Unlock the secret to healthy aging
250 mg
of Nicotinamide Riboside (NR)
50 mg
of the NAD precursor, Pterostilbene

The Core of Cellular Health
Nicotinamide Riboside (crystalline nicotinamide riboside chloride) NAD resides in every living cell in the body and has been strongly linked to keeping one's youth. NAD is the key to maintaining cellular metabolism, energy production and youthful vigor.

Product Classification

Vegan

Non-GMO

Gluten-Free

Good Manufacturing Practices
Key Ingredients & Benefits

Pterostilbene*
May help maintain NAD levels in aging adults
Supports healthy cognitive function
Helps to sustain neurological and cognitive health as we age
Promotes normal activity of the SIRT-1 gene
Powerful antioxidant that protects the body from the negative effects of free radicals

Nicotinamide Riboside (crystalline nicotinamide riboside chloride)*
Supports healthy NAD production
Supports cellular health
Helps maintain healthy levels of ATP production within the cell
Supports healthy cellular metabolism
May help combat the cellular aging process
Fountain of Youth
Cutting-edge science that renews cells and DNA so you are energized and mentally sharp while looking and feeling younger. Whether fighting aging or coping with a demanding lifestyle, reclaim your spark and thrive with Prime NAD+!
Frequently Asked Questions
What factors influence NAD replenishment in cells?
NAD replenishment depends on its consumption and synthesis, maintained through the Preiss-Handler, de novo biosynthesis, and salvage pathways. NAD precursors like NR, NMN, NA, NAM, and tryptophan help boost levels, and foods like broccoli, avocado, and niacin-rich sources naturally support this process.
What depletes NAD levels besides aging?
Unhealthy habits like smoking, alcohol use, poor diet, lack of exercise, inadequate sleep, and being overweight can deplete NAD levels.
What is the half-life of pterostilbene compared to resveratrol?
Pterostilbene has a longer half-life (105 minutes) than resveratrol (14 minutes), providing longer-lasting effects.
How do Prime NAD+ and Heart Health Advanced Co-Q10 differ in supporting cells?
NAD+ sparks energy production by initiating ATP creation, essential for metabolism. Co-Q10 acts as fuel for mitochondria, protecting them from oxidative stress and supporting cardiovascular health. Prime NAD+ focuses on cellular energy and longevity, while Co-Q10 supports overall mitochondrial function.
How can sirtuin activity be promoted?
Sirtuin activity, linked to cell lifespan, can be boosted with NR, pterostilbene, resveratrol, curcumin, exercise, and caloric restriction.
What are telomeres?
Telomeres are protective caps at the ends of chromosomes that indicate cellular age. Maintaining healthy NAD and sirtuin activity supports telomere health, which declines as cells divide and age.
Prime NAD+ Research Scope
30+
Trillion cells in the body are fueled by the NAD molecule
500+
The number of enzymatic reactions fueled by NAD
50%
The rate of loss of NAD by the age of 50
4x
Pterostilbene has a bioavailability of 80% compared to resveratrol's 20%
Reference List
- Amjad, S., Nisar, S., Bhat, A. A., Shah, A. R., Frenneaux, M. P., Fakhro, K., Haris, M., Reddy, R., Patay, Z., Baur, J., & Bagga, P. (2021). Role of NAD+ in regulating cellular and metabolic signaling pathways. Molecular metabolism, 49, 101195. https://doi.org/10.1016/j.molmet.2021.101195
- Sharma, A., Chabloz, S., Lapides, R. A., Roider, E., & Ewald, C. Y. (2023). Potential Synergistic Supplementation of NAD+ Promoting Compounds as a Strategy for Increasing Healthspan. Nutrients, 15(2), 445.
- Dellinger, R.W., Santos, S.R., Morris, M. et al. Repeat dose NRPT (nicotinamide riboside and pterostilbene) increases NAD+ levels in humans safely and sustainably: a randomized, double-blind, placebo-controlled study. npj Aging Mech Dis 3, 17 (2017). https://doi.org/10.1038/s41514-017-0016-9
