OPCs for Antioxidant Support
With more staying power than vitamin C and vitamin E
20x
more than vitamin C
50x
more than vitamin E
Oligomeric proanthocyanidins (OPCs) are bioflavonoids (complex organic compounds) found in fruits, vegetables and certain tree barks that provide exceptional nutritional benefits to the human body.
The Super Antioxidant in OPC-3: Pycnogenol®‡
Pycnogenol helps your skin cells maintain peak vitality.
Isotonix OPC-3® Beauty Blend contains the only isotonic form of Pycnogenol® in the world. Pycnogenol® is a plant extract from the bark of the French maritime pine tree and one of the most clinically researched and powerful bioflavonoids; its high polyphenol and antioxidant content helps promote skin health by providing a defense against skin damage and signs of aging.
Product Classification
Dairy Free
Isotonic
Good Manufacturing Practices
Vegetarian
No Detectable GMO
Gluten-Free
Embrace Inner Beauty, Defend Outer Youth
Help improve and maintain the appearance of healthy, beautiful skin with some of the most powerful free radical–scavenging antioxidants known to date, working behind the scenes to defend against damage and signs of aging. The purest and best-researched OPCs chosen for Isotonix OPC-3® Beauty Blend support your skin's ability to regenerate new epidermal cells, making beautiful skin more achievable. Our formulation targets all angles of beauty, from helping to minimize the visual appearance of fine lines and wrinkles to maintaining your inner youth through healthy cellular renewal.
Key Ingredients & Benefits
Pycnogenol®‡, Pine Bark Extract*
Maintains healthy collagen and elastin levels to help preserve the elasticity of skin
Helps support the skin’s natural defenses from harmful environmental pollutants and chemicals
Selectively binds to collagen and promotes the normal production of endothelial nitric oxide
Supports a smooth, soft and even-toned complexion
Hyaluronic Acid (as sodium hyaluronate)*
Promotes healing of minor skin injuries
Supports healthy tissue hydrodynamics, movement and the production of cells
Helps maintain healthy connective tissue and supports joint health
Promotes healthy functioning of the skin at the cellular level, which results in healthy, vibrant-looking skin
Bilberry Extract*
Supports healthy vision and venous circulation
Helps maintain healthy circulation by strengthening capillaries, arteries and veins
Helps maintain overall eye health
Grape Seed Extract & Red Wine Extract*
Helps maintain healthy cholesterol levels
Powerful antioxidants that provide skin with a defense against damage and signs of aging
Biotin*
Helps maintain healthy hair and nails
Promotes an increase in energy levels
Replenishes essential B vitamins that are important cofactors, promoting the normal metabolism of fats, carbohydrates and protein
Citrus Bioflavonoids Complex*
Promotes cardiovascular health and maintains vascular integrity
Helps maintain healthy circulation and cell vitality by strengthening capillaries, arteries and veins
Promotes collagen renewal, which supports firmness of the skin, joint cartilage and connective tissue
Antioxidant Power for Timeless Beauty
Featuring Pycnogenol®, the superstar antioxidant found in OPC-3®, this advanced formula helps the skin combat everyday environmental stressors, such as pollution and chemicals. Unlock smoother, more supple-looking skin and give your complexion the support it needs to look vibrant and refreshed, day after day.
Directions for Use
Pour 2 small capfuls (6.6 g) of Isotonix OPC-3® Beauty Blend powder into your favorite cup.
Add 4 fl oz of water and mix thoroughly.
Drink and enjoy! Maximum absorption occurs when taken on an empty stomach. If mixed with other Isotonix products, add 2 oz of water for each capful.
Isotonix Delivery System
:05 minutes
Isotonix Liquid Vitamins
- Formulated to survive digestion.
- Delivers concentrated nutrients to the site of absorption.
- Contains no fillers or binders.
- No artificial color or flavors.
:40 minutes
Standard Vitamin Tablet
- Contains lab-created coatings and lubricants.
- Often contains artificial colors, nutrients and flavors.
- Limited absorption of nutrient utilization.
Frequently Asked Questions
What other products pair well with Isotonix OPC-3 Beauty Blend?
For skin care, we recommend pairing this product with Lumière De Vie® Cleansing Gel, Lumière De Vie Daily Brightening Broad Spectrum SPF 50 or the Lumière De Vie NAD Creme. For hair products, pair with the Fixx Conditioning Hair Mask or the Fixx Thick Hair Shampoo & Conditioner. For additional supplements, pair Prime™ NAD+, Pure Collagen+ or Isotonix® Multimineral.
Who should take Isotonix OPC-3 Beauty Blend? Do OPCs contain benefits specific to women?
