This product is #1
5 out of 5 star rating. 
Strong Bones & Flexible Joints
200+
The human body has more than 200 bones and more than 200 joints that connect those bones.
21.1%
of Americans above 18 years old reported joint discomfort in a survey conducted in 2019–2021.
Women
reported higher percentages, 20.1% in comparison to men at 16.3%, regarding issues with joint health.
Formulated With the Super Antioxidant, Pycnogenol®‡
Pycnogenol® is a water-soluble, flavonoid complex with powerful benefits. Extracted from the bark of the French Maritime Pine tree, Pycnogenol® has been shown to help maintain the body’s natural defenses by inhibiting metabolic responses associated with the normal aging process. Additionally, studies have shown the ability of Pycnogenol® to cross-link collagen fibers and strengthen connective tissue proteins.
Product Classification
Good Manufacturing Practices
Isotonic
Dairy Free
Gluten-Free
No Detectable GMO
Prime Ingredients for Prime Joints
When choosing a joint health supplement, it’s common to see glucosamine, chondroitin and methylsulfonylmethane (MSM) among the main ingredients. Prime Joint is specifically formulated with hyaluronic acid, which has shown to be more bioavailable than chondroitin and provides the same benefits for tissue hydration, lubrication and cellular function as MSM in lower quantities. The addition of glucosamine and Pycnogenol® supports synovial fluid, cushioning and nourishing your joints and provides antioxidant support, helping your body respond to the effects of normal aging.*
Key Ingredients & Benefits
Pine Bark Extract (Pycnogenol®‡)*
Promotes blood flow and joint comfort associated with the normal aging process
Helps maintain joint comfort
Glucosamine (HCI)*
Supports healthy joint function
Promotes the normal production of synovial fluid
Hyaluronic acid*
Helps maintain strong, healthy cartilage
Promotes the body's healing process
Sodium (bicarbonate)*
Supports endurance and performance
Helps combat exercise fatigue
Potassium (bicarbonate)*
Helps maintain fluid balance
Keep in Your Prime
Help keep your joints young with the only product available delivering glucosamine, Pycnogenol® and hyaluronic acid in isotonic form for maximum absorption of nutrients.
Directions For Use
Pour 2 small capfuls (6.6 g) of Isotonix Prime Joint Support Formula powder into a cup.
Add 4 fl oz of water and mix thoroughly.
Take daily to maintain joint health. If mixed with other Isotonix products, add 2 oz of water for each capful.
Isotonix Delivery System
:05 minutes
Isotonix Liquid Vitamins
- Formulated to survive digestion.
- Delivers concentrated nutrients to the site of absorption.
- Contains no fillers or binders.
- No artificial color or flavors.
:40 minutes
Standard Vitamin Tablet
- Contains lab-created coatings and lubricants.
- Often contains artificial colors, nutrients and flavors.
- Limited absorption of nutrient utilization.
Frequently Asked Questions
What other products should I take with Prime Joint Support Formula by Isotonix to support my joint health?
Heart Health™ Essential Omega III is a great pair with Prime Joint Support Formula, as omega III fatty acids have been shown to support healthy joint lubrication.
How often should I take Prime Joint Support Formula by Isotonix?
This product is most effective when taken daily.
How much Pycnogenol® is in Prime Joint Support Formula by Isotonix?
There are 25 mg of Pycnogenol® in each daily serving.
What is the best way to store this product?
Keep Isotonix stored in a dry, cool place. If Isotonix are stored in the kitchen, keep them away from the stove, sink, heat-generating appliances or window ledges. If you live in a very humid area, you may store Isotonix products in the refrigerator — but not in the fruit and vegetables area.
Prime™ Joint Support Formula by Isotonix® Research Scope
558+
Studies on Pycnogenol® and human health
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
‡As Pycnogenol®. Pycnogenol is a registered trademark of Horphag Research Ltd. Use of this product may be protected by one or more U.S. patents and other international patents.
Reviews
Break down of ratings: (38) 5 star ratings. (7) 4 star ratings. (4) 3 star ratings. (0) 2 star ratings. (3) 1 star ratings.
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This product helps so much with my movement and joints. You can feel a difference when you don't take it at all....I recommend this one to everyone!
Response from Customer Service on 06/17/2026
Thank you so much for your enthusiastic review! We’re delighted to hear that nutraMetrix Prime™ Joint Support Formula by Isotonix® has made a real difference in your routine. Your recommendation means a lot to us, and we truly appreciate you sharing your experience. Thank you for being a valued part of our community!
Love flexibility
5 out of 5 star rating.
At one point, i was walking with a cane, and in continous discomfort. Love the joint support, full flexibility and no discomfort.
Response from Customer Service on 06/15/2026
Thank you so much for your wonderful review of Prime™ Joint Support Formula by Isotonix®! We're thrilled to hear it has helped you achieve greater flexibility and improved your daily routine. Your feedback is greatly appreciated. Thank you for being a valued customer!
Taking care of your joints
5 out of 5 star rating.
Over 50 years ago I was a high school athlete (gymnastics). Being young you never think how that can affect you later in life. Thank goodness for Prime Joint Support. I have been taking this product for over 20 years and I remain very active. I joke that I can play blocks with my Grandchildren on the floor and then stand up!! My joints remain strong with no discomfort. I look forward to many more active years of sports and activities with the Grandkids.
Response from Customer Service on 06/12/2026
Thank you so much for your inspiring review of Prime™ Joint Support Formula by Isotonix®! We're delighted to hear it's supported your active lifestyle for over 20 years and helps you stay strong and energetic for time with your grandchildren. Your story and positive outlook mean a lot to us. Thank you for being a valued customer and sharing your wellness journey!
Improved Knee Comfort
5 out of 5 star rating.
My husband had been dealing with ongoing knee discomfort for several months which made walking and exercising at the gym much more challenging for him than they use to be. It was recommended that he try adding the Isotonix Prime Joint along with the Glucosatrin Tablets to his daily supplement routine.
After taking both consistently, he began to notice a huge difference in how his knees felt during everyday activities. In addition, he was able to return to his long walks and daily gym workouts with out the same level of discomfort he had been experiencing.
Response from Customer Service on 06/11/2026
Thank you so much for sharing your husband’s experience with Prime™ Joint Support Formula by Isotonix® and Glucosatrin Bone & Joint Health! We’re thrilled to hear he noticed a significant improvement and was able to return to his long walks and gym workouts. Your feedback is truly appreciated, and we're grateful to be a part of his wellness routine. Thank you for being a valued customer!
Best product out there
5 out of 5 star rating.
Great product works great
Response from Customer Service on 05/18/2026
Thank you so much for your positive review of Prime™ Joint Support Formula by Isotonix®! We're thrilled to hear you think it's the best and that it works well for you. Your feedback means a lot to us, and we appreciate your support. Thank you for being a valued customer!
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