What Makes Ultra Prime™ Secretagogue HGH Enhancer Unique?
Ultra Prime represents the next generation of HGH-producing products that is far more advanced, concentrated and cost-effective than previous formulations. It uses a special blend of nutritional ingredients that will naturally increase the production and release of HGH by the pituitary gland. The very latest anti-aging neuroendocrine research reveals that hormone production is integral in maintaining optimal health. Market America is leading the anti-aging fight by developing a system of advanced nutraceuticals with scientifically based formulations.*
HGH, or human growth hormone, is the master hormone that drives the growth and development of the body. It causes the liver to produce powerful insulin-like growth factors (IGF), which contribute to the maintenance of lean body mass and the health of the body's vital organs.
Research has proven that HGH-secreting cells of the pituitary gland do not die; they maintain their ability to make significant amounts of natural growth hormone. As part of the aging process, less HGH circulates through the body, because the pituitary gland is not stimulating its production. A secretagogue enhancer stimulates the pituitary to naturally produce and secrete HGH, raising the level of this valuable hormone within the body. Ultra Prime serves as a trigger to safely and naturally stimulate the pituitary gland.*
The scientifically-based formulation in Ultra Prime Secretagogue HGH Enhancer features potent amino acids and nutrients that are combined in a precise peptide formulation with other biologically active nutrients. When taken as directed, these ingredients work synergistically as a powerful secretagogue to effectively raise HGH levels. Powerful amino acids such as L-Glutamine, L-Arginine, L-Lysine, Glycine and Colosotrum, which have been shown to increase HGH levels, and nutrients from Prime Factor, are combined in a precise peptide formulation with other biologically active proteins to effectively raise HGH levels.*
Ultra Prime Secretagogue HGH Enhancer is a natural secretagogue that works as an HGH releaser, raising HGH levels in an entirely physiological manner. It gently stimulates the endocrine system to produce and release its own HGH naturally. It works with the body and not against it. The ingredients work synergistically to maximize the effectiveness of the potent amino acids and active nutrients. You can now give your body a firm push in the right direction so it can help itself.*
Ultra Prime Secretagogue HGH Enhancer is not only superior to similar products in the marketplace; it is in a class by itself. The specific amino acids and other natural ingredients are the result of years of study and research. The ingredients in Ultra Prime Secretagogue HGH Enhancer have been scientifically proven to raise HGH levels in the body. The amounts of these ingredients have been carefully selected to provide you with the most powerful and natural HGH Secretagogue formulation on the market today.*
*These statements have not been evaluated by the Food and Drug Administration. This product(s) is not intended to diagnose, treat, cure or prevent any disease.
- Functions as a secretagogue to naturally increase the production and secretion of HGH by the brain’s pituitary gland
- Acts as a safe, natural and effective secretagogue “trigger” to wake up the pituitary gland
- Increases the production and secretion of your body’s own natural HGH
- Recreates a youthful, natural pattern of HGH production and release into the body
- Raises the level of HGH secreted by the body
- Serves to enhance the production of selected hormones that ordinarily diminish during the aging process
- Acts to significantly reverse the effects associated with the body growing older
- Helps maintain the health of the body’s vital organs
- Functions as an anabolic [agent] to build muscle
- Builds protein to create lean body mass
- Reshapes your body by building lean body mass and facilitating the breakdown of fat
- Helps increase strength Helps increase energy
- Maintains cardiovascular health
- Helps increase endurance
- Maintains immune health
- Assists in improving sexual vitality
- Increases the body’s metabolic rate to help break down fat and burn calories
- Influences the growth of cells that comprise bones, muscles and other organs throughout the body
- Maintains joint health
L-Arginine Aspartate: 2.5 g, L-Arginine: 3 g
L-arginine is an amino acid found in many foods such as dairy products, meat, poultry, fish, nuts and chocolate. It supports several processes in the body, including cell division, normal healing and immune function, and the secretion of important hormones in the body. L-arginine ultimately contributes to the secretion of human growth hormone (HGH) and prolactin via stimulating the pituitary gland and pancreatic release of glucagon and insulin. L-arginine also promotes the normal production of nitric oxide (NO), a substance that helps blood vessels remain relaxed (termed vasodilation). L-arginine supplements may prove to be a good way to maintain healthy circulation to the heart and other blood vessels. These effects have been exhibited in various double-blind, placebo-controlled studies.