- Covarrubias, A. J., Perrone, R., Grozio, A., & Verdin, E. (2021). NAD+ metabolism and its roles in cellular processes during ageing. Nature reviews. Molecular cell biology, 22(2), 119–141. https://doi.org/10.1038/s41580-020-00313-x
- What is NAD+ and Why Is it Important? (n.d.). Elysium Health. https://www.elysiumhealth.com/blogs/aging101/what-is-nad-and-why-is-it-important
- Clement, J., Wong, M., Poljak, A., Sachdev, P., & Braidy, N. (2019). The Plasma NAD+ Metabolome Is Dysregulated in "Normal" Aging. Rejuvenation research, 22(2), 121–130. https://doi.org/10.1089/rej.2018.2077
- Lindberg, S. (2023, May 5). Autophagy: What you need to know. Healthline. https://www.healthline.com/health/autophagy
- Superfoodly, & Superfoodly. (2021). Pterostilbene supplement benefits: Longevity miracle or hoax. Superfoodly https://superfoodly.com/pterostilbene-supplement-benefits-longevity-miracle-or-hoax/
- ProHealth Longevity. Sirtuins and your health: the. ProHealth.com. https://www.prohealth.com/blogs/control-how-you-age/activate-your-sirtuins
- Bsc, M. W. M. C. (2023). What foods are high in NAD. Satia - Health, Wellness, Nutrition. https://satia.com/blog/nad-why-it-matters-and-where-to-find-it
- Belenky P, Racette FG, Bogan KL, McClure JM, Smith JS, Brenner C. Nicotinamide Riboside Promotes Sir2 Silencing and Extends Lifespan via Nrk and Urh1/Pnp1/Meu1 Pathways to NAD. Cell. 2007 May 4;129:473-84.
- Billington RA, Travelli C, Ercolano E, Galli U, Roman CB, Grolla AA, Canonico PL, Condorelli F, Genazzani AA. Characterization of NAD Uptake in Mammalian Cells. THE JOURNAL OF BIOLOGICAL CHEMISTRY. 2008 Mar 7;283(10):6367-74.
- Buonvicino D, Ranieri G, Pittelli M, Lapucci A, Bragliola S, Chiarugi A. SIRT1-dependent restoration of NAD+ homeostasis after increased extracellular NAD+ exposure. Journal of Biological Chemistry. 2021 Jul 1;297(1).
- Christopher R. Martens et al. Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults. Nature Communications volume 9, Article number: 1286 (2018).
- de Ligt M, Bruls YMH, Hansen J, Habets MF, Havekes B, Nascimento EBM, Moonen-Kornips E, Schaart G, Zhang D, van Marken Lichtenbelt W, Schrauwen P, Schrauwen-Hinderling VB, Hesselink MKC Resveratrol and pterostilbene potently modulate autophagy. Scientific Reports. 2021.
- Dellinger RW, Santos SR, Morris M, et al. Repeat dose NRPT (nicotinamide riboside and pterostilbene) increases NAD+ levels in humans safely and sustainably: a randomized, double-blind, placebo-controlled study. NPJ Aging Mech Dis. 2017;3:17.
- Fang, EF, Lautrup, S, Hou, Y, Demarest, TG, Croteau, DL, Mattson, MP, Bohr, VA (2017). NAD+ in Aging: Molecular Mechanisms and Translational Implications. Trends in Molecular Medicine, 23(10), 899-916.
- Martens, C. R., Denman, B. A., Mazzo, M. R., et al. Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults Nature Communications. 2018.
- Massudi, H., Grant, R., Braidy, N., Guest, J., Farnsworth, B., & Guillemin, G. J. (2012). Age-associated changes in oxidative stress and NAD+ metabolism in human tissue. PloS one, 7(7), e42357.
- Mendelsohn AR, Larrick JW. The NAD+/PARP1/SIRT1 Axis in Aging. Rejuvenation Res. 2017 Jun;20(3):244-247. doi: 10.1089/rej.2017.1980. PMID: 28537485.
- Nagarajan S, Mohandas S, Ganesan K, Xu B, Ramkumar KM. New insights into dietary pterostilbene: Sources, metabolism, and health promotion effects. Molecules. 2022 Sep 25;27(19):6316.
- Chini CC, Zeidler JD, Kashyap S, Warner G, Chini EN. Evolving concepts in NAD+ metabolism. Cell metabolism. 2021 Jun 1;33(6):1076-87.
- Estrela JM, Ortega A, Mena S, Rodriguez ML, Asensi M. Pterostilbene: biomedical applications. Critical reviews in clinical laboratory sciences. 2013 May 1;50(3):65-78.
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