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Isotonix® Resveratrol

Isotonix® Resveratrol

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Poor cellular and cardiovascular health is becoming a worldwide epidemic. An unhealthy diet of processed, high-calorie, high-fat foods, pollution, smoking and sedentary lifestyles all contribute to poor cell and heart health. Scientists revealed The Fr...
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Isotonix® Resveratrol

Poor cellular and cardiovascular health is becoming a worldwide epidemic. An unhealthy diet of processed, high-calorie, high-fat foods, pollution, smoking and sedentary lifestyles all contribute to poor cell and heart health. Scientists revealed The French Paradox, which states that even though the French drink, smoke and eat high-fat foods they have some of the lowest incidences of poor cardiovascular and cellular health. Scientists attribute this to the large amounts of red wine that the French consume or, more importantly, an extract found in red wine: resveratrol. Resveratrol is an ingredient with incredible clinical research, revealing that it supports cardiovascular and normal cell health. Because wine is so highly processed, the actual amount of resveratrol is quite low. One would have to drink at least three bottles of red wine a day to experience the effects of resveratrol extract. Additionally, the content of resveratrol in red wine is inconsistent and varies by type of wine, region and processing techniques. Resveratrol extract or, more specifically, Resveravine®, which is a more concentrated form of resveratrol, ensures that the body reaps all of the benefits of resveratrol, without the ill effects from three bottles of wine.*

 

Isotonix Resveratrol is an isotonic-capable supplement, made from three patented ingredients: Resveravinewith 20% resveratrol extract, BioVin® Advanced with 5% resveratrol extract, and VitaBlue® (wild blueberry extract), designed to promote normal cell health. Isotonix Resveratrol works to maintain cell health, promote normal cell cycle activity, promote apoptosis (programmed cell death) in unhealthy cells, support the normal activity of the SIRT-1 gene, and promote cardiovascular health, by promoting healthy platelet activity, promoting vasorelaxation, and providing antioxidant protection of LDL particles. Resveravineis a combination of trans-resveratrol (20% purity) and viniferin extracted from vine stems, which work synergistically to enhance the effectiveness of resveratrol extract. Trans-resveratrol is the predominate isomer found in red wine grapes and juice, and Resveravine is 100 to 300 times more concentrated in trans-resveratrol than other products from grape skin. According to the Linus Pauling Institute at Oregon State University, trans-resveratrol may have a higher bioavailability than other isomers of resveratrol. Resveravine provides a higher level of free radical defense against oxidative stress, stronger promotion of normal cellular activity, and higher antioxidant protection of LDL particles than pure resveratrol extract.*

 

Studies of numerous species have shown that a reduction in calories has been linked to a longer lifespan. The SIRT-1 gene activates a critical component of calorie restriction in mammals and promotes fat metabolization. There is evidence that resveratrol may be a calorie restriction mimetic, a compound that mimics the effects of calorie restriction by targeting metabolic and stress response pathways affected by calorie restriction, but without restricting caloric intake, which may be helpful in promoting a longer lifespan. By promoting healthy SIRT-1 activity, resveratrol promotes healthy mitochondrial function and supports energy expenditure, thereby promoting a healthy weight.*

 

Isotonic, which means “same pressure,” bears the same chemical resemblance of the body’s blood, plasma and tears. All fluids in the body have a certain concentration, referred to as osmotic pressure. The body’s common osmotic pressure, which is isotonic, allows a consistent maintenance of body tissues. In order for a substance to be absorbed and used in the body’s metabolism, it must be in an isotonic state.