Glycine: 4 g
Glycine is the simplest amino acid used to make proteins. It works hand in hand with L-glutamine, another amino acid playing supporting brain function. Glycine has shown some positive implications in regard to supporting mental function. Another study hypothesizes that glycine may enhance memory and mental function. Glycine alone — and in combination with other amino acids — has shown to support normal healing.*
Proprietary Blend: L-Glutamine, Colostrum, L-Lysine (as L-Lysine HCL), Taurine, DNA/RNA (from brewer’s yeast)
L-Glutamine is an amino acid derived from another amino acid, glutamic acid. L-helps maintain the health of the immune system, digestive tract and muscle cells. It acts as fuel for the cells that line the intestines. Heavy exercise, infection, surgery and trauma can decrease the body's glutamine reserves, especially in muscle cells.
Colostrum is the clear/cloudy pre-milk that female mammals secrete prior to producing milk. Colostrum for dietary supplements is usually derived from cows and contains lactoferrin, lactoperoxidase, lysozyme, lactalbumin, glycoproteins, cytokines, polypeptides, growth factors, and vitamins and minerals. Colostrum is claimed to help support the immune system, healthy bowel movements, support the gastrointestinal tract, and improve exercise performance and recovery.
L-Lysine is a protein amino acid, classified as an essential amino acid, which means that it must be obtained through the diet. Some proteins, such as those found in meat, poultry and milk, are rich in L-lysine. Wheat germ is rich in L-lysine. Small amounts of free L-lysine are found in vegetables, vegetable juices, and in fermented foods like miso and yogurt. In the liver, L-lysine and other amino acids support protein production. It may promote the normal formation of D-glucose and glycogen, as well as lipids. It may also help to produce energy.
Taurine is a nonprotein amino acid and found in high amounts in the brain, retina, myocardium, skeletal and smooth muscle, platelets and neutrophils. It is plentiful in the fluids of muscle, lungs and nerve tissue. Dietary taurine mainly comes from animal food sources. Taurine is also present in plant food sources, as well as seaweeds in smaller amounts. It is classified as an essential amino acid, and it supports normal micelle formation and fat absorption. It’s important in the hydration of the body and gives an energy boost by stimulating the cells’ nutrient uptake, as well as promoting physical reaction time. Further, it boosts mental alertness and enhances the ability to concentrate. Taurine also has antioxidant activities and supports stable membranes. It helps maintain healthy cholesterol and blood pressure. It may also help maintain a healthy cardiovascular system while delivering detoxifying activities.
DNA/RNA is the genetic material that we all have stored in our bodies at most cellular levels, governing a variety of body processes. DNA, which makes up the genetic material, is made up of units called nucleotides. Some recent research shows that the body may not always produce adequate amounts of its own DNA and RNA. There are certain conditions in which the body requires dietary nucleic acids and or nucleotides to meet its physiological needs. These conditions include rapid growth, limited food supply and metabolic stress. Under these conditions, metabolic demand exceeds the capacity of de novo synthesis. Under these conditions, dietary nucleosides, nucleotides and nucleic acids become essential nutrients. Dietary nucleotides may spare the energetic cost of de novo synthesis of nucleotides. Dietary nucleic acids are found in plant and animal foods. DNA/RNA supplementation may support the immune system and promote normal tissue-regeneration.
Folate (as Folic Acid): 150 mcg
Folic acid is mainly found in fruits and vegetables. Dark, leafy greens, oranges and orange juice, beans and peas are the best sources, as well as Brewer’s yeast, which supplies additional B-vitamins.
Folic acid plays a key role by boosting the benefits of B12 supplementation. These two B-vitamins work together in maintaining normal red blood cells. Folic acid supports the normal utilization of amino acids and proteins, as well as promotes the normal construction of the material for DNA and RNA synthesis. Scientific studies have found that when working in tandem with folic acid, B12 is capable of promoting normal homocysteine levels. This works toward supporting a healthy nervous system.*
Magnesium (as magnesium citrate): 150 mg
Foods rich in magnesium include unpolished grains, nuts and green vegetables. Green, leafy vegetables are potent sources of magnesium. The average daily magnesium intake in the U.S. for males nine years and older is estimated to be about 323 milligrams; for females nine years and older, it is estimated to be around 228 milligrams.
