Best product out there
5 out of 5 star rating. 
Strong Bones & Flexible Joints
200+
The human body has more than 200 bones and more than 200 joints that connect those bones.
21.1%
of Americans above 18 years old reported joint discomfort in a survey conducted in 2019–2021.
Women
reported higher percentages, 20.1% in comparison to men at 16.3%, regarding issues with joint health.
Formulated With the Super Antioxidant, Pycnogenol®‡
Pycnogenol® is a water-soluble, flavonoid complex with powerful benefits. Extracted from the bark of the French Maritime Pine tree, Pycnogenol® has been shown to help maintain the body’s natural defenses by inhibiting metabolic responses associated with the normal aging process. Additionally, studies have shown the ability of Pycnogenol® to cross-link collagen fibers and strengthen connective tissue proteins.
Product Classification
Good Manufacturing Practices
Isotonic
Dairy Free
Gluten-Free
No Detectable GMO
Prime Ingredients for Prime Joints
When choosing a joint health supplement, it’s common to see glucosamine, chondroitin and methylsulfonylmethane (MSM) among the main ingredients. Prime Joint is specifically formulated with hyaluronic acid, which has shown to be more bioavailable than chondroitin and provides the same benefits for tissue hydration, lubrication and cellular function as MSM in lower quantities. The addition of glucosamine and Pycnogenol® supports synovial fluid, cushioning and nourishing your joints and provides antioxidant support, helping your body respond to the effects of normal aging.*
Key Ingredients & Benefits
Pine Bark Extract (Pycnogenol®‡)*
Promotes blood flow and joint comfort associated with the normal aging process
Helps maintain joint comfort
Glucosamine (HCI)*
Supports healthy joint function
Promotes the normal production of synovial fluid
Hyaluronic acid*
Helps maintain strong, healthy cartilage
Promotes the body's healing process
Sodium (bicarbonate)*
Supports endurance and performance
Helps combat exercise fatigue
Potassium (bicarbonate)*
Helps maintain fluid balance
Keep in Your Prime
Help keep your joints young with the only product available delivering glucosamine, Pycnogenol® and hyaluronic acid in isotonic form for maximum absorption of nutrients.
Directions For Use
Pour 2 small capfuls (6.6 g) of Isotonix Prime Joint Support Formula powder into a cup.
Add 4 fl oz of water and mix thoroughly.
Take daily to maintain joint health. If mixed with other Isotonix products, add 2 oz of water for each capful.
Isotonix Delivery System
:05 minutes
Isotonix Liquid Vitamins
- Formulated to survive digestion.
- Delivers concentrated nutrients to the site of absorption.
- Contains no fillers or binders.
- No artificial color or flavors.
:40 minutes
Standard Vitamin Tablet
- Contains lab-created coatings and lubricants.
- Often contains artificial colors, nutrients and flavors.
- Limited absorption of nutrient utilization.
Frequently Asked Questions
What other products should I take with Prime Joint Support Formula by Isotonix to support my joint health?
Heart Health™ Essential Omega III is a great pair with Prime Joint Support Formula, as omega III fatty acids have been shown to support healthy joint lubrication.
How often should I take Prime Joint Support Formula by Isotonix?
This product is most effective when taken daily.
How much Pycnogenol® is in Prime Joint Support Formula by Isotonix?
There are 25 mg of Pycnogenol® in each daily serving.
What is the best way to store this product?
Keep Isotonix stored in a dry, cool place. If Isotonix are stored in the kitchen, keep them away from the stove, sink, heat-generating appliances or window ledges. If you live in a very humid area, you may store Isotonix products in the refrigerator — but not in the fruit and vegetables area.
Prime™ Joint Support Formula by Isotonix® Research Scope
558+
Studies on Pycnogenol® and human health
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
‡As Pycnogenol®. Pycnogenol is a registered trademark of Horphag Research Ltd. Use of this product may be protected by one or more U.S. patents and other international patents.
Reviews
Break down of ratings: (34) 5 star ratings. (7) 4 star ratings. (4) 3 star ratings. (0) 2 star ratings. (3) 1 star ratings.
would recommend this product.
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Great product works great
Response from Customer Service on 05/18/2026
Thank you so much for your positive review of Prime™ Joint Support Formula by Isotonix®! We're thrilled to hear you think it's the best and that it works well for you. Your feedback means a lot to us, and we appreciate your support. Thank you for being a valued customer!
Huge shipping delays
1 out of 5 star rating.
Buyer beware: I strongly advise against ordering from this company. I placed a vitamin order on March 28th, and 35 days later (May 2nd), it still hasn’t arrived. This is the third time I’ve experienced significant delays, and the delivery window continues to worsen with every order.
Great Producdt
5 out of 5 star rating.
It works wonderes
Response from Customer Service on 03/12/2026
Thank you so much for your wonderful review! We're thrilled to hear that Prime™ Joint Support Formula by Isotonix® has worked so well for you. Your feedback means a lot to us—thank you for being a valued member of our community!
Great
5 out of 5 star rating.
Have been taking for over 14 years....It has always worked
Response from Customer Service on 03/03/2026
Thank you so much for your wonderful review! We're truly grateful for your loyalty and thrilled to hear that you've been taking Prime™ Joint Support Formula by Isotonix® for over 14 years. Your continued support and trust mean a lot to us—thank you for being such a valued member of our community!
Prime Joint
5 out of 5 star rating.
Love it!
Response from Customer Service on 06/06/2025
Thank you so much for your enthusiastic review of Prime™ Joint Support Formula by Isotonix®! We're thrilled to hear you’re loving it. Your feedback means a lot to us—thank you for being a valued part of our community!
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