 

Isotonix dietary supplements are delivered in an isotonic solution. This means that the body has less work to do to obtain maximum absorption of the nutrients. The isotonic state of the suspension allows nutrients to pass directly into the small intestine and rapidly absorb into the bloodstream. With Isotonix products, little nutritive value is lost, making the absorption of nutrients highly efficient while delivering maximum results.

striction in mammals and promotes fat metabolization. There is evidence that resveratrol may be a calorie restriction mimetic, a compound that mimics the effects of calorie restriction by targeting metabolic and stress response pathways affected by calorie restriction, but without restricting caloric intake, which may be helpful in promoting a longer lifespan. By promoting healthy SIRT-1 activity, resveratrol promotes healthy mitochondrial function and supports energy expenditure, thereby promoting a healthy weight.*

 

Isotonic, which means “same pressure,” bears the same chemical resemblance of the body’s blood, plasma and tears. All fluids in the body have a certain concentration, referred to as osmotic pressure. The body’s common osmotic pressure, which is isotonic, allows a consistent maintenance of body tissues. In order for a substance to be absorbed and used in the body’s metabolism, it must be in an isotonic state.

 

Isotonix dietary supplements are delivered in an isotonic solution. This means that the body has less work to do to obtain maximum absorption of the nutrients. The isotonic state of the suspension allows nutrients to pass directly into the small intestine and rapidly absorb into the bloodstream. With Isotonix products, little nutritive value is lost, making the absorption of nutrients highly efficient while delivering maximum results.

striction in mammals and promotes fat metabolization. There is evidence that resveratrol may be a calorie restriction mimetic, a compound that mimics the effects of calorie restriction by targeting metabolic and stress response pathways affected by calorie restriction, but without restricting caloric intake, which may be helpful in promoting a longer lifespan. By promoting healthy SIRT-1 activity, resveratrol promotes healthy mitochondrial function and supports energy expenditure, thereby promoting a healthy weight.*

 

Isotonic, which means “same pressure,” bears the same chemical resemblance of the body’s blood, plasma and tears. All fluids in the body have a certain concentration, referred to as osmotic pressure. The body’s common osmotic pressure, which is isotonic, allows a consistent maintenance of body tissues. In order for a substance to be absorbed and used in the body’s metabolism, it must be in an isotonic state.

 

Isotonix dietary supplements are delivered in an isotonic solution. This means that the body has less work to do to obtain maximum absorption of the nutrients. The isotonic state of the suspension allows nutrients to pass directly into the small intestine and rapidly absorb into the bloodstream. With Isotonix products, little nutritive value is lost, making the absorption of nutrients highly efficient while delivering maximum results.

striction in mammals and promotes fat metabolization. There is evidence that resveratrol may be a calorie restriction mimetic, a compound that mimics the effects of calorie restriction by targeting metabolic and stress response pathways affected by calorie restriction, but without restricting caloric intake, which may be helpful in promoting a longer lifespan. By promoting healthy SIRT-1 activity, resveratrol promotes healthy mitochondrial function and supports energy expenditure, thereby promoting a healthy weight.*

 

Isotonic, which means “same pressure,” bears the same chemical resemblance of the body’s blood, plasma and tears. All fluids in the body have a certain concentration, referred to as osmotic pressure. The body’s common osmotic pressure, which is isotonic, allows a consistent maintenance of body tissues. In order for a substance to be absorbed and used in the body’s metabolism, it must be in an isotonic state.

 

Isotonix dietary supplements are delivered in an isotonic solution. This means that the body has less work to do to obtain maximum absorption of the nutrients. The isotonic state of the suspension allows nutrients to pass directly into the small intestine and rapidly absorb into the bloodstream. With Isotonix products, little nutritive value is lost, making the absorption of nutrients highly efficient while delivering maximum results.

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The health properties associated with red wine have intrigued doctors and scientists for centuries, but only in recent times has intensive study revealed the unique benefits of resveratrol for both cardiovascular health and antioxidant defense at the cellular level. Only Isotonix provides resveratrol in its most bioavailable form, and surpasses competing products by incorporating an exceptional combination of BioVin® full spectrum grape extract and Resveravine®. This patented concentrate delivers up to 300 times the amount of trans-resveratrol as other products, offering protection against cholesterol oxidation, promoting vascular health and providing optimum ORAC value.

