Shop our Featured Stores! Earn Cashback now

Prime Joint Support Formula by Isotonix

Price  $73.50
Cashback$1.47
Cashback
As the body ages, many people experience joint discomfort. One option is to take a joint supplement to help promote overall bone and joint health. When looking at a joint supplement, there are three main ingredients found in most products on the market...
Single Bottle - (45 Servings)
Enter Quantity  
Ship Free
Calculate Shipping
by zip code
or by
state or country

One-time delivery
Save 5% by adding to AutoShip and never run out again!
  • Select an AutoShip eligible item, and toggle the "Add to AutoShip" option on the right.
  • Add as many of your favorite items as you like. Create as many AutoShips (with different delivery dates) as you need.
  • Receive a 5% discount on your AutoShip order of Market America products every time!
Something...
Add to Trend
Set Price Alert
Add to eGift
Add to Gift Registry
Save for later
|||
Store Info
 
Product Info
Prime Joint Support Formula by Isotonix

As the body ages, many people experience joint discomfort. One option is to take a joint supplement to help promote overall bone and joint health. When looking at a joint supplement, there are three main ingredients found in most products on the market: glucosamine, chondroitin and methylsulfonylmethane, more commonly referred to as MSM.

The research on both chondroitin and MSM is very controversial. Chondroitin, for instance, has very poor absorption due to its high molecular weight. Also, one of chondroitin’s mechanisms is to increase the hyaluronic acid content of synovial fluid; while the new Prime Joint Support Formula by Isotonix directly provides hyaluronic acid. Hyaluronic acid plays an important role in tissue hydration, lubrication and cellular function. Likewise, research on MSM is not conclusive. In fact, it takes large quantities of MSM daily (2-6 grams) to make a difference and see effects.*

On the other hand, the research behind glucosamine is consistent and its benefits effective. Prime Joint Support Formula contains glucosamine, naturally produced by the body and a key component of cartilage. An aminomonosaccharide (a combination of the amino acid — glutamine and a sugar — glucose), glucosamine is concentrated in joint cartilage, and has been scientifically proven to support healthy joint function and promote the normal production of synovial fluid, which lubricates your joints and regenerates cartilage.* 

Prime Joint Support Formula also contains the powerful antioxidant Pycnogenol®, which science has shown to inhibit the body’s over-active inflammatory processes associated with the normal aging process.

The body’s inflammatory response is a natural process. It is an essential component of the body’s defense system, and can be triggered from numerous internal and external factors. Pycnogenol has been shown help support the body’s defense system by inhibiting over active inflammatory responses associated with the normal aging process. To learn more the relationship between Pycnogenol and joint health, click the links below to access the full text studies.

http://www.pycnogenol.com/pdf/Pycnogenolforjointhealth.pdf
http://www.ncbi.nlm.nih.gov/pubmed/19508901
http://www.ncbi.nlm.nih.gov/pubmed/16441890

Furthermore, Prime Joint Support Formula is the only product on the market delivering glucosamine, Pycnogenol and hyaluronic acid in isotonic form.*

Isotonic, which means “same pressure,” bears the same chemical resemblance of the body’s blood, plasma and tears. All fluids in the body have a certain concentration, referred to as osmotic pressure. The body’s common osmotic pressure, which is isotonic, allows a consistent maintenance of body tissues. In order for a substance to be absorbed and used in the body’s metabolism, it must be in an isotonic state.

Isotonix® dietary supplements are delivered in an isotonic solution. This means that the body has less work to do to obtain maximum absorption of the nutrients. The isotonic state of the suspension allows nutrients to pass directly into the small intestine and rapidly absorb into the bloodstream. With Isotonix products, little nutritive value is lost, making the absorption of nutrients highly efficient while delivering maximum results.


