Formulated as the best antioxidant
Validated by research
20x
stronger than vitamin C
50x
stronger than vitamin E
95%
intestinal nutrient delivery for max absorption
Oligomeric proanthocyanadins (OPCs) are bioflavonoids (complex organic compounds) found in fruits, vegetables and certain tree barks that provide exceptional nutritional benefits to the human body.

The Super Antioxidant in OPC-3, Pycnogenol®‡
Isotonix OPC-3 contains the only isotonic form of Pycnogenol® in the world. Pycnogenol® is a natural plant extract from the bark of the French maritime pine tree and the most clinically researched and potent bioflavonoid.

Product Classification

Gluten-Free

No Detectable GMO

Isotonic

Vegan

Good Manufacturing Practices

Dairy Free
Directions for Use

Pour 1 small capful (3.3 g) of powder into a cup.

Add water 2 fl. oz/60 mL of water for each capful and stir.

Enjoy once a day. For maximum absorption take on an empty stomach.
Key Ingredients & Benefits

Grape Seed Extract*
Maintains healthy cholesterol levels

Red Wine Extract*
Powerful antioxidant

Bilberry Extract*
Powerful antioxidant
Supports healthy vision
Maintains healthy circulation

Citrus Extract (Bioflavaniods)*
Promotes cardiovascular health
Maintains healthy circulation

Pycnogenol®†, Pine Bark Extract*
Supports the normal dialation of blood vessels
Provides complete antioxidant protection
Combats free radicals
Supports a healthy complexion
Promotes healthy sperm quality
World's Most Powerful Antioxidant
Outperforming any conventional antioxidant on the market, discover this ultimate supplement designed to supercharge for health and longevity!
Isotonix Delivery System

:05 minutes
Isotonix Liquid Vitamins
- Formulated to survive digestion.
- Delivers concentrated nutrients to the site of absorption.
- Contains no fillers or binders.
- No artificial color or flavors.