The health properties associated with red wine have intrigued doctors and scientists for centuries, but only in recent times has intensive study revealed the unique benefits of resveratrol for both cardiovascular health and antioxidant defense at the cellular level. Only Isotonix provides resveratrol in its most bioavailable form, and surpasses competing products by incorporating an exceptional combination of BioVin® full spectrum grape extract and Resveravine®. This patented concentrate delivers up to 300 times the amount of trans-resveratrol as other products, offering protection against cholesterol oxidation, promoting vascular health and providing optimum ORAC value.


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FAQ
FAQ
  • Aggarwal B et al. Role of resveratrol in prevention and therapy of cancer: preclinical and clinical studies. Anticancer Research. 24(5A):2783-840, 2004.
  • Bauer, J. H., et al. An accelerated assay for the identification of lifespan-extending interventions in Drosophila melanogaster. Proc Natl Acad Sci U S A. 101:12980-12985, 2004.
  • Baur J et al. Resveratrol improves health and survival of mice on a high-calorie diet.
    Nature. 444(7117):337-42, 2006.
  •  Belguendouz, L., et al. Resveratrol inhibits metal ion-dependent and independent peroxidation of porcine low-density lipoproteins. Biochemical Pharmacology. 53(9):1347-1355, 1997.
  • Bhat K et al. Biological effects of resveratrol. Antioxidants and Redox Signaling. 3(6):1041-64, 2001. Review.
  • Borra M et al. Mechanism of human SIRT1 activation by resveratrol. Journal of Biological Chemistry. 280(17):17187-95, 2005.
  • Chen Y. Resveratrol-induced cellular apoptosis and cell cycle arrest in neuroblastoma cells and antitumor effects on neuroblastoma in mice. Surgery.136(1):57-66, 2004.
  • Dario et al. Resveratrol prolongs life span and retards the onset of age-related markers in a short-lived vertebrae. Current Biology, 2006.
  • Ding, X. Z., et al. Resveratrol inhibits proliferation and induces apoptosis in human pancreatic cancer cells. Pancreas. 25(4):71-76, 2002.
  • Dong Z. Molecular mechanism of the chemopreventive effect of resveratrol. Mutation Research. 523-524:145-150, 2003.
  • Donnelly L et al. Anti-inflammatory Effects of Resveratrol in Lung Epithelial Cells: Molecular Mechanisms. Am J Physiol Lung Cell Mol Physiol, 2004 .
  • Faria A et al. Antioxidant properties of prepared blueberry (Vaccinium myrtillus) extracts. Journal of Agricultural and Food Chemistry. 53(17):6896-902, 2005.
  • Frémont L. Biological effects of resveratrol. Life Sciences 66:663-673, 2000.
  • Fremont, L., et al. Antioxidant activity of resveratrol and alcohol-free wine polyphenols related to LDL oxidation and polyunsaturated fatty acids. Life Sciences. 64(26
    • Aggarwal B et al. Role of resveratrol in prevention and therapy of cancer: preclinical and clinical studies. Anticancer Research. 24(5A):2783-840, 2004.
    • Bauer, J. H., et al. An accelerated assay for the identification of lifespan-extending interventions in Drosophila melanogaster. Proc Natl Acad Sci U S A. 101:12980-12985, 2004.
    • Baur J et al. Resveratrol improves health and survival of mice on a high-calorie diet.
      Nature. 444(7117):337-42, 2006.
    •  Belguendouz, L., et al. Resveratrol inhibits metal ion-dependent and independent peroxidation of porcine low-density lipoproteins. Biochemical Pharmacology. 53(9):1347-1355, 1997.
    • Bhat K et al. Biological effects of resveratrol. Antioxidants and Redox Signaling. 3(6):1041-64, 2001. Review.
    • Borra M et al. Mechanism of human SIRT1 activation by resveratrol. Journal of Biological Chemistry. 280(17):17187-95, 2005.
    • Chen Y. Resveratrol-induced cellular apoptosis and cell cycle arrest in neuroblastoma cells and antitumor effects on neuroblastoma in mice. Surgery.136(1):57-66, 2004.
    • Dario et al. Resveratrol prolongs life span and retards the onset of age-related markers in a short-lived vertebrae. Current Biology, 2006.
    • Ding, X. Z., et al. Resveratrol inhibits proliferation and induces apoptosis in human pancreatic cancer cells. Pancreas. 25(4):71-76, 2002.
    • Dong Z. Molecular mechanism of the chemopreventive effect of resveratrol. Mutation Research. 523-524:145-150, 2003.