Anyone and everyone! We are constantly in environments that can be quite stressful on the delicate nature of our skin. Everyone should take precautions against the effects of stress, aging and the environment when it comes to maintaining skin health. In clinical trials, some OPCs were shown to help women who suffer from mild pain and cramping during menstruation. When women were supplemented with OPCs starting at least a week before their menstrual period, pain values were found to be significantly lowered. Men may also benefit from taking this product, as it is formulated for anyone interested in maintaining healthy, youthful-looking skin and performing their best.*
I am healthy and athletic; why should I take Isotonix OPC-3 Beauty Blend?
While everyone is vulnerable to the aging process caused by continuous free radical damage, athletes tend to be exposed to elevated levels of oxidative stress. Free radicals develop as byproducts during metabolism when calories are processed with oxygen. Athletes inhale 10 to 20 times more oxygen during physical activity over rest periods. The increase in activity creates additional free radicals, which are known to limit performance, as free radicals can take their toll on muscle tissue. Studies on recreational athletes have shown a 20% increase in endurance with OPCs compared to a control group receiving a placebo. Another study has shown that athletes using OPCs suffered significantly less muscle cramping during and after performing. Isotonix OPC-3 Beauty Blend helps maintain healthy blood flow, supporting oxygen supply to muscles.*
Does OPC-3 have visible benefits or rejuvenating effects?
As OPCs support collagen production in the skin, an increase in smoothness and support of elasticity are the natural results. It requires patience until skin cells have renewed significant amounts of collagen to show visible effects. Such an effect was objectively measured in women aged 40 years and older, in which skin smoothness increased after three months as measured by three-dimensional topography. It is essential to continuously take OPC-3 to maintain skin cell health.* On a short-term basis, many people notice a fresher-looking complexion; this is a result of healthy blood microcirculation, which helps detoxify the skin and support the nutrient supply. The damage caused by free radicals adds up over time. A cause for more worry is the fact that your body's own mechanisms to keep free radicals in check decline with increasing age, when you need them the most. Suddenly, we find ourselves confronted with some typical age-related problems. Some of the body’s cells are more vulnerable to free radicals than others. OPC-3 has the ability to go in and do a knockout job, cleaning and scavenging the free radicals that feast on cellular energy and take it away from vital processes.*
What are bioflavonoids? What sets Isotonix OPC-3 Beauty Blend apart from other bioflavonoid products?
Bioflavonoids are complex organic plant compounds. An increasing number of clinical studies have shown how bioflavonoids support health. Bioflavonoids found in OPCs play a key role in cardiovascular health and maintaining vascular integrity; they have been shown to demonstrate their support for healthy circulation and cell vitality. Normal collagen renewal is promoted, which supports firmness of the skin, joint cartilage and connective tissue. Isotonix OPC-3 offers scientifically supported OPCs, found to be one of the most powerful antioxidants for human health, including grape seed, red wine, bilberries and Pycnogenol®. In addition to being powerful antioxidants, these individual OPCs have been shown to provide a myriad of specific health benefits. The Isotonix delivery system is unique to OPC-3, which enables rapid and highly efficient absorption of the OPCs. The powerful nutrients, in combination with the highly effective delivery system, make OPC-3 the most powerful free radical-scavenging product available.*
Research Scope
558+
Studies on Pycnogenol® and Human Health
100
The number of active compounds found in Red Wine Extract
Reference List
- Devaraj, S., et al. Supplementation with a pine bark extract rich in polyphenols increases plasma antioxidant capacity and alters the plasma lipoprotein profile. Lipids 37:931-4, 2002.
- Fitzpatrick, D., et al. Endothelium-dependent vascular effects of Pycnogenol. Journal of Cardiovascular Pharmacology 32: 509-515, 1998.
- Frankel, E., et al. Inhibition of oxidation of human low-density lipoprotein by phenolic substances in red wine. Lancet 341: 454-7, 1993.
- Freedman, J., et al. Select flavonoids and whole juice from purple grapes inhibit platelet function and enhance nitric oxide release. Circulation 103:2792-8, 2001.
- Frémont, L. Biological effects of resveratrol. Life Sciences 66: 663-673, 2000.
- Miyagi, Y., et al. Inhibition of human low-density lipoprotein oxidation by flavonoids in red wine and grape juice. Am J Cardiol 0:1627-31, 1997.
- Monograph. Vaccinium myrtillus (bilberry). Altern Med Rev 6:500-4, 2001.
- Nuttall SL, Kendall MJ, Bombardelli E, Morazzoni P. An evaluation of the antioxidant activity of a standardized grape seed extract, Leucoselect. J Clin Pharm Ther 23: 385-89, 1998.
- Packer, L., et al. Antioxidant activity and biologic properties of a procyanidin-rich extract from pine (Pinus maritima) bark, pycnogenol. Free Radic Biol Med 27:704-24, 1999. Review.
