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Top 20 Customer Favorite

Prime Joint Support Formula by Isotonix, Top 20 Customer Favorite, Product Tested No Detectable GMO

$82.95

+ $1.66 / 2% Cashback

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Single Bottle (45 Servings) Code: 13081

As the body ages, many people experience joint discomfort. One option is to take a joint supplement to help promote overall bone and joint health. When looking at a joint supplement, there are three main ingredients found in most products on the...
See details   on Prime™ Joint Support Formula by Isotonix®

Benefits

Our exclusive solution for promoting optimal joint health and for bone and joint discomfort:

  • Only product on the market delivering glucosamine*, Pycnogenol® and hyaluronic acid in isotonic form
  • This winning combination of proven ingredients supports and helps maintain optimal joint health and flexibility:
    • Glucosamine - Supports healthy joint function and promotes the normal production of synovial fluid, which lubricates your joints and regenerates cartilage
    • Pycnogenol - Promotes blood flow and joint comfort associated with the normal aging process

    • Hyaluronic acid - Helps maintain strong, healthy cartilage and promotes normal healing

Additional Benefits

  • Keep your joints young
  • Helps maintain joint comfort
  • Supports normal, healthy levels of COX-2 and 5-LOX
  • Contains the combination of glucosamine with the super powerful antioxidant Pycnogenol and hyaluronic acid
  • Does not contain chondroitin (very poor absorption due to its high molecular weight)

*The source of glucosamine contains shellfish.

Prime Joint Support Formula by Isotonix. Contains 25mg of Pycnogenol, 1000mg of Glucosamine, and 25mg of Hyaluronic Acid. Unique among similiar products.

Product Classifications

Gluten-Free - The finished product contains no detectable gluten (<10ppm gluten)

No Detectable GMOs - The finished product contains no detectable genetically-modified organisms

Isotonic-Capable Drinkable Supplements - Easy-to-swallow supplements in liquid form are immediately available to the body for absorption

Quality Standards - GMP Operations and Standardized Ingredients

Checked For: Heavy Metals, Microbiological Contaminants, Allergens, Residual Solvents, Potency, Purity and Identity

Why Choose Prime Joint Support Formula by Isotonix?

As the body ages, many people experience joint discomfort. One option is to take a joint supplement to help promote overall bone and joint health. When looking at a joint supplement, there are three main ingredients found in most products on the market: glucosamine, chondroitin and methylsulfonylmethane, more commonly referred to as MSM.

The research on both chondroitin and MSM is very controversial. Chondroitin, for instance, has very poor absorption due to its high molecular weight. Also, one of chondroitin’s mechanisms is to increase the hyaluronic acid content of synovial fluid; while the new Prime Joint Support Formula by Isotonix directly provides hyaluronic acid. Hyaluronic acid plays an important role in tissue hydration, lubrication and cellular function. Likewise, research on MSM is not conclusive. In fact, it takes large quantities of MSM daily (2-6 grams) to make a difference and see effects.*

On the other hand, the research behind glucosamine is consistent and its benefits effective. Prime Joint Support Formula contains glucosamine, naturally produced by the body and a key component of cartilage. An aminomonosaccharide (a combination of the amino acid — glutamine and a sugar — glucose), glucosamine is concentrated in joint cartilage, and has been scientifically proven to support healthy joint function and promote the normal production of synovial fluid, which lubricates your joints and regenerates cartilage.*

The natural aging process affects everyone and proper exercise, sleep and supplementation are essential for healthy living. Prime Joint Support Formula also contains the powerful antioxidant Pycnogenol®, which science has shown help maintain the body’s natural defenses by inhibiting metabolic responses associated with the normal aging process. 

Learn More

Isotonix Delivery System

Isotonix - the World's Most Advanced Nutraceuticals
Isotonic, which means “same pressure,” bears the same chemical resemblance of the body’s blood, plasma and tears. All fluids in the body have a certain concentration, referred to as osmotic pressure. The body’s common osmotic pressure, which is isotonic, allows a consistent maintenance of body tissues. In order for a substance to be absorbed and used in the body’s metabolism, it must be transported in an isotonic state.

Isotonix dietary supplements are delivered in an isotonic solution. This means that the body has less work to do in obtaining maximum absorption. The isotonic state of the suspension allows nutrients to pass directly into the small intestine and be rapidly absorbed into the bloodstream.With Isotonix products, little nutritive value is lost, making the absorption of nutrients highly efficient while delivering maximum results.

Prime Joint Support Formula by Isotonix bottle and pour cap half filled with product

Ingredients

Glucosamine (HCl): 1000 mg
Glucosamine is a molecule that is naturally synthesized in the body from glucose and the amino acid glutamine. Glucosamine is an important constituent of glycosaminoglycans in cartilage matrix and synovial fluid. As our bodies age, we are less able to produce glucosamine, resulting in cartilage that is less flexible and weak. Although the mechanism is currently unclear, studies have shown that glucosamine supplementation can support normal, healthy cartilage cell production to help maintain overall joint health.