    • Donnelly L et al. Anti-inflammatory Effects of Resveratrol in Lung Epithelial Cells: Molecular Mechanisms. Am J Physiol Lung Cell Mol Physiol, 2004 .
    • Faria A et al. Antioxidant properties of prepared blueberry (Vaccinium myrtillus) extracts. Journal of Agricultural and Food Chemistry. 53(17):6896-902, 2005.
    • Frémont L. Biological effects of resveratrol. Life Sciences 66:663-673, 2000.
    • Fremont, L., et al. Antioxidant activity of resveratrol and alcohol-free wine polyphenols related to LDL oxidation and polyunsaturated fatty acids. Life Sciences. 64(26):2511-2521, 1999.
    • Garvin S et al. Resveratrol induces apoptosis and inhibits angiogenesis in human breast cancer xenografts in vivo. Cancer Letters. 231(1):113-22, 2006.
    • Goh S et al. The red wine antioxidant resveratrol prevents cardiomyocyte injury following ischemia-reperfusion via multiple sites and mechanisms. Antioxidant Redox Signal. 9(1):101-13, 2007.
    • Hao H et al. Mechanisms of cardiovascular protection by resveratrol. Journal of Medicinal Food. 7(3):290-298, 2004.
    • Heynekamp J et al. Substituted trans-stilbenes, including analogues of the natural product resveratrol, inhibit the human tumor necrosis factor alpha-induced activation of transcription factor nuclear factor kappaB. Journal of Medicinal Chemistry. 49(24):7182-9, 2006.
    • Holmes-McNary M and Baldwin A Jr. Chemopreventive properties of trans-resveratrol are associated with inhibition of activation of the IkappaB kinase. Cancer Research. 60:3477-3483, 2000.
    • Hou D et al. Molecular Mechanisms Behind the Chemopreventive Effects of Anthocyanidins. Journal of Biomedicine and Biotechnology. 2004: (5):321-325, 2004.
    • Hou D. Potential mechanisms of cancer chemoprevention by anthocyanins. Current Molecular Medicine. 3(2):149-159, 2003.
    • Howitz, K. T., et al. Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature. 425(6954):191-6, 2003.
    • Hung L et al. Cardioprotective effect of resveratrol, a natural antioxidant derived from grapes. Cardiovascular Research. 47:549-555, 2000.
    • Hung L et al. Resveratrol protects myocardial ischemia-reperfusion injury through both NO-dependent and NO-independent mechanisms. Free Radicals in Biology and Medicine. 36(6):774-81, 2004.
    • Hwang J et al. Resveratrol induces apoptosis in chemoresistant cancer cells via modulation of AMPK signaling pathway. Annals NY Academy of Sciences. 1095:441-8,2007.
    • Ignatowicz E and Baer W. Resveratrol, a natural chemopreventive agent against degenerative diseases. Polish Journal of Pharmacology. 53(6):557-69, 2001.
    • Jang M et al. Cancer chemopreventive activity of resveratrol, a):2511-2521, 1999.
    • Garvin S et al. Resveratrol induces apoptosis and inhibits angiogenesis in human breast cancer xenografts in vivo. Cancer Letters. 231(1):113-22, 2006.
    • Goh S et al. The red wine antioxidant resveratrol prevents cardiomyocyte injury following ischemia-reperfusion via multiple sites and mechanisms. Antioxidant Redox Signal. 9(1):101-13, 2007.
    • Hao H et al. Mechanisms of cardiovascular protection by resveratrol. Journal of Medicinal Food. 7(3):290-298, 2004.
    • Heynekamp J et al. Substituted trans-stilbenes, including analogues of the natural product resveratrol, inhibit the human tumor necrosis factor alpha-induced activation of transcription factor nuclear factor kappaB. Journal of Medicinal Chemistry. 49(24):7182-9, 2006.
    • Holmes-McNary M and Baldwin A Jr. Chemopreventive properties of trans-resveratrol are associated with inhibition of activation of the IkappaB kinase. Cancer Research. 60:3477-3483, 2000.
    • Hou D et al. Molecular Mechanisms Behind the Chemopreventive Effects of Anthocyanidins. Journal of Biomedicine and Biotechnology. 2004: (5):321-325, 2004.
    • Hou D. Potential mechanisms of cancer chemoprevention by anthocyanins. Current Molecular Medicine. 3(2):149-159, 2003.
    • Howitz, K. T., et al. Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature. 425(6954):191-6, 2003.
    • Hung L et al. Cardioprotective effect of resveratrol, a natural antioxidant derived from grapes. Cardiovascular Research. 47:549-555, 2000.
