Unlock the secret to healthy aging
250 mg
of Nicotinamide Riboside (NR)
50 mg
of the NAD precursor, Pterostilbene

The Core of Cellular Health
Nicotinamide Riboside (crystalline nicotinamide riboside chloride) NAD resides in every living cell in the body and has been strongly linked to keeping one's youth. NAD is the key to maintaining cellular metabolism, energy production and youthful vigor.

Product Classification

Vegan

Non-GMO

Gluten-Free

Good Manufacturing Practices
Key Ingredients & Benefits

Pterostilbene*
May help maintain NAD levels in aging adults
Supports healthy cognitive function
Helps to sustain neurological and cognitive health as we age
Promotes normal activity of the SIRT-1 gene
Powerful antioxidant that protects the body from the negative effects of free radicals

Nicotinamide Riboside (crystalline nicotinamide riboside chloride)*
Supports healthy NAD production
Supports cellular health
Helps maintain healthy levels of ATP production within the cell
Supports healthy cellular metabolism
May help combat the cellular aging process
Fountain of Youth
Cutting-edge science that renews cells and DNA so you are energized and mentally sharp while looking and feeling younger. Whether fighting aging or coping with a demanding lifestyle, reclaim your spark and thrive with Prime NAD+!
Frequently Asked Questions
What factors influence NAD replenishment in cells?
NAD replenishment depends on its consumption and synthesis, maintained through the Preiss-Handler, de novo biosynthesis, and salvage pathways. NAD precursors like NR, NMN, NA, NAM, and tryptophan help boost levels, and foods like broccoli, avocado, and niacin-rich sources naturally support this process.
What depletes NAD levels besides aging?
Unhealthy habits like smoking, alcohol use, poor diet, lack of exercise, inadequate sleep, and being overweight can deplete NAD levels.
What is the half-life of pterostilbene compared to resveratrol?
Pterostilbene has a longer half-life (105 minutes) than resveratrol (14 minutes), providing longer-lasting effects.
How do Prime NAD+ and Heart Health Advanced Co-Q10 differ in supporting cells?
NAD+ sparks energy production by initiating ATP creation, essential for metabolism. Co-Q10 acts as fuel for mitochondria, protecting them from oxidative stress and supporting cardiovascular health. Prime NAD+ focuses on cellular energy and longevity, while Co-Q10 supports overall mitochondrial function.
How can sirtuin activity be promoted?
Sirtuin activity, linked to cell lifespan, can be boosted with NR, pterostilbene, resveratrol, curcumin, exercise, and caloric restriction.
What are telomeres?
Telomeres are protective caps at the ends of chromosomes that indicate cellular age. Maintaining healthy NAD and sirtuin activity supports telomere health, which declines as cells divide and age.
Prime NAD+ Research Scope
30+
Trillion cells in the body are fueled by the NAD molecule
500+
The number of enzymatic reactions fueled by NAD
50%
The rate of loss of NAD by the age of 50
4x
Pterostilbene has a bioavailability of 80% compared to resveratrol's 20%
Reference List
- Amjad, S., Nisar, S., Bhat, A. A., Shah, A. R., Frenneaux, M. P., Fakhro, K., Haris, M., Reddy, R., Patay, Z., Baur, J., & Bagga, P. (2021). Role of NAD+ in regulating cellular and metabolic signaling pathways. Molecular metabolism, 49, 101195. https://doi.org/10.1016/j.molmet.2021.101195
- Sharma, A., Chabloz, S., Lapides, R. A., Roider, E., & Ewald, C. Y. (2023). Potential Synergistic Supplementation of NAD+ Promoting Compounds as a Strategy for Increasing Healthspan. Nutrients, 15(2), 445.
- Dellinger, R.W., Santos, S.R., Morris, M. et al. Repeat dose NRPT (nicotinamide riboside and pterostilbene) increases NAD+ levels in humans safely and sustainably: a randomized, double-blind, placebo-controlled study. npj Aging Mech Dis 3, 17 (2017). https://doi.org/10.1038/s41514-017-0016-9
