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Single Tube (4 fl. oz./118 ml)

Product Information

  • Works on both the epidermis and the dermis
  • Contains three peptide formulas
  • Matrixyl® supports the skin’s ability to produce its own collagen
  • Reduces the appearance of wrinkles and furrows (especially in the brow, forehead and eye areas)
  • Promotes the look of skin firmness and thickness
  • Reduces skin discolorations and increases hydration
  • Supports smooth skin texture and color
  • Reduces the appearance of stretch marks

Product Information


In today's world, looking beautiful is one of society's top priorities. One of the most important aspects of beauty is proper skincare. Our skin is the canvas to the rest of our beauty regimen.

Whether our concern is having a flawless complexion, a glowing and vibrant color or a smooth texture, finding the best ways to keep our skin looking amazing is of utmost importance. Our skin demonstrates to the world the time, effort and value we take to look our best.

Beautiful skin should last a lifetime. External factors like pollution and internal factors like oxidative damage and poor diet often stress the skin. This leaves the skin dry and dull or oily and dirty. As part of the natural aging process, the skin begins to develop deep wrinkles and furrows around the forehead, brow and eyes. The skin loses its natural luster and color. Pentaxyl may help to decrease the appearance of deep wrinkles and furrows, and to support natural collagen production and help skin appear firm and thicker.

Pentaxyl is a proprietary blend of herbal extracts and the breakthrough formulas of the Matrixyl® Complex and Argireline, which reduce the appearance of wrinkles and furrows, help skin look thicker and firmer, and gives the skin a youthful glow. Pentaxyl has harnessed the age-fighting power of "bio-peptide" technology, with three age-fighting bio-peptides (1) Pamitoyl-Pentapeptide-3 (Matrixyl) (2) Palmitoyl Oligopeptide (3) Acetyl Hexapeptide-3 (Argireline). Peptides are a low molecular weight amino acid group that are building blocks of proteins that make up plants and animals. Palmitoyl_Pentapeptide-3 was discovered at National Institute of Health.

Pentaxyl may temporarily reduce the appearance of stretch marks. Skin will take on a more youthful appearance. While nothing can rewind time, Pentaxyl has been shown to support a beautiful, resilient, flawless look by fighting against the visible signs of aging.


by PowerReviews

(based on 88 reviews)

Ratings Distribution

  • 5 Stars



  • 4 Stars



  • 3 Stars



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  • 1 Stars




of respondents would recommend this to a friend.


  • Smells great (39)
  • Non-greasy (37)
  • Moisturizes (33)
  • Softens skin (33)
  • Minimizes wrinkles (26)


    Best Uses

    • Daily use (33)
    • Fine lines/wrinkles (29)
    • Fine lines (22)
    • Sensitive skin (17)
    • Sun damage (17)
      • Reviewer Profile:
      • Beauty conscious (19), Budget shopper (19), Survivalist / minimalist (13), Brand buyer (7), Skin care professional (3)
      • Skin Type:
      • Normal (15), Combination (12), Dry (8), Oily (4)

    Reviewed by 88 customers

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    (1 of 1 customers found this review helpful)


    Over-rated but still a nice product

    By Aradel

    from Michigan, U.S.A.

    Comments about Pentaxyl®:

    I use Pentaxyl as recommended. So far it is doing a great job of moisturizing my skin, and I have seen improvements. However, the results are a far cry from positive comments I read before purchasing. I would still use Pentaxyl, but will be looking for something that lives up to its 'hype'.


    love it lasts for a loooong time

    By ChipP

    from USA

    Comments about Pentaxyl®:

    Exfoliate with the Timeless prescription exfoliating pads and moisturize with this for one week and people start commenting on how young you look. Love it.

    (1 of 1 customers found this review helpful)


    The Perfect Facial

    By RJ the Positive Example

    from Snohomish, WA

    Staff Reviewer

    Comments about Pentaxyl®:

    I'm a 65 yr. male and have used Pentaxyl since the day it was introduced as directed. Most consider me to be in my low 50's. I have had 100's of compliments about my complexion thru the years. I can't say enough about it.


