Don’t Let Stress Get the Best of You
Stress. Sleep. Mindfulness.
54%
of adults report that stress is one of the main factors keeping them from falling asleep, with Sunday night being the most difficult night for them to get to sleep. More than a third of adults said they get less than seven hours of sleep per night, on average.
17.3%
A National Institutes of Health survey found that the proportion of adults practicing meditation has more than doubled over the past two decades, increasing from 7.5% in 2002 to 17.3% in 2022. Many adults use meditation as a tool to relax and cope with stress.
54%
More than half of workers report that work-related stress has a negative impact on their home life every week or even daily, with an equal number saying it also disrupts their sleep.
Mood, Sleep and Calmness
Many people can benefit from slowing down a little. Designed for relaxation, Isotonix Essentials® Turn Down features a custom blend of vitamins, amino acids and minerals all in one easy-to-use packet. The formula contains effective key ingredients to help you quiet down your body, promote mental clarity, control mental tension and support healthy sleep quality.
Product Classification
Gluten-Free
Dairy Free
Isotonic
Good Manufacturing Practices
No Detectable GMO
Vegetarian
Key Ingredients & Benefits
Calcium*
Promotes normal regulation of parathyroid hormone
L-Tryptophan*
Helps enhance and stabilize mood
May promote calmness and relaxation
Vitamin D3*
Supports healthy sleep quality
Helps enhance and stabilize mood
Magnesium*
Promotes sleep
Helps to clear the mind and assists in releasing mental tension
Promotes cognitive health
Vitamin B6*
Promotes the normal conduction of nerve impulses
Acts as a cofactor for many enzymatic reactions involving L-tryptophan, including L-tryptophan’s conversion to serotonin
Niacin*
Promotes normal regulation of enzyme and hormone production
Helps retain healthy levels of serotonin
Slow Down and Smell the Roses
It’s hard to feel balanced and grounded sometimes, especially when you’re restless and worrying thoughts cut into your downtime. Sometimes you just need to free yourself from life’s to-do lists and hit the brakes on your ruminating mind. Bring some calm into your life with Isotonix Essentials® Turn Down.
Directions for Use
Pour the contents of the entire Isotonix Essentials® Turn Down packet into a cup.
Add 8 fl oz of water and stir until completely dissolved.
Enjoy once daily or as directed by your health care provider. Maximum absorption occurs when taken on an empty stomach.
Isotonix Delivery System
:05 minutes
Isotonix Liquid Vitamins
- Formulated to survive digestion.
- Delivers concentrated nutrients to the site of absorption.
- Contains no fillers or binders.
- No artificial color or flavors.
:40 minutes
Standard Vitamin Tablet
- Contains lab-created coatings and lubricants.
- Often contains artificial colors, nutrients and flavors.
- Limited absorption of nutrient utilization.
Frequently Asked Questions
What does Isotonix mean?
Isotonix dietary supplements are delivered in an isotonic liquid solution. This means that the body has less work to do in obtaining maximum absorption. The isotonic state of the suspension allows nutrients to pass efficiently into the small intestine and be rapidly delivered into the bloodstream. With Isotonix products, little nutritive value is lost, making the absorption of nutrients highly efficient while delivering maximum results.*
When should I take Isotonix Essentials® Turn Down?
Take this product when you are looking for moments of stress relief and relaxation. As a dietary supplement, take once daily or as directed by your health care provider.
How is Isotonix Essentials Turn Down different from other similar products on the market?
Isotonix Essentials Turn Down knows you need the building blocks to feel refreshed, and that is why we offer a blend of minerals and amino acids that support rest and relaxation. Our Turn Down formula helps enhance and stabilize your mood, promote mental clarity and supports healthy sleep quality.
Research Scope
Reference List
- aan het Rot, M., et al. Social behaviour and mood in everyday life: the effects of tryptophan in quarrelsome individuals. Journal of Psychiatry and Neuroscience. 31(4): 253-262, 2006.
- Baly DL, Schneiderman JS, Garcia-Welsh AL. Effect of manganese deficiency on insulin binding, glucose transport and metabolism in rat adipocytes. J Nutr. 1990; 120:1075-1079.
- Beattie JH, Peace HS. The influence of a low-boron diet and boron supplementation on bone, major mineral and sex steroid metabolism in postmenopausal women. Br J Nutr. 1993 May;69(3):871-84.
- Brilla, L. R., et al. Effect of magnesium supplementation on strength training in humans. J Am Coll Nutr. 11(3):326-329, 1992.
- Cools, R., et al. Tryptophan depletion disrupts the motivational guidance of goal-directed behavior as a function of trait impulsivity. Neuropsychopharmacology. 30:1362-1373, 2005.
