Unlock the Secret to Healthy Aging
50mg
of the NAD precursor, pterostilbene, which protects the body from the negative effects of free radicals.
5%
myristyl nicotinate to support healthy NAD levels, promoting a youthful, revitalized looking complexion.
Nicotinamide riboside and myristyl nicotinate are both precursors for NAD.

NAD+ Duo: Ready to Radiate from Within?
Don’t just fight aging — work with your biology. Get the NAD+ Duo and give your body a full-spectrum strategy for feeling better, thinking clearer and looking more radiant. Lumiere de Vie® NAD Crème and Prime™ NAD+ are the perfect pair, helping support a natural-looking glow and vibrant health inside and out.

Product Classification

Paraben-Free

Gluten-Free

No Detectable GMO

Vegan

Cruelty Free
Key Ingredients & Benefits

Nicotinamide Riboside (crystalline nicotinamide riboside chloride)*
Supports healthy NAD production
Supports cellular health
Helps maintain healthy levels of ATP production within the cell
Supports healthy cellular metabolism
Helps potentially combat the cellular aging process

Pterostilbene*
May help maintain NAD levels in aging adults
Supports healthy cognitive function
Helps to sustain neurological and cognitive health as we age
Promotes normal activity of the SIRT-1 gene
Protects the body from the negative effects of free radicals

Ginkgo biloba callus culture extract
Used in skincare and cosmetics
Soothes skin redness
Helps reduce appearance of wrinkles
Supports skin moisture

Myristyl nicotinate
Helps rejuvenate skin
Why NAD+ Matters
NAD+ is important to life; it fuels cellular energy, supports DNA health and supports cellular metabolism, but levels decline with age, stress and environmental exposure, leaving you with sluggish energy, dull skin and a body that doesn’t bounce back like it used to. That’s where the NAD+ Duo comes in, helping promote NAD+ levels from the inside out.*
Directions For Use

Morning Routine
Take two capsules of Prime™ NAD+. Apply Lumiere de Vie® NAD+ Crème after putting on serums and before sunscreen.

