Triple Threat Daily Regimen
Isotonix OPC-3
95% intestinal nutrient delivery for max absorption
Isotonix Magnesium
Support 300+ enzyme systems
Prime NAD+
The secret to healthy aging

Includes our top seller, Isotonix OPC-3
The super antioxidant in OPC-3, pine bark extract (Pycnogenol®)
Isotonix OPC-3 contains the only isotonic form of Pycnogenol, is a natural plant extract from the bark of the French maritime pine tree and the most clinically researched and powerful bioflavonoids in the world.
Pycnogenol® is a registered trademark of Horphag Research Ltd. Use of this product may be protected by one or more U.S. patents and other international patents.

Product Classification

Vegan

Gluten-Free

Non-GMO

Good Manufacturing Practices
Directions for use

Step 1 (Morning): Take Isotonix OPC-3 and the first capful of Isotonix Magnesium when you wake up.

Step 2 (Midday): Take Prime NAD+ before your midday meal.

Step 3 (Evening): Take the second capful of Isotonix Magnesium before you go to bed.
Key Ingredients & Benefits

Isotonix OPC-3®: Pycnogenol®, Pine Bark Extract*
Supports the normal dialation of blood vessels
Provides complete antioxidant protection
Combats free radicals
Supports a healthy complexion
Promotes healthy sperm quality

Isotonix OPC-3®: Bilberry Extract*
Powerful antioxidant
Supports healthy vision
Maintains healthy circulation

Isotonix® Magnesium: Magnesium (Citrate & Glycinate)*
Helps the body maintain a healthy level of magnesium, combatting magnesium deficiency
Promotes muscle health and comfort
Supports a healthy sleep quality
Promotes bone health