Magnesium is a component of the mineralized part of bone and is necessary for the metabolism of potassium and calcium in adults. It helps maintain normal levels of potassium, phosphorus, calcium, adrenaline and insulin. It also promotes the normal mobilization of calcium, transporting it inside the cell for further utilization, thus making it helpful in maintaining bone health. It promotes the normal functioning of muscle and nervous tissue. Magnesium supports the normal synthesis of all proteins, nucleic acids, nucleotides, cyclic adenosine monophosphate, lipids and carbohydrates. This mineral also promotes kidney and bladder health.
Magnesium promotes normal energy release, regulation of the body temperature, and proper nerve function, helping the body handle stress and regulating metabolism. Magnesium works with calcium to support the regulation of the heart and blood pressure. Importantly, magnesium promotes the building of healthy bones and teeth, and proper muscle development. If taken in relatively high amounts, it works with calcium and vitamin D to help keep bones strong.
What will Ultra Prime™ Secretagogue HGH Enhancer do for me?
Ultra Prime™ Secretagogue HGH Enhancer helps build muscle and increase secretion of human growth hormone (HGH), which governs the body’s growth, aging and health maintenance. HGH helps influence the growth of cells that naturally decline as you age.*
Are there any conditions where I cannot take Prime products?
As noted on the product warning, if you currently have any cancerous condition, had a reoccurrence of a malignancy or have any benign tumors, we are recommending that you do not take Prime.
If you have a history of any cancer or tumorous growths and you are more than five years in complete remission, we are suggesting that you check with your personal physician before taking this product and monitor the condition closely for any recurrence.
People with severe liver or kidney disease, uncontrolled diabetes, or those who are pregnant, should not take this product.
If you are suffering from any other complex medical condition or endocrinological disorder, you should discuss taking Prime with your physician first.
If your liver function tests are above the normal limits, you should consult with your private physician before taking this product.
Prime products are natural. We are not providing specific medical advice for any condition.
If you have specific questions regarding a particular medical condition you may have and the use of this product, please take the Prime educational literature to your private physician and discuss those issues in detail.
Can I take Prime if I have diseases of the thyroid?
If you are under the care of a physician for any medical condition, you should consult your physician before taking any dietary supplement.
Can I take Prime if I am on hormonal replacement therapy?
If you are under the care of a physician for any medical condition, you should consult your physician before taking any dietary supplement.
Can I have my serum growth hormone levels done by my doctor to see if Prime is working?
The best way to see if Prime is working for you is to give the product a three-month test trial and see how you feel. If you are seeing positive changes in the way you feel, continue taking the product.
Several Prime users have had their human growth hormone levels measured incorrectly. The measuring of growth hormone is very complex. Many labs use different techniques to measure HGH and due to lack of standardization, some of them may not be valid. Serum HGH must be measured while fasting in the early morning without any carbohydrates taken within three hours of the blood being drawn. It must be handled and processed correctly and is a very costly test. HGH surges in the blood stream throughout the day. It enters and leaves the blood stream quickly. Blood tests may miss that surge and show a low level.
If you decide to get your blood tested, it is important to measure Insulin-like Growth Factor type I levels to see if they are being increased. Remember that Human Growth Hormone stimulates the synthesis and release of Insulin-like Growth Factors of which IGF-I is the most abundant.
Most importantly, if you wish to have your blood tests done, you must first get baseline blood levels of HGH and IGF-I while off of Prime. You should stop the product for at least two weeks and then start Prime after your baseline blood tests have been done. After staying on Prime consistently for one to three months, you should get your blood test done in one to two hours after Prime ingestion.
Measuring HGH and IGF-I levels at different intervals while on Prime will serve no purpose. What you want to see is an increase in HGH and IGF-I levels in your blood while on Prime compared to while off Prime.
How is Human Growth Factor different from HGH secretagogues?
HGH secretagogues function as combination HGH stimulant and releasing compounds. These generally contain a combination of amino acids and peptides designed to enhance the pituitary gland’s ability to release HGH. Human Growth Factors are soluble proteins, vitamins and botanicals that act as humoral regulators, which modulate the functional activities of individual cells and tissues throughout the body.
- Abdelhamed AI, Reis SE, Sane DC, et al. No effect of an L-arginine-enriched medical food (HeartBars) on endothelial function and platelet aggregation in subjects with hypercholesterolemia. Am Heart J. 2003.;145:E15.