Pine Bark Extract (Pycnogenol®): 25 mg

Pycnogenol is a water-soluble, flavonoid complex with powerful benefits. Pycnogenol, similar to the proanthocyanins found in grape seeds, is extracted from the bark of the French Maritime Pine tree. Pycnogenol has been shown help maintain the body’s natural defenses by inhibiting metabolic responses associated with the normal aging process. Also known to promote healthy blood flow and help maintain joint comfort. Research has shown that Pycnogenol may inhibit the activation of NF-kappa B and AP-1. Pycnogenol supplementation can also promote normal COX-2 and 5-LOX gene expression, and support healthy leukotriene biosynthesis. In addition, studies have shown the ability of Pycnogenol to cross-link collagen fibers and strengthen connective tissue proteins. To learn more about the relationship between Pycnogenol and joint health, follow the links below to read the full text studies.

Hyaluronic Acid (Sodium Hyaluronate): 25 mg
Hyaluronic acid plays an important role in tissue hydration, lubrication and cellular function. Although it is produced naturally by the body, the level of hyaluronic acid diminishes with age, contributing to joint discomfort. It is a key component of cartilage, and is important for skin, joint and eye health. Hyaluronic acid has been shown to help maintain strong, healthy cartilage. It may also enhance synovial fluid production and promote normal healing.

Potassium (bicarbonate) 150 mg
Foods rich in potassium include fresh vegetables and fruits such as bananas, oranges, cantaloupe, avocado, raw spinach, cabbage and celery.

Potassium is stored in the muscles. Potassium is an essential macro mineral that helps to maintain fluid balance. It also plays a role in a wide variety of biochemical and physiological processes. Among other things, it is important in the transmission of nerve impulses, the contraction of cardiac, skeletal and smooth muscle, the production of energy, the synthesis of nucleic acids, the maintenance of intracellular tonicity and the maintenance of normal blood pressure. Potassium stimulates muscle relaxation and insulin release. It also promotes glycogen and protein synthesis. Potassium is an electrolyte that promotes proper heartbeat. Potassium is important in releasing energy from protein, fat and carbohydrates during metabolism. Potassium also regulates water balance and assists recuperative powers. Potassium is crucial for the elimination of wastes. Potassium is a natural pain desensitizer.

Sodium (bicarbonate) 25 mg
To combat fatigue, athletes in sprint-type sports take a form of sodium bicarbonate. During very intense exercise, lactic acid accumulation in the muscle cells can lead to premature fatigue and may reduce athletic performance. Sodium bicarbonate also improves endurance performance.

FAQs

How should Prime Joint Support Formula by Isotonix be taken?
On an empty stomach, take two capfuls daily or as directed by your healthcare professional.

What other products should I take with Prime Joint Support Formula by Isotonix to support my joint health?
Heart Health™ Essential Omega III is a great pair with Prime Joint Support Formula, as omega III fatty acids have been shown to support healthy joint lubrication.

How often should I take Prime Joint Support Formula by Isotonix?
This product is most effective when taken daily.

How much Pycnogenol® is in Prime Joint Support Formula by Isotonix?
There are 25 milligrams of Pycnogenol in each daily serving.

What is the best way to store this product?
Keep Isotonix stored in a dry, cool place. If Isotonix are stored in the kitchen, keep them away from the stove, sink, heat-generating appliances or window ledges. If you live in a very humid area, you may store Isotonix products in the refrigerator – but not in the fruit and vegetables area.

Science

  • James, C. and Uhl, T. A review of articular cartilage pathology and the use of glucosamine sulfate. Journal of Athletic Training. 36(4): 413-419, 2001.
  • Julovi, S., et al. Inhibition of interleukin-1beta-stimulated production of matrix metalloproteinases by hyaluronan via CD44 in human articular cartilage. Arthritis and Rheumatism. 50(2): 516-525, 2004.
  • Nakatani, S., et al. Glucosamine regulates differentiation of a chondrogenic cell line, ATDC5. Biological and Pharmaceutical Bulletin. 30(3): 433-438, 2007.
  • Ohno, S., et al. Hyaluronan oligosaccharides induce matrix metalloproteinase 13 via transcriptional activation of NFkappaB and p38 MAP kinase in articular chondrocytes. Journal of Biological Chemistry. 281(26): 17952-17960, 2006.
  • Poustie, M., et al. N-butyryl glucosamine increases matrix gene expression by chondrocytes. Journal of Pharmacology and Experimental Therapeutics. 311(2): 610-616, 2004.
  • Sasaki, A., et al. Hyaluronate inhibits the interleukin-1beta-induced expression of matrix metalloproteinase (MMP)-1 and MMP-3 in human synovial cells. The Tohoku Journal of Experimental Medicine. 204(2): 99-107, 2004.
  • Schäfer, A., et al. Inhibition of COX-1 and COX-2 activity by plasma of human volunteers after ingestion of French maritime pine bark extract (Pycnogenol®). Biomedicine and Pharmacotherapy. 60: 5-9, 2006.