Prime Anti-Aging Nutraceuticals® NAD+: Nicotinamide Riboside (crystalline nicotinamide riboside chloride)*
Supports healthy NAD production
Combat the cellular aging process
Promotes normal activity of the SIRT-1 gene
Supports cellular health and metabolism
Revitalize Your Body With Core 3 Health
Restore, rebuild and reset with Core 3 Health: three powerful products in three simple steps. Our hottest health superstars have been carefully selected for one triple-threat system for maximum effect and truly amazing results.
Frequently Asked Questions
When is the best time to take these products?
Take Isotonix OPC-3 and Isotonix Magnesium in the morning. Take Prime NAD+ 4–5 hours later, then another serving of Isotonix Magnesium before bed. This 1-2-3 system supports metabolic health and sleep.
Why is there sugar in Isotonix products?
The sugars make the solution isotonic, enhancing nutrient absorption into the bloodstream and optimizing the delivery of nutrients to target cells.
Does Core 3 Health work for second or third shift workers?
Yes, follow the 1-2-3 schedule based on your sleep cycle. Take Isotonix OPC-3 and Magnesium when you wake up, Prime NAD+ 4-5 hours later and Magnesium before bed.
What makes Isotonix OPC-3 unique?
Isotonix OPC-3 is delivered in an isotonic form for quick absorption. It combines powerful antioxidants like Pycnogenol, bilberry, and grape seed extracts, supporting cardiovascular health, joint flexibility, and free radical protection.
What makes Isotonix Magnesium unique?
Isotonix Magnesium provides 400 mg of highly bioavailable magnesium forms (glycinate and citrate), supporting brain function, muscle health, and stress management.
What makes Prime NAD+ unique?
Prime NAD+ supports NAD+ levels with 250 mg of nicotinamide riboside (NR) and 50 mg of pterostilbene, supporting cellular regeneration, mitochondrial health, and DNA integrity.
Is this product(s) FDA approved?
*These statements have not been evaluated by the Food and Drug Administration. This product(s) is not intended to diagnose, treat, cure or prevent any disease.
Research Scope
Reference List
Isotonix OPC-3
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- Devaraj, S., et al. Supplementation with a pine bark extract rich in polyphenols increases plasma antioxidant capacity and alters the plasma lipoprotein profile. Lipids 37:931-4, 2002.
- Fitzpatrick, D., et al. Endothelium-dependent vascular effects of Pycnogenol. Journal of Cardiovascular Pharmacology 32: 509-515, 1998.
- Frémont, L. Biological effects of resveratrol. Life Sciences 66: 663-673, 2000.
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- Murias M., et al. Resveratrol analogues as selective cyclooxygenase-2 inhibitors: synthesis and structure-activity relationship. , 2004.
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- Packer, L., et al. Antioxidant activity and biologic properties of a procyanidin-rich extract from pine (Pinus maritima) bark, pycnogenol. Free Radic Biol Med 27:704-24, 1999. Review.
- Schönlau, F., et al. The cosmeceutical Pycnogenol®. J Appl Cosmetology 20: 241-6, 2002.
- Segger, D. and Schönlau, F. Supplementation with Evelle® improves skin smoothness and elasticity in a double blind, placebo-controlled study with 62 women. Journal of Dermatological Treatment 15:222-26, 2004.
- Watson, R. Pycnogenol® and cardiovascular health. Evidence-Based Integrative Medicine 1: 27-32, 2003.
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Prime Anti-Aging Nutraceuticals NAD+
- Amjad, S., Nisar, S., Bhat, A. A., Shah, A. R., Frenneaux, M. P., Fakhro, K., Haris, M., Reddy, R., Patay, Z., Baur, J., & Bagga, P. (2021). Role of NAD+ in regulating cellular and metabolic signaling pathways. Molecular metabolism, 49, 101195. https://doi.org/10.1016/j.molmet.2021.101195
- Covarrubias, A. J., Perrone, R., Grozio, A., & Verdin, E. (2021). NAD+ metabolism and its roles in cellular processes during ageing. Nature reviews. Molecular cell biology, 22(2), 119–141. https://doi.org/10.1038/s41580-020-00313-x
- Clement, J., Wong, M., Poljak, A., Sachdev, P., & Braidy, N. (2019). The Plasma NAD+ Metabolome Is Dysregulated in ""Normal"" Aging. Rejuvenation research, 22(2), 121–130. https://doi.org/10.1089/rej.2018.2077
- Lindberg, S. (2023, May 5). Autophagy: What you need to know. Healthline. https://www.healthline.com/health/autophagy
- ProHealth Longevity. Sirtuins and your health: the. ProHealth.com. https://www.prohealth.com/blogs/control-how-you-age/activate-your-sirtuins
- Bsc, M. W. M. C. (2023). What foods are high in NAD. Satia - Health, Wellness, Nutrition. https://satia.com/blog/nad-why-it-matters-and-where-to-find-it
- Billington RA, Travelli C, Ercolano E, Galli U, Roman CB, Grolla AA, Canonico PL, Condorelli F, Genazzani AA. Characterization of NAD Uptake in Mammalian Cells. THE JOURNAL OF BIOLOGICAL CHEMISTRY. 2008 Mar 7;283(10):6367-74.