- AHFS Drug Information. Bethesda, Md: American Society of Hospital Pharmacists. 2000:2306–2307. Akobeng AK, Miller V, Stanton J, et al. Double-blind randomized controlled trial of glutamine-enriched polymeric diet in the treatment of active Crohn's disease. J Pediatr Gastroenterol Nutr . 2000; 30:78–84.
- Alverdy JC. Effects of glutamine-supplemented diets on immunology of the gut. JPEN J Parenter Enteral Nutr .1990; 14(suppl 4):109S–113S.
- Baecker N, Boese A, Schoenau E et al. L-Arginine, the Natural Precursor of NO, Is Not Effective for Preventing Bone Loss in Postmenopausal Women. J Bone Miner Res. 2005; 20:471-9.
- Baligan M, Giardina A, Giovannini G, et al. L-arginine and immunity. Study of pediatric subjects [translated from Italian]. Minerva Pediatr . 1997; 49:537–542.
- Battaglia C, Salvatori M, Maxia N, et al. Adjuvant L-arginine treatment for in-vitro fertilization in poor responder patients. Hum Reprod. 1999; 14:1690–1697.
- Beale R, Bryg D, Bihari D. Immunonutrition in the critically ill: A systematic review of clinical outcome. Crit Care Med. 1999; 27:2799–2805.
- Bednarz B, Jaxa-Chamiec T, Maciejewski P et al. Efficacy and safety of oral l-arginine in acute myocardial infarction. Results of multicenter, randomized, double-blind, placebo-controlled ARAMI pilot trial. Kardiol Pol. 2005; 62:421-427.
- Bednarz B, Wolk R, Chamiec T, et al. Effects of oral L-arginine supplementation on exercise-induced QT dispersion and exercise tolerance in stable angina pectoris. Int J Cardiol . 2000; 75:205–210.
- Boger RH, Bode-Boger SM, Thiele W, et al. Restoring vascular nitric oxide formation by L-arginine improves the symptoms of intermittent claudication in patients with peripheral arterial occlusive disease. J Am Coll Cardiol. 1998; 32:1336–1344.
- Bruinsma KA, Anderson BE, Prendergast JJ, et al. Effects of an L-arginine-enriched medical food in patients with type II diabetes [abstract]. Diabetes. 2001; 50(suppl 2):Abst #1796-PO.
- Buckley, Abbott, Martin, Brinkworth & Whyte Effect of an oral bovine colostrum supplement (intact TM ) on running performance. Abstract from: 1998 Australian Conference of Science and Medicine in Sport, Adelaide, South Australia, October 1998.
- Castell LM, Newsholme EA. Glutamine and the effects of exhaustive exercise upon the immune response. Can J Physiol Pharmacol. 1998; 76:524–532.
- Castell LM, Newsholme EA. The effects of oral glutamine supplementation on athletes after prolonged, exhaustive exercise. Nutrition. 1997; 13:738–742.
- Castell LM, Poortmans JR, Newsholme EA. Does glutamine have a role in reducing infections in athletes? Eur J Appl Physiol Occup Physiol. 1996; 73:488–490.
- Chen J, Wollman Y, Chernichovsky T, et al. Effect of oral administration of high-dose nitric oxide donor L-arginine in men with organic erectile dysfunction: results of a double-blind, randomized placebo-controlled study. BJU Int. 1999; 83:269–273.
- Civitelli R, Villareal DT, Agnusedei D, et al. Dietary L-lysine and calcium metabolism in humans. Nutrition . 1992; 8:400-405.
- Clark RH, Feleke G, Din M, et al. Nutritional treatment for acquired immunodeficiency virus-associated wasting using beta-hydroxy beta-methylbutyrate, glutamine, and arginine: a randomized, double-blind, placebo-controlled study. JPEN J Parenter Enteral Nutr . 2000; 24:133–139.
- Daniele B, Perrone F, Gallo C, et al. Oral glutamine in the prevention of fluorouracil induced intestinal toxicity: a double blind, placebo controlled, randomised trial. Gut. 2001;48:28–33.
- De Aloysio D, Mantuano R, Mauloni M, et al. The clinical use of arginine aspartate in male infertility. Acta Eur Fertil . 1982; 13:133–167.