    I love this product

    By RogerR

    from USA

    Comments about Pentaxyl®:

    I've used many face moisturizers and treatments and I think Pentaxyl is one of the best I've used. I personally like the way it makes my skin feel and look. It's super easy to apply and not greasy or heavy. Pentaxyl is a great face product.


    Does what it says it does!

    By BK

    from Pittsburgh PA

    Verified Buyer

    Comments about Pentaxyl®:

    Have bought this again and again because it works for me!

    Displaying reviews 1-5

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    Acetyl Hexapeptide-3
    Acetyl Hexapeptide-3 is a unique blend of three amino acids that has been reported to reduce the appearance of wrinkles on the forehead and eyes caused by facial expression muscles. 

    Palmitoyl Oligopeptide
    Palmitoyl oligopeptide, a fragment of collagen, is a chain of five amino acids bonded together and linked to a fatty acid. Research has shown that palmitoyl oligopeptide can promote normal collagen, elastin, hyaluronic acid and glycosaminoglycans in the skin, providing your skin with a smoother, more youthful-looking appearance.

    Bearberry & Licorice Extracts
    Bearberry is a woody plant also known also as Uva ursi. The leaves contain numerous active ingredients, the most important of which is arbutin. These ingredients are responsible for the ability of Bearberry extracts to brighten the skin and help maintain healthy skin coloration.

    Licoricepromotes brightening of the skin to reduce the appearance of blotchy skin and hyper-pigmentation. It also helps soothe dry and irritated skin, and helps provide moisture and skin nourishment.

    Vitamin A
    Vitamin A is a natural antioxidant vitamin that helps to protect and nourish your skin. Vitamin A helps to maintain healthy collagen in your skin and protect your skin from free radicals, giving your skin a supple, healthy and more youthful appearance.

    Vitamin C
    Vitamin C is an important antioxidant vitamin that is essential for maintaining your skin’s natural collagen. By supporting your skin’s natural collagen, vitamin C helps your skin achieve a firmer, suppler and more youthful glow.

    Vitamin E
    Vitamin E is a powerful natural antioxidant vitamin that helps to protect and nourish your skin. Vitamin E helps to moisturize your skin while also protecting it from environmental factors, giving your skin a healthy and more youthful appearance.

    Matrixyl is the trademark name for palmitoyl pentapeptide-3. This breakthrough ingredient supports healthy collagen in the skin. Matrixyl becomes even more effective when combined with other peptides.


    How much Pentaxyl do I need to use?
    Pentaxyl is extremely concentrated and a little goes a long way. Typically, you only need an amount equal to the size of a dime to cover the facial area and about the size of a quarter when using Pentaxyl on stretch marks. These sizes may vary depending on the areas you are covering.

    When will I begin to see results?
    Pentaxyl's proprietary compounds may produce a visible reduction in the appearance of stretch marks (prominent because of their depth, length, and texture) and existing wrinkles in about 28 days.

    Will Pentaxyl help with old wrinkles/stretch marks?
    Absolutely! Pentaxyl can help no matter how long you've had your wrinkles/stretch marks - whether it's been 10 days or 10 years.

    Can I use Pentaxyl on the wrinkles/circles underneath my eyes?
    The correct way to apply Pentaxyl to the eye area is to softly massage it into the skin covering the orbital bone around the eye. Do not apply Pentaxyl directly underneath the eye or on top of the eyelid. Please use VitaShield Eye Cream which also contains Matrixyl.

    Can I use Pentaxyl with other skincare products?
    Pentaxyl can be used with virtually all other facial products. We suggest that you test any combination of skincare products on the inside of your forearm before applying it to your face. Of course, if you are using a prescription skincare product you should consult your physician. Remember, always apply Pentaxyl first, then if needed, you may apply a moisturizer or on top of Pentaxyl.

    Does Pentaxyl work on all colors of skin?