- Schönlau, F., et al. The cosmeceutical Pycnogenol ® . J Appl Cosmetology 20: 241-6, 2002.
- Segger, D. and Schönlau, F. Supplementation with Evelle ® improves skin smoothness and elasticity in a double blind, placebo-controlled study with 62 women. Journal of Dermatological Treatment 15:222-26, 2004.
- Shi, J., et al. Polyphenolics in grape seeds-biochemistry and functionality. J Med Food 6:291-9, 2003. Review.
- Wallerath, T., et al. Resveratrol, a polyphenolic phytoalexin present in red wine, enhances expression and activity of endothelial nitric oxide synthase. Circulation 106:1652-8, 2002.
- Watson, R. Pycnogenol ® and cardiovascular health. Evidence-Based Integrative Medicine 1: 27-32, 2003.
- Bagchi, D, et al. Oxygen free radical scavenging abilities of vitamins C and E, and a grape seed proanthocyanidin extract in vitro. Res Commun Mol Pathol Pharmacol 95:179-89, 1997.
- Cao G, Alessio H, Cultler R. Oxygen-radical absorbance capacity assay for antioxidants. Fre Rad Biol & Med 14:301-11, 1993.
- Drew B, Leeuwenburgh C. Aging and the role of reactive nitrogen species. Ann NY Acad Sci 959:66-81, 2002.
- Graham DY, Smith JL, Bouvet, AA. What happens to tablets in the stomach. J Pharm Sci 79:420-24, 1990.
- Koparker AD, Augsburger LL, Shangraw RF. Intrinsic dissolution rates of tablet fillers and binders and their influence on the dissolution of drugs from tablet formulations. Pharm Res 7:80-85, 1990.
- Mazza G, Kay CD, Cottrell T, Holub BJ. Absorption of anthocyanins from blueberries and serum antioxidant status in human subjects. J Agric Food Chem 50:7731-37, 2002.
- Soloway MS, Smith RA. J Am Med Assoc 260:1465, 1988.
- Zheng W, Wang SY. Oxygen radical absorbing capacity of phenolics in blueberries, cranberries, chokeberries, and lingonberries. J Agric Food Chem 51:502-9, 2003.
*These statements have not been evaluated by the Food and Drug Administration. This product(s) is not intended to diagnose, treat, cure or prevent any disease.
‡As Pycnogenol®. Pycnogenol is a registered trademark of Horphag Research Ltd. Use of this product may be protected by one or more U.S. patents and other international patents.
Reviews
Customer Rating
4.7 out of 5 star rating.
(67 reviews)
would recommend this product.
- Newest
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This product works wonders as we age! For my over 70’s skin, it made it tighter and younger looking! Even made the fine age lines disappear. No need for magic creams…this product is all you’ll need!
Response from Customer Service on 04/14/2026
Thank you so much for your wonderful review! We're thrilled to hear that Isotonix OPC-3® Beauty Blend has made such a positive change for your skin and that you're enjoying the results. Your feedback and enthusiasm mean a lot to us—thank you for being a valued member of our community!
Wonderful
by Anonymous
on 03/12/2026
Slow delivery but great product
Response from Customer Service on 03/12/2026
Thank you so much for your thoughtful review! We're delighted to hear you love Isotonix OPC-3® Beauty Blend. We appreciate your patience regarding the delivery and value your feedback. Thank you for being a valued member of our community!
Wonderful
by Anonymous
on 03/03/2026
It is fantastic
Response from Customer Service on 03/03/2026
Thank you so much for your wonderful review! We're thrilled to hear that you think Isotonix OPC-3® Beauty Blend is fantastic. Your feedback means a lot to us—thank you for being a valued member of our community!
Who doesn’t want glass skin?
by TashaL
Shop Consultant
on 02/21/2025
Since I started using this product, my skin has transformed from dull to dazzling. It's like a magic potion that really works! 100% recommend
Response from Customer Service on 02/24/2025
Thank you for your amazing review of Isotonix OPC-3® Beauty Blend! We're ecstatic to hear about your skin's transformation from dull to dazzling and that it's working like a magic potion for you. Your 100% recommendation is incredibly rewarding for us, and it's wonderful to be part of your skincare journey. Thank you for choosing Isotonix Beauty Blend and for sharing such fantastic feedback!
60 Is Just A Number
by Anonymous
on 11/10/2024
I will be 60 in 6 months! My skin and hair is incredible and I know it is because I take the Isotonix OPC3 Beauty Blend daily!
Response from Customer Service on 11/11/2024
Thank you for your wonderful review of Isotonix OPC-3® Beauty Blend! We're thrilled to hear that it has contributed to your incredible skin and hair. Your enthusiasm and dedication are truly inspiring. Thank you for including our product in your beauty routine and for sharing your experience with us!
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