Gluten-Free - The finished product contains no detectable gluten (<10ppm gluten)

Quality Standards - GMP Operations and Standardized Ingredients

Checked For: Heavy Metals, Microbiological Contaminants, Allergens, Residual Solvents, Potency, Purity and Identity

Curcumin Extreme™ is a supplement that promotes numerous biological functions, including overall liver health and normal production of detoxification enzymes, helping to scavenge toxins in the body that can build up over time. Curcumin Extreme also promotes overall cell integrity, cognitive health, and maintenance of healthy glutathione levels. Glutathione is known as the master antioxidant in the human body that preserves and protects the liver, brain and other body tissues from free radicals. Furthermore, glutathione supports two other powerful antioxidants, vitamins C and E.*

Curcumin Extreme features the patented and significantly researched ingredient, Curcugreen™^†. Scientists have long been aware of the wide array of health benefits from the Indian spice Curcuma longa (common name: turmeric), which is the source of the phytochemical curcumin. In general, most curcumins have poor bioavailability (poor absorption), often requiring high serving sizes or enhancers in order to promote better absorption. Unlike many curcumin products on the market, Curcumin Extreme™ with Curcugreen^†™ provides exceptional bioavailability so you can actively receive maximum benefits.

Curcugreen™ is safe and does not contain any synthetic enhancers.₁ It also delivers a significant amount of bioactive curcumin into the blood and demonstrates high bioavailability. Unlike many of its competitors, Curcugreen™ is a turmeric extract, containing a proprietary blend of curcuminoids and turmeric oils.₁ The AR tumerone^± compound in turmeric supports the bio-activity and absorption of the curcumin in Curcugreen™ without harming the integrity of the product.₁

Curcumin Extreme also includes broccoli seed extract, a powerful source of sulphoraphane glucosinolates. Sulforaphanes support the normal production of phase II liver detoxification enzymes including glutathione synthase, heme-oxygenase and catalase. Glutathione is considered the master antioxidant in the human body that serves to protect the brain and other body tissues from free radicals.

This product is free of these common allergens: gluten, soy, wheat and dairy.

^†Curcugreen™ is a trademark of Arjuna Natural Ltd. CurcuGreen™ was previously sold under the trademark BCM-95®/Bio-curcumax®/Bio-curcumin®.

^±AR-tumerone is a major bioactive compound and the most powerful element of Curcuma longa.

What is curcumin?
Curcumin is present in the spice turmeric and frequently used in Indian food. Its chemical makeup is responsible for the yellow coloring of turmeric and is its most active ingredient. For thousands of years, curcumin was used to promote health in India and other parts of Asia. Curcumin is known for being a powerful antioxidant in addition to offering many other health benefits.*

What is glutathione and why is it important?
Glutathione is an antioxidant made of amino acids that the body produces in the liver. It plays an important part in phase II of the detoxification process, helps protect the body against toxins, combats against free radicals and oxidative stress, and promotes immune health.*

I’ve heard that curcumin’s bioavailability is not high. Does that mean Curcumin Extreme™ will absorb poorly?
Curcumin does in fact have poor bioavailability and is rapidly metabolized – meaning it needs a little help to make the most of its benefits. Curcumin Extreme™ tackles this issue with Curcugreen™^†, a safe, clinically studied ingredient with excellent bioavailability so your body can better reap the health benefits of active curcumin.*

Who should take Curcumin Extreme™?
Anyone 18 years of age or older can take Curcumin Extreme™, especially those who want to support normal liver detoxification activity, help maintain healthy glutathione levels, and promote neurological health and a healthy immune system.*

If you are currently using warfarin (Coumadin®) or other antiplatelet/ anticoagulant, you should not use this product. If you are using any other, prescription drugs or have an ongoing medical condition, consult your healthcare provider before using this product. Women who are pregnant or breastfeeding should not use this product. Keep out of the reach of children. Store in a cool, dry place. Do not use if safety seal is broken or missing.

Can men and women take this product?
Yes. However, women who are pregnant or breastfeeding should not take this product. Also, anyone who is currently using warfarin (Coumadin®) or other antiplatelet/anticoagulant, you should not use this product. If you are using any other, prescription drugs or have an ongoing medical condition, consult your healthcare provider before using this product.

What is the recommended daily serving for Curcumin Extreme?
Take one (1) capsule daily with or without a meal.

When should I start to see/feel the effects of this product? What should I expect?
The antioxidant benefits of curcumin should be noticeable in about four to six weeks. Please remember that everyone’s body is different. For some it may take longer to notice the benefits of curcumin. You should expect to feel better and healthier overall.*

Should I refrain from taking my medications while using Curcumin Extreme™, or can I take both?
If you are currently using warfarin (Coumadin®) or other antiplatelet/anticoagulant, you should not use this product. If you are using any other, prescription drugs or have an ongoing medical condition, consult your healthcare provider before using this product. Your physician can properly advise you about the best course of action regarding your prescription medications. Women who are pregnant or breastfeeding should not use this product.

Are any side effects associated with Curcumin Extreme™?
Side effects are uncommon and are generally limited to mild stomach distress. If you have any concerns, you should speak to your health provider.

Are there any warnings associated with taking Curcumin Extreme™?
If you are currently using warfarin (Coumadin®) or other antiplatelet/anticoagulant, you should not use this product. If you are using any other, prescription drugs or have an ongoing medical condition, consult your healthcare provider before using this product. Women who are pregnant or breastfeeding should not use this product.

