Formulated as the best antioxidant
Validated by research
20x
stronger than vitamin C
50x
stronger than vitamin E
95%
intestinal nutrient delivery for max absorption
Oligomeric proanthocyanadins (OPCs) are bioflavonoids (complex organic compounds) found in fruits, vegetables and certain tree barks that provide exceptional nutritional benefits to the human body.

The Super Antioxidant in OPC-3
Pycnogenol® Isotonix OPC-3 contains the only isotonic form of Pycnogenol® in the world. Pycnogenol® is a natural plant extract from the bark of the French maritime pine tree and the most clinically researched and potent bioflavonoid.

Product Classification

Gluten-Free

Non-GMO

Isotonic

Vegan

Good Manufacturing Practices

Dairy Free
Directions for use

Pour 1 small capful (3.3 g) of powder into a cup.

Add water 2 fl. oz/60 mL of water for each capful and stir.

Enjoy once a day. For maximum absorption take an empty stomach.
Key Ingredients & Benefits

Grape Seed Extract*
Maintains healthy cholesterol levels

Red Wine Extract*
Powerful antioxidant

Bilberry Extract*
Powerful antioxidant
Supports healthy vision
Maintains healthy circulation

Citrus Extract (Bioflavaniods)*
Promotes cardiovascular health
Maintains healthy circulation
World's Most Powerful Antioxidant
Outperforming any conventional antioxidant on the market, discover this ultimate supplement designed to supercharge for health and longevity!
Isotonix Delivery System

:05 minutes
Isotonix Liquid Vitamins
- Formulated to survive digestion.
- Delivers concentrated nutrients to the site of absorption.
- Contains no fillers or binders.
- No artificial color or flavors.

:40 minutes
Standard Vitamin Tablet
- Contains lab-created coatings and lubricants.
- Often contains artificial colors, nutrients and flavors.
- Limited absorption of nutrient utilization.
Frequently Asked Questions
What makes Isotonix OPC-3 special?
Isotonix OPC-3 contains bioflavonoids, plant compounds that support cardiovascular health, healthy circulation and skin, joint and tissue integrity; it uses a unique Isotonix delivery system for fast, effective absorption and includes scientifically proven antioxidants to fight free radicals, making it one of the most powerful products available.
How quickly does Isotonix OPC-3 work?
Thanks to its liquid, isotonic form, Isotonix OPC-3 is absorbed quickly by the small intestine, entering the bloodstream within minutes; this rapid absorption allows the body to benefit almost immediately.
Why should everyone take Isotonix OPC-3?
Free radicals cause oxidative stress, which contributes to aging, circulation and heart and immune health. OPCs are powerful antioxidants — with more staying power than vitamins C and E — that help neutralize free radicals. Taking OPC-3 daily is essential for combating free radical damage and promoting health.
Why should healthy or athletic people use Isotonix OPC-3?
Even athletes experience free radical damage from increased oxygen use during exercise, which can affect muscle performance and endurance. Studies show OPCs promote endurance, reduce mild muscle cramps and support healthy blood flow, helping muscles recover and perform.
Does OPC-3 benefit people who menstruate?
Yes, studies show OPCs mensural cramps.
What is Pycnogenol?
Pycnogenol is a patented extract from French maritime pine bark, supported by over 120 clinical studies; it acts as a powerful antioxidant, helping maintain healthy circulation, blood pressure and blood vessel function by promoting nitric oxide production.
Research Scope on OPC-3®
558+
Studies on Pycnogenol® and Human Health
100
The number of active compounds found in Red Wine Extract
3
Independent studies for Isotonix OPC-3®
4x
The bioavailability of Isotonix OPC-3® compared to a tablet form
Reference List
- Devaraj, S., et al. Supplementation with a pine bark extract rich in polyphenols increases plasma antioxidant capacity and alters the plasma lipoprotein profile. Lipids 37:931-4, 2002.
- Fitzpatrick, D., et al. Endothelium-dependent vascular effects of Pycnogenol. Journal of Cardiovascular Pharmacology 32: 509-515, 1998.
- Frankel, E., et al. Inhibition of oxidation of human low-density lipoprotein by phenolic substances in red wine. Lancet 341: 454-7, 1993.
- Freedman, J., et al. Select flavonoids and whole juice from purple grapes inhibit platelet function and enhance nitric oxide release. Circulation 103:2792-8, 2001.
- Frémont, L. Biological effects of resveratrol. Life Sciences 66: 663-673, 2000.
- Manna, S., et al. Resveratrol suppresses TNF-Induced activation of nuclear transcription factors NF-kB, activator protein-1, and apoptosis: potential role of reactive oxygen intermediates and lipid peroxidation. The Journal of Immunology 164: 6509-19, 2000.
- Miyagi, Y., et al. Inhibition of human low-density lipoprotein oxidation by flavonoids in red wine and grape juice. Am J Cardiol 0:1627-31, 1997.
- Monograph. Vaccinium myrtillus (bilberry). Altern Med Rev 6:500-4, 2001.
- Murias M., et al. Resveratrol analogues as selective cyclooxygenase-2 inhibitors: synthesis and structure-activity relationship. , 2004.
- Nuttall SL, Kendall MJ, Bombardelli E, Morazzoni P. An evaluation of the antioxidant activity of a standardized grape seed extract, Leucoselect. J Clin Pharm Ther 23: 385-89, 1998.
- Packer, L., et al. Antioxidant activity and biologic properties of a procyanidin-rich extract from pine (Pinus maritima) bark, pycnogenol. Free Radic Biol Med 27:704-24, 1999. Review.
- Schönlau, F., et al. The cosmeceutical Pycnogenol®. J Appl Cosmetology 20: 241-6, 2002.
- Segger, D. and Schönlau, F. Supplementation with Evelle® improves skin smoothness and elasticity in a double blind, placebo-controlled study with 62 women. Journal of Dermatological Treatment 15:222-26, 2004.
- Shi, J., et al. Polyphenolics in grape seeds-biochemistry and functionality. J Med Food 6:291-9, 2003. Review.
- Wallerath, T., et al. Resveratrol, a polyphenolic phytoalexin present in red wine, enhances expression and activity of endothelial nitric oxide synthase. Circulation 106:1652-8, 2002.
- Watson, R. Pycnogenol® and cardiovascular health. Evidence-Based Integrative Medicine 1: 27-32, 2003.
Product Label Details
*These statements have not been evaluated by the Food and Drug Administration. This product(s) is not intended to diagnose, treat, cure or prevent any disease.