- De Gouw HW, Verbruggen MB, Twiss IM, et al. Effect of oral L-arginine on airway hyperresponsiveness to histamine in asthma. Thorax. 1999; 54:1033-1035.
- De Koning TJ, Duran M, Dorland L, et al. Beneficial effects of L-serine and glycine in the management of seizures in 3-phosphoglycerate dehydrogenase deficiency. Ann Neurol . 1998; 44:261–265.
- De Nicola L, Bellizzi V, Minutolo R, et al. Randomized, double-blind, placebo controlled study of arginine supplementation in chronic renal failure. Kidney Int. 1999; 56:674–684.
- Den Hond E, Hiele M, Peeters M, et al. Effect of long-term oral glutamine supplements on small intestinal permeability in patients with Crohn's disease. JPEN J Parenter Enteral Nutr . 1999; 23:7–11.
- Di Giovanna JJ, Blank H. Failure of lysine in frequently recurrent herpes simplex infection. Treatment and prophylaxis. Arch Dermatol . 1984; 120:48-51.
- Diaz P, Bhaskara S, Dursun SM et al. Double-blind, Placebo-Controlled, Crossover Trial of Clozapine Plus Glycine in Refractory Schizophrenia Negative Results. J Clin Psychopharmacol . 2005; 25:277-278.
- Evins AE, Fitzgerald SM, Wine L, et al. Placebo-controlled trial of glycine added to clozapine in schizophrenia. Am J Psychiatry . 2000; 157:826-828.
- File SE, Fluck E, Fernandes C. Beneficial effects of glycine (Bioglycin) on memory and attention in young and middle-aged adults. J Clin Psychopharmacol . 1999; 19:506–512.
- Flondin NW. The metabolic roles, pharmacology, and toxicology of lysine. J Am Coll Nutr. 1997; 16:7-21.
- Fox AD, Kripke SA, Berman JR, et al. Reduction of the severity of enterocolitis by glutamine-supplemented enteral diets. Surg Forum . 1987; 38:43–44.
- Fries MH, Rinaldo P, Schmidt-Sommerfeld E, et al. Isovaleric acidemia: response to a leucine load after three weeks of supplementation with glycine, L-carnitine, and combined glycine-carnitine therapy. J Pediatr . 1996; 129:449–452.
- Fujita T, Sakurai K. Efficacy of glutamine-enriched enteral nutrition in an experimental model of mucosal ulcerative colitis. Br J Surg . 1995; 82:749–751.
- Garcia-de-Lorenzo A, Zarazaga A, Garcia-Luna PP, et al. Clinical evidence for enteral nutritional support with glutamine: a systematic review. Nutrition . 2003; 19:805-11.
- Grasemann H, Grasemann C, Kurtz F, et al. Oral L-arginine supplementation in cystic fibrosis patients: a placebo-controlled study. Eur Respir J . 2005; 25:62-8.
- Greenberg and Cello. 1996. Treatment of severe diarrhea caused by Cryptosporidium parvum with oral bovine immunoglobulins concentrate in patients with AIDS. J. AIDS and Hum. Retrovirol. 13:348-354.
- Griffith RS, De Long DC, Nelson JD. Relation of L-arginine—lysine antagonism to herpes simplex growth in tissue culture. Chemotherapy. 1981; 27:209-213.
- Griffith RS, DeLong DC, Nelson J. Relation of arginine-lysine antagonism to herpes simplex growth in tissue culture. Chemotherapy. 1981; 27:209–213.
- Griffith RS, Walsh DE, Myrmel KH, et al. Success of L-lysine therapy in frequently recurrent herpes simplex infection. Treatment and prophylaxis. Dermatologica . 1987; 175:183-190.
- Griffiths RD, Jones C, Palmer TE. Six-month outcome of critically ill patients given glutamine-supplemented parenteral nutrition. Nutrition . 1997; 13:295–302.
- Gusev EI, Skvortsova VI, Dambinova SA, et al. Neuroprotective effects of glycine for therapy of acute ischaemic stroke. Cerebrovasc Dis . 2000; 10:49–60.
- Hambrecht R, Hilbrich L, Erbs S, et al. Correction of endothelial dysfunction in chronic heart failure: additional effects of exercise training and oral L-arginine supplementation. J Am Coll Cardiol. 2000; 35:706–713.
