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5 out of 5 star rating. 
Supporting Healthy Blood Flow and Circulation
Isotonix OPC-3® + Curcumin Extreme™
Isotonix OPC-3®
Contains the only isotonic form of Pycnogenol® in the world. Pycnogenol® is a natural plant extract from the bark of the French maritime pine tree and the most clinically researched and potent bioflavonoid.
Curcumin Extreme™
Formulated with Curcugreen™, a turmeric extract containing a proprietary blend of curcuminoids and turmeric oils. It delivers a significant amount of bioactive curcumin into the blood, demonstrating its high bioavailability.
The dynamic combination makes them ideal choices for those looking to support their cardiovascular health or achieve various lifestyle goals, be it fitness or healthy aging.
Vascular Health Power Pair: OPCs & Curcuminoids
Both oligomeric proanthocyanidins (OPCs) from Pycnogenol® and curcuminoids‡ have been studied for their potential benefits on lymphatic drainage. Lymphatic vessels are responsible for carrying excess fluid away from tissues throughout the body and maintaining a proper balance between different parts of the body. Together, OPCs and curcuminoids support effective toxin filtration, working synergistically through the lymphatic system and your body’s natural detoxification organs. Elevate your wellness routine and experience the difference with this vascular health power pair!
Product Classification
Vegan
Gluten-Free
Good Manufacturing Practices
The Perfect Mix for Detox and Antioxidant Support
Experience comprehensive wellness with the dynamic duo of Isotonix OPC-3® and Curcumin Extreme™. Together, these powerful supplements not only support your overall health but also promote healthy circulation by helping maintain a healthy cardiovascular system and oxygen flow. Beyond vascular support, the powerful blend of oligomeric proanthocyanidins (OPCs) and curcuminoids helps neutralize oxidative stress and supports a healthy metabolism and immune system. Enjoy the benefits of healthy vascular filtration, especially crucial as we age and our bodies become less efficient at eliminating waste. Rediscover vitality and support your body from the inside out with promising antioxidant support.
Key Ingredients & Benefits
Curcumin Extreme: Selenium (L-Selenomethionine)*
Helps maintain a healthy immune system
Helps to maintain cognitive health as we age
Isotonix OPC-3: Pycnogenol®¶, Pine Bark Extract*
Supports the normal dilation of blood vessels
Provides complete antioxidant protection
Combats free radicals
Supports a healthy complexion
Promotes healthy sperm quality
Curcumin Extreme: Curcugreen™† (proprietary blend of curcuminoids and turmeric oils)*
Promotes normal immune cell — brain (neuron) interactions to maintain cognitive health
Supports normal glutathione synthesis
Supports normal liver detoxification activity and overall liver health
Helps maintain overall cell integrity
Isotonix OPC-3: Grape Seed Extract & Citrus Extract (Bioflavoniods)*
Helps maintains healthy cholesterol levels
Promotes cardiovascular health
Maintains healthy circulation
Curcumin Extreme: Broccoli Seed Extract (4% Glucosinolates)*
Promotes the normal production of detoxification enzymes
Promotes normal cell cycle activity
Helps maintain healthy glutathione levels
Isotonix OPC-3: Bilberry Extract*
Powerful antioxidant
Supports healthy vision
Maintains healthy circulation
World's Most Powerful Antioxidant
Outperforming any conventional antioxidant on the market, discover this ultimate supplement designed to supercharge health and longevity!
Detoxify Your Body
Experience the transformative benefits of detox with Curcumin Extreme™ — a revolutionary blend of Curcugreen™, broccoli seed extract and selenium. Elevate your overall liver health while optimizing the normal production of detoxification enzymes to efficiently sweep away toxins that accumulate over time. Support your cognitive health and cellular integrity, while also maintaining healthy glutathione levels, essential for robust immune support and vitality.
Frequently Asked Questions
What sets Isotonix OPC-3® apart from other bioflavonoid products?