Reviews
Customer Rating
4.6 out of 5 star rating.
(327 reviews)
would recommend this product.
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Customer Images
This product is off the charts - I'm seriously lacking sufficient praise!!!!
Response from Customer Service on 02/24/2025
Thank you for your enthusiastic review of Isotonix OPC-3®! We're thrilled to hear that you find it "off the charts" and appreciate your kind words. Your excitement and satisfaction are the ultimate compliments, and we're grateful for your support. Thank you for choosing Isotonix OPC-3® and for being part of our community!
Love it!
by SamanthaC
on 01/24/2025
Carla and Keith Jackson introduced me to the product. I love love the benefits I recieved from using this product! It's great. My job has me on my feet the whole time and my energy is sky high now.
Response from Customer Service on 01/24/2025
Thank you for your enthusiastic review of Isotonix OPC-3®! We're thrilled to hear that you love the benefits and have experienced increased energy, especially with a job that keeps you on your feet. It's wonderful to know that Carla and Keith Jackson introduced you to our product, and we're delighted that it's making a positive impact in your daily routine. Your feedback is greatly appreciated, and we thank you for choosing Isotonix OPC-3®!
OPC 3
by TrishR
Shop Consultant
on 01/06/2025
Great antioxidant supplement for helping with my sinuses issues , can’t be without this solution Ty
Response from Customer Service on 01/06/2025
Thank you for your positive review of Isotonix OPC-3®! We're delighted to hear that you've found it to be a great antioxidant supplement and an essential part of your routine. Your support and satisfaction are greatly appreciated. Thank you for choosing Isotonix OPC-3® and for sharing your experience with us!
Excellent Product
by JustinN
on 12/04/2024
My family has been using OPC-3 and Isotonix products for years and we love them!
Response from Customer Service on 12/05/2024
Thank you for your fantastic review of Isotonix OPC-3®! We're delighted to hear that it has been a beloved part of your family's routine for years. Your continued support and love for our products mean the world to us. Thank you for choosing Isotonix and for sharing your positive experience!
Great product
by tinaw
on 11/13/2024
I’ve been using Market America's Core 3 products, and the results have been fantastic! The blend of essential supplements has noticeably boosted my energy, helped with focus, and supported my overall health. It’s a great foundational set for anyone looking to improve wellness in an easy and effective way.
Response from Customer Service on 11/14/2024
Thank you for your wonderful review of Isotonix OPC-3® and Market America's Core 3 products! We're thrilled to hear about the fantastic results you've experienced, including increased energy, improved focus, and overall wellness support. Your positive feedback is truly appreciated, and we're delighted to be a part of your health journey. Thank you for choosing our products and sharing your experience with us!
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