- Covarrubias, A. J., Perrone, R., Grozio, A., & Verdin, E. (2021). NAD+ metabolism and its roles in cellular processes during ageing. Nature reviews. Molecular cell biology, 22(2), 119–141. https://doi.org/10.1038/s41580-020-00313-x
- What is NAD+ and Why Is it Important? (n.d.). Elysium Health. https://www.elysiumhealth.com/blogs/aging101/what-is-nad-and-why-is-it-important
- Clement, J., Wong, M., Poljak, A., Sachdev, P., & Braidy, N. (2019). The Plasma NAD+ Metabolome Is Dysregulated in "Normal" Aging. Rejuvenation research, 22(2), 121–130. https://doi.org/10.1089/rej.2018.2077
- Lindberg, S. (2023, May 5). Autophagy: What you need to know. Healthline. https://www.healthline.com/health/autophagy
- Superfoodly, & Superfoodly. (2021). Pterostilbene supplement benefits: Longevity miracle or hoax. Superfoodly https://superfoodly.com/pterostilbene-supplement-benefits-longevity-miracle-or-hoax/
- ProHealth Longevity. Sirtuins and your health: the. ProHealth.com. https://www.prohealth.com/blogs/control-how-you-age/activate-your-sirtuins
- Bsc, M. W. M. C. (2023). What foods are high in NAD. Satia - Health, Wellness, Nutrition. https://satia.com/blog/nad-why-it-matters-and-where-to-find-it
- Belenky P, Racette FG, Bogan KL, McClure JM, Smith JS, Brenner C. Nicotinamide Riboside Promotes Sir2 Silencing and Extends Lifespan via Nrk and Urh1/Pnp1/Meu1 Pathways to NAD. Cell. 2007 May 4;129:473-84.
- Billington RA, Travelli C, Ercolano E, Galli U, Roman CB, Grolla AA, Canonico PL, Condorelli F, Genazzani AA. Characterization of NAD Uptake in Mammalian Cells. THE JOURNAL OF BIOLOGICAL CHEMISTRY. 2008 Mar 7;283(10):6367-74.
- Buonvicino D, Ranieri G, Pittelli M, Lapucci A, Bragliola S, Chiarugi A. SIRT1-dependent restoration of NAD+ homeostasis after increased extracellular NAD+ exposure. Journal of Biological Chemistry. 2021 Jul 1;297(1).
- Christopher R. Martens et al. Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults. Nature Communications volume 9, Article number: 1286 (2018).
- de Ligt M, Bruls YMH, Hansen J, Habets MF, Havekes B, Nascimento EBM, Moonen-Kornips E, Schaart G, Zhang D, van Marken Lichtenbelt W, Schrauwen P, Schrauwen-Hinderling VB, Hesselink MKC Resveratrol and pterostilbene potently modulate autophagy. Scientific Reports. 2021.
- Dellinger RW, Santos SR, Morris M, et al. Repeat dose NRPT (nicotinamide riboside and pterostilbene) increases NAD+ levels in humans safely and sustainably: a randomized, double-blind, placebo-controlled study. NPJ Aging Mech Dis. 2017;3:17.
- Fang, EF, Lautrup, S, Hou, Y, Demarest, TG, Croteau, DL, Mattson, MP, Bohr, VA (2017). NAD+ in Aging: Molecular Mechanisms and Translational Implications. Trends in Molecular Medicine, 23(10), 899-916.
- Martens, C. R., Denman, B. A., Mazzo, M. R., et al. Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults Nature Communications. 2018.
- Massudi, H., Grant, R., Braidy, N., Guest, J., Farnsworth, B., & Guillemin, G. J. (2012). Age-associated changes in oxidative stress and NAD+ metabolism in human tissue. PloS one, 7(7), e42357.
- Mendelsohn AR, Larrick JW. The NAD+/PARP1/SIRT1 Axis in Aging. Rejuvenation Res. 2017 Jun;20(3):244-247. doi: 10.1089/rej.2017.1980. PMID: 28537485.
- Nagarajan S, Mohandas S, Ganesan K, Xu B, Ramkumar KM. New insights into dietary pterostilbene: Sources, metabolism, and health promotion effects. Molecules. 2022 Sep 25;27(19):6316.
- Chini CC, Zeidler JD, Kashyap S, Warner G, Chini EN. Evolving concepts in NAD+ metabolism. Cell metabolism. 2021 Jun 1;33(6):1076-87.
- Estrela JM, Ortega A, Mena S, Rodriguez ML, Asensi M. Pterostilbene: biomedical applications. Critical reviews in clinical laboratory sciences. 2013 May 1;50(3):65-78.
Product Label Details
*These statements have not been evaluated by the Food and Drug Administration. This product(s) is not intended to diagnose, treat, cure or prevent any disease.