- Dawson-Hughes B, Harris SS, Krall EA, Dallal GE. Effect of calcium and vitamin D supplementation on bone density on men and women 65 years of age and older. N Engl J Med. 1997; 337:670-676.
- Del-Ben, C., et al. Serotonergic modulation of face-emotion recognition. Brazilian Journal of Medical and Biological Research. 41(4): 263-269, 2008.
- Dietary Reference Intakes for Calcium, Phosphorous, Magnesium, Vitamin D, and Fluoride. Washington, DC: National Academy Press; 1997.
- Durlach J, Durlach V, Bac P, et al. Magnesium and therapeutics. Magnes Res. 1994; 7:313-328.
- Griffiths , W., et al. Tryptophan and sleep in young adults. Psychophysiology. 9(3): 345-356, 1972.
- Gruber H et al. Magnesium deficiency: effect on bone mineral density in the mouse appendicular skeleton. BMC Musculoskelet Disord. 4(1):7, 2003.
- Hartmann, E. and Spinweber, C. Sleep induced by L-tryptophan. Effect of dosages within the normal dietary intake. The Journal of Nervous and Mental Disease. 167(8): 497-499, 1979.
- Huskisson E et al. The influence of micronutrients on cognitive function and performance. J Int Med Res. 35(1):1-19, 2007. Review.
- Hussain S, Ali SF. Manganese scavenges superoxide and hydroxyl radicals: an in vitro study in rats. Neuroscience Letters. 1999; 261:21-24.
- Institute of Medicine. Food and Nutrition Board. Dietary Reference Intakes: Calcium, Phosphorus, Magnesium, Vitamin D and Fluoride. National Academy Press. Washington, DC, 1999.
- Keen CL, Ensunsa JL, Watson MH, et al. Nutritional aspects of manganese from experimental studies. Neurotoxicol. 1999; 20:213-223.
- Kobrin SM and Goldfarb S. Magnesium Deficiency. Semin Nephrol. 10:525-35, 1990.
- Martini LA. Magnesium supplementation and bone turnover. Nutr Rev. 1999; 57:227-229.
- Murphy, S., et al. Tryptophan supplementation induces a positive bias in the processing of emotional material in healthy female volunteers. Psychopharmacology ( Berlin ). 187(1): 121-130, 2006.
- Naghii MR, Wall PM, Samman S. The boron content of selected foods and the estimation of its daily intake among free-living subjects. J Am Coll Nutr. 1996 Dec;15(6):614-9.
- New SA et al. Nutritional influences on bone mineral density: a cross-sectional study in premenopausal women. Am J Clin Nutr. 65:1831-9, 1997.
- Newnham RE. Essentiality of boron for healthy bones and joints. Environ Health Perspect. 1994;102:83-85
- Nielsen FH. Studies on the relationship between boron and magnesium which possibly affects the formation and maintenance of bones. Magnes Trace Elem. 1990;9:61-69
- Nielsen FH. Ultratrace minerals. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease, 9th ed. Baltimore, MD: Williams and Wilkins; 1999:283-303.
- Penland J.G. The importance of boron nutrition for brain and psychological function. Biol Trace Elem Res. 1998; 66:299-317.
- Reid IR, Ames RW, Evans MC, et al. Effect of calcium supplementation on bone loss in postmenopausal women. N Engl J Med. 1993; 328:460-464.
- Rubinsztein, J., et al. Acute dietary tryptophan depletion impairs maintenance of affective set and delayed visual recognition in healthy volunteers. Psychopharmacology. 154: 319-326, 2001.
- Russo, S, et al. Tryptophan as a link between psychopathology and somatic states. Psychosomatic Medicine. 65: 665-671, 2003.
- Ryder K et al. Magnesium intake from food and supplements is associated with bone mineral density in healthy older white subjects. J Am Geriatr Soc. 53(11):1875-1880, 2005.
- Saris NE, Mervaala E, et al. Magnesium: an update on physiological, clinical, and analytical aspects. Clinica Chimica Acta. 294:1-26, 2000.
- Saris N-EL, Mervaala E, Karppanen H, et al. Magnesium. An update on physiological, clinical and analytical aspects (review). Clinica Chimica Acta. 2000; 294:1-26.
- Saris, N.-E. L., et al. Magnesium: an update on physiological, clinical and analytical aspects. Clinica Chimica Acta. 294:1-26, 2000.
- Shils ME. Magnesium. In: Shils M, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams and Wilkins; 1999:169-192.
- Singh N, Singh PN, Hershman JM. Effect of calcium carbonate on the absorption of levothyroxine. JAMA. 2000; 283:2822-2825.