    • Hung L et al. Resveratrol protects myocardial ischemia-reperfusion injury through both NO-dependent and NO-independent mechanisms. Free Radicals in Biology and Medicine. 36(6):774-81, 2004.
    • Hwang J et al. Resveratrol induces apoptosis in chemoresistant cancer cells via modulation of AMPK signaling pathway. Annals NY Academy of Sciences. 1095:441-8,2007.
    • Ignatowicz E and Baer W. Resveratrol, a natural chemopreventive agent against degenerative diseases. Polish Journal of Pharmacology. 53(6):557-69, 2001.
    • Jang M et al. Cancer chemopreventive activity of resveratrol, a natural product derived from grapes. Science. 275:218-220, 1997.
    • Jang M et al. Cancer chemopreventive activity of resveratrol. Drugs in Experimental Clinical Research. 25:65-77, 1999.
    • Kaeberlein M et al. Substrate-specific activation of sirtuins by resveratrol. Journal of Biological Chemistry. 280(17):17038-45, 2005.
    • Kim, Y. A., et al. Antiproliferative effect of resveratrol in human prostate carcinoma cells. Journal of Medicinal Food. 6(4):273-280, 2003.
    • Kopp P. Resveratrol, a phytoestrogen found in red wine. A possible explanation for the conundrum of the 'French paradox'? European Journal of Endocrinology. 138(6):619-620, 1998.
    • Kundu, J. K., et al. Resveratrol inhibits phorbol ester-induced cyclooxygenase-2 expression in mouse skin: MAPKs and AP-1 as potential molecular targets. Biofactors. 21(1-4):33-39, 2004.
    • Lagouge M et al. Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT-1 and PGC-1alpha. Cell. 127(6):1109-22, 2006.
    • Lepoivre M et al. Resveratrol, a remarkable inhibitor of ribonucleotide reductase. FEBS Letters. 421:277-279, 1998.
    • Lin J et al. Chemoprevention of cancer and cardiovascular disease by resveratrol.
      Proceedings of the National Science Council Republic of China. 23(3):99-106, 1999. Review.
    • Manna S et al. Resveratrol suppresses TNF-induced activation of nuclear transcription factors NF-kappaB, activator protein-1 and apoptosis: potential role of oxygen intermediates and lipid peroxidation. Journal of Immunology. 164(12):6509-6516, 2000.
    • Martín A et al. Resveratrol, a polyphenol found in grapes, suppresses oxidative damage and stimulates apoptosis during early colonic inflammation in rats. Biochemical Pharmacology. 67(7):1399-410, 2004.
    • Martín A et al. The effects of resveratrol, a phytoalexin derived from red wines, on chronic inflammation induced in an experimentally induced colitis model. British Journal of Pharmacology. 147(8):873-85, 2006.
    • Martinez J and Moreno J. Effect of resveratrol, a natural polyphenolic compound, on reactive oxygen species and prostaglandin production. Biochemical Pharmacology. 59:865-870, 2000.
    • Mgbonyebi O. Antiproliferative effect of synthetic resveratrol on human breast epithelial cells. International Journal of Oncology. 12(4):865-869, 1998 natural product derived from grapes. Science. 275:218-220, 1997.
    • Jang M et al. Cancer chemopreventive activity of resveratrol. Drugs in Experimental Clinical Research. 25:65-77, 1999.
    • Kaeberlein M et al. Substrate-specific activation of sirtuins by resveratrol. Journal of Biological Chemistry. 280(17):17038-45, 2005.
    • Kim, Y. A., et al. Antiproliferative effect of resveratrol in human prostate carcinoma cells. Journal of Medicinal Food. 6(4):273-280, 2003.
    • Kopp P. Resveratrol, a phytoestrogen found in red wine. A possible explanation for the conundrum of the 'French paradox'? European Journal of Endocrinology. 138(6):619-620, 1998.
    • Kundu, J. K., et al. Resveratrol inhibits phorbol ester-induced cyclooxygenase-2 expression in mouse skin: MAPKs and AP-1 as potential molecular targets. Biofactors. 21(1-4):33-39, 2004.
    • Lagouge M et al. Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT-1 and PGC-1alpha. Cell. 127(6):1109-22, 2006.
    • Lepoivre M et al. Resveratrol, a remarkable inhibitor of ribonucleotide reductase. FEBS Letters. 421:277-279, 1998.
    • Lin J et al. Chemoprevention of cancer and cardiovascular disease by resveratrol.
      Proceedings of the National Science Council Republic of China. 23(3):99-106, 1999. Review.