Compare
Benefits
Ingredients
Science
FAQ
  • Belcaro, G., et al. Variations in C-reactive protein, plasma free radicals and fibrinogen values in patients with osteoarthritis treated with Pycnogenol®. Redox Report. 13(6): 271-276, 2008.
  • Blewis, M., et al. A model of synovial fluid lubricant composition in normal and injured joints. European Cells and Materials. 13: 26-39, 2007.
  • Braham, R., et al. The effect of glucosamine supplementation on people experiencing regular knee pain. British Journal of Sports Medicine. 37(1): 45-49, 2003.
  • Canali, R., et al. The anti-inflammatory pharmacology of Pycnogenol® in humans involves COX-2 and 5-LOX mRNA expression in leukocytes. International Immunopharmacology. 9(10): 1145-1149, 2009.
  • Chang, X., et al. Inhibition of antithrombin by hyaluronic acid may be involved in the pathogenesis of rheumatoid arthritis. Arthritis Research and Therapy. 7(2): R268-R273, 2005.
  • Chou, M., et al. Effects of chondroitin and glucosamine sulfate in a dietary bar formulation on inflammation, interleukin-1beta, matrix metalloprotease-9, and cartilage damage in arthritis. Experimental Biology and Medicine. 230(4): 255-262, 2005.
  • Cisár, P., et al. Effect of pine bark extract (Pycnogenol®) on symptoms of knee osteoarthritis. Phytotherapy Research. 22: 1087-1092, 2008.
  • Elliott, A., et al. Serum hyaluronan levels and radiographic knee and hip osteoarthritis in African Americans and Caucasians in the Johnston County Osteoarthritis Project. Arthritis and Rheumatism. 52(1): 105-111, 2005.
  • Farid, R., et al. Pycnogenol® supplementation reduces pain and stiffness and improves physical function in adults with knee osteoarthritis. Nutrition Research. 27: 692-697, 2007.
  • Gaby, A. Natural treatments for osteoarthritis. Alternative Medicine Review. 4(5): 330-341, 1999.
  • Gouze, J., et al. Exogenous glucosamine globally protects chondrocytes from the arthritogenic effects of IL-1beta. Arthritis Research and Therapy. 8(6): R173
  • Grimm, T., et al. Inhibition of NF-kappaB activation and MMP-9 secretion by plasma of human volunteers after ingestion of maritime pine bark extract (Pycnogenol®). Journal of Inflammation. 3: 1-15, 2006.
  • Hua, J., et al. Inhibitory actions of glucosamine, a therapeutic agent for osteoarthritis, on the functions of neutrophils. Journal of Leukocyte Biology. 71(4): 632-640, 2002.
  • James, C. and Uhl, T. A review of articular cartilage pathology and the use of glucosamine sulfate. Journal of Athletic Training. 36(4): 413-419, 2001.
  • Julovi, S., et al. Inhibition of interleukin-1beta-stimulated production of matrix metalloproteinases by hyaluronan via CD44 in human articular cartilage. Arthritis and Rheumatism. 50(2): 516-525, 2004.
  • Laurent, T., et al. Functions of hyaluronan. Annals of the Rheumatic Disease. 54(5): 429-432, 1995.
  • Kelly, G. The role of glucosamine sulfate and chondroitin sulfates in the treatment of degenerative joint disease. Alternative Medicine Review. 3(1): 27-39, 1998.
  • McDonald, J. and Levick, J. Hyaluronan reduces fluid escape rate from rabbit knee joints disparately from its effect on fluidity. Experimental Physiology. 79(1): 103-106, 1994.
  • Nakatani, S., et al. Glucosamine regulates differentiation of a chondrogenic cell line, ATDC5. Biological and Pharmaceutical Bulletin. 30(3): 433-438, 2007.
  • Ohno, S., et al. Hyaluronan oligosaccharides induce matrix metalloproteinase 13 via transcriptional activation of NFkappaB and p38 MAP kinase in articular chondrocytes. Journal of Biological Chemistry. 281(26): 17952-17960, 2006.
  • Poustie, M., et al. N-butyryl glucosamine increases matrix gene expression by chondrocytes. Journal of Pharmacology and Experimental Therapeutics. 311(2): 610-616, 2004.
  • Reginster, J., et al. Current concepts in the therapeutic management of osteoarthritis with glucosamine. Bulletin (Hospital for Joint Disease). 63(1-2): 31-36, 2005.
  • Reginster, J., et al. Long-term effects of glucosamine sulphate on osteoarthritis progression: a randomized, placebo-controlled clinical trial. Lancet. 357(9252): 251-256, 2001.
  • Richy, F., et al. Structural and symptomatic efficacy of glucosamine and chondroitin in knee osteoarthritis: a comprehensive meta-analysis. Archives of Internal Medicine. 163(13): 1514-1522, 2003.
  • Santangelo, K., et al. Effects of hyaluronan treatment on lipopolysaccharide-challenged fibroblast-like synovial cells. Arthritis Research and Therapy. 9(1): R1, 2007.
  • Sasaki, A., et al. Hyaluronate inhibits the interleukin-1beta-induced expression of matrix metalloproteinase (MMP)-1 and MMP-3 in human synovial cells. The Tohoku Journal of Experimental Medicine. 204(2): 99-107, 2004.
  • Schäfer, A., et al. Inhibition of COX-1 and COX-2 activity by plasma of human volunteers after ingestion of French maritime pine bark extract (Pycnogenol®). Biomedicine and Pharmacotherapy. 60: 5-9, 2006.

