growth and repair of tissues, help maintain normal blood pressure and help maintain water and electrolyte balance in the body.
What does “Activated” refer to in Isotonix Activated B Complex?
Activated refers to the active forms of vitamins B6, B12 and folic acid. Using forms other than these activated forms requires that the vitamins be enzymatically activated prior to utilization by the body. Not only does this take time and energy within the body, there are circumstances in which this reaction is either slowed or inhibited.
What is the source of fish in Heart Health™ Essential Omega 3 Fish Oil with Vitamin E?
The source of the fish oil is anchovies and sardines.
Are there any warnings or contraindications for products in the Optimal Wellness Kit?
Isotonix Multivitamin and Isotonix Activated B Complex are vegetarian products and contain no wheat, gluten, soy, yeast, artificial flavor, starch, salt, preservatives or milk. Heart Health Essential Omega III Fish Oil with Vitamin E is derived from fish and, therefore, you should not take it if you are allergic to seafood.
If you are currently using any prescription drugs, have ongoing medical condition, or if you are pregnant or breastfeeding, you should consult your healthcare provider before using this product.
Is the fish oil used in Heart Health Essential Omega III Fish Oil with Vitamin E tested for heavy metals?
Yes. The fish oil is tested twice, once from the manufacturer and then by an independent testing company. The fish oil used is laboratory-tested for mercury, lead, PCB and other heavy metals. We only use fish oil that meets or exceeds standards set by Canada (CFIA), the European Union (EU) and the United States (CRN).