    • Manna S et al. Resveratrol suppresses TNF-induced activation of nuclear transcription factors NF-kappaB, activator protein-1 and apoptosis: potential role of oxygen intermediates and lipid peroxidation. Journal of Immunology. 164(12):6509-6516, 2000.
    • Martín A et al. Resveratrol, a polyphenol found in grapes, suppresses oxidative damage and stimulates apoptosis during early colonic inflammation in rats. Biochemical Pharmacology. 67(7):1399-410, 2004.
    • Martín A et al. The effects of resveratrol, a phytoalexin derived from red wines, on chronic inflammation induced in an experimentally induced colitis model. British Journal of Pharmacology. 147(8):873-85, 2006.
    • Martinez J and Moreno J. Effect of resveratrol, a natural polyphenolic compound, on reactive oxygen species and prostaglandin production. Biochemical Pharmacology. 59:865-870, 2000.
    • Mgbonyebi O. Antiproliferative effect of synthetic resveratrol on human breast epithelial cells. International Journal of Oncology. 12(4):865-869, 1998.
    • Nielsen M et al. Resveratrol reverses tumor-promoter-induced inhibition of gap-junctional intercellular communication. Biochemical and Biophysical Research Communications. 275:804-809, 2000.
    • Olas B and Wachowicz B. Resveratrol and vitamin C as antioxidants in blood platelets. Thrombosis Research. 106(2):143-8, 2002.
    • Olas B and Wachowicz B. Resveratrol reduces oxidative stress induced by platinum compounds in blood platelets. General Physiology and Biophysics. 23(3):315-26, 2004.
    • Olas B et al. Effect of resveratrol, a natural polyphenolic compound, on platelet activation induced by endotoxin or thrombin. Thrombosis Research. 107(3-4):141-5, 2002.
    • Olas B et al. Resveratrol protects against peroxynitrite-induced thiol oxidation in blood platelets. Cellular and Molecular Biology Letters. 9(4A):577-87, 2004.
    • Pace-Asciak C et al. The red wine phenolics trans-resveratrol and quercetin block human platelet aggregation and eicosanoid synthesis: implications for protection against coronary heart disease. Clin Chim Acta. 235:207-219, 1995
    • Picard F et al. Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma. Nature. 429(6993):771-776, 2004.
    • Porcu M et al. The emerging therapeutic potential of sirtuin-interacting drugs: from cell death to lifespan extension. Trends in Pharmacological Sciences 26, 2005.
    • Pozo-Guisado, E., et al. Resveratrol-induced apoptosis in MCF-7 human breast cancer cells involves a caspase-independent mechanism with downregulation of Bcl-2 and NF-kappaB. International Journal of Cancer 115(1):74-84, 2005.
    • Provinciali M et al. Effect of resveratrol on the development of spontaneous mammary tumors in HER-2/neu transgenic mice. International Journal of Cancer. 115(1):36-45, 2005.
    • Sato M et al. Journal of Cardiovascular Pharmacology. 35(2):263-268, 2000.
    • Schneider Y et al. Anti-proliferative effect of resveratrol, a natural component of grapes and wine, on human colonic cancer cells. Cancer Letters. 158(1):85-91, 2000.
    • Sinclair D et al. Resveratrol improves health and survival of mice on a high-calorie diet. Nature, 2006.
    • Nielsen M et al. Resveratrol reverses tumor-promoter-induced inhibition of gap-junctional intercellular communication. Biochemical and Biophysical Research Communications. 275:804-809, 2000.
    • Olas B and Wachowicz B. Resveratrol and vitamin C as antioxidants in blood platelets. Thrombosis Research. 106(2):143-8, 2002.
    • Olas B and Wachowicz B. Resveratrol reduces oxidative stress induced by platinum compounds in blood platelets. General Physiology and Biophysics. 23(3):315-26, 2004.
    • Olas B et al. Effect of resveratrol, a natural polyphenolic compound, on platelet activation induced by endotoxin or thrombin. Thrombosis Research. 107(3-4):141-5, 2002.
    • Olas B et al. Resveratrol protects against peroxynitrite-induced thiol oxidation in blood platelets. Cellular and Molecular Biology Letters. 9(4A):577-87, 2004.
    • Pace-Asciak C et al. The red wine phenolics trans-resveratrol and quercetin block human platelet aggregation and eicosanoid synthesis: implications for protection against coronary heart disease. Clin Chim Acta. 235:207-219, 1995
    • Picard F et al. Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma. Nature. 429(6993):771-776, 2004.