REVIEW SNAPSHOT®

by PowerReviews
Isotonix®Prime Joint Support Formula by Isotonix
 
4.6

(based on 47 reviews)

Ratings Distribution

  • 5 Stars

     

    (34)

  • 4 Stars

     

    (11)

  • 3 Stars

     

    (0)

  • 2 Stars

     

    (1)

  • 1 Stars

     

    (1)

88%

of respondents would recommend this to a friend.

Pros

  • Simple to take (6)
  • Increases flexibility (5)
  • Good value (4)
  • Relieves pain (4)

Cons

    Best Uses

    • Everyday use (7)
    • Older people (4)
    • Athletes (3)
    • Injury recovery (3)
      • Reviewer Profile:
      • First time user (6), Health conscious (4)

    Reviewed by 47 customers

    Sort by

    Displaying reviews 1-5

    Back to top

    Previous | Next »

    (1 of 1 customers found this review helpful)

     
    5.0

    IT WORKS!!!

    By BevG

    from USA

    Comments about Isotonix® Prime Joint Support Formula by Isotonix:

    I've been using this since the end of February of this year. And it works!!! The main reason I purchased this was to help my spine. Very glad I did. Plus, my knees feel better - and they're not why I originally began using this! I absolutely recommend this for your joints!

    (2 of 2 customers found this review helpful)

     
    5.0

    works great

    By sarahc

    from USA

    Comments about Isotonix® Prime Joint Support Formula by Isotonix:

    After 3 days, this supplement really began to work and now I have virtually no pain in my knees which is impressive with how much time I am on my feet! Love it and will continue to take it!

    (1 of 1 customers found this review helpful)

     
    5.0

    No More Pain

    By Mary JeanH

    from USA

    Comments about Isotonix® Prime Joint Support Formula by Isotonix:

    My husband who I met 10 years ago, had a noticeable limp and alot of pain in his knees. He is 6'10" and played college and pro basketball. Numerous surgeries created his issues, but since taking Prime Joint Support for over a year, the limp and pain are both gone!!

     
    5.0

    Amazing!

    By RickH

    from USA

    Comments about Isotonix® Prime Joint Support Formula by Isotonix:

    I just had to post this! I had fallen in the house and twice withing the following two days got almost stuck in the bent over position. Both times I immediately took a cap and 1/2 of this product and within 15 min or less the issue was greatly improved! WOO HOO! I know I do need to see my chiropractor, but this works better and faster than any anti-inflammatory OTC drugs and is not a drug! I always take it anyway, but for those times an extra shot is needed... it worked for me!

    (1 of 1 customers found this review helpful)

     
    5.0

    life changing

    By DonnaB

    from USA

    Comments about Isotonix® Prime Joint Support Formula by Isotonix:

    I have had arthritis in my hands for the last 15 years. I've taken many supplements to alleviate the pain but nothing worked. I started taking Prime Joint three months ago. It took approximately two months for me to notice a difference but it was worth the wait. It has changed my life. If you are suffering from joint pain, I highly recommend this product.

    Displaying reviews 1-5

    Back to top

    Previous | Next »

     
    Product information and prices are provided by merchants and/or third party sources. At SHOP.COM we do everything we can to ensure the accuracy of the product information or prices displayed, but occasionally, errors occur. Please notify SHOP.COM of any information or pricing inaccuracies so that we may immediately notify the merchants to correct the problem. We apologize for any inconvenience this may cause.

    Thanks for signing up for email deals!

    We'll send the emails to:

    Here at SHOP.COM, we take your privacy very seriously. Please take the time to review our privacy policy.

    Happy shopping!

    Close