:40 minutes
Standard Vitamin Tablet
- Contains lab-created coatings and lubricants.
- Often contains artificial colors, nutrients and flavors.
- Limited absorption of nutrient utilization.
Frequently Asked Questions
What makes Isotonix OPC-3 special?
Isotonix OPC-3 contains bioflavonoids, plant compounds that support cardiovascular health, healthy circulation and skin, joint and tissue integrity; it uses a unique Isotonix delivery system for fast, effective absorption and includes scientifically proven antioxidants to fight free radicals, making it one of the most powerful products available.
How quickly does Isotonix OPC-3 work?
Thanks to its liquid, isotonic form, Isotonix OPC-3 is absorbed quickly by the small intestine, entering the bloodstream within minutes; this rapid absorption allows the body to benefit almost immediately.
Why should everyone take Isotonix OPC-3?
Free radicals cause oxidative stress, which contributes to aging, circulation and heart and immune health. OPCs are powerful antioxidants — with more staying power than vitamins C and E — that help neutralize free radicals. Taking OPC-3 daily is essential for combating free radical damage and promoting health.
Why should healthy or athletic people use Isotonix OPC-3?
Even athletes experience free radical damage from increased oxygen use during exercise, which can affect muscle performance and endurance. Studies show OPCs promote endurance, reduce mild muscle cramps and support healthy blood flow, helping muscles recover and perform.
Does OPC-3 benefit people who menstruate?
Yes, studies show OPCs can help mensural cramps.
What is Pycnogenol®?
Pycnogenol® is a patented extract from French maritime pine bark, supported by over 120 clinical studies; it acts as a powerful antioxidant, helping maintain healthy circulation, blood pressure and blood vessel function by promoting nitric oxide production.
Research Scope on OPC-3
558+
Studies on Pycnogenol® and Human Health
100
The number of active compounds found in Red Wine Extract
3
Independent studies for Isotonix OPC-3®
4x
The bioavailability of Isotonix OPC-3® compared to a tablet form
Reference List
- Devaraj, S., et al. Supplementation with a pine bark extract rich in polyphenols increases plasma antioxidant capacity and alters the plasma lipoprotein profile. Lipids 37:931-4, 2002.
- Fitzpatrick, D., et al. Endothelium-dependent vascular effects of Pycnogenol. Journal of Cardiovascular Pharmacology 32: 509-515, 1998.
- Frankel, E., et al. Inhibition of oxidation of human low-density lipoprotein by phenolic substances in red wine. Lancet 341: 454-7, 1993.
- Freedman, J., et al. Select flavonoids and whole juice from purple grapes inhibit platelet function and enhance nitric oxide release. Circulation 103:2792-8, 2001.
- Frémont, L. Biological effects of resveratrol. Life Sciences 66: 663-673, 2000.
- Manna, S., et al. Resveratrol suppresses TNF-Induced activation of nuclear transcription factors NF-kB, activator protein-1, and apoptosis: potential role of reactive oxygen intermediates and lipid peroxidation. The Journal of Immunology 164: 6509-19, 2000.
- Miyagi, Y., et al. Inhibition of human low-density lipoprotein oxidation by flavonoids in red wine and grape juice. Am J Cardiol 0:1627-31, 1997.
- Monograph. Vaccinium myrtillus (bilberry). Altern Med Rev 6:500-4, 2001.
- Murias M., et al. Resveratrol analogues as selective cyclooxygenase-2 inhibitors: synthesis and structure-activity relationship. , 2004.
- Nuttall SL, Kendall MJ, Bombardelli E, Morazzoni P. An evaluation of the antioxidant activity of a standardized grape seed extract, Leucoselect. J Clin Pharm Ther 23: 385-89, 1998.
- Packer, L., et al. Antioxidant activity and biologic properties of a procyanidin-rich extract from pine (Pinus maritima) bark, pycnogenol. Free Radic Biol Med 27:704-24, 1999. Review.
- Schönlau, F., et al. The cosmeceutical Pycnogenol®. J Appl Cosmetology 20: 241-6, 2002.
- Segger, D. and Schönlau, F. Supplementation with Evelle® improves skin smoothness and elasticity in a double blind, placebo-controlled study with 62 women. Journal of Dermatological Treatment 15:222-26, 2004.
- Shi, J., et al. Polyphenolics in grape seeds-biochemistry and functionality. J Med Food 6:291-9, 2003. Review.
- Wallerath, T., et al. Resveratrol, a polyphenolic phytoalexin present in red wine, enhances expression and activity of endothelial nitric oxide synthase. Circulation 106:1652-8, 2002.
- Watson, R. Pycnogenol® and cardiovascular health. Evidence-Based Integrative Medicine 1: 27-32, 2003.
*These statements have not been evaluated by the Food and Drug Administration. This product(s) is not intended to diagnose, treat, cure or prevent any disease.
‡As Pycnogenol®. Pycnogenol is a registered trademark of Horphag Research Ltd. Use of this product may be protected by one or more U.S. patents and other international patents.
Reviews
Customer Rating
4.6 out of 5 star rating.
(340 reviews)
would recommend this product.
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Customer Images
I have been taking OPC-3 for many years and I would not go without it. So the product is 5 stars, as many issues I used to deal with are gone - BUT the new cap is not at all good for measuring the water - you can hardly see the line for the 1 serving measurement. What was wrong with the previous caps? I agree with others who have the same issue. I'm saving my old caps, please bring them back! I also like the old label coloring on the bottles better than the new, as it was easier to differentiate the products. Why mess with a good thing?
Miracle Purple Powder
by ANGELES
Shop Consultant
on 06/03/2025
Isotonix OPC-3 is my top recommendation for those seeking convenient antioxidant support. The easy-to-mix powder and pleasant taste make it simple to add to any wellness routine.
Response from Customer Service on 06/04/2025
Thank you so much for your fantastic review of Isotonix OPC-3®! We’re delighted to hear how much you enjoy the convenience, taste, and how easily it fits into your wellness routine. Your recommendation means a great deal to us. Thank you for being a valued part of our community and for sharing your positive experience!
GAME CHANGER!!!!
by MichaelA
Shop Consultant
on 06/03/2025
"After consistently using OPC-3 for the past year, I’ve noticed positive changes in my energy, digestion, joint comfort, and overall well-being. It has truly become an important part of my daily wellness routine. For me, it’s been a game changer."
Response from Customer Service on 06/04/2025
Thank you so much for your enthusiastic review of Isotonix OPC-3®! We're thrilled to hear that you've experienced such positive changes and that OPC-3® has become an essential part of your daily wellness routine. Your feedback and support mean a lot to us. Thank you for being a valued member of our community and sharing your experience!
Love this stuff
by TimothyA
on 06/03/2025
Supports my wellness and tastes great. Easy to take.
Response from Customer Service on 06/04/2025
Thank you so much for your wonderful review of Isotonix OPC-3®! We’re happy to hear that you’re enjoying the taste and convenience, and that it supports your wellness. Your feedback means a lot to us—thank you for being a valued part of our community!
OPC-3
by PATTIL
Shop Consultant
on 06/03/2025
I’ve been using Isotonix OPC-3 for a few weeks and have noticed it supports my overall well-being. It’s easy to mix and has a pleasant taste. I like that it’s a convenient addition to my daily routine.
Response from Customer Service on 06/04/2025
Thank you so much for your thoughtful review of Isotonix OPC-3®! We’re happy to hear that you’re enjoying the convenience and taste of the product, and that it’s been a positive addition to your daily routine. Your feedback is greatly appreciated—thank you for choosing Isotonix OPC-3® and for being a valued member of our community!
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