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Prime Joint Support Formula by Isotonix

Price  $73.50
$1.47
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As we age, many of us experience joint discomfort. One way of dealing with this is to take a supplement that supports bone and joint health. Like many joint health supplements, Prime Joint Support Formula by Isotonix provides the benefits of glucosamin...
Single Bottle (45 Servings)
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Prime Joint Support Formula by Isotonix

As we age, many of us experience joint discomfort. One way of dealing with this is to take a supplement that supports bone and joint health. Like many joint health supplements, Prime Joint Support Formula by Isotonix provides the benefits of glucosamine, a key ingredient that has been scientifically proven to support healthy joint function and promote the normal production of synovial fluid, which lubricates your joints.

What sets Prime Joint Support Formula by Isotonix apart is the combination of glucosamine with the powerful antioxidant Pycnogenol and hyaluronic acid - the only product among joint health supplements to deliver all three in isotonic form. The Isotonix Delivery System allows the body to do less work to obtain maximum absorption of the nutrients and superior results for your joint health.

Pycnogenol - a super antioxidant - has been shown in clinical studies to support relief from temporary inflammation associated with the normal aging process and daily activity. Hyaluronic acid helps maintain strong, healthy cartilage and promotes normal healing.

Many joint health supplements include the ingredients chondroitin and MSM (methylsulfonylmethane), but research on these two ingredients differs. One of chondroitin's mechanisms is to increase hyaluronic acid content; Prime Joint Support Formula by Isotonix instead provides hyaluronic acid directly. Meanwhile, research on MSM shows it takes large quantities of MSM daily (2-6 grams) to make a difference and see effects.

That's why we developed Prime Joint Support Formula by Isotonix to include proven joint health ingredients to help maintain optimal joint health by maintaining your joints' fluidity and flexibility, helping relieve temporary, day-to-day inflammation, and promoting the normal production and revival of your joints' cartilage.


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Benefits
Ingredients
Science
FAQ
  • Belcaro, G., et al. Variations in C-reactive protein, plasma free radicals and fibrinogen values in patients with osteoarthritis treated with Pycnogenol®. Redox Report. 13(6): 271-276, 2008.
  • Blewis, M., et al. A model of synovial fluid lubricant composition in normal and injured joints. European Cells and Materials. 13: 26-39, 2007.
  • Braham, R., et al. The effect of glucosamine supplementation on people experiencing regular knee pain. British Journal of Sports Medicine. 37(1): 45-49, 2003.
  • Canali, R., et al. The anti-inflammatory pharmacology of Pycnogenol® in humans involves COX-2 and 5-LOX mRNA expression in leukocytes. International Immunopharmacology. 9(10): 1145-1149, 2009.
  • Chang, X., et al. Inhibition of antithrombin by hyaluronic acid may be involved in the pathogenesis of rheumatoid arthritis. Arthritis Research and Therapy. 7(2): R268-R273, 2005.
  • Chou, M., et al. Effects of chondroitin and glucosamine sulfate in a dietary bar formulation on inflammation, interleukin-1beta, matrix metalloprotease-9, and cartilage damage in arthritis. Experimental Biology and Medicine. 230(4): 255-262, 2005.
  • Cisár, P., et al. Effect of pine bark extract (Pycnogenol®) on symptoms of knee osteoarthritis. Phytotherapy Research. 22: 1087-1092, 2008.
  • Elliott, A., et al. Serum hyaluronan levels and radiographic knee and hip osteoarthritis in African Americans and Caucasians in the Johnston County Osteoarthritis Project. Arthritis and Rheumatism. 52(1): 105-111, 2005.
  • Farid, R., et al. Pycnogenol® supplementation reduces pain and stiffness and improves physical function in adults with knee osteoarthritis. Nutrition Research. 27: 692-697, 2007.
  • Gaby, A. Natural treatments for osteoarthritis. Alternative Medicine Review. 4(5): 330-341, 1999.
  • Gouze, J., et al. Exogenous glucosamine globally protects chondrocytes from the arthritogenic effects of IL-1beta. Arthritis Research and Therapy. 8(6): R173
  • Grimm, T., et al. Inhibition of NF-kappaB activation and MMP-9 secretion by plasma of human volunteers after ingestion of maritime pine bark extract (Pycnogenol®). Journal of Inflammation. 3: 1-15, 2006.
  • Hua, J., et al. Inhibitory actions of glucosamine, a therapeutic agent for osteoarthritis, on the functions of neutrophils. Journal of Leukocyte Biology. 71(4): 632-640, 2002.
  • James, C. and Uhl, T. A review of articular cartilage pathology and the use of glucosamine sulfate. Journal of Athletic Training. 36(4): 413-419, 2001.
  • Julovi, S., et al. Inhibition of interleukin-1beta-stimulated production of matrix metalloproteinases by hyaluronan via CD44 in human articular cartilage. Arthritis and Rheumatism. 50(2): 516-525, 2004.
  • Laurent, T., et al. Functions of hyaluronan. Annals of the Rheumatic Disease. 54(5): 429-432, 1995.
  • Kelly, G. The role of glucosamine sulfate and chondroitin sulfates in the treatment of degenerative joint disease. Alternative Medicine Review. 3(1): 27-39, 1998.
  • McDonald, J. and Levick, J. Hyaluronan reduces fluid escape rate from rabbit knee joints disparately from its effect on fluidity. Experimental Physiology. 79(1): 103-106, 1994.
  • Nakatani, S., et al. Glucosamine regulates differentiation of a chondrogenic cell line, ATDC5. Biological and Pharmaceutical Bulletin. 30(3): 433-438, 2007.
  • Ohno, S., et al. Hyaluronan oligosaccharides induce matrix metalloproteinase 13 via transcriptional activation of NFkappaB and p38 MAP kinase in articular chondrocytes. Journal of Biological Chemistry. 281(26): 17952-17960, 2006.
  • Poustie, M., et al. N-butyryl glucosamine increases matrix gene expression by chondrocytes. Journal of Pharmacology and Experimental Therapeutics. 311(2): 610-616, 2004.
  • Reginster, J., et al. Current concepts in the therapeutic management of osteoarthritis with glucosamine. Bulletin (Hospital for Joint Disease). 63(1-2): 31-36, 2005.
  • Reginster, J., et al. Long-term effects of glucosamine sulphate on osteoarthritis progression: a randomized, placebo-controlled clinical trial. Lancet. 357(9252): 251-256, 2001.
  • Richy, F., et al. Structural and symptomatic efficacy of glucosamine and chondroitin in knee osteoarthritis: a comprehensive meta-analysis. Archives of Internal Medicine. 163(13): 1514-1522, 2003.
  • Santangelo, K., et al. Effects of hyaluronan treatment on lipopolysaccharide-challenged fibroblast-like synovial cells. Arthritis Research and Therapy. 9(1): R1, 2007.
  • Sasaki, A., et al. Hyaluronate inhibits the interleukin-1beta-induced expression of matrix metalloproteinase (MMP)-1 and MMP-3 in human synovial cells. The Tohoku Journal of Experimental Medicine. 204(2): 99-107, 2004.
  • Schäfer, A., et al. Inhibition of COX-1 and COX-2 activity by plasma of human volunteers after ingestion of French maritime pine bark extract (Pycnogenol®). Biomedicine and Pharmacotherapy. 60: 5-9, 2006.