    • Porcu M et al. The emerging therapeutic potential of sirtuin-interacting drugs: from cell death to lifespan extension. Trends in Pharmacological Sciences 26, 2005.
    • Pozo-Guisado, E., et al. Resveratrol-induced apoptosis in MCF-7 human breast cancer cells involves a caspase-independent mechanism with downregulation of Bcl-2 and NF-kappaB. International Journal of Cancer 115(1):74-84, 2005.
    • Provinciali M et al. Effect of resveratrol on the development of spontaneous mammary tumors in HER-2/neu transgenic mice. International Journal of Cancer. 115(1):36-45, 2005.
    • Sato M et al. Journal of Cardiovascular Pharmacology. 35(2):263-268, 2000.
    • Schneider Y et al. Anti-proliferative effect of resveratrol, a natural component of grapes and wine, on human colonic cancer cells. Cancer Letters. 158(1):85-91, 2000.
    • Sinclair D et al. Resveratrol improves health and survival of mice on a high-calorie diet. Nature, 2006.
    • Sovak M. Grape extract, resveratrol, and its analogs: a review. Journal of Medicinal Food. 4(2):93-105, 2001.
    • Subbaramaiah K et al. Resveratrol inhibits cyclooxygenase-2 transcription and activity in phorbol ester-treated human mammary epithelial cells. Journal of Biological Chemistry. 273:21875-21882, 1998.
    • Subbaramaiah K et al. Resveratrol inhibits cyclooxygenase-2 transcription in human mammary epithelial cells. Annal NY Academy Sciences. 889:214-223, 2000.
    • Szende B et al. Dose-dependent effect of resveratrol on proliferation and apoptosis in endothelial and tumor cell cultures. Experimental and Molecular Medicine. 32(2):88-92, 2000.
    • Tsai S et al. Suppression of nitric oxide synthase and the down-regulation of the activation of NF-kappaB in macrophages by resveratrol. British Journal of Pharmacology 126:673-680, 1999.
    • Wang Z et al. Effects of red wine and wine polyphenol resveratrol on platelet aggregation in vivo and in vitro. International Journal of Molecular Medicine. 9(1):77-9, 2002.
    • Yi W et al. Phenolic compounds from blueberries can inhibit colon cancer cell proliferation and induce apoptosis. Journal of Agricultural and Food Chemistry 53(18):7320-9, 2005.
    • Zou J et al. Effect of red wine and wine polyphenol resveratrol on endothelial function in hypercholesterolemic rabbits. Int J Mol Med. 11(3):317-20, 2003.
    • Zou J et al. Suppression of mitogenesis and regulation of cell cycle traverse by resveratrol in cultured smooth muscle cells. International Journal of Oncology. 15:647-651, 1999.
    e="Verdana">Sovak M. Grape extract, resveratrol, and its analogs: a review. Journal of Medicinal Food. 4(2):93-105, 2001.
  • Subbaramaiah K et al. Resveratrol inhibits cyclooxygenase-2 transcription and activity in phorbol ester-treated human mammary epithelial cells. Journal of Biological Chemistry. 273:21875-21882, 1998.
  • Subbaramaiah K et al. Resveratrol inhibits cyclooxygenase-2 transcription in human mammary epithelial cells. Annal NY Academy Sciences. 889:214-223, 2000.
  • Szende B et al. Dose-dependent effect of resveratrol on proliferation and apoptosis in endothelial and tumor cell cultures. Experimental and Molecular Medicine. 32(2):88-92, 2000.
  • Tsai S et al. Suppression of nitric oxide synthase and the down-regulation of the activation of NF-kappaB in macrophages by resveratrol. British Journal of Pharmacology 126:673-680, 1999.
  • Wang Z et al. Effects of red wine and wine polyphenol resveratrol on platelet aggregation in vivo and in vitro. International Journal of Molecular Medicine. 9(1):77-9, 2002.
  • Yi W et al. Phenolic compounds from blueberries can inhibit colon cancer cell proliferation and induce apoptosis. Journal of Agricultural and Food Chemistry 53(18):7320-9, 2005.
  • Zou J et al. Effect of red wine and wine polyphenol resveratrol on endothelial function in hypercholesterolemic rabbits. Int J Mol Med. 11(3):317-20, 2003.
  • Zou J et al. Suppression of mitogenesis and regulation of cell cycle traverse by resveratrol in cultured smooth muscle cells. International Journal of Oncology. 15:647-651, 1999.
*These statements have not been evaluated by the Food and Drug Administration. This product(s) is not intended to diagnose, treat, cure or prevent any disease.