- Harvey SG, Gibson JR, Burke CA. L-cysteine, glycine and dl-threonine in the treatment of hypostatic leg ulceration: a placebo-controlled study. Pharmatherapeutica . 1985; 4:227–230.
- Heresco-Levy U, Ermilov M, Lichtenberg P, et al. High-dose glycine added to olanzapine and risperidone for the treatment of schizophrenia. Biol Psychiatry. 2004; 55:165-71.
- Heresco-Levy U, Javitt DC, Ermilov M, et al. Efficacy of high-dose glycine in the treatment of enduring negative symptoms of schizophrenia. Arch Gen Psychiatry . 1999; 56:29–36.
- Huffman FG, Walgren ME. L-Glutamine supplementation improves nelfinavir-associated diarrhea in HIV-infected individuals. HIV Clin Trials . 2003; 4:324-9.
- Itoh T, Ito T, Ohba S, et al. Effect of carnitine administration on glycine metabolism in patients with isovaleric acidemia: significance of acetylcarnitine determination to estimate the proper carnitine dose. Tohoku JExp Med . 1996; 179:101–109.
- Javitt DC, Balla A, Sershen H, et al. A.E. Bennett Research Award. Reversal of phencyclidine-induced effects by glycine and glycine transport inhibitors. Biol Psychiatry . 1999; 45:668–679.
- Javitt DC, Zylberman I, Zukin SR, et al. Amelioration of negative symptoms in schizophrenia by glycine. Am J Psychiatry . 1994; 151:1234–1236.
- Javitt DC. Management of negative symptoms of schizophrenia. Curr Psychiatry Rep . 2001; 3:413-417.
- Kelly, Chetham, Keates, Bostwick, Roush, Castagliuolo, LaMont and Pothoulakis. 1997. Survival of anti-Clostridium difficile bovine immunoglobulin concentrate in the human gastrointestinal tract. Antimicrobial Agents and Chemother. 41;236-241.
- Kelly, Pothoulakis, Vavva, Castagliuolo, Bostwick, O'Keane, Keates and LaMont. 1996. Anti-Clostridium difficile bovine immunoglobulin concentrate inhibits cytotoxicity and enterotoxicity of C. difficile toxins. Antimicrobial Agents and Chemother. 40:373-379.
- Khan F, Litchfield SJ, McLaren M, et al. Oral L-arginine supplementation and cutaneous vascular responses in patients with primary Raynaud's phenomenon. Arthritis Rheum . 1997; 40:352–357.
- Khogali SE, Pringle SD, Weryk BV, et al. Is glutamine beneficial in ischemic heart disease? Nutrition. 2002; 18:123–126.
- Korting GE, Smith SD, Wheeler MA, et al. A randomized double-blind trial of oral L-arginine for treatment of interstitial cystitis. J Urol. 1999; 161:558–565.
- Lebret T, Herve JM, Gorny P, et al. Efficacy and safety of a novel combination of L-arginine glutamate and yohimbine hydrochloride: a new oral therapy for erectile dysfunction. Eur Urol. 2002; 41:608-613.
- Lo JC, Chertow GM, Rennke H, Seifter JL. Fanconi's syndrome and tubulointestinal nephritis in association with L-lysine ingestion. Am J Kidney Dis. 1996; 28:614-617.
- Luiking YC, Weusten BL, Portincasa P, et al. Effects of long-term oral L-arginine on esophageal motility and gallbladder dynamics in healthy humans. Am J Physiol . 1998;274(6 pt 1):G984–G991.
- Mackinnon LT, Hooper SL. Plasma glutamine and upper respiratory tract infection during intensified training in swimmers. Med Sci Sports Exerc. 1996;28:285–290.
- Mansoor JK, Morrissey BM, Walby WF et al. L-Arginine Supplementation Enhances Exhaled NO, Breath Condensate VEGF, and Headache at 4342 m. High Alt Med Biol. 2005;6:289-300.
- Martinez-Abundis E, Kam-Ramos AM, Hernandez-Salazar E, Gonzalez-Ortiz. Effect of glycine on insulin secretion, fasting and postprandial glucose levels in patients with type 2 diabetes mellitus. 18th International Diabetes Federation Congress, Paris, August 24-29, 2003;abstract 758.