- Steritei, R. How to get a good nights sleep with tryptophan. NaturDoctor. 2007. (www.naturdoctor.com/Chapters/Research/Insomnia.pdf)
- Sutherland B, Strong P, King JC. Determining human dietary requirements for boron. Biol Trace Elem Res. 1998 Winter;66(1-3):193-204.
- Talbot JR, Guardo P, Seccia S, et al. Calcium bioavailability and parathyroid hormone acute changes after oral intake of dairy and nondairy products in healthy volunteers. Osteoporosis Int. 1999; 10:137-142.
- Tranquilli AL et al. Calcium, phosphorus and magnesium intakes correlate with bone mineral content in postmenopausal women. Gynecol Endocrinol. 8:55-8, 1994.
- Tucker KL, Hannan MT, Chen H, Cupples LA, Wilson PW, Kiel DP. Potassium, magnesium, and fruit and vegetable intakes are associated with greater bone mineral density in elderly men and women. Am J Clin Nutr. 69(4):727-36, 1999.
- Voderholzer, U., et al. Impact of experimentally induced serotonin deficiency by tryptophan depletion on sleep EEG in healthy subjects. Neuropsychopharmacology 18(2): 112-124, 1998.
- Volpe SL, Taper LJ, Meacham S. The relationship between boron and magnesium status and bone mineral density in the human: a review. Magnes Res. 1993;6:291-296
- Vormann J. Magnesium: nutrition and metabolism. Molecular Aspects of Medicine. 24:27-37, 2003.
- Weaver CM, Heaney RP. Calcium. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams and Wilkins; 1999:141-155.
- Wester PO. Magnesium. Am J Clin Nutr. 45:1305-12, 1987.
- Wolf RL, Cauley JA, Baker CE, et al. Factors associated with calcium absorption efficiency in pre- and perimenopausal women. Am J Clin Nutr. 2000; 72:466-471.
- Yu-Yahiro, J. A. Electrolytes and their relationship to normal and abnormal muscle function. Orthop Nurs. 13(5):38-40, 1994.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Reviews
Customer Rating
4.5 out of 5 star rating.
(58 reviews)
would recommend this product.
- Newest
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Customer Images
帮我提前好的睡眠
Response from Customer Service on 05/26/2026
非常感谢您对 Isotonix Essentials® Turn Down 留下的评价!得知这款产品帮助您获得了一夜好眠,我们感到非常高兴。您的反馈对我们意义重大。感谢您作为我们尊贵的顾客!
Thank you so much for your review of Isotonix Essentials® Turn Down! We're delighted to hear it helped you achieve a good night's rest. Your feedback means a lot to us. Thank you for being a valued customer!
My aunt and my friends had big improvements in the
by XIAOJ
Shop Consultant
on 03/02/2026
Within 1-3 months, my aunt was sharing her excitement about how great her sleep became to her friends! My friend has been sleeping so well as well.
Response from Customer Service on 03/03/2026
Thank you so much for your wonderful review! We're delighted to hear about the positive benefits your aunt and friends have had with Isotonix Essentials® Turn Down. It’s great to know that it’s made such a change for them. Your feedback means a lot to us—thank you for sharing and for being a valued member of our community!
Great product!
by JANICEW
Shop Consultant
on 02/18/2026
My husband swears by this for better sleep and less frequent trips to the bathroom!!!
Response from Customer Service on 02/18/2026
Thank you so much for your wonderful review! We're delighted to hear that Isotonix Essentials® Turn Down has made a positive change for your husband. Your feedback truly means a lot to us—thank you for being a valued part of our community!
Helps with the CHANGE
by AubreyL
Shop Consultant
on 01/17/2026
I was doing a lot of research lately, because my body is changing and I do not like it. I was doing a lot of research on what do or to help me with my perimenopause/menopause and this is an all in one. I started using it again, sharing it with my girlfriends, and it is a hit. Easy to mix, helps you calm down after a busy day and gives you the nutrients your body needs. I am sharing this gem with all of my girlfriends and those who have trouble with sleep. Thank you for this AMAZING product!
Response from Customer Service on 01/20/2026
Thank you so much for your fantastic review! We’re thrilled to hear that Isotonix Essentials® Turn Down has become such a helpful part of your routine. It’s wonderful that you’re sharing your experience and spreading the word to your friends as well. Your support and enthusiasm mean a lot to us—thank you for being a valued member of our community!
My husband loves this product
by JANICEW
Shop Consultant
on 12/30/2025
He is getting a much more restful sleep with turn down, and not getting up as many times during the night
Response from Customer Service on 12/30/2025
Thank you so much for sharing your feedback on Isotonix Essentials® Turn Down! We’re delighted to hear that your husband is experiencing more restful sleep and feeling the benefits of the product. Your experience means a lot to us—thank you for being a valued customer!
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