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Isotonix® Resveratrol
 
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(based on 32 reviews)

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of respondents would recommend this to a friend.

Pros

  • Simple to take (19)
  • Good taste (15)
  • Acts quickly (9)
  • Produces results (9)
  • Boosts energy (6)

Cons

  • No results (3)

Best Uses

  • Daily use (15)
  • Women (9)
  • Daily prevention (8)
  • Older people (8)
  • Men (7)
    • Reviewer Profile:
    • Regular user (12), First time user (11), Health conscious (9)

Reviewed by 32 customers

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Displaying reviews 1-5

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4.0

I think it works

By WenluanZ

from USA

Comments about Isotonix® Resveratrol:

I am not sure about its effect. My rash is almost gone while I take essential kit and Astaxanthin at the same time. So I think they all contribute to this.

(0 of 1 customers found this review helpful)

 
5.0

Great stuff. Taste gret

By Fang-ting AKA AmandaL

from USA

Comments about Isotonix® Resveratrol:

Great stuff. Taste gret

 
5.0

Awesome

By MarkM

from USA

Comments about Isotonix® Resveratrol:

Love this product & take it every day!

 
5.0

Powerful Antioxident!

By CatM

from USA

Comments about Isotonix® Resveratrol:

I think the last person reviewed it forgot to give it stars. This is a very powerful antioxident and it tastes very good too. I'm glad this product is available in isotonix form. I take it with my OPC-3 every morning!

 
5.0

Excellent Product

By looking good

from toms river, nj

Verified Buyer

Comments about Isotonix® Resveratrol:

This product was referred to me by my doctor years ago and I was sold on it and have continued to buy it. It promotes itself because of the ingredients it contains and how effective they seem to be.
I have gotten many compliments on how healthy and young I look for my age.

Displaying reviews 1-5

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