Product Label Details

Prime Joint Support Formula by Isotonix

Supplement Facts

Serving Size:  2 Capfuls (6.6 g)

Servings per Container: 45

Amount Per Serving

% Daily Value

Calories

10

**

Total Carbohydrate

2g

<1%

Total Sugars

2g

**

Includes 2g added sugar

4%

Vitamin A

150mg RAE

17%

Sodium (Bicarbonate)

25mg

1%

Potassium (Bicarbonate)

150mg

4%

Glucoamine (HCI)

1000mg

**

Pine Bark Extract

25mg

****

Sodium Huyalurante

25mg

Mixed Tocopherols

80  mg

**

* Daily Value not established.

Other ingredients: Fructose, orange juice powder, citric acid, maltodextrin, malic acid, orange flavor, mango flavor, silicon dioxide, rebaudioside A (stevia leaf), Lo Han fruit extract and stearic acid.

Contains: Shellfish (crab, shrimp)

Directions for use: Pour 2 level, white bottle capfuls of powder into a cup. Add 4 oz/ 120 ml (line on the overcap indicates 2 oz/60 ml) of water and stir. As a dietary supplement, take once daily or as directed by your healthcare provider. Maximum absorption occurs when taken on an empty stomach. This product is isotonic only if the specified amounts of powder and water are used.

WARNING: If you are currently using warfarin (Coumadin®), other antiplatelet/anticoagulant drugs, antihypertensive drugs, or have an ongoing medical condition, you should consult your healthcare provider before using this product. If you have a known allergy to shell fish, you should not use this product. Women who are pregnant or breastfeeding should not use this product.

This product contains no added wheat, soy, yeast, gluten, artificial flavors, starch, salt, preservatives or milk.

KEEP OUT OF THE REACH OF CHILDREN. Store in a cool, dry place. Do not use if safety seal is broken or missing.

These statements have not been evaluated by the Food and Drug Administration.

This product is not intended to diagnose, treat, cure or prevent any disease.

Reviews

Customer Rating

4.4 out of 5 star rating.

(40 reviews)

Break down of ratings:
(27) 5 star ratings.
or, 68% of total reviews.
(7) 4 star ratings.
or, 18% of total reviews.
(4) 3 star ratings.
or, 10% of total reviews.
(0) 2 star ratings.
or, 0% of total reviews.
(2) 1 star ratings.
or, 5% of total reviews.
86%

would recommend this product.

Write a Review

Prime

5 out of 5 star rating.

by ARLENEL

Shop Consultant

Shop Consultant is an independent distributor of this product.

on 03/22/2023

Very east to take. Highly recommend.

Response from Customer Service on 03/23/2023

Dear Valued Customer,

Thank you for taking the time to share your thoughts on the Prime™ Joint Support Formula by Isotonix®! We are so happy to hear you are pleased with the product!

Thank you again!
The Product Information Team

Amazing product

5 out of 5 star rating.

by RafaelC

on 04/16/2021

Prime line is simply incredible results.

Response from Customer Service on 04/17/2021

Dear Valued Customer,

Thank you for taking the time to share your thoughts on the Prime Joint Support Formula by Isotonix®! We are happy to hear you are pleased with the product!

Thank you again!
The Product Information Team

Amazing product

5 out of 5 star rating.

by RafaelC

on 04/16/2021

Prime line is simply incredible results.

Response from Customer Service on 04/17/2021

Dear Valued Customer,

Thank you for taking the time to share your thoughts on the Prime Joint Support Formula by Isotonix®! We are happy to hear you are pleased with the product!

Thank you again!
The Product Information Team

feel the difference

5 out of 5 star rating.

by DianaB

Shop Consultant

Shop Consultant is an independent distributor of this product.

on 11/11/2020

i definitely feel the difference when I do not take this product regularly. My knees start to click and crackle and my ankles feel less flexible even though I work out well. This is a needed product for me.

Response from Customer Service on 11/11/2020

Dear Valued Customer,

Thank you for taking the time to share your thoughts on the Prime Joint Support Formula by Isotonix! We are happy to hear you are pleased with the product.

Thank you again!
The Product Information Team

Awesome product!

5 out of 5 star rating.

by JimB

Shop Consultant

Shop Consultant is an independent distributor of this product.

on 10/16/2020

My wife and I have been taking the product for about 3 weeks now and already feeling a benefit from it!

Response from Customer Service on 10/16/2020

Dear Valued Customer,

Thank you for taking the time to share your thoughts on the Prime Joint Support Formula by Isotonix! We are happy to hear you are pleased with the product.

Thank you again!
The Product Information Team

Shoppers found this review helpful

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