- Christopher R. Martens et al. Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults. Nature Communications volume 9, Article number: 1286 (2018).
- de Ligt M, Bruls YMH, Hansen J, Habets MF, Havekes B, Nascimento EBM, Moonen-Kornips E, Schaart G, Zhang D, van Marken Lichtenbelt W, Schrauwen P, Schrauwen-Hinderling VB, Hesselink MKC Resveratrol and pterostilbene potently modulate autophagy. Scientific Reports. 2021.
- Dellinger RW, Santos SR, Morris M, et al. Repeat dose NRPT (nicotinamide riboside and pterostilbene) increases NAD+ levels in humans safely and sustainably: a randomized, double-blind, placebo-controlled study. NPJ Aging Mech Dis. 2017;3:17.
- Fang, EF, Lautrup, S, Hou, Y, Demarest, TG, Croteau, DL, Mattson, MP, Bohr, VA (2017). NAD+ in Aging: Molecular Mechanisms and Translational Implications. Trends in Molecular Medicine, 23(10), 899-916.
- Hanhineva K, Törrönen R, Bondia-Pons I, Pekkinen J, Kolehmainen M, Mykkänen H, Poutanen K. Impact of dietary polyphenols on carbohydrate metabolism. Int J Mol Sci. 2010 Mar 31;11(4):1365-402. doi: 10.3390/ijms11041365. PMID: 20480025; PMCID: PMC2871121.
- Kim Y, Keogh JB, Clifton PM. Polyphenols and Glycemic Control. Nutrients. 2016 Jan 5;8(1):17. doi: 10.3390/nu8010017. PMID: 26742071; PMCID: PMC4728631.
- Maiese K. Moving to the Rhythm with Clock (Circadian) Genes, Autophagy, mTOR, and SIRT1 in Degenerative Disease and Cancer. Curr Neurovasc Res. 2017;14(3):299-304. doi: 10.2174/1567202614666170718092010. PMID: 28721811; PMCID: PMC5600856.
- Martens, C. R., Denman, B. A., Mazzo, M. R., et al. Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults Nature Communications. 2018.
- Massudi, H., Grant, R., Braidy, N., Guest, J., Farnsworth, B., & Guillemin, G. J. (2012). Age-associated changes in oxidative stress and NAD+ metabolism in human tissue. PloS one, 7(7), e42357.
- Mendelsohn AR, Larrick JW. The NAD+/PARP1/SIRT1 Axis in Aging. Rejuvenation Res. 2017 Jun;20(3):244-247. doi: 10.1089/rej.2017.1980. PMID: 28537485.
- Nagarajan S, Mohandas S, Ganesan K, Xu B, Ramkumar KM. New insights into dietary pterostilbene: Sources, metabolism, and health promotion effects. Molecules. 2022 Sep 25;27(19):6316.
- Chini CC, Zeidler JD, Kashyap S, Warner G, Chini EN. Evolving concepts in NAD+ metabolism. Cell metabolism. 2021 Jun 1;33(6):1076-87.
- Estrela JM, Ortega A, Mena S, Rodriguez ML, Asensi M. Pterostilbene: biomedical applications. Critical reviews in clinical laboratory sciences. 2013 May 1;50(3):65-78.
Isotonix Magnesium
- Institute of Medicine. Food and Nutrition Board. Dietary Reference Intakes: Calcium, Phosphorus, Magnesium, Vitamin D and Fluoride. National Academy Press. Washington, DC, 1999.
- Wester PO. Magnesium. Am J Clin Nutr. 45:1305-12, 1987.
- Saris NE, Mervaala E, et al. Magnesium: an update on physiological, clinical, and analytical aspects. Clinica Chimica Acta. 294:1-26, 2000.
- Vormann J. Magnesium: nutrition and metabolism. Molecular Aspects of Medicine. 24:27-37, 2003.
- Rude KR. Magnesium metabolism and deficiency. Endocrinol Metab Clin North Am. 22:377-95, 1993.
- Kobrin SM and Goldfarb S. Magnesium Deficiency. Semin Nephrol. 10:525-35, 1990.
- Tucker KL, Hannan MT, Chen H, Cupples LA, Wilson PW, Kiel DP. Potassium, magnesium, and fruit and vegetable intakes are associated with greater bone mineral density in elderly men and women. Am J Clin Nutr. 69(4):727-36, 1999.
- Institute of Medicine. Food and Nutrition Board. Dietary Reference Intakes: Calcium, Phosphorus, Magnesium, Vitamin D and Fluoride. National Academy Press. Washington, DC, 1999.
- New SA et al. Nutritional influences on bone mineral density: a cross-sectional study in premenopausal women. Am J Clin Nutr. 65:1831-9, 1997.
- Gruber H et al. Magnesium deficiency: effect on bone mineral density in the mouse appendicular skeleton. BMC Musculoskelet Disord. 4(1):7, 2003.
- Ryder K et al. Magnesium intake from food and supplements is associated with bone mineral density in healthy older white subjects. J Am Geriatr Soc. 53(11):1875-1880, 2005.
- Rude R et al. Magnesium deficiency and osteoporosis: animal and human observations. J Nutr Biochem. 15(12):710-716, 2004.
- Bilbey, D.L. J., et al. Muscle cramps and magnesium deficiency: case reports. Can Fam Physician. 42:1348-51, 1996.
- Dahle, L. O., et al. The effect of oral magnesium substitution on pregnancy-induced leg cramps. Am J Obstet Gynecol. 173(1):175-180, 1995.
- Saris, N.-E. L., et al. Magnesium: an update on physiological, clinical and analytical aspects. Clinica Chimica Acta. 294:1-26, 2000.
- Serizawa N, Nishimuta M, Kodama N, Shimada M, Yoshitake Y, Hongu N, Ota M, Yano T. Salt Restriction Affects the Excretions of Minerals (Na, K, Ca, Mg, P and Zn) in the Second Voided Fasting Early Morning Urine. J Nutr Sci Vitaminol (Tokyo). 2019;65(2):142-147. doi: 10.3177/jnsv.65.142. PMID: 31061282.