- Maxwell A. Annual meeting of American College of Cardiology, 1999. Maxwell AJ, Anderson BE, Cooke JP. Nutritional therapy for peripheral arterial disease: a double-blind, placebo-controlled, randomized trial of HeartBar. Vasc Med. 2000;5(1):11-9.
- Maxwell AJ, Zapien MP, Pearce GL, et al. Randomized trial of a medical food for the dietary management of chronic, stable angina. J Am Coll Cardiol . 2002; 39:37–45.
- McCune MA, Perry HO, Muller SA, O'Fallon WM. Treatment of recurrent herpes simplex infections with L-lysine monohydrochloride. Cutis . 1984; 34:366-373.
- Mebane AH. L-Glutamine and mania [letter]. Am J Psychiatry. 1984; 141:1302–1303. Mero, A., Miikkulainen, H., Riski, J., Pakkanen, R., Aalto, J., Takala, T. (1997). Effects of bovine colostrum supplementation on serum IGF-1, IgG, hormone and saliva IgA during training. J. Appl. Physiol. 83(4): 1144-1151.
- Meston CM, Worcel M. The effects of yohimbine plus L-arginine glutamate on sexual arousal in postmenopausal women with sexual arousal disorder. Arch Sex Behav. 2002; 31:323-332.
- Meston CM, Worcel M. The effects of yohimbine plus L-arginine glutamate on sexual arousal in postmenopausal women with sexual arousal disorder. Arch Sex Behav. 2002; 31:323-332.
- Moriguti JC, Ferriolli E, Donadi EA et al. Effects of arginine supplementation on the humoral and innate immune response of older people. Eur J Clin Nutr. 2005 Jul 27 [Epub ahead of print].
- Morris CR, Morris Jr. SM, Hagar W, et al. Arginine therapy: a new treatment for pulmonary hypertension in sickle cell disease? Am J Respir Crit Care Med . 2003; 168:63-9.
- Mroueh A. Effect of arginine on oligospermia. Fertil Steril . 1970; 21:217–219. Parker JO, Parker JD, Caldwell RW, et al. The effect of supplemental L-arginine on tolerance development during continuous transdermal nitroglycerin therapy. J Am Coll Cardiol. 2002;39:1199-1203.
- Piatti PM, Monti LD, Valsecchi G, et al. Long-term oral L-arginine administration improves peripheral and hepatic insulin sensitivity in type 2 diabetic patients. Diabetes Care. 2001;24:875–880.
- Playford RJ, Floyd DN, Macdonald CE, Calnan DP , Adenekan RO, Johnson W, Goodlad RA, Marchbank T. Bovine colostrum is a health food supplement which prevents NSAID induced gut damage. Gut 1999 May: 44(5): 653-8.
- Potkin SG, Jin Y, Bunney BG, et al. Effect of clozapine and adjunctive high-dose glycine in treatment-resistant schizophrenia. Am J Psychiatry . 1999; 156:145–147.
- Pryor JP, Blandy JP, Evans P, et al. Controlled clinical trial of arginine for infertile men with oligozoospermia. Br J Urol. 1978; 50:47-50.
- Quan ZF, Yang C, Li N, Li JS. Effect of glutamine on change in early postoperative intestinal permeability and its relation to systemic inflammatory response. World J Gastroenterol . 2004; 10:1992-4.
- Rajamohan T, Kurup PA. Lysine: arginine ratio of a protein influences cholesterol metabolism: Part 1-studies on sesame protein having low lysine: arginine ratio. Indian J Exp Biol . 1997; 35:1218-1223.
- Rector TS, Bank AJ, Mullen KA, et al. Randomized, double-blind, placebo-controlled study of supplemental oral L-arginine in patients with heart failure. Circulation . 1996; 93:2135–2141.
- Rohde T, MacLean DA, Hartkopp A, et al. The immune system and serum glutamine during a triathlon. Eur J Appl Physiol . 1996; 74:428–434.
- Rose ML, Cattley RC, Dunn C, et al. Dietary glycine prevents the development of liver tumors caused by the peroxisome proliferator WY-14, 643. Carcinogenesis . 1999; 20:2075–2081.
- Rowbottom DG, Keast D, Morton AR, et al. The emerging role of glutamine as an indicator of exercise stress and overtraining. Sports Med . 1996; 21:80–97.