Isotonix OPC-3® offers OPCs, found to be the most powerful antioxidants for human health. In addition to being powerful antioxidants, these individual OPCs have been shown to provide a myriad of specific health benefits. This science-driven selection of OPCs is unique to OPC-3, as is the Isotonix® delivery system, which enables rapid and highly efficient absorption of the OPCs.*
Why should I take both Isotonix OPC-3 and Curcumin Extreme?
Due to the multitude of environmental stressors that can cause oxidative stress, leading to the formation of multiple free radicals, we need a combination of powerful antioxidants to help protect all areas of our bodies. Curcumin Extreme and Isotonix OPC-3 contain important antioxidants with multiple benefits to the body. OPCs are bioflavonoids (complex organic plant compounds) found in fruits, vegetables and certain tree barks that provide exceptional nutritional benefits to the human body. Studies have shown OPCs to be more powerful than vitamins C and E in neutralizing free radicals.* Curcumin Extreme promotes overall cell integrity and maintenance of healthy glutathione levels. Glutathione, one of the body’s key antioxidants, supports two other powerful antioxidants: vitamins C and E.
What other Market America products work well with The Vascular Detox Combo?
Isotonix® Bromelain Plus, with its unique combination of bromelain, white willow bark and protease, promotes your body’s immune system, helping support the body’s normal ability to heal itself on a cellular and muscular level. Thanks to its unique formula, Isotonix Bromelain Plus helps support your body’s ability to engage in cellular house cleaning, breaking down that protein layer to support your immune system, offering superior cellular support.
I've heard that curcumin's bioavailability is not high. Does that mean Curcumin Extreme will absorb poorly?
Conventional curcumin does in fact have poor bioavailability and is rapidly metabolized — meaning it needs a little help to make the most of its benefits. Curcumin Extreme tackles this issue with Curcugreen™, a safe, clinically studied ingredient with excellent bioavailability and high concentration of curcuminoids at 88%. Curcumin Extreme helps your body better reap the health benefits of active curcumin.
What are the directions for use?
Isotonix OPC-3® — Pour 1 small capful (3.3 g) of powder into a cup. Add 2 fl. oz/60 mL of water for each capful and stir. Enjoy once a day. For maximum absorption, take on an empty stomach.
Curcumin Extreme™ — Take 1 capsule daily, or as directed by your health care practitioner. Curcumin is naturally fat-soluble, so pairing it with food helps support absorption and maximize benefits.
Research Scope
4x
That is four times as concentrated as Curcumin Extreme™'s top competitor in the marketplace.
7x
The Curcugreen™ turmeric extract in Curcumin Extreme™ offers up to seven times higher bioavailability compared to standard curcumin powders.
25
Selenium is vital for over 25 proteins and enzymes, including glutathione peroxidase — one of the body’s most critical antioxidant defense systems — yet it’s missing from most formulas on the market.
4x
The bioavailability of Isotonix OPC-3® compared to a tablet form
558+
Studies on Pycnogenol® and Human Health
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
¶As Pycnogenol®. Pycnogenol is a registered trademark of Horphag Research Ltd. Use of this product may be protected by one or more U.S. patents and other international patents.
†Curcugreen™ is a trademark and patented composition of Arjuna Natural Pvt Ltd.
‡Curcuminoids are compounds in the spice, turmeric. One of these compounds is curcumin, which is the main active ingredient.
AR-tumerone is a major bioactive compound and the most powerful element of Curcuma longa.
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Response from Customer Service on 02/26/2026
非常感謝您的回饋！我們很高興得知血管排毒組合已成為您日常生活中不可或缺的一部分。您的支持對我們意義重大—感謝您成為我們社群的重要成員！
Thank you so much for your feedback! We’re glad to hear that the Vascular Detox Combo has been a valuable part of your routine. Your support means a lot to us—thank you for being a valued member of our community!
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