Most comprehensive anti-oxidant
5 out of 5 star rating. 
Have Low Energy? Recharge Fast.
In today's nonstop world, it's easy to feel drained — and even harder when stress chips away at your performance.
What Studies Show
Nearly 38% of U.S. workers report low energy or fatigue.*
82% of new parents get 5 hours of sleep or less per night.*
Parents with children 2-12 experience low energy due to work-home balance and time pressures.*
Why Your Energy Is Slipping
This isn't just about a rough night's sleep! Think about how impossible it is to avoid screentime, processed foods, and pollution. And when was the last time you had a relaxing workday? Maybe never! Maybe this seems normal because so many experience it, but the reason behind it all is more disturbing.
So, What is Actually Happening?
Free radicals generated by stress, environmental toxins, and poor diet are causing damage to your very cells. That is what leaving your mind and body feeling sluggish and drained. Over time, this oxidative load slows cellular function, impacts circulation, and even makes it harder for your body to deliver oxygen and nutrients efficiently. When your cells are under stress, your energy tanks — and it shows in your mood, focus, stamina, and even motivation.
The Solution
If you're tired all the time, constantly drinking coffee isn't the answer -- you need something to protect you from free radicals. That's why antioxidants are so important. They help protect cells, support circulation, maintain a healthy heart and give you a surge of energy. And that's why people rave about how they feel when they take the world's most powerful antioxidant: Isotonix OPC-3.
Bestseller for 30 Years
Millions of bottles have sold around the world and people say they feel a difference in their energy levels, fast and long-term. OPC-3 has remained a top performer for three decades because people keep coming back to it. From busy parents to corporate professionals to athletes, customers consistently report feeling more energized, more capable, and more motivated to take on their day. Many say they didn't realize how low their energy was until they felt the difference OPC-3 makes.
tablets
free of binders, fillers, coatings
unknown
formulated to survive digestion
delivered in 5 minutes
95% intestinal nutrient delivery
How OPC-3 Restores Energy:
Isotonix OPC-3 is packed with powerful plant-based antioxidants from grape seed, pine bark, and red wine extract. Research on OPCs show they help the body maintain healthy nitric-oxide levels, which play a key role in circulation. Better circulation means better delivery of oxygen and nutrients to your cells — including the mitochondria that power your energy production. Oxidative stress can strain this process, and the antioxidants in OPC-3 help combat that stress so cells can work more efficiently. When your cells work better, you feel better — clearer, more awake and energized.
Formulated with the Best Ingredients
One of the main ingredients in Isotonix OPC-3 is Pycnogenol®, a natural plant extract from the bark of the French maritime pine tree and the most clinically researched and powerful bioflavonoid! This is the ONLY isotonic form of this ingredient in the world, making OPC-3 the obvious choice for those who want incredible results.
A study on healthy adults showed that Pycnogenol® helped support microcirculation — the delivery system that transports oxygen and nutrients to your cells. Healthy circulation means your body can produce energy more efficiently, helping you feel more awake, more alert, and less run down.* OPCs also help support healthy nitric oxide levels, which further promote blood flow and energy production. Healthy circulation = better energy, period.
Pycnogenol®*
Supports the normal dilation of blood vessels. Provides complete antioxidant.
Grape Seed Extract*
Maintains healthy cholesterol levels.
Bilberry Extract*
Powerful antioxidant. Supports healthy vision. Maintains healthy circulation.
Citrus Extract*
Powerful antioxidant. Supports healthy vision. Maintains healthy circulation.
Red Wine Extract*
Powerful antioxidant. Supports healthy vision. Maintains healthy circulation.
“The difference is night and day”
Start Feeling Like Yourself Again
You deserve to wake up knowing you can actually power through your day — stay alert in meetings, be productive without crashing, and think clearly when deadlines loom.
Low energy doesn't have to be your “new normal.” When you support your cells, your circulation, and your brain, everything changes — your mornings, your mood, your productivity, and your entire day. OPC-3 gives your body what it needs to finally feel energized again.
* These statements have not been evaluated by the Food and Drug Administration. This product(s) is not intended to diagnose, treat, cure or prevent any disease.
‡ As Pycnogenol®. Pycnogenol is a registered trademark of Horphag Research Ltd. Use of this product may be protected by one or more U.S. patents and other international patents.
What People are Saying
Break down of ratings: (305) 5 star ratings. (28) 4 star ratings. (14) 3 star ratings. (4) 2 star ratings. (19) 1 star ratings.
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Nothing beats OPC-3. It should be the4 baseline antioxidant in any formula but this product is the only truly isotonic-capable one that I've seen on the market.
Absolutely Fantastic
5 out of 5 star rating.
Love OPC been taking it for over 25 years.. Of all the supplements I've taken and tried through the years OPC has been the best and I will continue to take it everyday.
Response from Customer Service on 05/28/2026
Thank you for your wonderful review! It’s awesome to know that you have been part of the Isotonix family for over 25 years and still hold the same love and appreciation for Isotonix OPC-3® for Adults & Children Ages 4+ since the beginning. Your continued loyalty and positive experience truly mean a lot to us. Thank you for making Isotonix OPC-3® a trusted part of your daily routine and for being such a valued customer!
OPC3 is an all time lifer product
5 out of 5 star rating.
For over 28 years OPC3 has been our non negotiable supplement. It is the world's most powerful antioxident and has assisted in blessing me with good health.
Thank you Market America!
Response from Customer Service on 05/28/2026
Thank you so much for your wonderful review! It’s inspiring to hear that you’ve made Isotonix OPC-3® for Adults & Children Ages 4+ a non-negotiable part of your routine for over 28 years. Your ongoing loyalty and appreciation mean a great deal to us. Thank you for your kind words and for being a valued part of the Isotonix family, your support truly motivates us every day!
OPC-3
5 out of 5 star rating.
Been using this product for over a decade and I know it has been very beneficial to my overall health, top notch quality and service on all the products from Shop. com, thanks again...
Response from Customer Service on 05/12/2026
Thank you so much for your loyal support and wonderful feedback on Isotonix OPC-3®! We’re delighted to hear you’ve been enjoying the product for over a decade and that you’ve had a great experience with our quality and service. Your trust and satisfaction mean a great deal to us. Thank you for choosing Shop.com and Isotonix® as part of your wellness journey!
25 years and growing!
5 out of 5 star rating.
I have taken this product for 25 years plus and I would rather leave my cell phone at home than to go without this product. Thank me later!
Response from Customer Service on 05/04/2026
Thank you so much for sharing your incredible dedication to Isotonix OPC-3® over the past 25 years! We're honored that you consider it an essential part of your daily routine and appreciate your passion for the product. Your loyalty and enthusiasm mean a lot to us. Thank you for being such a valued member of our community!
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