- Rytlewski K, Olszanecki R, Korbut R et al. Effects of prolonged oral supplementation with l-arginine on blood pressure and nitric oxide synthesis in preeclampsia. Eur J Clin Invest. 2005; 35:32-7.
- Schachter A, Friedman S, Goldman JA, et al. Treatment of oligospermia with the amino acid arginine. Int J Gynaecol Obstet. 1973; 11:206–209.
- Schulman SP, Becker LC, Kass DA, et al. L-Arginine therapy in acute myocardial infarction. The Vascular Interaction With Age in Myocardial Infarction (VINTAGE MI) randomized clinical trial. JAMA. 2006; 295(1): 58-64.
- Semba J. Glycine therapy of schizophrenia; its rationale and a review of clinical trials [translated from Japanese]. Nihon Shinkei Seishin Yakurigaku Zasshi . 1998; 18:71–80.
- Shabert JK, Winslow C, Lacey JM, et al. Glutamine-antioxidant supplementation increases body cell mass in AIDS patients with weight loss: a randomized, double-blind controlled trial. Nutrition . 1999; 15:860–864.
- Sopala M, Schweizer S, Schafer N, et al. Neuroprotective activity of a nanoparticulate formulation of the glycineB site antagonist MRZ 2/576 in transient focal ischaemia in rats. Arzneimittelforschung . 2002; 52:168-74.
- Staff AC, Berge L, Haugen G, et al. Dietary supplementation with L-arginine or placebo in women with pre-eclampsia. Acta Obstet Gynecol Scand . 2004; 83:103-7.
- Tacket, Binion, Bostwick, Losonsky, Roy and Edelman. 1992. Efficacy of bovine milk immunoglobulins concentrate in preventing illness after Shigella flexneri challenge. Amer. J. Trop. Med. Hyg. 47:276-283.
- Takahashi, Eisenhuth, Lee, Schachtele, Laible and Binion. 1992. Nonspecific antibacterial factors in milk from cows immunized with human oral bacterial pathogens. J. Dairy Sci. 75:1810-1820.
- Tanimura J. Studies on arginine in human semen. II. The effects of medication with L-arginine-HCl on male infertility. Bull Osaka Med Sch . 1967; 13:84–89.
- Tatlisumak T, Takano K, Meiler MR, Fisher M. A glycine site antagonist ZD9379 reduces number of spreading depressions and infarct size in rats with permanent middle cerebral artery occlusion. Acta Neurochir Suppl . 2000; 76:331-333.
- Thein DJ, Hurt WC. Lysine as a prophylactic agent in the treatment of recurrent herpes simplex labialis. Oral Surg Oral Med Oral Pathol. 1984; 58:659-666.
- Thurman RG, Zhong Z, von Frankenberg M, et al. Prevention of cyclosporine-induced nephrotoxicity with dietary glycine. Transplantation . 1997;63:1661–1667.
- Tollemar, Gross, Dolgiras, Jarstrand, Ringdén and Hammarström. 1999. Fungal prophylaxis by reduction of fungal colonization by oral administration of bovine anti-Candida antibodies in bone marrow transplant recipients. Bone Marrow Transpl. 23:283-290.
- Van der Hulst RR, van Kreel BK, von Meyenfeldt MF, et al. Glutamine and the preservation of gut integrity. Lancet . 1993; 341:1363–1365.
- Warny, Fatimi, Bostwick, Laine, Lebel, LaMont, Pothoulakis, Kelly. 1999. Bovine immunoglobulins concentrate-Clostridium difficile retains C. difficile toxin neutralizing activity after passage through the human stomach and small intestine. Gut 44:212-217.
- Watanabe G, Tomiyama H, Doba N. Effects of oral administration of L-arginine on renal function in patients with heart failure. J Hypertens. 2000;18:229–234.
- Yin M, Ikejima K, Arteel GE, et al. Glycine accelerates recovery from alcohol-induced liver injury. J Pharmacol Exp Ther . 1998; 286:1014–1019.
- Zhong Z, Arteel GE, Connor HD, et al. Cyclosporin A increases hypoxia and free radical production in rat kidneys: prevention by dietary glycine. Am J Physiol . 1998;275:F595–RF604.
- Zoli G, Care M, Falco F, et al. Effect of oral glutamine on intestinal permeability and nutritional status in Crohn's disease [abstract]. Gastroenterology . 1995;108:A766.