Evening Routine:
Reapply Lumiere de Vie NAD+ Crème to face and neck to lock in moisture overnight.
Frequently Asked Questions
What are the two factors that play into the continuous replenishment of NAD in the cells?
The consumption and synthesis of NAD are two factors that play into the concentration levels of NAD within cells. There are three pathways responsible for maintaining this balance: the Preiss-Handler pathway, the de novo biosynthesis pathway and the salvage pathway. Each of these pathways works in different ways to help the precursor NR, as well as other NAD precursors, convert into NAD for the body’s cells. The NAD precursor NR is specifically linked to the salvage pathway.
How does Prime NAD+ differ from Heart Health™ Advanced Coenzyme Q10 (Co-Q10) on a cellular level and Awake® Energy Shot on an energy level?
With age, the body produces less Co-Q10. Heart Health Advanced Co-Q10 aids in Co-Q10 production, which helps supply energy to every cell of the human body and promotes cardiovascular health. Awake Energy Shot is formulated with B vitamins and caffeine to provide a quick boost or bump of energy when needed. Prime NAD+ is not a short-lived type of energy supplement; it’s an energy supplement for cellular health.
What are NAD precursors?
Various sources of vitamin B3, including nicotinamide riboside (NR), nicotinic acid (NA), nicotinamide (NAM), nicotinamide mononucleotide (NMN) and tryptophan (Trp), are known as precursors of NAD, meaning they support the production of NAD.
How often should I use Lumiere de Vie NAD Crème?
Lumiere de Vie NAD Crème should be part of your daily routine. Simply apply the product to your face and neck after cleansing and toning. For best results, use twice daily paired with Prime Anti-Aging Nutraceuticals® NAD+.
What skin types can use Lumière de Vie NAD Crème?
Lumière de Vie NAD Crème is suitable for all skin types, including dry, oily, combination and sensitive skin; its balanced formula is designed to nourish without feeling heavy or greasy.
Can Lumière de Vie NAD Crème be layered with other skincare products?
Yes! It’s designed to integrate seamlessly into your existing routine. Apply it after serums and before sunscreen in the morning or as your final step in the evening. It can be used alongside actives like retinol, AHAs or vitamin C. If using strong actives, apply them first and follow with NAD Crème.
NAD+ Duo Research Scope
60%
Pterostilbene is 60% more bioavailable and has a 91-minute longer half-life than resveratrol.
12 weeks
In a 12-week study, myristyl nicotinate has been shown to increase NAD levels in the skin and reduce water loss.
Reference List
- Amjad, S., Nisar, S., Bhat, A. A., Shah, A. R., Frenneaux, M. P., Fakhro, K., Haris, M., Reddy, R., Patay, Z., Baur, J., & Bagga, P. (2021). Role of NAD+ in regulating cellular and metabolic signaling pathways. Molecular metabolism, 49, 101195. https://doi.org/10.1016/j.molmet.2021.101195
- Dellinger, R.W., Santos, S.R., Morris, M. et al. Repeat dose NRPT (nicotinamide riboside and pterostilbene) increases NAD+ levels in humans safely and sustainably: a randomized, double-blind, placebo-controlled study. npj Aging Mech Dis 3, 17 (2017). https://doi.org/10.1038/s41514-017-0016-9
- Covarrubias, A. J., Perrone, R., Grozio, A., & Verdin, E. (2021). NAD+ metabolism and its roles in cellular processes during ageing. Nature reviews. Molecular cell biology, 22(2), 119–141. https://doi.org/10.1038/s41580-020-00313-x
- What is NAD+ and Why Is it Important? (n.d.). Elysium Health. https://www.elysiumhealth.com/blogs/aging101/what-is-nad-and-why-is-it-important
- Clement, J., Wong, M., Poljak, A., Sachdev, P., & Braidy, N. (2019). The Plasma NAD+ Metabolome Is Dysregulated in "Normal" Aging. Rejuvenation research, 22(2), 121–130. https://doi.org/10.1089/rej.2018.2077
- Superfoodly, & Superfoodly. (2021). Pterostilbene supplement benefits: Longevity miracle or hoax. Superfoodly https://superfoodly.com/pterostilbene-supplement-benefits-longevity-miracle-or-hoax/
- ProHealth Longevity. Sirtuins and your health: the. ProHealth.com. https://www.prohealth.com/blogs/control-how-you-age/activate-your-sirtuins
- Bsc, M. W. M. C. (2023). What foods are high in NAD. Satia - Health, Wellness, Nutrition. https://satia.com/blog/nad-why-it-matters-and-where-to-find-it
- Billington RA, Travelli C, Ercolano E, Galli U, Roman CB, Grolla AA, Canonico PL, Condorelli F, Genazzani AA. Characterization of NAD Uptake in Mammalian Cells. THE JOURNAL OF BIOLOGICAL CHEMISTRY. 2008 Mar 7;283(10):6367-74.
- Buonvicino D, Ranieri G, Pittelli M, Lapucci A, Bragliola S, Chiarugi A. SIRT1-dependent restoration of NAD+ homeostasis after increased extracellular NAD+ exposure. Journal of Biological Chemistry. 2021 Jul 1;297(1).
- Christopher R. Martens et al. Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults. Nature Communications volume 9, Article number: 1286 (2018).
- Dellinger RW, Santos SR, Morris M, et al. Repeat dose NRPT (nicotinamide riboside and pterostilbene) increases NAD+ levels in humans safely and sustainably: a randomized, double-blind, placebo-controlled study. NPJ Aging Mech Dis. 2017;3:17.
- Fang, EF, Lautrup, S, Hou, Y, Demarest, TG, Croteau, DL, Mattson, MP, Bohr, VA (2017). NAD+ in Aging: Molecular Mechanisms and Translational Implications. Trends in Molecular Medicine, 23(10), 899-916.
- Martens, C. R., Denman, B. A., Mazzo, M. R., et al. Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults Nature Communications. 2018.
- Massudi, H., Grant, R., Braidy, N., Guest, J., Farnsworth, B., & Guillemin, G. J. (2012). Age-associated changes in oxidative stress and NAD+ metabolism in human tissue. PloS one, 7(7), e42357.
- Mendelsohn AR, Larrick JW. The NAD+/PARP1/SIRT1 Axis in Aging. Rejuvenation Res. 2017 Jun;20(3):244-247. doi: 10.1089/rej.2017.1980. PMID: 28537485.
- Nagarajan S, Mohandas S, Ganesan K, Xu B, Ramkumar KM. New insights into dietary pterostilbene: Sources, metabolism, and health promotion effects. Molecules. 2022 Sep 25;27(19):6316.
- Chini CC, Zeidler JD, Kashyap S, Warner G, Chini EN. Evolving concepts in NAD+ metabolism. Cell metabolism. 2021 Jun 1;33(6):1076-87.
- Estrela JM, Ortega A, Mena S, Rodriguez ML, Asensi M. Pterostilbene: biomedical applications. Critical reviews in clinical laboratory sciences. 2013 May 1;50(3):65-78.
*These statements have not been evaluated by the Food and Drug Administration. This product(s) is not intended to diagnose, treat, cure or prevent any disease.
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