Reviews
Customer Rating
4.6 out of 5 star rating.
(31 reviews)
would recommend this product.
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No compromise on this one! This product's been a game-changer for my skin - it's smoother, brighter, and all-around amazing! 10/10!
Response from Customer Service on 02/24/2025
Thank you for your glowing review of Prime Anti-Aging Nutraceuticals® NAD+! We're thrilled to hear that it's been a game-changer for your skin, making it smoother, brighter, and all-around amazing. Your perfect 10/10 rating means a lot to us, and we're delighted to be part of your journey towards achieving that glow up. Thank you for choosing our product and sharing your fantastic results!
逆龄又增加体力能量的好产品
by 伟杨
on 01/07/2025
I love this NAD+ very much as I can feel the increase in energy. I now enjoy so much when I go to the gym. This is the best product I can find in China.
我非常喜欢这款 NAD+,因为我能感觉到能量的增加。现在我去健身房时非常享受。这是我在中国能找到的最好的产品。
Response from Customer Service on 01/07/2025
非常感谢您分享您使用 Prime Anti-Aging Nutraceuticals® NAD+ 的积极体验!我们很高兴听到您注意到精力充沛,并且增强了您去健身房的乐趣。您的反馈鼓励我们继续致力于质量和客户满意度。我们非常感谢您对我们品牌的支持和信任。
Thank you so much for sharing your positive experience with Prime Anti-Aging Nutraceuticals® NAD+! We are happy to hear that you noticed increased energy and enhanced enjoyment of going to the gym. Your feedback encourages us to continue our commitment to quality and customer satisfaction. We greatly appreciate your support and trust in our brand.
A staple in my anti-aging regimen
by JULIA AND CHRISM
Shop Consultant
on 12/07/2024
Since taking the NAD+ I am sleeping better and have more sustained energy during the day, without the midday crash. Also, my endurance and post workout recovery have improved. It has made such a difference for me. I won’t go a day without it!
Response from Customer Service on 12/09/2024
Thank you so much for your wonderful review of Prime Anti-Aging Nutraceuticals® NAD+! We're thrilled to hear that it has become a staple in your anti-aging regimen and has positively benefited your energy levels, sleep quality, and post-workout recovery. It's inspiring to know that you're experiencing such benefits and that the product has made a significant difference for you. Thank you for choosing Prime NAD+ and for sharing your experience with us!
Allergic reaction
by Anonymous
on 11/29/2024
My face was swollen and started to feel like it was filling up with fluid after taking this. I’m very disappointed with how expensive these products are my commitment to the company for years and there extremely stringent return system. No help to me - it’s just a costly loss.
Response from Customer Service on 12/05/2024
We sincerely apologize for the experience you had with Prime Anti-Aging Nutraceuticals® NAD+. We understand how disappointing it can be when a product does not meet expectations and causes an unexpected reaction. Your long-term commitment to our company is greatly valued, and we regret any inconvenience you have faced. A Product Information Specialist will reach out to you shortly to further assist you with this matter. Thank you for bringing this to our attention, and please know that we are here to help.
我发表的产品评论
by zhifengw
Shop Consultant
on 10/28/2024
产品效果显著,物有所值👍
Response from Customer Service on 10/29/2024
感謝您對 Prime Anti-Aging Nutraceuticals® NAD+ 的評論!我們很高興聽到您發現該產品有效且值得投資。非常感謝您的回饋,我們感謝您的支持。感謝您選擇我們的產品!
Thank you for your review of Prime Anti-Aging Nutraceuticals® NAD+! We're thrilled to hear that you find the product effective and worth the investment. Your feedback is greatly appreciated, and we're grateful for your support. Thank you for choosing our product!
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