REVIEW SNAPSHOT®

by PowerReviews
Isotonix®Prime Joint Support Formula by Isotonix
 
4.6

(based on 52 reviews)

Ratings Distribution

  • 5 Stars

     

    (37)

  • 4 Stars

     

    (12)

  • 3 Stars

     

    (1)

  • 2 Stars

     

    (1)

  • 1 Stars

     

    (1)

86%

of respondents would recommend this to a friend.

Pros

  • Simple to take (6)
  • Good value (5)
  • Increases flexibility (5)
  • Relieves pain (4)
  • Easy to take (3)

Cons

    Best Uses

    • Everyday use (9)
    • Older people (4)
    • Athletes (3)
    • Injury recovery (3)
      • Reviewer Profile:
      • First time user (6), Health conscious (4), Health enthusiast (3)

    Reviewed by 52 customers

    Sort by

    Displaying reviews 1-5

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    Previous | Next »

     
    5.0

    Prime Joint Support~ OPT the Greatest

    By California

    from Monterey Park

    About Me Rarely Work Out

    Verified Buyer

    Pros

    • Easy To Take
    • Effective
    • Tastes Good

    Cons

      Best Uses

      • Everyday Use
      • Men

      Comments about Isotonix® Prime Joint Support Formula by Isotonix:

      helps great for my join pain

      (0 of 1 customers found this review helpful)

       
      4.0

      unbelievable product.

      By manny

      from Ceiba, PR.

      About Me Very Active

      Pros

        Cons

        • Shellfish

        Best Uses

          Comments about Isotonix® Prime Joint Support Formula by Isotonix:

          I just bought the product and will start to use it. I do a lot of weight lifting and as u know your joints takes a lot of beating. My only concern is that it contains shellfish. How much I don't know. I'm somewhat allergic to shellfish. But I will take it.

          (1 of 1 customers found this review helpful)

           
          5.0

          Single serving packets

          By Barbara

          from New York city

          Comments about Isotonix® Prime Joint Support Formula by Isotonix:

          Just a suggestion. Why not make all these products in single serving packets that are easy to put in a purse, bag, backpack. It's not logical to carry around bottles every day. The packets would be wonderful

          (2 of 2 customers found this review helpful)

           
          3.0

          Humidity is the enemy here.

          By Kris

          from Baltimore, MD

          About Me Health Enthusiast , Rarely Work Out

          Verified Buyer

          Pros

          • Tastes Good

          Cons

          • Difficult To Take
          • My House Was Too Humid

          Best Uses

          • In Am Before Other Food
          • Take In Am On Empty Stoma

          Comments about Isotonix® Prime Joint Support Formula by Isotonix:

          My house is too humid and the cap would get too sticky, and I kept making a mess, so I gave it to a friend. If the delivery of the product is changed, I will try it again.

          (2 of 2 customers found this review helpful)

           
          5.0

          I would buy this product again and again

          By Cindy the nurse

          from Plymouth, NH

          About Me Health Enthusiast , Nutritionist

          SHOP CONSULTANT

          Pros

          • Easy To Take
          • Effective
          • Good Value
          • Nutritional
          • Tastes Good

          Cons

            Best Uses

            • Joint Pain Relief

            Comments about Isotonix® Prime Joint Support Formula by Isotonix:

            I take this formula every morning with my other supplements and my joints are feeling better.

            Displaying reviews 1-5

            Back to top

            Previous | Next »

             
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