OPCs for Antioxidant Support
With more staying power than vitamin C and vitamin E
20x
more than vitamin C
50x
more than vitamin E
Oligomeric proanthocyanidins (OPCs) are bioflavonoids (complex organic compounds) found in fruits, vegetables and certain tree barks that provide exceptional nutritional benefits to the human body.
The Super Antioxidant in OPC-3, Pycnogenol®‡
Pycnogenol® is a plant extract from the bark of the French maritime pine tree and one of the most clinically researched and powerful bioflavonoids.
Product Classification
Good Manufacturing Practices
Gluten-Free
No Detectable GMO
Vegan
Dairy Free
On-the-Go Antioxidant Support
The combination of these powerful OPCs is unique to OPC-3. OPC-3 Chews provide you with all the benefits of Isotonix OPC-3® in a delicious and convenient soft chew alternative that uses natural flavors, colors and sweeteners. OPC-3 Chews are designed to deliver strong antioxidant defense, as well as a variety of other health benefits, including cardiovascular and immune support, maintenance of joint flexibility and much more.
Key Ingredients & Benefits
Grape Seed Extract*
Maintains healthy cholesterol levels
Red Wine Extract*
Powerful antioxidant
Bilberry Extract*
Powerful antioxidant
Supports healthy vision
Maintains healthy circulation
Citrus Extract (Bioflavaniods)*
Promotes cardiovascular health
Maintains healthy circulation
Pycnogenol®‡, Pine Bark Extract*
Supports the normal dilation of blood vessels
Provides complete antioxidant protection
Combats free radicals
Supports a healthy complexion
Promotes healthy sperm quality
World's Most Powerful Antioxidant
Outperforming any conventional antioxidant on the market, discover this ultimate supplement designed to supercharge for health and longevity!
Frequently Asked Questions
What are OPCs?
OPC-3 Chews include some of the most powerful bioflavonoids, biologically active members of plant-derived compounds, currently known to research scientists. These bioflavonoids are scientifically termed “oligomeric proanthocyanidins,” commonly abbreviated “OPCs.” The best-researched OPCs include grape seed, red wine, grape skin, bilberries, citrus fruit and pine bark extract, or Pycnogenol®†.* This exclusive blend of powerful OPCs delivers comprehensive support for whole-body wellness. OPC-3 helps combat free radicals, support cardiovascular health, promote healthy circulation and maintain healthy cholesterol levels. It also aids joint flexibility, visual acuity, skin health and blood glucose balance — all while supporting nitric oxide levels, blood vessel dilation and even sperm quality.*
What is a free radical?
A free radical is a molecule with an unpaired electron in its outermost shell. These unpaired electrons tend to be highly reactive, resulting in chemical reactions such as oxidation. Because they have one or more unpaired electrons, free radicals are highly unstable. They scavenge the body to grab or donate electrons, impacting cells, proteins and DNA. Free radicals are naturally occurring; however, air pollution, stress, smoking, heavy exercising and aging all contribute to the creation of harmful free radicals. Free radicals can cause oxidative stress in the body. Normally, the body can protect itself from free radicals, but if antioxidants are unavailable or if free radical production becomes excessive, oxidation can occur.
What are antioxidants?
Antioxidants are cell protectors, neutralizing free radicals by donating an electron to the outermost shell of unbalanced molecules, rendering them harmless. Antioxidants are nutrients — like vitamins and minerals — and enzymes that can counteract the effects of the physiological process of oxidation in bodily tissues. Antioxidants work in two ways: chain-breaking and prevention. Some chain-breaking antioxidants include vitamins A, C and E.
What is a bioflavonoid?
Bioflavonoids are complex organic plant compounds. Plants and fruits differ in colors based on the specific bioflavonoids they contain. An increasing number of clinical studies have shown how bioflavonoids support health, with the bioflavonoids found in OPCs playing a key role in cardiovascular health and maintaining vascular integrity. Bioflavonoids have been shown to support healthy circulation and cell vitality. Normal collagen renewal is promoted, which supports firmness of the skin, joint cartilage and connective tissue.
Why should everyone take OPC-3?
Everyone is subject to the impact of free radicals and oxidative stress. Free radicals develop as byproducts of physiological processes that occur within the body. The impacts may add up over the years; this process is largely responsible for the aging process.* OPCs are the most powerful free radical neutralizers, and you get the best of all OPCs by taking OPC-3 Chews. Regular use every day is vital for keeping free radicals in check for a long and healthy life.*
How do OPC-3 Chews compare to Isotonix OPC-3?
A single OPC-3 Chew contains 25 grams of Pycnogenol®† — the same amount in a single serving of our Isotonix OPC-3 product. OPC-3 Chews are a delicious and convenient way to get your OPC-3, perfect for travel or extra busy days.
Research Scope
558+
Studies on Pycnogenol® and Human Health
100
The number of active compounds found in Red Wine Extract
Research Scope
- Devaraj, S., et al. Supplementation with a pine bark extract rich in polyphenols increases plasma antioxidant capacity and alters the plasma lipoprotein profile. Lipids 37:931-4, 2002.