Does Curcumin Extreme™ contain any common allergens?
This product is free from these common allergens: soy, wheat, gluten and dairy. 

What other Market America products work well with Curcumin Extreme™?
Due to the multitude of environmental stressors that can cause oxidative stress, leading to multiple free radicals forming, we need a combination of powerful antioxidants to help protect all areas of our bodies. In additional to Curcumin Extreme, Isotonix OPC-3^® is another important antioxidant with multiple benefits to the body. Oligomeric proanthocyanidins (OPCs) are bioflavonoids (complex organic plant compounds) found in fruits, vegetables and certain tree barks that provide exceptional nutritional benefits to the human body. Studies have shown OPCs to be more powerful than vitamin C and vitamin E in neutralizing free radicals.*

Prime™Joint Support Formula by Isotonix® is another product that contains glucosamine, Pycnogenol and hyaluronic acid to help maintain joint comfort and keep joints young. Incorporating Prime Joint Support Formula into your daily regimen can help maintain healthy joint fluidity and flexibility. *

*You should always consult your physician before adding new supplements to your daily routine.

Sources:

1. Arjuna Natural. (n.d.). Curcugreen. Retrieved from http://www.arjunanatural.com/Curcugreen.html.
2. Dickinson, D.A. et al. Curcumin alters EpRE and AP-1 binding complexes and elevates glutamate-cysteine ligase gene expression. The FASEB Journal: 17(3):473-5. doi:10.1096/fj.02-0566fje, 2003
3. Poligone, B. and Baldwin, A. Positive and Negative Regulation of NF-κB by COX-2: Roles of Different Prostaglandins. Journal of Biological Chemistry: 276, 38658-38664. doi: 10.1074/jbc.M106599200, 2001
4. National Center for Biotechnology Information. PubChem Compound Database; CID=105024, https://pubchem.ncbi.nlm.nih.gov/compound/105024

^†Curcugreen™ is a trademark of Arjuna Natural Ltd.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

• Araujo, C. and Leon, L. Biological activities of Curcuma longa L. Memorias do Instituto Oswaldo Cruz. 96(5): 723-728, 2001.
• Biswas, S., et al. Curcumin induces glutathione biosynthesis and inhibits NF-kappaB activation and interleukin-8 release in alveolar epithelial cells: mechanism of free radical scavenging activity. Antioxidants and Redox Signaling. 7(1-2): 32-41, 2005.
• Cheng, Y., et al. Effects of curcumin on peroxisome proliferator-activated receptor gamma expression and nuclear translocation/redistribution in culture-activated rat hepatic stellate cells. Chinese Medical Journal. 120(9): 794-801, 2007.
• Dickinson, D., et al. Curcumin alters EpRE and AP-1 binding complexes and elevates glutamate-cysteine ligase gene expression. FASEB. 17(3): 473-475, 2003.
• Hatcher, H. et al. Curcumin: From ancient medicine to current clinical trials. Cellular and Molecular Life Sciences : CMLS, 65(11), 1631–1652. http://doi.org/10.1007/s00018-008-7452-4, 2008
• Jagetia, G. and Aggarwal, B. "Spicing up" of the immune system by curcumin. Journal of Clinical Immunology. 27(1): 19-35, 2007.
• Kaur, G., et al. Inhibition of oxidative stress and cytokine activity by curcumin in amelioration of endotoxin-induced experimental hepatoxicity in rodents. Clinical and Experimental Immunology. 145(2): 313-321, 2006.
• Kim, G., et al. Curcumin inhibits immunostimulatory function of dendritic cells: MAPKs and translocation of NF-kappa B as potential targets. Journal of Immunology. 174(12): 8116-8124, 2005.
• Lin, J. Molecular targets of curcumin. Advances in Experimental Medicine and Biology. 595: 227-243, 2007.
• Maheshwari, R., et al. Multiple biological activities of curcumin: a short review. Life Sciences. 78(18): 2081-2087, 2006.
• Monograph. Curcuma longa (turmeric). Alternative Medicine Review. 6(suppl): S62-S66, 2001.
• Morimitsu, Y., et al. A sulforaphane analogue that potently activates the Nrf2-dependent detoxification pathway. Journal of Biological Chemistry. 277(5): 3456-3463, 2002.

CURCUMIN EXTREME™

• Helps promote normal cell cycle activity†

• Supports normal liver detoxification activity†

• Helps maintain healthy glutathione levels†

DIETARY SUPPLEMENT

30 Capsules

Other ingredients:

Vegetable capsule, rice flour, magnesium stearate, silicon dioxide.

Gluten Free.

‡ As Curcugreen™. Curcugreen is a registered trademark and patented composition of Arjuna Natural Pvt Ltd.

Directions for use:

Take one capsule dally, with or without a meal.

WARNING:

If you are currently taking warfarin (Coumadin) or other antiplatelet/anticoagulant medications, do not use this product. If you are using any other prescription drugs or have an ongoing medical condition, consult your healthcare provider before using this product. If you are pregnant or breastfeeding, do not use this product.

KEEP OUT OF THE REACH OF CHILDREN.

Keep tightly closed in a cool, dry place. Avoid exposure to excessive heat. Do not use if safety seal is broken or missing.

†These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.