- Yamanaka R, Tabata S, Shindo Y, Hotta K, Suzuki K, Soga T, Oka K. Mitochondrial Mg(2+) homeostasis decides cellular energy metabolism and vulnerability to stress. Sci Rep. 2016 Jul 26;6:30027. doi: 10.1038/srep30027. PMID: 27458051; PMCID: PMC4960558.
- Dmitrašinović G, Pešić V, Stanić D, Plećaš-Solarović B, Dajak M, Ignjatović S. ACTH, Cortisol and IL-6 Levels in Athletes following Magnesium Supplementation. J Med Biochem. 2016 Nov 2;35(4):375-384. doi: 10.1515/jomb-2016-0021. PMID: 28670189; PMCID: PMC5471632
- Yu-Yahiro, J. A. Electrolytes and their relationship to normal and abnormal muscle function. Orthop Nurs. 13(5):38-40, 1994.
- Brilla, L. R., et al. Effect of magnesium supplementation on strength training in humans. J Am Coll Nutr. 11(3):326-329, 1992.
- Sato-Mito N et al. The midpoint of sleep is associated with dietary intake and dietary behavior among young Japanese women. Sleep Med. 12(3):289-94, 2011.
- Saris, N.-E. L., et al. Magnesium: an update on physiological, clinical and analytical aspects. Clinica Chimica Acta. 294:1-26, 2000.
- Huskisson E et al. The influence of micronutrients on cognitive function and performance. J Int Med Res. 35(1):1-19, 2007. Review.
- Inna Slutsky et al. Enhancement of Learning and Memory by Elevating Brain Magnesium. Neuron. 65(2):165-77, 2010.
- Arab A, Rafie N, Amani R, Shirani F. The Role of Magnesium in Sleep Health: a Systematic Review of Available Literature. Biol Trace Elem Res. 2023 Jan;201(1):121-128. doi: 10.1007/s12011-022-03162-1. Epub 2022 Feb 19. PMID: 35184264.
Reviews
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5.0 out of 5 star rating.
(57 reviews)
would recommend this product.
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I feel so good!
Response from Customer Service on 02/25/2025
Thank you for your uplifting review of Core 3 Health! We're thrilled to hear that it's made you feel so good and has truly changed the game for you. Your satisfaction and well-being are our top priorities, and we're delighted to be a part of your positive experience. Thank you for choosing Core 3 Health!
CORE 3 LIFE!
by ANAH
Shop Consultant
on 02/08/2025
Core3 Health regimen has been instrumental in my overall cognitive health, maintaining energy levels throughout my busy schedule & turning back the hands of time as I get close to 60 yrs young!
Response from Customer Service on 02/11/2025
Thank you for your amazing review of Core 3 Health! We’re thrilled to hear that our regimen has been instrumental in supporting your cognitive health, maintaining your energy levels, and helping you feel youthful. Your journey and feedback truly inspire us, and we’re honored to be a part of your daily routine. Thank you for choosing Core 3 Health and for sharing your positive experience with us!
MY PRODUCT REVIEW
by JoachimM
Shop Consultant
on 01/21/2025
I have been using these 3 supplements for months now and really love the amazing results that i have noted. I have been more energized and my skin has been glowing. I have also been sleeping like a baby.
Response from Customer Service on 01/22/2025
Thank you for your fantastic review of Core 3 Health! We're thrilled to hear that you've been enjoying amazing results, including increased energy, glowing skin, and restful sleep. Your positive feedback is immensely appreciated, and we're delighted that our supplements are making a meaningful difference in your daily routine. Thank you for choosing Core 3 Health!
Core 3 Health is a key part of my overall wellness
by JosephM
Shop Consultant
on 12/06/2024
We all know to eat healthy exercise daily but we also need to supplement wisely. Core 3 Heath gives me what I need to feel years younger than I am!
Response from Customer Service on 12/06/2024
Thank you for your wonderful review of nutraMetrix® Core 3 Health! We're delighted to hear that it plays a key role in your overall wellness routine and helps you feel revitalized. It's great to know that you appreciate the importance of supplementing wisely alongside a healthy lifestyle. Your trust and recognition mean a lot to us, and we're honored to support you on your wellness journey. Thank you for choosing Core 3 Health!
Taking care of my health is a priority!
by PaulW
Shop Consultant
on 12/03/2024
I take them every day and I see a difference in my overall health. Won't live without them.
Grateful and Blessed 🙏 ☘️
Response from Customer Service on 12/04/2024
Thank you for your wonderful review of Core 3 Health! We're thrilled to hear about the positive difference it's made on your overall well-being. Knowing that it has become an essential part of your daily routine is incredibly rewarding for us. We're grateful to have you as a valued customer and appreciate your kind words. Thank you for choosing Core 3 Health to support your wellness journey!
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