- Fitzpatrick, D., et al. Endothelium-dependent vascular effects of Pycnogenol. Journal of Cardiovascular Pharmacology 32: 509-515, 1998.
- Frankel, E., et al. Inhibition of oxidation of human low-density lipoprotein by phenolic substances in red wine. Lancet 341: 454-7, 1993.
- Freedman, J., et al. Select flavonoids and whole juice from purple grapes inhibit platelet function and enhance nitric oxide release. Circulation 103:2792-8, 2001.
- Frémont, L. Biological effects of resveratrol. Life Sciences 66: 663-673, 2000.
- Miyagi, Y., et al. Inhibition of human low-density lipoprotein oxidation by flavonoids in red wine and grape juice. Am J Cardiol 0:1627-31, 1997.
- Monograph. Vaccinium myrtillus (bilberry). Altern Med Rev 6:500-4, 2001.
- Murias M., et al. Resveratrol analogues as selective cyclooxygenase-2 inhibitors: synthesis and structure-activity relationship. , 2004.
- Nuttall SL, Kendall MJ, Bombardelli E, Morazzoni P. An evaluation of the antioxidant activity of a standardized grape seed extract, Leucoselect. J Clin Pharm Ther 23: 385-89, 1998.
- Packer, L., et al. Antioxidant activity and biologic properties of a procyanidin-rich extract from pine (Pinus maritima) bark, pycnogenol. Free Radic Biol Med 27:704-24, 1999. Review.
- Schönlau, F., et al. The cosmeceutical Pycnogenol®. J Appl Cosmetology 20: 241-6, 2002.
- Shi, J., et al. Polyphenolics in grape seeds-biochemistry and functionality. J Med Food 6:291-9, 2003. Review.
- Watson, R. Pycnogenol® and cardiovascular health. Evidence-Based Integrative Medicine 1: 27-32, 2003.
*These statements have not been evaluated by the Food and Drug Administration. This product(s) is not intended to diagnose, treat, cure or prevent any disease.
‡As Pycnogenol®. Pycnogenol is a registered trademark of Horphag Research Ltd. Use of this product may be protected by one or more U.S. patents and other international patents.
Reviews
Customer Rating
4.9 out of 5 star rating.
(91 reviews)
would recommend this product.
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I've been taking OPC-3 Chews for years. I feel wonderful.
Antioxidants have many benefits. I will be an OPC-3 customer for life.
Response from Customer Service on 05/29/2026
Thank you so much for your fantastic review of OPC-3® Chews! We're thrilled to hear you've been enjoying them for years and feel wonderful. Your passion for antioxidants and loyalty as a lifelong customer mean a lot to us. Thank you for being a valued member of our community!
Love the convenience.
by DebbieF
on 05/28/2026
OPC gummy I love it.
On the go convenience.
Response from Customer Service on 05/28/2026
Thank you so much for sharing your feedback about OPC-3® Chews! We’re glad you enjoy the chew option and find it convenient for your busy lifestyle. Your support is greatly appreciated. Thank you for choosing OPC-3® Chews and being a valued customer!
OPC chews
by ChristopherN
on 04/14/2026
I had gotten these originally for traveling, so I wouldn't need to carry and mix the powdered opc.
These taste good, chew easy and provide the antioxidants same as the powder but travel better.
Response from Customer Service on 04/15/2026
Thank you so much for your wonderful review! We're delighted to hear that OPC-3® Chews have made traveling easier and more convenient for you, while still providing great taste and antioxidant support. Your feedback means a lot to us—thank you for being a valued member of our community!
Best antioxidant in the world
by AidaV
on 02/11/2026
I’ve been using this product for my autistic grandson since 2007, It has worked wonders on him; better concentration, decreased hyperactivity, excellent health.
He was able to finish High School without missing one single day or year. It’s excellent for your joints, heart, immune system ect,etc. The list of benefits is long. Just try it.
Response from Customer Service on 02/11/2026
Thank you so much for sharing your heartfelt review and for your long-term trust in OPC-3® Chews. We’re thrilled to hear about the positive change it has had on your grandson and his overall well-being. Your feedback and personal story mean so much to us, and we’re grateful you’ve made OPC-3® Chews part of your family’s routine. Thank you for being a valued member of our community!
A “Sweet Treat” that is actually good for you
by SHELAHN
Shop Consultant
on 02/05/2026
I have these in my bag every day for 7 years
Love to treat myself to a sweet chew that is good for my mind, body and soul
Thank you for having OPC3 in an easily shared form
Shelah Nealon
Response from Customer Service on 02/05/2026
Thank you so much for your wonderful review! We're thrilled to hear that OPC-3® Chews have been your daily treat for so many years and that you enjoy sharing them with others. Your enthusiasm and continued support truly mean a lot to us. Thank you for making OPC-3® Chews a part of your routine!
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